The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Bacterial co-infection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis
Open accessAbstract
Background Bacterial co-pathogens are commonly identified in viral respiratory infections and are important causes of morbidity and mortality. The prevalence of bacterial infection in patients infected with SARS-CoV-2 is not well understood. Aims To determine the prevalence of bacterial co-infection (at presentation) and secondary infection (after presentation) in patients with COVID-19. Sources We performed a systematic search of MEDLINE, OVID Epub and EMBASE databases for English language literature from 2019 to April 16, 2020. Studies were included if they (a) evaluated patients with confirmed COVID-19 and (b) reported the prevalence of acute bacterial infection. Content Data were extracted by a single reviewer and cross-checked by a second reviewer. The main outcome was the proportion of COVID-19 patients with an acute bacterial infection. Any bacteria detected from non-respiratory-tract or non-bloodstream sources were excluded. Of 1308 studies screened, 24 were eligible and included in the rapid review representing 3338 patients with COVID-19 evaluated for acute bacterial infection. In the meta-analysis, bacterial co-infection (estimated on presentation) was identified in 3.5% of patients (95%CI 0.4–6.7%) and secondary bacterial infection in 14.3% of patients (95%CI 9.6–18.9%). The overall proportion of COVID-19 patients with bacterial infection was 6.9% (95%CI 4.3–9.5%). Bacterial infection was more common in critically ill patients (8.1%, 95%CI 2.3–13.8%). The majority of patients with COVID-19 received antibiotics (71.9%, 95%CI 56.1 to 87.7%). Implications Bacterial co-infection is relatively infrequent in hospitalized patients with COVID-19. The majority of these patients may not require empirical antibacterial treatment.
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“We pooled proportion data across studies using a random effects meta-analysis with the DerSimonianeLaird method [12].”
MethodCharacteristics and outcomes of 21 critically ill patients with COVID-19 in Washington State
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Co-infections in people with COVID-19: a systematic review and meta-analysis.
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Critically Ill Patients With 2009 Influenza A(H1N1) Infection in Canada
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Cochrane Rapid Reviews Methods Group offers evidence-informed guidance to conduct rapid reviews
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Cited by
Yeoh, Y. K., Zuo, T., Lui, G. C.-Y., Zhang, F., Liu, Q., Li, A. Y., Chung, A. C., Cheung, C. P., Tso, E. Y., Fung, K. S., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-323020 · Cited by 1,317
Vaughn, V. M., Gandhi, T. N., Petty, L. A., Patel, P. K., Prescott, H. C., Malani, A. N., Ratz, D., McLaughlin, E., Chopra, V., & Flanders, S. A. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1239 · Cited by 396
Sulis, G., Batomen, B., Kotwani, A., Pai, M., & Gandra, S. (2021) · PLoS Medicine · doi:10.1371/journal.pmed.1003682 · Cited by 117
Sono, T. M., Yeika, E., Cook, A., Kalungia, A., Opanga, S. A., Acolatse, J. E. E., Sefah, I. A., Jelić, A. G., Campbell, S., Lorenzetti, G., et al. (2023) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2023.2259106 · Cited by 95
Bolatchiev, A., Baturin, V., Shchetinin, E., & Bolatchieva, E. (2022) · Antibiotics · doi:10.3390/antibiotics11030411 · Cited by 26
Metadata
- Authors
- Langford, B. J., So, M., Raybardhan, S., Leung, V., Westwood, D., MacFadden, D. R., Soucy, J.-P. R., & Daneman, N.
- Venue
- Clinical Microbiology and Infection
- Publisher
- Elsevier BV
- Published
- 2020-12
- Volume
- 26
- Issue
- 12
- Pages
- 1622-1629
- ISSN
- 1198-743X (ISSN-L)
- OpenAlex
- W3043975336
- Cited by
- 1,569
- References
- 15
- FWCI
- 36.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Langford, B. J., So, M., Raybardhan, S., Leung, V., Westwood, D., MacFadden, D. R., Soucy, J.-P. R., & Daneman, N. (2020). Bacterial co-infection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis. Clinical Microbiology and Infection. https://doi.org/10.1016/j.cmi.2020.07.016
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