Interleukin-6.

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

Shaw, G. D., & Kamen, R. (1986) · Cell · doi:10.1016/0092-8674(86)90341-7 · Cited by 3,946 · see citing works

The Immunoglobulin Superfamily—Domains for Cell Surface Recognition

Williams, A., & Barclay, A. N. (1988) · Annual Review of Immunology · doi:10.1146/annurev.iy.06.040188.002121 · Cited by 2,251 · see citing works

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S.-I., Nakajima, K., Koyama, K., Iwamatsu, A., et al. (1986) · Nature · doi:10.1038/324073a0 · Cited by 2,139 · see citing works

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.

Gauldie, J., Richards, C. D., Harnish, D. C., Lansdorp, P. M., & Baumann, H. J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.20.7251 · Cited by 1,635 · see citing works

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

Kawano, M., Hirano, T., Matsuda, T., Taga, T., Horii, Y., Iwato, K., Asaoku, H., Tang, B., Tanabe, O., Tanaka, H., et al. (1988) · Nature · doi:10.1038/332083a0 · Cited by 1,633 · see citing works

Murine Models of Systemic Lupus Erythematosus

Theofilopoulos, A. N., & Dixon, F. J. (1985) · Advances in immunology · doi:10.1016/s0065-2776(08)60342-9 · Cited by 1,553 · see citing works

THE PHENOMENON OF THE ACUTE PHASE RESPONSE*

Kushner, I. (1982) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1982.tb22124.x · Cited by 1,494 · see citing works

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T., & Kishimoto, T. (1989) · Cell · doi:10.1016/0092-8674(89)90438-8 · Cited by 1,396 · see citing works

Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor

Yamasaki, K., Taga, T., Hirata, Y., Yawata, H., Kawanishi, Y., Seed, B., Taniguchi, T., Hirano, T., & Kishimoto, T. (1988) · Science · doi:10.1126/science.3136546 · Cited by 1,061 · see citing works

Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman’s disease

Yoshizaki, K., Matsuda, T., Nishimoto, N., Kuritani, T., Taeho, L., Aozasa, K., Nakahata, T., Kawai, H., Tagoh, H., & Komori, T. (1989) · Blood · doi:10.1182/blood.v74.4.1360.1360 · Cited by 928 · see citing works

The molecular biology and functions of the granulocyte-macrophage colony-stimulating factors

Metcalf, D. (1986) · Blood · doi:10.1182/blood.v67.2.257.257 · Cited by 888 · see citing works

cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

Sims, J. E., March, C. J., Cosman, D. J., Widmer, M. B., MacDonald, H. R., McMahan, C. J., Grubin, C. E., Wignall, J. M., Jackson, J. L., Call, S. M., et al. (1988) · Science · doi:10.1126/science.2969618 · Cited by 877 · see citing works

Two types of mouse helper T-cell clone Implications for immune regulation.

Mosmann, T., & Coffman, R. (1987) · Immunology today (Amsterdam. Regular ed.) · doi:10.1016/0167-5699(87)90171-x · Cited by 826 · see citing works

Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor

Nagata, S., Tsuchiya, M., Asano, S., Kaziro, Y., Yamazaki, T., Yamamoto, O., Hirata, Y., Kubota, N., Oh‐eda, M., Nomura, H., et al. (1986) · Nature · doi:10.1038/319415a0 · Cited by 812 · see citing works

Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors.

Ikebuchi, K., Wong, G. G., Clark, S., Ihle, J. N., Hirai, Y., & Ogawa, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9035 · Cited by 800 · see citing works

Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis

Hirano, T., Matsuda, T., Turner, M., Miyasaka, N., Buchan, G., Tang, B., Sato, K., Shimi, M., Maid, R., Feldmann, M., et al. (1988) · European Journal of Immunology · doi:10.1002/eji.1830181122 · Cited by 784 · see citing works

The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells

Muraguchi, A., Hirano, T., Tang, B., Matsuda, T., Horii, Y., Nakajima, K., & Kishimoto, T. (1988) · The Journal of experimental medicine · doi:10.1084/jem.167.2.332 · Cited by 783 · see citing works

Tumour necrosis factors α and β inhibit virus replication and synergize with interferons

Wong, G. H., & Goeddel, D. V. (1986) · Nature · doi:10.1038/323819a0 · Cited by 707 · see citing works

Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2).

