TGF‐β‐induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

TGF-β SIGNAL TRANSDUCTION

Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,571 · see citing works

Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80257-3 · Cited by 4,246 · see citing works

Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R. T., Gao, Y.-H., Inada, M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80258-5 · Cited by 4,244 · see citing works

TGF-β signalling from cell membrane to nucleus through SMAD proteins

Heldin, C., Miyazono, K., & ten Dijke, P. (1997) · Nature · doi:10.1038/37284 · Cited by 3,697 · see citing works

Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development

Otto, F., Thornell, A., Crompton, T., Denzel, A., Gilmour, K. C., Rosewell, I. R., Stamp, G., Beddington, R. S. P., Mundlos, S., Olsen, B. R., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80259-7 · Cited by 2,813 · see citing works

Transcriptional control by the TGF‐β/Smad signaling system

Massagué, J., & Wotton, D. (2000) · The EMBO Journal · doi:10.1093/emboj/19.8.1745 · Cited by 1,969 · see citing works

Direct binding of Smad3 and Smad4 to critical TGFβ‐inducible elements in the promoter of human plasminogen activator inhibitor‐type 1 gene

Dennler, S., Itoh, S., Vivien, D., ten Dijke, P., Huet, S., & Gauthier, J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.3091 · Cited by 1,793 · see citing works

Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia

Mundlos, S., Otto, F., Mundlos, C., Mulliken, J. B., Aylsworth, A. S., Albright, S. G., Lindhout, D., Cole, W. G., Henn, W., Knoll, J. H. M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80260-3 · Cited by 1,502 · see citing works

Transcriptional Activators of TGF-β Responses: Smads

Derynck, R., Zhang, Y. E., & Feng, X. (1998) · Cell · doi:10.1016/s0092-8674(00)81696-7 · Cited by 1,035 · see citing works

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

Lagna, G., Hata, A., Hemmati‐Brivanlou, A., & Massagué, J. (1996) · Nature · doi:10.1038/383832a0 · Cited by 905 · see citing works

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

Zhang, Y. E., Feng, X., Wu, R.-Y., & Derynck, R. (1996) · Nature · doi:10.1038/383168a0 · Cited by 873 · see citing works

Runx2 Is a Common Target of Transforming Growth Factor β1 and Bone Morphogenetic Protein 2, and Cooperation between Runx2 and Smad5 Induces Osteoblast-Specific Gene Expression in the Pluripotent Mesenchymal Precursor Cell Line C2C12

Lee, K., Kim, H., Li, Q., Chi, X., Ueta, C., Komori, T., Wozney, J. M., Kim, E., Choi, J.-Y., Ryoo, H., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8783-8792.2000 · Cited by 867 · see citing works

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

Zhang, Y., Feng, X.-H., & Derynck, R. (1998) · Nature · doi:10.1038/29814 · Cited by 809 · see citing works

A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic developmentPreprint

Ducy, P. F., Starbuck, M., Priemel, M., Shen, J., Pinero, G. J., Geoffroy, V., Amling, M., & Karsenty, G. (1999) · Genes & Development · doi:10.1101/gad.13.8.1025 · Cited by 772 · see citing works

Two Distinct Osteoblast-Specific cis-Acting Elements Control Expression of a Mouse Osteocalcin Gene

Ducy, P. F., & Karsenty, G. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.4.1858 · Cited by 570 · see citing works

Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia

Lee, B., Thirunavukkarasu, K., Zhou, L., Pastore, L., Baldini, A., Hecht, J. T., Geoffrey, V., Ducy, P. F., & Karsenty, G. (1997) · Nature Genetics · doi:10.1038/ng0797-307 · Cited by 567 · see citing works

A Smad Transcriptional Corepressor

Wotton, D., Lo, R. S., Lee, S., & Massagué, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80712-6 · Cited by 554 · see citing works

Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro.

