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Specificity of the interaction between phosphatidylinositol 4,5‐bisphosphate and the profilin:actin complex
Abstract
Profilactin, the profiling:actin complex, which is present in large amounts in extracts of many types of eukaryotic cells, appears to serve as the precursor of microfilaments. It was reported recently that profilactin interacts specifically with phosphatidylinositol 4,5‐bisphosphate (PtdIns(4,5)P 2) (Lassing and Lindberg: Nature 314:472–474, 1985.) The present paper describes in detail the behaviour of profilactin and profilin in the presence of different types of phospholipids and neutral lipids under different conditions. PtdIns(4,5)P 2 is the only phospholipid found so far which in the presence of 80 mM KC1 and at Ca 2+ concentrations below 10−5 M effectively dissociates profilactin with the resulting polymerization of the actin. Phosphatidylinositol 4‐monophosphate exhibits some activity but phosphatidylinositol is inactive. Both calf spleen profilin and profilin from human platelets form stable complexes with PtdIns(4,5)P 2 micelles. PtdIns(4,5)P 2 is active also when incorporated together with other phospholipids in mixed vesicles.
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Cited by
Functional significance of cell volume regulatory mechanisms
LANG, F., BUSCH, G. L., RITTER, M., VÖLKL, H., WALDEGGER, S., GULBINS, E., & HÄUSSINGER, D. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.247 · Cited by 1,891
On the Crawling of Animal Cells
Stossel, T. P. (1993) · Science · doi:10.1126/science.8493552 · Cited by 1,011
The structure of crystalline profilin–β-actin
Schutt, C. E., Myslik, J. C., Rozycki, M. D., Goonesekere, N. C. W., & Lindberg, U. (1993) · Nature · doi:10.1038/365810a0 · Cited by 664
Self-citationKapeller, R., & Cantley, L. C. (1994) · BioEssays · doi:10.1002/bies.950160810 · Cited by 638
Regulation of Phospholipase C-γ1 by Profilin and Tyrosine Phosphorylation
Goldschmidt-Clermont, P. J., Kim, J. W., Machesky, L. M., Rhee, S. G., & Pollard, T. D. (1991) · Science · doi:10.1126/science.1848725 · Cited by 527
Metadata
- Authors
- Lassing, I., & Lindberg, U.
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 1988-07
- Volume
- 37
- Issue
- 3
- Pages
- 255-267
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W2167948821
- Cited by
- 164
- References
- 0
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lassing, I., & Lindberg, U. (1988). Specificity of the interaction between phosphatidylinositol 4,5‐bisphosphate and the profilin:actin complex. Journal of Cellular Biochemistry. https://doi.org/10.1002/jcb.240370302
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