Hirano, T., Taga, T., Nakano, N., Yasukawa, K., Kashiwamura, S., Shimizu, K., Nakajima, K., Pyun, K., & Kishimoto, T. (1985) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.82.16.5490 · Cited by 691 · see citing works

Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.

Snick, J. V., Cayphas, S., Vink, A., Uyttenhove, C., Coulie, P. G., Rubira, M. R., & Simpson, R. J. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9679 · Cited by 679 · see citing works

Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.

Damme, J. V., Opdenakker, G., Simpson, R. J., Rubira, M. R., Cayphas, S., Vink, A., Billiau, A., & Snick, J. V. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.165.3.914 · Cited by 669 · see citing works

Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukaemia

Sachs, L. (1978) · Nature · doi:10.1038/274535a0 · Cited by 593 · see citing works

IgG1 plasmacytosis in interleukin 6 transgenic mice

Suematsu, S., Matsuda, T., Aozasa, K., Akira, S., Nakano, N., Ohno, S., Miyazaki, J., Yamamura, K., Hirano, T., & Kishimoto, T. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7547 · Cited by 586 · see citing works

Molecular Regulation of B Lymphocyte Response

Kishimoto, T., & Hirano, T. (1988) · Annual Review of Immunology · doi:10.1146/annurev.iy.06.040188.002413 · Cited by 567 · see citing works

B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes.

Lotz, M., Jirik, F. R., Kabouridis, P. S., Tsoukas, C. D., Hirano, T., Kishimoto, T., & Carson, D. A. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.3.1253 · Cited by 526 · see citing works

Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities.

Lee, F. H. H., Yokota, T., Otsuka, T., Meyerson, P., Villaret, D. B., Coffman, R. L., Mosmann, T. R., Rennick, D. M., Roehm, N. W., & Smith, C. A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.7.2061 · Cited by 524 · see citing works

Differentiation of a cell line of myeloid leukemia

Ichikawa, Y. (1969) · Journal of Cellular Physiology · doi:10.1002/jcp.1040740303 · Cited by 516 · see citing works

Structure and expression of human B cell stimulatory factor‐2 (BSF‐2/IL‐6) gene.

Yasukawa, K., Hirano, T., Watanabe, Y., Muratani, K., Matsuda, T., Nakai, S., & Kishimoto, T. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02598.x · Cited by 503 · see citing works

Structure and expression of cDNA and genes for human interferon‐beta‐2, a distinct species inducible by growth‐stimulatory cytokines.

Zilberstein, A., Ruggieri, R., Korn, J. H., & Revel, M. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04531.x · Cited by 486 · see citing works

Corticotropin-Releasing Activity of Monokines

Woloski, B. M. R. N. J., Smith, E. M., Meyer, W. J., Fuller, G. M., & Blalock, J. E. (1985) · Science · doi:10.1126/science.2997929 · Cited by 486 · see citing works

SERUM LEVELS OF INTERLEUKIN-6 AND ACUTE PHASE RESPONSES

Nijsten, M. W., de Groot, E. R., ten Duis, H. J., Klasen, H. J., Hack, C. E., & Aarden, L. A. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91413-9 · Cited by 457 · see citing works

Recombinant human interleukin‐6 (IL‐6/BSF‐2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes

Castell, J. V., Gómez-Lechón, M. J., David, M., Hirano, T., Kishimoto, T., & Heinrich, P. C. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80766-x · Cited by 452 · see citing works

Interleukin-6 is a potent thrombopoietic factor in vivo in mice

Ishibashi, T., Kimura, H., Shikama, Y., Uchida, T., KARIYONE, S., Hirano, T., Kishimoto, T., Takatsuki, F., & Akiyama, Y. (1989) · Blood · doi:10.1182/blood.v74.4.1241.1241 · Cited by 431 · see citing works

Induction of Neuronal Differentiation in PC12 Cells by B-Cell Stimulatory Factor 2/Interleukin 6

Satoh, T., Nakamura, S., Taga, T., Matsuda, T., Hirano, T., Kishimoto, T., & Kaziro, Y. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.8.3546-3549.1988 · Cited by 414 · see citing works

Interleukin 6 is involved in interleukin 1‐induced activities

Helle, M., Brakenhoff, J. P. J., de Groot, E. R., & Aarden, L. A. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180619 · Cited by 409 · see citing works

Human interleukin 6 is a direct promoter of maturation of megakaryocytes in vitro.

