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Differentiation of a cell line of myeloid leukemia
Abstract
A cell line was established in vitro from a spontaneous myeloid leukemia of SL strain mice. This cell line was cytologically identified as myeloblast, and its normal differentiation appeared to be completely blocked in mass culture. When the line cells were seeded in soft agar with a conditioned medium from normal cells, either macrophages or neutrophil granulocytes appeared from a single clone. The rate of formation of colonies containing differentiated cells always increased with an increase in the concentration of conditioned medium. The conditioned medium from this line cell was not as effective as was that from normal cells in inducing differentiation.
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Citations
Cited by
Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3.
Abe, E., Miyaura, C., Sakagami, H., Takeda, M., Konno, K., Yamazaki, T., Yoshiki, S., & Suda, T. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.8.4990 · Cited by 1,020
Human myeloid leukemia cell lines: a review
Koeffler, H., & Golde, D. (1980) · Blood · doi:10.1182/blood.v56.3.344.344 · Cited by 349
Characterization of murine CD34, a marker for hematopoietic progenitor and stem cells
Krause, D., Ito, T., Fackler, M., Smith, O., Collector, M., Sharkis, S., & May, W. (1994) · Blood · doi:10.1182/blood.v84.3.691.691 · Cited by 290
Hirano, T., & Kishimoto, T. (1990) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-49295-2_14 · Cited by 57
Metadata
- Authors
- Ichikawa, Y.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 1969-12
- Volume
- 74
- Issue
- 3
- Pages
- 223-234
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W1972119462
- Cited by
- 509
- References
- 0
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ichikawa, Y. (1969). Differentiation of a cell line of myeloid leukemia. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.1040740303
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