Robey, P. G., Young, M. F., Flanders, K. C., Roche, N. S., Kondaiah, P., Reddi, A. H., Termine, J. D., Sporn, M. B., & Roberts, A. B. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.105.1.457 · Cited by 550 · see citing works

Signaling of transforming growth factor‐β family members through Smad proteins

Itoh, S., Itoh, F., Goumans, M., & ten Dijke, P. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01828.x · Cited by 530 · see citing works

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activationPreprint

Feng, X., Zhang, Y. E., Wu, R.-Y., & Derynck, R. (1998) · Genes & Development · doi:10.1101/gad.12.14.2153 · Cited by 525 · see citing works

TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300Preprint

Janknecht, R., Wells, N. J., & Hunter, T. R. (1998) · Genes & Development · doi:10.1101/gad.12.14.2114 · Cited by 507 · see citing works

Transforming Growth Factor-β Gene Family Members and Bone*

Horowitz, M. C., Wozney, J. M., & McCarthy, T. L. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-1-27 · Cited by 496 · see citing works

Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor β-Mediated Signal Transduction

Datto, M., Frederick, J. P., Pan, L., Borton, A. J., Zhuang, Y., & Wang, X. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2495 · Cited by 472 · see citing works

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signalingPreprint

Luo, K., Stroschein, S. L., Wang, W., Chen, D. Y., Martens, E., Zhou, S., & Zhou, Q. (1999) · Genes & Development · doi:10.1101/gad.13.17.2196 · Cited by 468 · see citing works

Cbfa1 Isoforms Exert Functional Differences in Osteoblast Differentiation

Harada, H., Tagashira, S., Fujiwara, M., Ogawa, S., Katsumata, T., Yamaguchi, A., Komori, T., & Nakatsuka, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.11.6972 · Cited by 451 · see citing works

Interaction and Functional Cooperation of PEBP2/CBF with Smads

Hanai, J.-I., Chen, L. F., Kanno, T., Ohtani‐Fujita, N., Kim, W. Y., Guo, W.-H., Imamura, T., Ishidou, Y., Fukuchi, M., Shi, M.-J., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.44.31577 · Cited by 445 · see citing works

A functional interaction between the histone deacetylase Rpd3 and the corepressor Groucho in Drosophila developmentPreprint

Chen, G., Fernandez, J., Mische, S. M., & Courey, A. J. (1999) · Genes & Development · doi:10.1101/gad.13.17.2218 · Cited by 444 · see citing works

Convergence of Transforming Growth Factor-β and Vitamin D Signaling Pathways on SMAD Transcriptional Coactivators

Yanagisawa, J., Yanagi, Y., Masuhiro, Y., Suzawa, M., Watanabe, M., Kashiwagi, K., Toriyabe, T., Kawabata, M., Miyazono, K., & Kato, S. (1999) · Science · doi:10.1126/science.283.5406.1317 · Cited by 443 · see citing works

Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-β and Wnt pathways

Labbé, E., Letamendı́a, A., & Attisano, L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.150152697 · Cited by 442 · see citing works

Regulation of Smad Activity

Wrana, J. L. (2000) · Cell · doi:10.1016/s0092-8674(00)81556-1 · Cited by 421 · see citing works

Roles of Bone Morphogenetic Protein Type I Receptors and Smad Proteins in Osteoblast and Chondroblast Differentiation

Fujii, M., Takeda, K., Imamura, T., Aoki, H., Sampath, T. K., ENOMOTO, S., Kawabata, M., Kato, M., Ichijo, H., & Miyazono, K. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.11.3801 · Cited by 411 · see citing works

Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF‐β

Feng, X., Lin, X., & Derynck, R. (2000) · The EMBO Journal · doi:10.1093/emboj/19.19.5178 · Cited by 397 · see citing works

Role of Smad Proteins and Transcription Factor Sp1 in p21Waf1/Cip1 Regulation by Transforming Growth Factor-β

Pardali, K., Kurisaki, A., Morén, A., ten Dijke, P., Kardassis, D., & Moustakas, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909467199 · Cited by 392 · see citing works

Differential Roles for Bone Morphogenetic Protein (BMP) Receptor Type IB and IA in Differentiation and Specification of Mesenchymal Precursor Cells to Osteoblast and Adipocyte Lineages