Ishibashi, T., Kimura, H., Uchida, T., KARIYONE, S., Friese, P., & Burstein, S. A. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.15.5953 · Cited by 406 · see citing works

Induction of rat acute‐phase proteins by interleukin 6 in vivo

Geiger, T. M., Andus, T., Klapproth, J., Hirano, T., Kishimoto, T., & Heinrich, P. C. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180510 · Cited by 401 · see citing works

A Macrophage-Derived Factor Required by Plasmacytomas for Survival and Proliferation in Vitro

Nordan, R. P., & Potter, M. (1986) · Science · doi:10.1126/science.3726549 · Cited by 375 · see citing works

B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes.

Takai, Y., Wong, G. G., Clark, S., Burakoff, S. J., & Herrmann, S. H. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.2.508 · Cited by 366 · see citing works

Factors Affecting B-Cell Growth and Differentiation

Kishimoto, T. (1985) · Annual Review of Immunology · doi:10.1146/annurev.iy.03.040185.001025 · Cited by 360 · see citing works

IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells.

Okada, M., Kitahara, M., Kishimoto, S., Matsuda, T., Hirano, T., & Kishimoto, T. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.5.1543 · Cited by 360 · see citing works

Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production

Hirano, T., Taga, T., Yasukawa, K., Nakajima, K., Nakano, N., Takatsuki, F., Shimizu, M., Murashima, A., Tsunasawa, S., & Sakiyama, F. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.1.228 · Cited by 351 · see citing works

B-cell-stimulatory factor 2 (beta 2 interferon) functions as a second signal for interleukin 2 production by mature murine T cells.

Garman, R. D., Jacobs, K. A., Clark, S., & Raulet, D. H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7629 · Cited by 349 · see citing works

Structural analysis of the sequence coding for an inducible 26‐kDa protein in human fibroblasts

Haegeman, G., Content, J., Volckaert, G., DERYNCK, R., Tavernier, J. H., & Fiers, W. (1986) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1986.tb09931.x · Cited by 336 · see citing works

Two interferon mRNAs in human fibroblasts: in vitro translation and Escherichia coli cloning studies.

Weissenbach, J., Chernajovsky, Y., Zeevi, M., Shulman, L. M., Soreq, H., Nir, U., Wallach, D., Perricaudet, M., Tiollais, P., & Revel, M. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.12.7152 · Cited by 335 · see citing works

Purification of a factor inducing differentiation of mouse myeloid leukemic M1 cells from conditioned medium of mouse fibroblast L929 cells.

Tomida, M., Yamamoto-Yamaguchi, Y., & Hozumi, M. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)90609-5 · Cited by 317 · see citing works

Induction of Plasma-Cell Neoplasms in Strain BALB/c Mice with Mineral Oil and Mineral Oil Adjuvants

Potter, M., & BOYCE, C. R. (1962) · Nature · doi:10.1038/1931086a0 · Cited by 309 · see citing works

Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution, and regulation of their expression.

Taga, T., Kawanishi, Y., Hardy, R. R., Hirano, T., & Kishimoto, T. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.166.4.967 · Cited by 309 · see citing works

Establishment of an interleukin 6 (IL 6)/B cell stimulatory factor 2‐dependent cell line and preparation of anti‐IL 6 monoclonal antibodies

Matsuda, T., Hirano, T., & Kishimoto, T. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180618 · Cited by 304 · see citing works

Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human.

