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Association Between Serum Soluble Low‐Density Lipoprotein Receptor Levels and Metabolic Factors in Healthy Japanese Individuals
Abstract
Background: Soluble low‐density lipoprotein receptor (sLDL‐R) is formed by cleavage of the extracellular domain of low‐density lipoprotein receptor (LDL‐R). It is unclear whether serum sLDL‐R is a marker of diseases associated with triglyceride (TG) metabolism. We investigated the association between serum sLDL‐R concentrations and other biochemical parameters in healthy Japanese individuals. Methods: Study subjects consisted of 102 healthy adult Japanese volunteers (42 men, 60 women) with body mass index (BMI) < 30 kg/m 2 and serum TGs, LDL cholesterol (LDL‐C), aspartate aminotransferase, alanine aminotransferase, γ‐glutamyl transpeptidase, and glucose concentrations within normal ranges. Serum sLDL‐R concentrations were determined by enzyme‐linked immunosorbent assay and their correlations with biochemical parameters were analyzed. Results: Mean serum sLDL‐R concentration was 120.9 ± 39.9 ng/ml. Serum sLDL‐R levels were significantly and positively correlated with BMI (r s = 0.252) and TG (r s = 0.408) and LDL‐C (r s = 0.325) concentrations. Multiple regression analysis adjusted for age, gender, and smoking showed that BMI (β = 0.274), TG (β = 0.328), and LDL‐C (β = 0.224) were factors independently correlated with sLDL‐R levels. Conclusion: Serum sLDL‐R concentration may be a marker of diseases associated with TG metabolism. This is the first report to date describing the clinical relevance of sLDL‐R.
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Serum levels of sLDLR are positively correlated with plasma LDL-C levels.
“Serum levels of sLDLR are positively correlated with plasma LDL-C levels11,14.”
From Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis (2021) · cites this paper as [11]
Two independent studies revealed a mild but significant correlation between serum concentrations of sLDLR and LDL-C in healthy adult Japanese and Canadian white populations.
“Consistently, two independent studies revealed a mild but significant correlation between serum concentrations of sLDLR and LDL-C in healthy adult Japanese and Canadian white population11,14.”
From Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis (2021) · cites this paper as [11]
Serum sLDLR levels have been positively correlated with high plasma triglycerides and LDL levels.
“This mechanism may explain why serum sLDLR levels have been positively correlated with high plasma triglycerides and LDL levels [97,98].”
From The low-density lipoprotein receptor: Emerging post-transcriptional regulatory mechanisms (2025) · cites this paper as [98]
Plasma levels of soluble LDLR (sLDLR) are positively correlated with circulating LDL-C levels.
“It has been reported that plasma levels of sLDLR are positively correlated to circulating LDL-C levels (15–17).”
From Identification of amino acid residues in the MT-loop of MT1-MMP critical for its ability to cleave low-density lipoprotein receptor (2022) · cites this paper as [16]
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Alabi, A., Xia, X.-D., Gu, H.-M., Wang, F., Deng, S.-J., Yang, N., Adijiang, A., Douglas, D. N., Kneteman, N. M., Xue, Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22167-3 · Cited by 63
The low-density lipoprotein receptor: Emerging post-transcriptional regulatory mechanisms
Ndoj, K., Meurs, A., Papaioannou, D., Bjune, K., & Zelcer, N. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.119082 · Cited by 17
Wang, M., Alabi, A., Gu, H.-M., Gill, G., Zhang, Z., Jarad, S., Xia, X.-D., Shen, Y., Wang, G.-Q., & Zhang, D.-W. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.917238 · Cited by 13
Metadata
- Authors
- Shimohiro, H., Taniguchi, S., Koda, M., Sakai, C., & Yamada, S.
- Venue
- Journal of Clinical Laboratory Analysis
- Publisher
- Wiley
- Published
- 2014-03-28
- Volume
- 29
- Issue
- 1
- Pages
- 52-56
- ISSN
- 0887-8013
- 1098-2825
- Cited by
- 20
- References
- 0
- Language
- en
- Funders
- Department of Clinical Laboratory Medicine, Jichi Medical University
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