Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., & Denko, N. C. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.012 · Cited by 2,267 · see citing works

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase

Selak, M. A., Armour, S. M., MacKenzie, E. D., Boulahbel, H., Watson, D. G., Mansfield, K. D., Pan, Y., Simon, M. C., Thompson, C. B., & Gottlieb, E. (2005) · Cancer Cell · doi:10.1016/j.ccr.2004.11.022 · Cited by 2,108 · see citing works

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia

Chandel, N. S., McClintock, D. S., Feliciano, C. E., Wood, T. M., Melendez, J. A., Rodriguez, A. M., & Schumacker, P. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001914200 · Cited by 2,000 · see citing works

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

Chandel, N. S., Maltepe, E., Goldwasser, E., Mathieu, C. E., Simon, M. C., & Schumacker, P. T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11715 · Cited by 1,926 · see citing works

Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

Lando, D., Peet, D. J., Whelan, D. A., Gorman, J. J., & Whitelaw, M. L. (2002) · Science · doi:10.1126/science.1068592 · Cited by 1,558 · see citing works

Untitled work

(2000) · PubMed · Cited by 1,445 · see citing works

An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis

Birsoy, K., Wang, T., Chen, W. W., Freinkman, E., Abu-Remaileh, M., & Sabatini, D. M. (2015) · Cell · doi:10.1016/j.cell.2015.07.016 · Cited by 1,388 · see citing works

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

Mahon, P. C., Hirota, K., & Semenza, G. L. (2001) · Genes & Development · doi:10.1101/gad.924501 · Cited by 1,385 · see citing works

Hypoxic control of metastasis

Rankin, E. B., & Giaccia, A. J. (2016) · Science · doi:10.1126/science.aaf4405 · Cited by 1,340 · see citing works

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

Semenza, G. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67230 · Cited by 1,335 · see citing works

HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression

Laughner, E., Taghavi, P., Chiles, K., Mahon, P. C., & Semenza, G. L. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.12.3995-4004.2001 · Cited by 1,256 · see citing works

Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin

Hudson, C. C., Liu, M., Chiang, G. G., Otterness, D. M., Loomis, D. C., Kaper, F., Giaccia, A. J., & Abraham, R. T. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.20.7004-7014.2002 · Cited by 1,186 · see citing works

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

Wheaton, W. W., Weinberg, S. E., Hamanaka, R. B., Soberanes, S., Sullivan, L. B., Anso, E., Glasauer, A., Dufour, E., Mutlu, G. M., Budigner, G. S., et al. (2014) · eLife · doi:10.7554/elife.02242 · Cited by 1,105 · see citing works

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.

Ravi, R. K., Mookerjee, B., Bhujwalla, Z. M., Sutter, T. R., Artemov, D., Zeng, Q., Dillehay, L. E., Madan, A., Semenza, G. L., & Bedi, A. (2000) · PubMed Central · Cited by 1,099 · see citing works

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α

Ravi, R., Mookerjee, B., Bhujwalla, Z. M., Sutter, C. H., Artemov, D., Zeng, Q., Dillehay, L. E., Madan, A., Semenza, G. L., & Bedi, A. (2000) · Genes & Development · doi:10.1101/gad.14.1.34 · Cited by 967 · see citing works

Hypoxia-Inducible Factors: Master Regulators of Cancer Progression

Schito, L., & Semenza, G. L. (2016) · Trends in Cancer · doi:10.1016/j.trecan.2016.10.016 · Cited by 962 · see citing works

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

Faubert, B., Boily, G., Izreig, S., Griss, T., Samborska, B., Dong, Z., Dupuy, F., Chambers, C., Fuerth, B. J., Viollet, B., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.001 · Cited by 901 · see citing works

Hydroxylation of HIF-1: Oxygen Sensing at the Molecular Level

Semenza, G. L. (2004) · Physiology · doi:10.1152/physiol.00001.2004 · Cited by 901 · see citing works

Loss of <i>PTEN</i> facilitates HIF-1-mediated gene expression

Zundel, W., Schindler, C., Haas-Kogan, D., Koong, A., Kaper, F., Chen, E., Gottschalk, A. R., Ryan, H. E., Johnson, R. S., Jefferson, A. B., et al. (2000) · Genes &amp; Development · doi:10.1101/gad.14.4.391 · Cited by 840 · see citing works

Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effect in Carcinogenesis

Lu, H., Forbes, R. A., & Verma, A. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202487200 · Cited by 839 · see citing works

Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.