Tanabe, O., Akira, S., Kamiya, T., Wong, G. G., Hirano, T., & Kishimoto, T. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.11.3875 · Cited by 292 · see citing works

Recombinant human B cell stimulatory factor 2 (BSF‐2/IFN‐β2) regulates β‐fibrinogen and albumin mRNA levels in Fao‐9 cells

Andus, T., Geiger, T. M., Hirano, T., Northoff, H., Ganter, U., Bauer, J., Kishimoto, T., & Heinrich, P. C. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80344-7 · Cited by 292 · see citing works

cDNA cloning of murine interleukin-HP1: homology with human interleukin 6

Snick, J. V., Cayphas, S., Szikora, J., Renauld, J., Roost, E. V., Boon, T., & Sirnpson, R. J. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180202 · Cited by 282 · see citing works

Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts: role in the induction of interleukin 6.

Zhang, Y. H., Lin, J. X., Yip, Y. K., & Vilček, J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6802 · Cited by 281 · see citing works

Regulation of BSF-2/IL-6 production by human mononuclear cells. Macrophage-dependent synthesis of BSF-2/IL-6 by T cells.

Horii, Y., Muraguchi, A., Suematsu, S., Matsuda, T., Yoshizaki, K., Hirano, T., & Kishimoto, T. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.5.1529 · Cited by 279 · see citing works

Is There Evidence for a Non-Antigen Specific Diffusable Chemical Mediator from the Thymus-Derived Cell in the Initiation of the Immune Response?**Supported by U. S. Public Health Service Research Grant AI-08795-03 and American Cancer Society Research Grant E-395-D.

Dutton, R. W., Falkoff, R. J. M., Hirst, J. A., Hoffmann, M. K., Kappler, J. W., Kettman, J. R., Lesley, J., & Vann, D. C. (1971) · Elsevier eBooks · doi:10.1016/b978-0-12-057550-3.50033-8 · Cited by 274 · see citing works

Monocyte-Derived Human B-Cell Growth Factor Identified as Interferon-β 2 (BSF-2, IL-6)

Tosato, G., Seamon, K. B., Goldman, N. D., Sehgal, P. B., May, L. T., Washington, G. C., Jones, K. D., & Pike, S. E. (1988) · Science · doi:10.1126/science.2829354 · Cited by 272 · see citing works

Synthesis of interleukin 6 (interferon-beta 2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cyclic AMP.

Zhang, Y., Lin, J. X., & Vilček, J. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68768-x · Cited by 260 · see citing works

T cell growth and differentiation induced by interleukin-HP1/IL-6, the murine hybridoma/plasmacytoma growth factor.

Uyttenhove, C., Coulie, P. G., & Snick, J. V. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.4.1417 · Cited by 251 · see citing works

Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients.

Frei, K., Leist, T. P., Meager, A., Gallo, P., Leppert, D., Zinkernagel, R. M., & Fontana, A. (1988) · The Journal of experimental medicine · doi:10.1084/jem.168.1.449 · Cited by 245 · see citing works

Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1

Damme, J. V., LEY, M. D., Opdenakker, G., Billiau, A., Somer, P. D., & BEEUMEN, J. V. (1985) · Nature · doi:10.1038/314266a0 · Cited by 236 · see citing works

The Molecular Control of Blood Cell Development

Sachs, L. (1987) · Science · doi:10.1126/science.3317831 · Cited by 227 · see citing works

Stimulation of rat mesangial cell proliferation by macrophage interleukin 1.

Lovett, D. H., Ryan, J. L., & Sterzel, R. B. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.131.6.2830 · Cited by 218 · see citing works

Genes coding for RNA polymerase β subunit in bacteria

Lisitsyn, N. A., MONASTYRSKAYA, G. S., & Sverdlov, E. D. (1988) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1988.tb14384.x · Cited by 217 · see citing works

B cell growth modulating and differentiating activity of recombinant human 26‐kd protein (BSF‐2, HuIFN‐beta 2, HPGF).

POUPART, P., Vandenabeele, P., Cayphas, S., Snick, J. V., Haegeman, G., Kruys, V., Fiers, W., & Content, J. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02357.x · Cited by 214 · see citing works

Identification of alpha 2-macroglobulin as a carrier protein for IL-6.

Matsuda, T., Hirano, T., Nagasawa, S., & Kishimoto, T. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.1.148 · Cited by 211 · see citing works

Activation of the human "beta 2-interferon/hepatocyte-stimulating factor/interleukin 6" promoter by cytokines, viruses, and second messenger agonists.

