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Cited by 1,344Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthAtherosclerosis and Cardiovascular Diseases

The LDL Receptor

Open access
Goldstein, Joseph L., Brown, Michael S.·2009·Arteriosclerosis, Thrombosis, and Vascular Biology
DOI 10.1161/atvbaha.108.179564PMC PMC2740366
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Abstract

In this article, the history of the LDL receptor is recounted by its codiscoverers. Their early work on the LDL receptor explained a genetic cause of heart attacks and led to new ways of thinking about cholesterol metabolism. The LDL receptor discovery also introduced three general concepts to cell biology: receptor-mediated endocytosis, receptor recycling, and feedback regulation of receptors. The latter concept provides the mechanism by which statins selectively lower plasma LDL, reducing heart attacks and prolonging life.

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Crossref · 10.1161/atvbaha.108.179564

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  • LDLR trafficking is a tightly regulated and temporally dynamic process, involving rapid internalization, endosomal sorting, and either recycling or degradation.

    “This is especially relevant given that LDLR trafficking is a tightly regulated and temporally dynamic process, involving rapid internalization, endosomal sorting, and either recycling or degradation 43 .”

    From Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover (2026) · cites this paper as [43]

    In “Receptor-Mediated Endocytosis: Origin of the Concept” (page unavailable), the paper describes rapid LDL receptor internalization, dissociation from LDL in endosomes, and recycling to the cell surface about every 10 minutes. It describes degradation of the LDL cargo, but does not establish degradation as an alternative fate of the receptor. (LLM, conf=0.86)

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Cites

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Research works printed but not linked: 52

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Cited by

Sorted by citations

Authors
Goldstein, J. L., & Brown, M. S.
Affiliations
The University of Texas Southwestern Medical Center (US)
ORCID
Venue
Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2009-04
Volume
29
Issue
4
Pages
431-438
ISSN
  • 1079-5642 (ISSN-L)
  • 1524-4636
DOI
10.1161/atvbaha.108.179564
PMC
PMC2740366
OpenAlex
W2127791131
Cited by
1,344
References
3
Citations by year
2026: 62 · 2025: 80 · 2024: 87 · 2023: 98 · 2022: 103 · 2021: 96 · 2020: 100 · 2019: 62 · 2018: 85 · 2017: 65 · 2016: 79 · 2015: 87 · 2014: 88 · 2013: 74 · 2012: 60
FWCI
9.49
Type
journal article
Language
en
Open access
Locations
  • Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (HL20948)
  • National Heart, Lung, and Blood Institute (HL-20948, P01HL020948)
Topics
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords
LDL receptor, history of discovery, familial hypercholesterolemia, cholesterol metabolism, receptor-mediated endocytosis, receptor recycling, statins, plasma LDL cholesterol, myocardial infarction
MeSH terms
Animals, Cholesterol, Endocytosis, Humans, Hydroxymethylglutaryl CoA Reductases, Lipoproteins, LDL, Myocardial Infarction, Receptors, LDL, Signal Transduction, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Protein Transport, Feedback, Physiological, History, 20th Century, History, 21st Century

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