Chen, D., Ji, X., Harris, M. A., Feng, J. Q., Karsenty, G., Celeste, A. J., Rosen, V., Mundy, G. R., & Harris, S. E. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.1.295 · Cited by 382 · see citing works

Role of the α2-Integrin in Osteoblast-specific Gene Expression and Activation of the Osf2 Transcription Factor

Xiao, G., Wang, D., Benson, M. D., Karsenty, G., & Franceschi, R. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32988 · Cited by 376 · see citing works

c-Ski Acts as a Transcriptional Co-repressor in Transforming Growth Factor-β Signaling through Interaction with Smads

Akiyoshi, S., Inoue, H., Hanai, J., Kusanagi, K., Nemoto, N., Miyazono, K., & Kawabata, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.35269 · Cited by 373 · see citing works

The oncoprotein Evi-1 represses TGF-β signalling by inhibiting Smad3

Kurokawa, M., Mitani, K., Irie, K., Matsuyama, T., Takahashi, T., Chiba, S., Yazaki, Y., Matsumoto, K., & Hirai, H. (1998) · Nature · doi:10.1038/27945 · Cited by 371 · see citing works

Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype.

Erlebacher, A., & Derynck, R. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.132.1.195 · Cited by 371 · see citing works

The t(8;21) Fusion Protein Interferes with AML-1B-Dependent Transcriptional Activation

Meyers, S., Lenny, N., & Hiebert, S. W. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.4.1974 · Cited by 368 · see citing works

Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells

Liu, X., Sun, Y., Constantinescu, S. N., Karam, E., Weinberg, R. A., & Lodish, H. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10669 · Cited by 356 · see citing works

Cbfa1 Contributes to the Osteoblast-specific Expression of type I collagen Genes

Kern, B., Shen, J. J., Starbuck, M. W., & Karsenty, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006215200 · Cited by 353 · see citing works

ATF-2 Is a Common Nuclear Target of Smad and TAK1 Pathways in Transforming Growth Factor-β Signaling

Sano, Y., Harada, J., Tashiro, S., Goto‐Mandeville, R., Maekawa, T., & Ishii, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8949 · Cited by 345 · see citing works

Positive and negative regulation of TGF-β signaling

Miyazono, K. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.7.1101 · Cited by 341 · see citing works

A RUNX2/PEBP2 αA/ CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia

Zhang, Y., Yasui, N., Ito, K., Huang, G., Fujii, M., Hanai, J., Nogami, H., Ochi, T., Miyazono, K., & Ito, Y. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.180309597 · Cited by 332 · see citing works

Smads bind directly to the Jun family of AP-1 transcription factors

Liberati, N. T., Datto, M., Frederick, J. P., Shen, X., Wong, C., Rougier-Chapman, E. M., & Wang, X. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.4844 · Cited by 327 · see citing works

Roles of Autocrine TGF-β Receptor and Smad Signaling in Adipocyte Differentiation

Choy, L., Skillington, J., & Derynck, R. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.3.667 · Cited by 323 · see citing works

The genetic transformation of bone biologyPreprint

Karsenty, G. (1999) · Genes & Development · doi:10.1101/gad.13.23.3037 · Cited by 307 · see citing works

Transforming Growth Factor-β Stimulates the Production of Osteoprotegerin/Osteoclastogenesis Inhibitory Factor by Bone Marrow Stromal Cells

Takai, H., Kanematsu, M., Yano, K., Tsuda, E., Higashio, K., Ikeda, K., Watanabe, K., & Yamada, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.42.27091 · Cited by 299 · see citing works

Role of active and latent transforming growth factor β in bone formation

Bonewald, L. F., & Dallas, S. L. (1994) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240550312 · Cited by 297 · see citing works

Differentiation of Human Marrow Stromal Precursor Cells: Bone Morphogenetic Protein-2 Increases OSF2/CBFA1, Enhances Osteoblast Commitment, and Inhibits Late Adipocyte Maturation

Gori, F., Thomas, T., Hicok, K. C., Spelsberg, T. C., & Riggs, B. L. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.9.1522 · Cited by 294 · see citing works