Ryan, H. E., Poloni, M., McNulty, W., Elson, D., Gassmann, M., Arbeit, J. M., & Johnson, R. S. (2000) · PubMed · Cited by 786 · see citing works

Transcriptional regulation by hypoxia inducible factors

Dengler, V. L., Galbraith, M. D., & Espinosa, J. M. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.838205 · Cited by 774 · see citing works

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

Brunelle, J. K., Bell, E. L., Quesada, N. M., Vercauteren, K., Tiranti, V., Zeviani, M., Scarpulla, R. C., & Chandel, N. S. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.002 · Cited by 763 · see citing works

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

Koivunen, P., Lee, S., Duncan, C. G., Lopez, G., Lu, G., Ramkissoon, S., Losman, J. A., Joensuu, P., Bergmann, U., Gross, S., et al. (2012) · Nature · doi:10.1038/nature10898 · Cited by 727 · see citing works

Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α

Hagen, T., Taylor, C. T., Lam, F., & Moncada, S. (2003) · Science · doi:10.1126/science.1088805 · Cited by 704 · see citing works

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1α-degradative pathway

Isaacs, J. S., Jung, Y.-J., Mimnaugh, E. G., Martinez, A., Cuttitta, F., & Neckers, L. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204733200 · Cited by 663 · see citing works

SUMO-Specific Protease 1 Is Essential for Stabilization of HIF1α during Hypoxia

Cheng, J., Kang, X., Zhang, S., & Yeh, E. T. H. (2007) · Cell · doi:10.1016/j.cell.2007.08.045 · Cited by 624 · see citing works

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

Xu, Q., Briggs, J., Park, S., Niu, G., Kortylewski, M., Zhang, S., Gritsko, T., Turkson, J., Kay, H. D., Semenza, G. L., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208719 · Cited by 576 · see citing works

Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators

Déry, M.-A. C., Michaud, M. D., & Richard, D. E. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.08.012 · Cited by 545 · see citing works

AMPK maintains cellular metabolic homeostasis through regulation of mitochondrial reactive oxygen species

Rabinovitch, R. C., Samborska, B., Faubert, B., Ma, E. H., Gravel, S.-P., Andrzejewski, S., Raissi, T. C., Pause, A., St.-Pierre, J., & Jones, R. G. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.026 · Cited by 543 · see citing works

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis

Sonveaux, P., Copetti, T., De Saedeleer, C. J., Végran, F., Verrax, J., Kennedy, K. M., Moon, E. J., Dhup, S., Danhier, P., Frérart, F., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033418 · Cited by 536 · see citing works

RACK1 Competes with HSP90 for Binding to HIF-1α and Is Required for O2-Independent and HSP90 Inhibitor-Induced Degradation of HIF-1α

Liu, Y. V., Baek, J. H., Zhang, H., Diez, R., Cole, R. N., & Semenza, G. L. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.001 · Cited by 477 · see citing works

Regulation of Hypoxia-Inducible Factor-1a by Reactive Oxygen Species : New Developments in an Old Debate

Movafagh, S., Crook, S., & Vo, K. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25074 · Cited by 469 · see citing works

miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity

Puisségur, M.-P., Mazure, N. M., Bertero, T., Pradelli, L. A., Grosso, S., Robbe-Sermesant, K., Maurin, T., Lebrigand, K., Cardinaud, B., Hofman, V., et al. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.119 · Cited by 422 · see citing works

Induction of Hypoxia-inducible Factor-1α by Transcriptional and Translational Mechanisms

Pagé, E. L., Robitaille, G., Pouysségur, J., & Richard, D. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209114200 · Cited by 385 · see citing works

Cell-Permeating <i>α</i> -Ketoglutarate Derivatives Alleviate Pseudohypoxia in Succinate Dehydrogenase-Deficient Cells

MacKenzie, E. D., Selak, M. A., Tennant, D. A., Payne, L. J., Crosby, S., Frederiksen, C. M., Watson, D. G., & Gottlieb, E. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01927-06 · Cited by 359 · see citing works