Ray, A., Tatter, S. B., May, L. T., & Sehgal, P. B. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6701 · Cited by 209 · see citing works

Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved.

May, L. T., HELFGOTT, D. C., & Sehgal, P. B. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.23.8957 · Cited by 206 · see citing works

Nonrandom chromosome changes involving the Ig gene-carrying chromosomes 12 and 6 in pristane-induced mouse plasmacytomas

Ohno, S., Babonits, M., Wiener, F., Spira, J., Klein, G., & Potter, M. (1979) · Cell · doi:10.1016/0092-8674(79)90212-5 · Cited by 201 · see citing works

Induction of proliferation and Ig production in human B leukemic cells by anti-immunoglobulins and T cell factors.

Yoshizaki, K., Nakagawa, T., Kaieda, T., Muraguchi, A., Yamamura, Y., & Kishimoto, T. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.128.3.1296 · Cited by 198 · see citing works

The myeloid blood cell differentiation-inducing protein MGI-2A is interleukin-6

Shabo, Y., Lotem, J., Rubinstein, M., Revel, M., Clark, S., Wolf, S., Kamen, R., & Sachs, L. (1988) · Blood · doi:10.1182/blood.v72.6.2070.2070 · Cited by 197 · see citing works

Bacterial lipopolysaccharide (endotoxin) enhances expression and secretion of beta 2 interferon by human fibroblasts.

HELFGOTT, D. C., May, L. T., Sthoeger, Z. M., Tamm, I., & Sehgal, P. B. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.166.5.1300 · Cited by 191 · see citing works

Eosinophil differentiation factor also has B-cell growth factor activity: proposed name interleukin 4.

Sanderson, C. J., O’Garra, A., Warren, D. J., & Klaus, G. G. B. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.2.437 · Cited by 190 · see citing works

Transcriptional regulation of the interferon- beta 2/B cell differentiation factor BSF-2/hepatocyte-stimulating factor gene in human fibroblasts by other cytokines.

Walther, Z., May, L. T., & Sehgal, P. B. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.3.974 · Cited by 184 · see citing works

B cell growth factors and B cell differentiation factor from human T hybridomas. Two distinct kinds of B cell growth factor and their synergism in B cell proliferation.

Okada, M., Sakaguchi, N., Yoshimura, N., Hara, H., Shimizu, K., Yoshida, N., Yoshizaki, K., Kishimoto, S., Yamamura, Y., & Kishimoto, T. (1983) · The Journal of Experimental Medicine · doi:10.1084/jem.157.2.583 · Cited by 182 · see citing works

Growth inhibition of human breast carcinoma and leukemia/lymphoma cell lines by recombinant interferon-beta 2.

Chen, L., Mory, Y. Y., Zilberstein, A., & Revel, M. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.21.8037 · Cited by 179 · see citing works

Isolation and characterization of the cDNA for murine granulocyte colony-stimulating factor.

Tsuchiya, M., Asano, S., Kaziro, Y., & Nagata, S. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.20.7633 · Cited by 176 · see citing works

A cytokine network in human diploid fibroblasts: interactions of beta-interferons, tumor necrosis factor, platelet-derived growth factor, and interleukin-1.

Kohase, M., May, L. T., Tamm, I., Vilček, J., & Sehgal, P. B. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.1.273 · Cited by 174 · see citing works

Interleukin 1 and poly(rI) · poly(rC) induce production of a hybridoma growth factor by human fibroblasts

Damme, J. V., Cayphas, S., Opdenakker, G., Billiau, A., & Snick, J. V. (1987) · European Journal of Immunology · doi:10.1002/eji.1830170102 · Cited by 172 · see citing works

Induction of a 26-kDa-protein mRNA in human cells treated with an interleukin-1-related, leukocyte-derived factor

Content, J., Wit, L. D., POUPART, P., Opdenakker, G., Damme, J. V., & Billiau, A. (1985) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1985.tb09191.x · Cited by 169 · see citing works

Interleukin-HP1, a T cell-derived hybridoma growth factor that supports the in vitro growth of murine plasmacytomas.

