Evaluation of serum autoantibody levels in the diagnosis of ovarian endometrioma
Open accessAbstract
Objective: We analyzed autoantibodies against tumor‐associated antigens (TAAs) in the serum of patients with endometrioma and healthy controls to determine whether autoantibodies can be accurate biomarkers for the diagnosis of ovarian endometrioma. Methods: Serum samples were obtained from 56 patients with endometriosis and 66 healthy women who served as normal controls. The titers of antibodies against a panel of eight TAAs were analyzed using enzyme‐linked immunosorbent assay. Results: We found that the serum IGFII mRNA‐binding protein 1 (IMP1) autoantibody and cyclin B1 autoantibody could discriminate between healthy controls and endometriosis patients (AUC–ROC 0.777; 95% confidence interval [CI] 0.694–0.860, P<0.0005, and AUC–ROC 0.614; 95%confidence interval [CI] 0.513–0.714, P=0.031, respectively). Using 0.073 and 0.007 as the cutoff values for IMP1 and Cyclin B1 autoantibody, respectively, the sensitivity and specificity of IMP1 were 85.7 and 63.6%, respectively. When cylcin B1 was combined with IMP1, the specificity increased to 72.7% and the sensitivity slightly decreased to 83.9%. Conclusions: Our data suggest that IMP1 alone or combined with cyclin B1 seems to fulfill the requirements of sensitivity and specificity to become a useful clinical biomarker of endometrioma. However, further studies will be required to establish the predictive value and to support the clinical use of IMP1/cyclin B1 in the diagnosis and/or screening of endometriosis. J. Clin. Lab. Anal. 24:357–362, 2010. © 2010 Wiley‐Liss, Inc.
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In patients with ovarian endometrioma, autoantibodies against IMP1 were significantly higher than in healthy controls.
“In patients with ovarian endometrioma, autoantibodies against Insulin-like growth factor 2 mRNA-binding protein 1 (IMP1) were significantly higher than in healthy controls [79].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [79]
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Update on biomarkers for the detection of endometriosis
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“In patients with ovarian endometrioma, autoantibodies against Insulin-like growth factor 2mRNA-binding protein 1 (IMP1) were significantly higher than in healthy controls [79].”
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- Authors
- Yi, Y., Wang, S., Chao, C., Su, C., Lee, Y., & Chen, L.
- Affiliations
- Taichung Veterans General Hospital (TW)
- Chung Shan Medical University (TW)
- Venue
- Journal of Clinical Laboratory Analysis
- Publisher
- Wiley
- Published
- 2010-01
- Volume
- 24
- Issue
- 5
- Pages
- 357-362
- ISSN
- 0887-8013 (ISSN-L)
- 1098-2825
- PMC
- PMC6647576
- OpenAlex
- W1997544588
- Cited by
- 12
- References
- 31
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2018: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Laboratory Analysis (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chung Shan Medical University
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- endometrioma, endometriosis, serum autoantibodies, tumor-associated antigens, IMP-1, cyclin B1, diagnostic biomarkers, sensitivity and specificity
- MeSH terms
- Adolescent, Adult, Autoantibodies, Endometriosis, Enzyme-Linked Immunosorbent Assay, Female, Humans, Middle Aged, Ovarian Neoplasms, Prognosis, Sensitivity and Specificity, Biomarkers, Tumor, Case-Control Studies, RNA-Binding Proteins, Young Adult, Cyclin B1
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