The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Antibiotic resistance: The challenges and some emerging strategies for tackling a global menace
Open accessAbstract
Background: Antibiotic resistance is currently the most serious global threat to the effective treatment of bacterial infections. Antibiotic resistance has been established to adversely affect both clinical and therapeutic outcomes, with consequences ranging from treatment failures and the need for expensive and safer alternative drugs to the cost of higher rates of morbidity and mortality, longer hospitalization, and high‐healthcare costs. The search for new antibiotics and other antimicrobials continues to be a pressing need in humanity's battle against bacterial infections. Antibiotic resistance appears inevitable, and there is a continuous lack of interest in investing in new antibiotic research by pharmaceutical industries. This review summarized some new strategies for tackling antibiotic resistance in bacteria. Methods: To provide an overview of the recent research, we look at some new strategies for preventing resistance and/or reviving bacteria's susceptibility to already existing antibiotics. Results: Substantial pieces of evidence suggest that antimicrobials interact with host immunity, leading to potent indirect effects that improve antibacterial activities and may result in more swift and complete bactericidal effects. A new class of antibiotics referred to as immuno‐antibiotics and the targeting of some biochemical resistance pathway components including inhibition of SOS response and hydrogen sulfide as biochemical underlying networks of bacteria can be considered as new emerging strategies to combat antibiotic resistance in bacteria. Conclusion: This review highlighted and discussed immuno‐antibiotics and inhibition of SOS response and hydrogen sulfide as biochemical underlying networks of bacteria as new weapons against antibiotic resistance in bacteria.
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2 retracted
Wu, Q., Sabokroo, N., Wang, Y., Hashemian, M., Karamollahi, S., & Kouhsari, E. (2021) · Antimicrobial Resistance and Infection Control · doi:10.1186/s13756-021-00967-y · Cited by 101
RetractedRETRACTED ARTICLE: IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance
Singh, K. S., Sharma, R., Reddy, P. A. N., Vonteddu, P., Good, M., Sundarrajan, A., Choi, H., Muthumani, K., Kossenkov, A. V., Goldman, A. R., et al. (2020) · Nature · doi:10.1038/s41586-020-03074-x · Cited by 57
RetractedGlobal burden of bacterial antimicrobial resistance in 2019: a systematic analysis
Murray, C. J. L., Ikuta, K. S., Sharara, F., Swetschinski, L., Robles Aguilar, G., Gray, A., Han, C., Bisignano, C., Rao, P., Wool, E., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(21)02724-0 · Cited by 16,316
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A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics
Kohanski, M. A., Dwyer, D. J., Hayete, B., Lawrence, C. A., & Collins, J. J. (2007) · Cell · doi:10.1016/j.cell.2007.06.049 · Cited by 2,982
An overview of the antimicrobial resistance mechanisms of bacteria
C Reygaert, W., & Department of Biomedical Sciences, O. U. W. B. S. O. M. (2018) · AIMS Microbiology · doi:10.3934/microbiol.2018.3.482 · Cited by 1,893
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The threat of antimicrobial resistance in developing countries: causes and control strategies
Ayukekbong, J. A., Ntemgwa, M., & Atabe, A. N. (2017) · Antimicrobial Resistance & Infection Control · doi:10.1186/s13756-017-0208-x · Cited by 1,315
Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects
Uddin, T. M., Chakraborty, A. J., Khusro, A., Zidan, B. R. M., Mitra, S., Emran, T. B., Dhama, K., Ripon, M. K. H., Gajdács, M., Sahibzada, M. U. K., et al. (2021) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2021.10.020 · Cited by 1,311
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Cited by
Mafe, A. N., & Büsselberg, D. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17070820 · Cited by 18
Li, W., Huang, B., Guo, M., Zeng, Z., Cai, T., Feng, L., Zhang, X., Guo, L., Jiang, X., Yin, Y., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115773 · Cited by 13
Optimal protein allocation controls the inhibition of GltA and AcnB in Neisseria gonorrhoeae
Shahreen, N., Chowdhury, N. B., & Saha, R. (2024) · Pathogens and Disease · doi:10.1093/femspd/ftae023 · Cited by 6
Ngan, H. D., Huy, B. L., Uyen, C. L., Phuong, H. B. T., & Xuan, H. L. (2025) · European Food Research and Technology · doi:10.1007/s00217-025-04754-6 · Cited by 3
Metadata
- Authors
- Chinemerem Nwobodo, D., Ugwu, M. C., Oliseloke Anie, C., Al‐Ouqaili, M. T. S., Chinedu Ikem, J., Victor Chigozie, U., & Saki, M.
- Venue
- Journal of Clinical Laboratory Analysis
- Publisher
- Wiley
- Published
- 2022-08-10
- Volume
- 36
- Issue
- 9
- Pages
- e24655-e24655
- ISSN
- 0887-8013 (ISSN-L)
- 1098-2825
- OpenAlex
- W4291019815
- Cited by
- 985
- References
- 58
- FWCI
- 54.08
- Type
- journal article
- Language
- en
- Open access
- gold
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- Chinemerem Nwobodo, D., Ugwu, M. C., Oliseloke Anie, C., Al‐Ouqaili, M. T. S., Chinedu Ikem, J., Victor Chigozie, U., & Saki, M. (2022). Antibiotic resistance: The challenges and some emerging strategies for tackling a global menace. Journal of Clinical Laboratory Analysis. https://doi.org/10.1002/jcla.24655
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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