Snick, J. V., Vink, A., Cayphas, S., & Uyttenhove, C. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.165.3.641 · Cited by 169 · see citing works

Synergistic activation of human t cells by interleukin 1 and interleukin 6

Houssiau, F. A., Coulie, P. G., Olive, D., & Snick, J. V. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180427 · Cited by 152 · see citing works

The human “interferon-β2/hepatocyte stimulating factor/interleukin-6” gene: DNA polymorphism studies and localization to chromosome 7p21

Bowcock, A. M., Kidd, J. R., Lathrop, M. G., Daneshvar, L., May, L. T., Ray, A., Sehgal, P. B., Kídd, K. K., & Cavalli-Sforza, L. L. (1988) · Genomics · doi:10.1016/0888-7543(88)90152-8 · Cited by 150 · see citing works

Human endothelial culture supernatant (HECS): a growth factor for hybridomas.

Astaldi, G. C. B., Janssen, M. C., Lansdorp, P. M., Willems, C., Zeijlemaker, W. P., & Oosterhof, F. (1980) · The Journal of Immunology · doi:10.4049/jimmunol.125.4.1411 · Cited by 147 · see citing works

Purification and NH2-terminal sequence of a plasmacytoma growth factor derived from the murine macrophage cell line P388D1.

Nordan, R. P., Pumphrey, J. G., & Rudikoff, S. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.3.813 · Cited by 146 · see citing works

The role of interferon-β 1 and the 26-kDa protein (interferon-beta 2) as mediators of the antiviral effect of interleukin 1 and tumor necrosis factor.

Damme, J. V., LEY, M. D., SNICK, J. V., Dinarello, C. A., & Billiau, A. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.6.1867 · Cited by 135 · see citing works

Rapid enhancement of beta 2-interferon/B-cell differentiation factor BSF-2 gene expression in human fibroblasts by diacylglycerols and the calcium ionophore A23187.

Sehgal, P. B., Walther, Z., & Tamm, I. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.11.3663 · Cited by 127 · see citing works

Human chromosome 7 carries the beta 2 interferon gene.

Sehgal, P. B., Zilberstein, A., Ruggieri, R. M., May, L. T., Ferguson‐Smith, A. C., Slate, D. L., Revel, M., & Ruddle, F. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.14.5219 · Cited by 127 · see citing works

Regulation of the acute phase and immune responses in viral disease. Enhanced expression of the beta 2-interferon/hepatocyte-stimulating factor/interleukin 6 gene in virus-infected human fibroblasts.

Sehgal, P. B., HELFGOTT, D. C., Santhanam, U., Tatter, S. B., Clarick, R. H., Ghrayeb, J., & May, L. T. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.6.1951 · Cited by 126 · see citing works

B cell growth and differentiation activity of interleukin‐hp1 and related murine plasmacytoma growth factors. synergy with interleukin 1

Vink, A., Coulie, P. G., Wauters, P., Nordan, R. P., & SNICK, J. V. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180418 · Cited by 124 · see citing works

Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta.

Content, J., Wit, L. D., Piérard, D., Derynck, R., Clercq, E. D., & Fiers, W. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.9.2768 · Cited by 123 · see citing works

Human recombinant IL-6/B cell stimulatory factor 2 augments murine antigen-specific antibody responses in vitro and in vivo.

Takatsuki, F., Okano, A., Suzuki, C., Chieda, R., Takahara, Y., Hirano, T., Kishimoto, T., Hamuro, J., & Akiyama, Y. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.9.3072 · Cited by 110 · see citing works

Enhancement of the interleukin 2 receptor expression on T cells by multiple B-lymphotropic lymphokines

Noma, T., Mizuta, T.-R., Rosén, A., Hirano, T., Kishimoto, T., & Honjo, T. (1987) · Immunology Letters · doi:10.1016/0165-2478(87)90032-0 · Cited by 106 · see citing works

Increased expression of myc-related oncogene mRNA characterizes most BALB/c plasmacytomas induced by pristane or Abelson murine leukemia virus.

