The DOI matches its Crossref record.
Viability of human diploid cells as a function of in vitro age
Abstract
The fraction of cell capable of division was determined for (1) population of the human diploid cell strains, WI38 after different numbers of subcultivations in vitro and (2) a single population of WI38 cells at intervals throughout its entire in vitro lifespan. In both cases the percentage of cells capable of division decreased with increasing age in tissue culture. The rate and the magnitude of the decrease is sufficient to account for the limited in vitro lifespan reported by other investigators. Furthermore, the decrease in the fraction of cells capable of division in similar in some respects of senescence among human populations.
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Citations
Cited by
Cellular senescence and DNA synthesis
Cristofalo, V. J., & Sharf, B. B. (1973) · Experimental Cell Research · doi:10.1016/0014-4827(73)90394-7 · Cited by 536
Smith, J. R., & Whitney, R. G. (1980) · Science · doi:10.1126/science.7350644 · Cited by 289
VARIATION IN THE LIFE-SPAN OF CLONES DERIVED FROM HUMAN DIPLOID CELL STRAINS
Smith, J. R., & Hayflick, L. (1974) · The Journal of Cell Biology · doi:10.1083/jcb.62.1.48 · Cited by 271
Relationship between cell replication and volume in senescent human diploid fibroblasts
Mitsui, Y., & Schneider, E. L. (1976) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(76)90007-5 · Cited by 165
Metadata
- Authors
- Merz, G. S., & Ross, J. D.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 1969-12
- Volume
- 74
- Issue
- 3
- Pages
- 219-221
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2033476353
- Cited by
- 177
- References
- 0
- FWCI
- 12.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Merz, G. S., & Ross, J. D. (1969). Viability of human diploid cells as a function of in vitro age. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.1040740302
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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