Synergistic cooperation of TFE3 and Smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 genePreprint

Hua, X., Liu, X., Ansari, D. O., & Lodish, H. F. (1998) · Genes & Development · doi:10.1101/gad.12.19.3084 · Cited by 283 · see citing works

Ultrastructural analysis of bone nodules formed in vitro by isolated fetal rat calvaria cells

Bhargava, U., Bar-Lev, M., Bellows, C. G., & Aubin, J. E. (1988) · Bone · doi:10.1016/8756-3282(88)90005-1 · Cited by 279 · see citing works

Human Transforming Growth Factor- β3: Recombinant Expression, Purification, and Biological Activities in Comparison with Transforming Growth Factors-β 1 and -β2

Graycar, J. L., Miller, D. A., Arrick, B. A., Lyons, R. M., Moses, H. L., & Derynck, R. (1989) · Molecular Endocrinology · doi:10.1210/mend-3-12-1977 · Cited by 266 · see citing works

Interaction of the Ski Oncoprotein with Smad3 Regulates TGF-β Signaling

Sun, Y., Liu, X., Eaton, E. N., Lane, W. S., Lodish, H. F., & Weinberg, R. A. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80201-4 · Cited by 263 · see citing works

Two Domains Unique to Osteoblast-Specific Transcription Factor Osf2/Cbfa1 Contribute to Its Transactivation Function and Its Inability To Heterodimerize with Cbfβ

Thirunavukkarasu, K., Mahajan, M., McLarren, K. W., Stifani, S., & Karsenty, G. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4197 · Cited by 252 · see citing works

Groucho-Dependent and -Independent Repression Activities of Runt Domain Proteins

Aronson, B. D., Fisher, A. L., Blechman, K. M., Caudy, M. A., & Gergen, J. P. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.5581 · Cited by 251 · see citing works

The Tissue-Specific Nuclear Matrix Protein, NMP-2, Is a Member of the AML/PEBP2/Runt Domain Transcription Factor Family: Interactions with the Osteocalcin Gene Promoter

Merriman, H. L., van Wijnen, A. J., Hiebert, S. W., Bidwell, J. P., Fey, E. G., Lian, J. B., Stein, J. L., & Stein, G. S. (1995) · Biochemistry · doi:10.1021/bi00040a025 · Cited by 247 · see citing works

Regulation of Smad signalling by protein associations and signalling crosstalk

Zhang, Y. E., & Derynck, R. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01579-2 · Cited by 243 · see citing works

Osteoblastic Responses to TGF-β during Bone Remodeling

Erlebacher, A., Filvaroff, E. H., Ye, J., & Derynck, R. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.7.1903 · Cited by 234 · see citing works

Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBFα/AML/PEBP2α) dependent activation of tissue-specific gene transcription

Javed, A., Guo, B., Hiebert, S. W., Choi, J., Green, J., Zhao, S.-C., Osborne, M. A., Stifani, S., Stein, J. L., Lian, J. B., et al. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.12.2221 · Cited by 232 · see citing works

Antagonistic Regulation of Type I Collagen Gene Expression by Interferon-γ and Transforming Growth Factor-β

Ghosh, A. K., Yuan, W., Mori, Y., Chen, S.-J., & Varga, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m004709200 · Cited by 225 · see citing works

The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression.

Desbois, C., Hogue, D. A., & Karsenty, G. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42240-x · Cited by 222 · see citing works

Skeletal Growth Factors

CANALIS, E. M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-375098-3.50020-2 · Cited by 208 · see citing works

Induction of interferon-γ production in Th1 CD4+ T cells: evidence for two distinct pathways for promoter activation

Yang, J., Murphy, T. L., Ouyang, W., & MURPHY, K. M. M. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199902)29:02 · Cited by 195 · see citing works

Ascorbic Acid-Dependent Activation of the Osteocalcin Promoter in MC3T3-E1 Preosteoblasts: Requirement for Collagen Matrix Synthesis and the Presence of an Intact OSE2 Sequence

