Cited by 469Cancer, Hypoxia, and MetabolismRedox biology and oxidative stressNitric Oxide and Endothelin Effects

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Regulation of Hypoxia-Inducible Factor-1a by Reactive Oxygen Species : New Developments in an Old Debate

Movafagh, Shahrzad, Crook, Sean, Vo, Kim·2015·Journal of Cellular Biochemistry

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Abstract

Hypoxia-Inducible Factor-1 (HIF-1) has been largely studied for its role in cell survival in hypoxic conditions. The regulation of HIF-1 is a complex process and involves a number of molecules and pathways. Among these mechanisms a direct regulatory role of reactive oxygen species (ROS) on HIF-1 alpha subunit has received a great deal of attention and the existing body of literature includes many contradictory findings. Other intermediates such as nitric oxide (NO), specific microRNAs (miR), and transcriptional and post-translational modification have also been implicated as players in ROS mediated HIF-1a regulation. The focus of this review is to present the past conflicting evidence along with more recent findings in order to relate various aspects of this complex process. Aside from the direct role of ROS on HIF-1a regulation under hypoxia and normoxia, we analyzed the effect of different sources and concentrations of NO and the interplay between superoxide (SO) and NO in this process. We also present findings on transcriptional and translational regulation of HIF-1a via ROS and the interplay with microRNAs in this process. This review further provides insight on ERK and PI3K/AKT signaling as a common mechanism relating several pathways of ROS mediated HIF-1a regulation. Ultimately further research and discovery regarding HIF-1 regulation by oxidative stress is warranted for better understanding of disease development and potential therapeutics for pathologies such as canc…

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Nitric Oxide Induces Hypoxia-inducible Factor 1 Activation That Is Dependent on MAPK and Phosphatidylinositol 3-Kinase Signaling
Kasuno, K., Takabuchi, S., Fukuda, K., Kizaka‐Kondoh, S., Yodoi, J., Adachi, T., Semenza, G. L., & Hirota, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308197200 · Cited by 226
Retracted
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia
Chandel, N. S., McClintock, D. S., Feliciano, C. E., Wood, T. M., Melendez, J. A., Rodriguez, A. M., & Schumacker, P. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001914200 · Cited by 2,000
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
Chandel, N. S., Maltepe, E., Goldwasser, E., Mathieu, C. E., Simon, M. C., & Schumacker, P. T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11715 · Cited by 1,926
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
Guzy, R. D., Hoyos, B., Robin, E., Chen, H., Liu, L., Mansfield, K. D., Simon, M. C., Hammerling, U., & Schumacker, P. T. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.001 · Cited by 1,545
Hydroxylation of HIF-1: Oxygen Sensing at the Molecular Level
Semenza, G. L. (2004) · Physiology · doi:10.1152/physiol.00001.2004 · Cited by 923
Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation
Brunelle, J. K., Bell, E. L., Quesada, N. M., Vercauteren, K., Tiranti, V., Zeviani, M., Scarpulla, R. C., & Chandel, N. S. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.002 · Cited by 763
Hypoxia-Inducible mir-210 Regulates Normoxic Gene Expression Involved in Tumor Initiation
Huang, X., Ding, L., Bennewith, K. L., Tong, R. T., Welford, S. M., Ang, K. K., Story, M. D., Le, Q., & Giaccia, A. J. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.006 · Cited by 634
The Mitochondrial Production of Reactive Oxygen Species: Mechanisms and Implications in Human Pathology
Lenaz, G. (2001) · IUBMB Life · doi:10.1080/15216540152845957 · Cited by 585

Show all 50 references

Research works printed but not linked: 2

Brüne, 2007, Methods in enzymology, 463
Hagen, 2012, Oxygen versus Reactive Oxygen in the Regulation of HIF-1: The Balance Tips, Biochem Res Int, e436981

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Authors: Movafagh, S., Crook, S., & Vo, K.
Affiliations: Shenandoah University (US)
Corresponding author: Movafagh, Shahrzad
ORCID: Movafagh, Shahrzad
Venue: Journal of Cellular Biochemistry
Publisher: Wiley
Published: 2015-03-09
Volume: 116
Issue: 5
Pages: 696-703
ISSN: 0730-2312 (ISSN-L)
DOI: 10.1002/jcb.25074
OpenAlex: W1899746275
Cited by: 469
References: 50
Citations by year: 2026: 23 · 2025: 42 · 2024: 39 · 2023: 56 · 2022: 56 · 2021: 66 · 2020: 54 · 2019: 39 · 2018: 29 · 2017: 31 · 2016: 22 · 2015: 12
FWCI: 2.10
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 176 d)
Locations: Journal of Cellular Biochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: hypoxia-inducible factor-1α, reactive oxygen species, nitric oxide, superoxide, microRNA, post-translational modification, transcriptional regulation, ERK signaling, PI3K/Akt signaling, oxidative stress, hypoxia, ischemia-reperfusion injury, cancer
MeSH terms: Humans, Mitochondria, Nitric Oxide, Superoxides, Signal Transduction, Cell Hypoxia, Reactive Oxygen Species, Phosphatidylinositol 3-Kinases, MAP Kinase Signaling System, MicroRNAs, Proto-Oncogene Proteins c-akt, Hypoxia-Inducible Factor 1, alpha Subunit

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Regulation of Hypoxia-Inducible Factor-1a by Reactive Oxygen Species : New Developments in an Old Debate

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