Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression
Abstract
Reactive oxygen species (ROS) have long been considered as cytotoxic. However, recent evidence indicates a prominent role of ROS as signaling molecules in the response to hormones, growth and coagulation factors, cytokines and other factors as well as to changes in oxygen tension. The hypoxia-inducible transcription factors (HIFs) are key players in the cellular response to changes in oxygen tension. Recently, HIFs have also been shown to respond to the above-mentioned non-hypoxic stimuli. In this article, the role of ROS in the regulation of HIF-1 under hypoxic and non-hypoxic conditions is summarized.
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NOX-derived ROS modulate HIF transcriptional activity and target gene expression, directly linking redox signaling to hypoxia-responsive genetic programs.
“Work by Görlach, Kietzmann, and colleagues demonstrated that NOX-derived ROS modulate HIF transcriptional activity and target gene expression, directly linking redox signaling to hypoxia-responsive genetic programs [152,205].”
From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [205]
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“Work by G ¨ orlach, Kietzmann, and colleagues demonstrated that NOX-derived ROS modulate HIF transcriptional activity and target gene expression, directly linking redox signaling to hypoxia-responsive genetic programs [152,205].”
- Authors
- Kietzmann, T., & Görlach, A.
- Affiliations
- University of Kaiserslautern (DE)
- Deutsches Herzzentrum München (DE)
- Corresponding author
- Görlach, Agnes
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2005-08
- Volume
- 16
- Issue
- 4-5
- Pages
- 474-486
- ISSN
- 1084-9521 (ISSN-L)
- OpenAlex
- W1999335215
- Cited by
- 295
- References
- 17
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 5 · 2023: 12 · 2022: 9 · 2021: 19 · 2020: 13 · 2019: 12 · 2018: 14 · 2017: 13 · 2016: 11 · 2015: 13 · 2014: 13 · 2013: 16 · 2012: 13
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Funders
- European Commission
- Deutsche Forschungsgemeinschaft
- Deutsche Krebshilfe
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- reactive oxygen species, hypoxia-inducible factor, HIF-1, hypoxia, gene expression regulation, oxygen sensing, redox signaling, transcriptional regulation
- MeSH terms
- Animals, Hypoxia, Gene Expression Regulation, Humans, Signal Transduction, Reactive Oxygen Species, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit
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