Xiao, G., Cui, Y., Ducy, P. F., Karsenty, G., & Franceschi, R. T. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.8.9955 · Cited by 194 · see citing works

The Osteoblast-specific Transcription Factor Cbfa1 Contributes to the Expression of Osteoprotegerin, a Potent Inhibitor of Osteoclast Differentiation and Function

Thirunavukkarasu, K., Halladay, D., Miles, R. R., Yang, X., Galvin, R. J. S., Chandrasekhar, S., Martin, T. J., & Onyia, J. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000322200 · Cited by 181 · see citing works

CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor β transcriptional responses in endothelial cells

Topper, J. N., DiChiara, M. R., Brown, J. D., Williams, A. J., Falb, D., Collins, T., & Gimbrone, M. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9506 · Cited by 180 · see citing works

Differential effects of translational inhibition in cis and in trans on the decay of the unstable yeast MFA2 mRNA

Beelman, C. A., & Parker, R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36937-5 · Cited by 173 · see citing works

Tumor Necrosis Factor-α Inhibits Transforming Growth Factor-β /Smad Signaling in Human Dermal Fibroblasts via AP-1 Activation

Verrecchia, F., Pessah, M., Atfi, A., & Mauviel, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005310200 · Cited by 170 · see citing works

A PEBP2α/AML-1-related Factor Increases Osteocalcin Promoter Activity through Its Binding to an Osteoblast-specific cis-Acting Element

Geoffroy, V., Ducy, P. F., & Karsenty, G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.52.30973 · Cited by 169 · see citing works

An AML-1 consensus sequence binds an osteoblast-specific complex and transcriptionally activates the osteocalcin gene.

Banerjee, C., Hiebert, S. W., Stein, J. L., Lian, J. B., & Stein, G. S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4968 · Cited by 164 · see citing works

Complementation between kinase‐defective and activation‐defective TGF‐beta receptors reveals a novel form of receptor cooperativity essential for signaling.

Weis‐Garcia, F., & Massagué, J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00358.x · Cited by 158 · see citing works

Reduction in Transforming Growth Factor β Receptor I Expression and Transcription Factor CBFa1 on Bone Cells by Glucocorticoid

Chang, D. J., Ji, C., Kim, K. K., Casinghino, S. R., & McCarthy, T. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.4892 · Cited by 157 · see citing works

Specificity in transforming growth factor β-induced transcription of the plasminogen activator inhibitor-1 gene: Interactions of promoter DNA, transcription factor μE3, and Smad proteins

Hua, X., Miller, Z., Wu, G., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13130 · Cited by 155 · see citing works

Transforming Growth Factor-β (TGF-β)-induced Down-regulation of Cyclin A Expression Requires a Functional TGF-β Receptor Complex

Feng, X., Filvaroff, E. H., & Derynck, R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.41.24237 · Cited by 155 · see citing works

Localization of Smads, the TGF-β Family Intracellular Signaling Components During Endochondral Ossification

Sakou, T., Onishi, T., Yamamoto, T., Nagamine, T., Sampath, T. K., & ten Dijke, P. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.7.1145 · Cited by 150 · see citing works

Smad and AML Proteins Synergistically Confer Transforming Growth Factor β1 Responsiveness to Human Germ-line IgA Genes

Pardali, E., Xie, X., Tsapogas, P., Itoh, S., Arvanitidis, K. I., Heldin, C., ten Dijke, P., Grundström, T., & Sideras, P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3552 · Cited by 148 · see citing works

A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction.

