The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Intraclonal Variation in Proliferative Potential of Human Diploid Fibroblasts: Stochastic Mechanism for Cellular Aging
Abstract
At several points during the growth of a clone of human embryonic lung fibroblasts in vitro, 100 to 200 cells were removed at random and the proliferative potential of each cell was determined. At each sample point, a wide variation in remaining population doubling ability was observed among the individual cells and the distributions of doubling potentials were distinctly bimodal. Furthermore, the two cells arising from a single mitosis differed in their ability to proliferate by as many as eight population doublings (256-fold in the number of cells produced). The results suggest that a stochastic process is responsible for determining the limited proliferative potential of human embryonic lung fibroblasts.
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Citations
Cites
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Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.
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A STOCHASTIC MODEL OF STEM CELL PROLIFERATION, BASED ON THE GROWTH OF SPLEEN COLONY-FORMING CELLS
Till, J. E., McCulloch, E. A., & Siminovitch, L. (1964) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.51.1.29 · Cited by 890
The relationship between in vitro cellular aging and in vivo human age.
Schneider, E. L., & Mitsui, Y. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.10.3584 · Cited by 569
Cellular senescence and DNA synthesis
Cristofalo, V. J., & Sharf, B. B. (1973) · Experimental Cell Research · doi:10.1016/0014-4827(73)90394-7 · Cited by 536
Clonal selection, attenuation and differentiation in an in vitro model of hyperplasia.
Martin, G. M., Sprague, C. A., Norwood, T. H., & Pendergrass, W. R. (1974) · PubMed · Cited by 303
VARIATION IN THE LIFE-SPAN OF CLONES DERIVED FROM HUMAN DIPLOID CELL STRAINS
Smith, J. R., & Hayflick, L. (1974) · The Journal of Cell Biology · doi:10.1083/jcb.62.1.48 · Cited by 271
Self-citationBell, E., Marek, L. F., Levinstone, D. S., Merrill, C., Sher, S., Young, I. T., & Eden, M. (1978) · Science · doi:10.1126/science.725592 · Cited by 190
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Self-citation
Cited by
Oxidative stress shortens telomeres
von Zglinicki, T. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02110-2 · Cited by 2,524
Three clonal types of keratinocyte with different capacities for multiplication.
Barrandon, Y., & Green, H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.8.2302 · Cited by 1,294
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence
Passos, J. F., Saretzki, G., Ahmed, S., Nelson, G., Richter, T., Peters, H., Wappler, I., Birket, M. J., Harold, G., Schaeuble, K., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050110 · Cited by 796
“This argument is strengthened by the observation of intraclonal variation in replicative lifespan of human fibroblasts, which indicates that stochastic factors must determine the potential for each individual cell to divide [7].”
BackgroundToussaint, O., Medrano, E. E., & von Zglinicki, T. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00180-7 · Cited by 713
Extensive allelic variation and ultrashort telomeres in senescent human cells
Baird, D. M., Rowson, J., Wynford-Thomas, D., & Kipling, D. (2003) · Nature Genetics · doi:10.1038/ng1084 · Cited by 570
Metadata
- Authors
- Smith, J. R., & Whitney, R. G.
- Venue
- Science
- Published
- 1980-01-04
- Volume
- 207
- Issue
- 4426
- Pages
- 82-84
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2025704802
- Cited by
- 289
- References
- 13
- FWCI
- 15.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Smith, J. R., & Whitney, R. G. (1980). Intraclonal Variation in Proliferative Potential of Human Diploid Fibroblasts: Stochastic Mechanism for Cellular Aging. Science. https://doi.org/10.1126/science.7350644
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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