The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
VARIATION IN THE LIFE-SPAN OF CLONES DERIVED FROM HUMAN DIPLOID CELL STRAINS
Open accessAbstract
The doubling potential of several hundred clones derived from WI-38 and WI-26 cell cultures has been determined. Clones were isolated at various population doubling levels (PDLs) during the finite in vitro life-span of the mass (uncloned) cultures. In all cases, there was a large variation in population doubling potential (or life-span) among the clones isolated from a single mass culture. When clones were isolated from mass cultures which had undergone eight or nine population doublings, only about 50% of the clones were capable of more than eight population doublings. This percentage was further reduced when clones were isolated from mass cultures at higher PDLs. Mass cultures appear to be composed of two subpopulation classes: one with a low population doubling potential, and the other with a higher population doubling potential. Nevertheless, the highest doubling potential observed in clones isolated from any single culture was about the same as the doubling potential of the mass culture from which single cells were taken.
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Citations
Cites
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
Self-citationThe limited in vitro lifetime of human diploid cell strains
Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876
Self-citationCellular senescence and DNA synthesis
Cristofalo, V. J., & Sharf, B. B. (1973) · Experimental Cell Research · doi:10.1016/0014-4827(73)90394-7 · Cited by 536
The division cycle and RNA-synthesis in diploid human cells at different passage levels in vitro
Macieira-Coelho, A., Pontén, J., & Philipson, L. (1966) · Experimental Cell Research · doi:10.1016/0014-4827(66)90280-1 · Cited by 273
Viability of human diploid cells as a function of in vitro age
Merz, G. S., & Ross, J. D. (1969) · Journal of Cellular Physiology · doi:10.1002/jcp.1040740302 · Cited by 177
Fate of HL-A antigens in aging cultured human diploid cell strains
Brautbar, C., Payne, R. C., & Hayflick, L. (1972) · Experimental Cell Research · doi:10.1016/0014-4827(72)90516-2 · Cited by 43
Self-citationCatalase turnover in human diploid cell cultures
Mellman, W. J., SCHIMKE, R. T., & Hayflick, L. (1972) · Experimental Cell Research · doi:10.1016/0014-4827(72)90064-x · Cited by 28
Self-citation
Cited by
Three clonal types of keratinocyte with different capacities for multiplication.
Barrandon, Y., & Green, H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.8.2302 · Cited by 1,294
Precursor Cells of Mechanocytes
Friedenstein, A. J. (1976) · International Review of Cytology · doi:10.1016/s0074-7696(08)60092-3 · Cited by 742
Replicative Senescence: the Human Fibroblast Comes of Age
Goldstein, S. (1990) · Science · doi:10.1126/science.2204114 · Cited by 653
Replicative Senescence: Implications for in Vivo Aging and Tumor Suppression
Smith, J. R., & Pereira-Smith, O. M. (1996) · Science · doi:10.1126/science.273.5271.63 · Cited by 547
Self-citationSmith, J. R., & Whitney, R. G. (1980) · Science · doi:10.1126/science.7350644 · Cited by 289
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Metadata
- Authors
- Smith, J. R., & Hayflick, L.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1974-07-01
- Volume
- 62
- Issue
- 1
- Pages
- 48-53
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1995906420
- Cited by
- 271
- References
- 7
- FWCI
- 17.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Smith, J. R., & Hayflick, L. (1974). VARIATION IN THE LIFE-SPAN OF CLONES DERIVED FROM HUMAN DIPLOID CELL STRAINS. The Journal of Cell Biology. https://doi.org/10.1083/jcb.62.1.48
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