Kim, R. H., Wang, D., Tsang, M., Martin, J. M., Huff, C., de Caestecker, M. P., Parks, W. T., Meng, X., Lechleider, R. J., Wang, T., et al. (2000) · PubMed Central · Cited by 133 · see citing works

Potential Role of Cbfa1, an Essential Transcriptional Factor for Osteoblast Differentiation, in Osteoclastogenesis: Regulation of mRNA Expression ofOsteoclast Differentiation Factor(ODF)

Gao, Y., Shinki, T., Yuasa, T., Kataoka-Enomoto, H., Komori, T., Suda, T., & Yamaguchi, A. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9643 · Cited by 131 · see citing works

Follicle Stimulating Hormone-Regulated Expression of Serum/Glucocorticoid-Inducible Kinase in Rat Ovarian Granulosa Cells: A Functional Role for the Sp1 Family in Promoter Activity

Alliston, T. N., Maiyar, A. C., Buse, P., Firestone, G. L., & Richards, J. S. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.13.0033 · Cited by 130 · see citing works

Transcriptional Regulation of the Transforming Growth Factor-β-inducible Mouse Germ Line Ig α Constant Region Gene by Functional Cooperation of Smad, CREB, and AML Family Members

Zhang, Y. E., & Derynck, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001526200 · Cited by 130 · see citing works

1,25-Dihydroxyvitamin D3 Inhibits Osteocalcin Expression in Mouse through an Indirect Mechanism

Zhang, R., Ducy, P. F., & Karsenty, G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.1.110 · Cited by 112 · see citing works

Transcriptional Regulation of Osteocalcin Production by Transforming Growth Factor-β in Rat Osteoblast-Like Cells

Noda, M. (1989) · Endocrinology · doi:10.1210/endo-124-2-612 · Cited by 111 · see citing works

Structural and Functional Characterization of the Transforming Growth Factor-β-induced Smad3/c-Jun Transcriptional Cooperativity

Qing, J., Zhang, Y. E., & Derynck, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004731200 · Cited by 110 · see citing works

E1A Inhibits Transforming Growth Factor-β Signaling through Binding to Smad Proteins

Nishihara, A., Hanai, J., Imamura, T., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28716 · Cited by 108 · see citing works

Ligand-independent Activation of Transforming Growth Factor (TGF) β Signaling Pathways by Heteromeric Cytoplasmic Domains of TGF-β Receptors

Feng, X., & Derynck, R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.22.13123 · Cited by 108 · see citing works

CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter.

Shi, M. J., & Stavnezer, J. (1998) · PubMed · Cited by 105 · see citing works

Functional Hierarchy between Two OSE2 Elements in the Control of Osteocalcin Gene Expression in Vivo

Frendo, J., Xiao, G., Fuchs, S., Franceschi, R. T., Karsenty, G., & Ducy, P. F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.46.30509 · Cited by 104 · see citing works

Immortalized murine osteoblasts derived from BMP 2-T-antigen expressing transgenic mice.

Ghosh‐Choudhury, N., Windle, J. J., Koop, B. A., et al. (1996) · Endocrinology · doi:10.1210/endo.137.1.8536632 · Cited by 95 · see citing works

Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements

Lin, Y. C., & Stavnezer, J. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.9.2914 · Cited by 94 · see citing works

c-Jun Inhibits Transforming Growth Factor β-mediated Transcription by Repressing Smad3 Transcriptional Activity

Dennler, S., Prunier, C., Ferrand, N., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910358199 · Cited by 86 · see citing works

Smad2 Overexpression Enhances Smad4 Gene Expression and Suppresses CBFA1 Gene Expression in Osteoblastic Osteosarcoma ROS17/2.8 Cells and Primary Rat Calvaria Cells

Li, J., Tsuji, K., Komori, T., Miyazono, K., Wrana, J. L., Ito, Y., Nifuji, A., & Noda, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.31009 · Cited by 55 · see citing works

TGF-β Signaling in Tumor Suppression and Cancer Progression

Derynck, R., Akhurst, R. J., & Balmain, A. (2001) · Nature Genetics · doi:10.1038/ng1001-117 · Cited by 2,275 · see citing works

Specificity, versatility, and control of TGF-β family signaling

Derynck, R., & Budi, E. H. (2019) · Science Signaling · doi:10.1126/scisignal.aav5183 · Cited by 785 · see citing works

Transforming Growth Factor-β1 to the Bone

Janssens, K., ten Dijke, P., Janssens, S., & Van Hul, W. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0001 · Cited by 710 · see citing works

Bone remodeling: an operational process ensuring survival and bone mechanical competence

Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482 · see citing works

Modeling the interactions between osteoblast and osteoclast activities in bone remodeling

Lemaire, V., Tobin, F. L., Greller, L. D., Cho, C. R., & Suva, L. J. (2004) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2004.03.023 · Cited by 452 · see citing works

Transforming growth factor‐β in stem cells and tissue homeostasis

Xu, X., Zheng, L., Yuan, Q., Zhen, G., Crane, J. L., Zhou, X., & Cao, X. (2018) · Bone Research · doi:10.1038/s41413-017-0005-4 · Cited by 414 · see citing works

TGF-β inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3

Liu, D., Black, B. L., & Derynck, R. (2001) · Genes & Development · doi:10.1101/gad.925901 · Cited by 399 · see citing works

Transforming Growth Factor-β Inhibits Adipocyte Differentiation by Smad3 Interacting with CCAAT/Enhancer-binding Protein (C/EBP) and Repressing C/EBP Transactivation Function

Choy, L., & Derynck, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212259200 · Cited by 343 · see citing works

Cell–Matrix Interactions in the Pathobiology of Calcific Aortic Valve Disease: Critical Roles for Matricellular, Matricrine, and Matrix Mechanics Cues

Chen, J.-H., & Simmons, C. A. (2011) · Circulation Research · doi:10.1161/circresaha.110.234237 · Cited by 289 · see citing works

Age-related molecular genetic changes of murine bone marrow mesenchymal stem cells

Wilson, A., Shehadeh, L. A., Yu, H., & Webster, K. A. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-229 · Cited by 135 · see citing works

High-Dose TGF-β1 Impairs Mesenchymal Stem Cell–Mediated Bone Regeneration via Bmp2 Inhibition

Xu, J., Liu, J., Gan, Y., Dai, K., Zhao, J., Huang, M., Huang, Y., Zhuang, Y., & Zhang, X. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3871 · Cited by 68 · see citing works

Bone Marrow Mesenchymal Stromal Cells in Multiple Myeloma: Their Role as Active Contributors to Myeloma Progression

Maiso, P., Mogollón, P., Ocio, E. M., & Garayoa, M. (2021) · Cancers · doi:10.3390/cancers13112542 · Cited by 48 · see citing works

The Osteocyte Transcriptome Is Extensively Dysregulated in Mouse Models of Osteogenesis Imperfecta

Zimmerman, S. M., Dimori, M., Heard‐Lipsmeyer, M. E., & Morello, R. (2019) · JBMR Plus · doi:10.1002/jbm4.10171 · Cited by 41 · see citing works

Irisin reduces bone fracture by facilitating osteogenesis and antagonizing TGF-β/Smad signaling in a growing mouse model of osteogenesis imperfecta

Sun, B., Wu, H., Lu, J., Zhang, R., Shen, X., Gu, Y., Shi, C., Zhang, Y., & Yuan, W. (2023) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2022.10.012 · Cited by 28 · see citing works

The Zebrafish - Cellular and Developmental Biology, Part B Developmental Biology

(2016) · Methods in cell biology · doi:10.1016/s0091-679x(16)x0004-0 · Cited by 3 · see citing works

Developmental Biology

Trainor, P. A. (2016) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2015.11.029 · Cited by 30 · see citing works

LHX6 is essential for the migration of human pluripotent stem cell-derived GABAergic interneurons

Yuan, F., Fang, K.-H., Hong, Y., Xu, S., Xu, M., Pan, Y., & Liu, Y. (2020) · Protein & Cell · doi:10.1007/s13238-019-00686-6 · Cited by 16 · see citing works

Expression of hyaluronan synthases upregulated by thyroid hormone is involved in intestinal stem cell development during Xenopus laevis metamorphosis

Fujimoto, K., Hasebe, T., Kajita, M., et al. (2018) · Development Genes and Evolution · doi:10.1007/s00427-018-0623-x · Cited by 5 · see citing works

Developmental biology, the stem cell of biological disciplines

Gilbert, S. F. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2003691 · Cited by 36 · see citing works