HIF-1 regulation: not so easy come, easy go

Koh, M. Y., Spivak-Kroizman, T. R., & Powis, G. (2008) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2008.08.002 · Cited by 339 · see citing works

Hypoxia-Inducible Factor-1α Is a Key Regulator of Metastasis in a Transgenic Model of Cancer Initiation and Progression

Liao, D., Corle, C., Seagroves, T. N., & Johnson, R. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2701 · Cited by 339 · see citing works

Multiple Factors Affecting Cellular Redox Status and Energy Metabolism Modulate Hypoxia-Inducible Factor Prolyl Hydroxylase Activity In Vivo and In Vitro

Pan, Y., Mansfield, K. D., Bertozzi, C. C., Rudenko, V., Chan, D. A., Giaccia, A. J., & Simon, M. C. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01223-06 · Cited by 332 · see citing works

Generating specificity and diversity in the transcriptional response to hypoxia

Lendahl, U., Lee, K. L., Yang, H. H., & Poellinger, L. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2665 · Cited by 330 · see citing works

Induction of HIF‐1α expression by intermittent hypoxia: Involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR

Yuan, G., Nanduri, J., Khan, S. A., Semenza, G. L., & Prabhakar, N. R. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21537 · Cited by 310 · see citing works

Modeling the Genetic Regulation of Cancer Metabolism: Interplay between Glycolysis and Oxidative Phosphorylation

Yu, L., Lu, M., Jia, D., Ma, J., Ben‐Jacob, E., Levine, H., Kaipparettu, B. A., & Onuchic, J. N. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2074 · Cited by 272 · see citing works

Regulation of Angiogenesis by Hypoxia and Hypoxia‐Inducible Factors

Hickey, M. M., & Simon, M. C. (2006) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(06)76007-0 · Cited by 268 · see citing works

Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells

Jung, S., Yang, W. K., Kim, J., Kim, H. S., Kim, E. J., Yun, H., Park, H., Kim, S. S., Choe, W., Kang, I., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn032 · Cited by 246 · see citing works

Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation

Hubbi, M. E., Hu, H., Gupta, K., Ahmed, I., Levchenko, A., & Semenza, G. L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.414771 · Cited by 239 · see citing works

BAY 87‐2243, a highly potent and selective inhibitor of hypoxia‐induced gene activation has antitumor activities by inhibition of mitochondrial complex I

Ellinghaus, P., Heisler, I., Unterschemmann, K., Haerter, M., Beck, H., Greschat, S., Ehrmann, A., Summer, H., Flamme, I., Oehme, F., et al. (2013) · Cancer Medicine · doi:10.1002/cam4.112 · Cited by 230 · see citing works

UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α

Goto, Y., Zeng, L., Yeom, C. J., Zhu, Y., Morinibu, A., Shinomiya, K., Kobayashi, M., Hirota, K., Itasaka, S., Yoshimura, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms7153 · Cited by 229 · see citing works

MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines

Grosso, S., Doyen, J., Parks, S. K., Bertero, T., Paye, A., Cardinaud, B., Gounon, P., Lacas‐Gervais, S., Noël, A., Pouysségur, J., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.71 · Cited by 216 · see citing works

Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis

Kim, Y., Nam, H. J., Lee, J., Park, D. Y., Kim, C., Yu, Y. S., Kim, D., Park, S. W., Bhin, J., Hwang, D., et al. (2016) · Nature Communications · doi:10.1038/ncomms10347 · Cited by 212 · see citing works

The Role of Mitochondria in the Regulation of Hypoxia-inducible Factor 1 Expression during Hypoxia

Agani, F. H., Pichiule, P., Chavez, J. C., & LaManna, J. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005643200 · Cited by 210 · see citing works

Reactive oxygen species and HIF-1 signalling in cancer

Galanis, Α., Pappa, A., Giannakakis, A., Lanitis, E., Laniti, D. D., & Sandaltzopoulos, R. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.02.028 · Cited by 207 · see citing works

mTOR and HIF-1α-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome

Shackelford, D. B., Vasquez, D. S., Corbeil, J., Wu, S., Leblanc, M., Wu, C., Vera, D. R., & Shaw, R. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900465106 · Cited by 204 · see citing works

Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

Vaux, E. C., Metzen, E., Yeates, K. M., & Ratcliffe, P. J. (2001) · Blood · doi:10.1182/blood.v98.2.296 · Cited by 198 · see citing works

Vanadate-induced Expression of Hypoxia-inducible Factor 1α and Vascular Endothelial Growth Factor through Phosphatidylinositol 3-Kinase/Akt Pathway and Reactive Oxygen Species

Gao, N., Ding, M., Zheng, J. Z., Zhang, Z., Leonard, S. S., Liu, K. J., Shi, X., & Jiang, B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200082200 · Cited by 190 · see citing works

Stabilization of Hypoxia-inducible Factor-1α Protein in Hypoxia Occurs Independently of Mitochondrial Reactive Oxygen Species Production

Chua, Y. L., Dufour, E., Dassa, E. P., Rustin, P., Jacobs, H. T., Taylor, C. T., & Hagen, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.158485 · Cited by 189 · see citing works

Redox regulation of the hypoxia-inducible factor

Pouysségur, J., & Mechta-Grigoriou, F. (2006) · Biological Chemistry · doi:10.1515/bc.2006.167 · Cited by 186 · see citing works

AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer

Hardie, D. G. (2011) · Biochemical Society Transactions · doi:10.1042/bst0390001 · Cited by 177 · see citing works

Signal Transducer and Activator of Transcription 3 Is Required for Hypoxia-Inducible Factor-1α RNA Expression in Both Tumor Cells and Tumor-Associated Myeloid Cells

Niu, G., Briggs, J., Deng, J., Ma, Y., Lee, H., Kortylewski, M., Kujawski, M., Kay, H. D., Cress, W. D., Jove, R., et al. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-2177 · Cited by 177 · see citing works

Hypoxia-Inducible Factors (HIFs) and Phosphorylation: Impact on Stability, Localization, and Transactivity

Kietzmann, T., Mennerich, D., & Dimova, E. Y. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00011 · Cited by 176 · see citing works

RACK1 vs. HSP90: Competition for HIF-1α Degradation vs. Stabilization

Liu, Y. V., & Semenza, G. L. (2007) · Cell Cycle · doi:10.4161/cc.6.6.3981 · Cited by 162 · see citing works

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions

Burr, S. P., Costa, A. S. H., Grice, G. L., Timms, R. T., Lobb, I. T., Freisinger, P., Dodd, R. B., Dougan, G., Lehner, P. J., Frezza, C., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.015 · Cited by 155 · see citing works

Reactive Oxygen Species-generating Mitochondrial DNA Mutation Up-regulates Hypoxia-inducible Factor-1α Gene Transcription via Phosphatidylinositol 3-Kinase-Akt/Protein Kinase C/Histone Deacetylase Pathway

Koshikawa, N., Hayashi, J.-I., Nakagawara, A., & Takenaga, K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.054221 · Cited by 147 · see citing works

Calcineurin Promotes Hypoxia-inducible Factor 1α Expression by Dephosphorylating RACK1 and Blocking RACK1 Dimerization

Liu, Y. V., Hubbi, M. E., Pan, F., McDonald, K. R., Mansharamani, M., Cole, R. N., Liu, J. O., & Semenza, G. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705015200 · Cited by 146 · see citing works

Inborn and acquired metabolic defects in cancer

Frezza, C., Pollard, P. J., & Gottlieb, E. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0728-4 · Cited by 146 · see citing works

Oxygen Sensing and HIF-1 Activation Does Not Require an Active Mitochondrial Respiratory Chain Electron-transfer Pathway

Srinivas, V., Leshchinsky, I., Sang, N., King, M. P., Minchenko, О. H., & Caro, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100177200 · Cited by 143 · see citing works

Myc Posttranscriptionally Induces HIF1 Protein and Target Gene Expression in Normal and Cancer Cells

Doe, M. R., Ascano, J. M., Kaur, M., & Cole, M. D. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-2371 · Cited by 142 · see citing works

The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation

Yan, M., Gingras, M., Dunlop, E. A., Nouët, Y., Dupuy, F., Jalali, Z., Possik, E., Coull, B. J., Kharitidi, D., Dydensborg, A. B., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci71749 · Cited by 134 · see citing works

Targeting Heat Shock Protein 90 Overrides the Resistance of Lung Cancer Cells by Blocking Radiation-Induced Stabilization of Hypoxia-Inducible Factor-1α

