The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Role of active and latent transforming growth factor β in bone formation
Abstract
At first reading the statement “TGFβ stimulates bone formation but inhibits mineralization” may appear to be an oxymoron. However, the bone formation process can take weeks to months to complete, and the unique properties of TGFβ allow this factor to be stored in bone matrix in a latent form, ready to be activated and inactivated at key, pivotal stages in this long process. TGFβ may act to trigger the cascade of events that ultimately leads to new bone formation. However, once this process is initiated, TGFβ must then be inactivated or removed because if present in the later stages of bone formation, mineralization will be inhibited. The unique properties of TGFβ and its role in bone remodeling are the subject of this review. © 1994 Wiley‐Liss, Inc.
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Kulkarni, A. B., Huh, C. G., Becker, D., Geiser, A., Lyght, M., Flanders, K. C., Roberts, A. B., Sporn, M. B., Ward, J. M., & Karlsson, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.770 · Cited by 1,967
Osteoclast synthesis and secretion and activation of latent transforming growth factor β
Oursler, M. J. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650090402 · Cited by 153
Breen, E. C., Ignotz, R. A., McCabe, L., Stein, J. L., Stein, G. S., & Lian, J. B. (1994) · Journal of Cellular Physiology · doi:10.1002/jcp.1041600214 · Cited by 138
Cited by
Alliston, T., Choy, L., Ducy, P., Karsenty, G., & Derynck, R. (2001) · The EMBO Journal · doi:10.1093/emboj/20.9.2254 · Cited by 526
Modeling the interactions between osteoblast and osteoclast activities in bone remodeling
Lemaire, V., Tobin, F. L., Greller, L. D., Cho, C. R., & Suva, L. J. (2004) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2004.03.023 · Cited by 452
Growth factors for bone growth and repair: IGF, TGFβ and BMP
Linkhart, T. A., Mohan, S., & Baylink, D. J. (1996) · Bone · doi:10.1016/s8756-3282(96)00138-x · Cited by 440
Jian, B., Narula, N., Li, Q.-Y., Mohler, E. R., & Levy, R. J. (2003) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(02)04312-6 · Cited by 438
Karsdal, M. A., Fjording, M. S., Foged, N. T., Delaissé, J.-M., & Lochter, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008738200 · Cited by 81
Metadata
- Authors
- Bonewald, L. F., & Dallas, S. L.
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 1994-07
- Volume
- 55
- Issue
- 3
- Pages
- 350-357
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W2005201208
- Cited by
- 298
- References
- 3
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bonewald, L. F., & Dallas, S. L. (1994). Role of active and latent transforming growth factor β in bone formation. Journal of Cellular Biochemistry. https://doi.org/10.1002/jcb.240550312
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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