Kim, W., Oh, S. H., Woo, J. K., Hong, W. K., & Lee, H. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-0505 · Cited by 131 · see citing works

Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact

Doege, K., Heine, S., Jensen, I., Jelkmann, W., & Metzen, E. (2005) · Blood · doi:10.1182/blood-2005-03-1138 · Cited by 128 · see citing works

SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation

Seo, K.-S., Park, J.-H., Heo, J. Y., Jing, K., Han, J., Min, K.-N., Kim, C., Koh, G. Y., Lim, K., Kang, G.-Y., et al. (2014) · Oncogene · doi:10.1038/onc.2014.76 · Cited by 126 · see citing works

Learning from oncocytic tumors: Why choose inefficient mitochondria?

Gasparre, G., Romeo, G. C., Rugolo, M., & Porcelli, A. M. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.08.006 · Cited by 125 · see citing works

The genetic and metabolic signature of oncocytic transformation implicates HIF1α destabilization

Porcelli, A. M., Ghelli, A. M., Ceccarelli, C., Lang, M., Cenacchi, G., Capristo, M., Pennisi, L. F., Morra, I., CICCARELLI, E., Melcarne, A., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp566 · Cited by 121 · see citing works

Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death

Tennant, D. A., Frezza, C., MacKenzie, E. D., Nguyen, Q., Zheng, L., Selak, M. A., Roberts, D. L., Dive, C., Watson, D. G., Aboagye, E. O., et al. (2009) · Oncogene · doi:10.1038/onc.2009.250 · Cited by 117 · see citing works

Metformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma

Zhou, X., Chen, J., Gao, Y., Deng, M., Liu, H., Liang, M., Shi, B., Fu, X., Chen, Y., Chen, L., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6418 · Cited by 109 · see citing works

A Splice Variant of the Human Ion Channel TRPM2 Modulates Neuroblastoma Tumor Growth through Hypoxia-inducible Factor (HIF)-1/2α

Chen, S.-J., Hoffman, N. E., Shanmughapriya, S., Bao, L., Keefer, K. A., Conrad, K., Merali, S., Takahashi, Y., Abraham, T., Hirschler‐Laszkiewicz, I., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.620922 · Cited by 106 · see citing works

TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation

Amelio, I., Inoue, S., Markert, E. K., Levine, A. J., Knight, R. A., Mak, T. W., & Melino, G. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410609111 · Cited by 103 · see citing works

A Mutation Threshold Distinguishes the Antitumorigenic Effects of the Mitochondrial Gene MTND1 , an Oncojanus Function

Gasparre, G., Kurelac, I., Capristo, M., Iommarini, L., Ghelli, A. M., Ceccarelli, C., Nicoletti, G., Nanni, P., Giovanni, C. D., Scotlandi, K., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1042 · Cited by 102 · see citing works

Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment

Iommarini, L., Kurelac, I., Capristo, M., Calvaruso, M. A., Giorgio, V., Bergamini, C., Ghelli, A. M., Nanni, P., Giovanni, C. D., Carelli, V., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt533 · Cited by 101 · see citing works

MDM2 Regulates Hypoxic Hypoxia-inducible Factor 1α Stability in an E3 Ligase, Proteasome, and PTEN-Phosphatidylinositol 3-Kinase-AKT-dependent Manner

Joshi, S., Singh, A. R., & Durden, D. L. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.587493 · Cited by 96 · see citing works

Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis

Zeng, L., Morinibu, A., Kobayashi, M., Zhu, Y., Wang, X., Gotö, Y., Yeom, C. J., Zhao, T., Hirota, K., Shinomiya, K., et al. (2014) · Oncogene · doi:10.1038/onc.2014.411 · Cited by 96 · see citing works

Role of HIF-1 as a transcription factor involved in embryonic development, cancer progression and apoptosis (review).

Minet, E., Michel, G., Remacle, J., & Michiels, C. (2000) · International Journal of Molecular Medicine · doi:10.3892/ijmm.5.3.253 · Cited by 92 · see citing works

Hypoxia-dependent activation of HIF into a transcriptional regulator

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Mitochondrial oxygen sensing: regulation of hypoxia-inducible factor by mitochondrial generated reactive oxygen species

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