Mushinski, J. F., Bauer, S. R., Potter, M., & Reddy, E. P. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.4.1073 · Cited by 94 · see citing works

Interleukin 2-dependent and interleukin 2-independent pathways of regulation of thymocyte function by interleukin 6.

Le, J., Fredrickson, G. G., Reis, L. F. L., Diamantstein, T., Hirano, T., Kishimoto, T., & Vilček, J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.22.8643 · Cited by 90 · see citing works

The requirement of an adherent cell substratum for the growth of developing plasmacytoma cells in vivo.

Cancro, M. P., & Potter, M. (1976) · The Journal of Experimental Medicine · doi:10.1084/jem.144.6.1554 · Cited by 88 · see citing works

Absence of antiviral activity in recombinant B cell stimulatory factor 2 (BSF-2)

Hirano, T., Matsuda, T., Hosoi, K., Okano, A., Matsui, H., & Kishimoto, T. (1988) · Immunology Letters · doi:10.1016/0165-2478(88)90099-5 · Cited by 86 · see citing works

Regulation of Antibody Response in Vitro

Kishimoto, T., & Ishizaka, K. (1973) · The Journal of Immunology · doi:10.4049/jimmunol.111.4.1194 · Cited by 83 · see citing works

Characterization of macrophage- and granulocyte-inducing proteins for normal and leukemic myeloid cells produced by the Krebs ascites tumor

Lipton, J. H., & Sachs, L. (1981) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(81)90486-4 · Cited by 81 · see citing works

Interleukin-6 (B-cell stimulatory factor 2)-dependent growth of a Lennert's lymphoma-derived T-cell line (KT-3)

Shimizu, S., Hirano, T., Yoshioka, R., Sugai, S., Matsuda, T., Taga, T., Kishimoto, T., & Konda, S. K. R. (1988) · Blood · doi:10.1182/blood.v72.5.1826.1826 · Cited by 77 · see citing works

Effect of B cell differentiation factor (BCDF) on biosynthesis and secretion of immunoglobulin molecules in human B cell lines.

Kikutani, H., Taga, T., Akira, S., Kishi, H., Miki, Y., Saiki, O., Yamamura, Y., & Kishimoto, T. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.134.2.990 · Cited by 73 · see citing works

Human helper T cell factor(s). IV. Demonstration of a human late-acting B cell differentiation factor acting on Staphylococcus aureus Cowan I-stimulated B cells.

Hirano, T., Teranishi, T., Lin, B., & Onoue, K. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.133.2.798 · Cited by 72 · see citing works

High‐affinity binding sites for human 26‐kDa protein (interleukin 6, B cell stimulatory factor‐2, human hybridoma plasmacytoma growth factor, interferon‐β2), different from those of type I interferon (α,β), on lymphoblastoid cells

Coulie, P. G., Vanhecke, A., Damme, J. V., Cayphas, S., POUPART, P., Wit, L. D., & Content, J. (1987) · European Journal of Immunology · doi:10.1002/eji.1830171008 · Cited by 66 · see citing works

Identification of IL-6 as a T cell-derived factor that enhances the proliferative response of thymocytes to IL-4 and phorbol myristate acetate.

Hodgkin, P. D., Bond, M. W., O’Garra, A., Frank, G. M., Lee, F. H. H., Coffman, R. L., Zlotnik, A., & Howard, M. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.1.151 · Cited by 64 · see citing works

Demonstration of the involvement of interleukin 2 in the differentiation of Staphylococcus aureus Cowan I-stimulated B cells.

Teranishi, T., Hirano, T., Lin, B. H., & Onoue, K. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.133.6.3062 · Cited by 60 · see citing works

Antiviral action of tumor necrosis factor in human fibroblasts is not mediated by B cell stimulatory factor 2/IFN- beta 2, and is inhibited by specific antibodies to IFN- beta .

Reis, L. F. L., Le, J., Hirano, T., Kishimoto, T., & Vilček, J. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.5.1566 · Cited by 51 · see citing works

IN VITRO EXPANSION OF THE MURINE PLURIPOTENT HEMOPOIETIC STEM CELL POPULATION IN RESPONSE TO INTERLEUKIN 3 AND INTERLEUKIN 6

OKANO, A., SUZUKI, C., Takatsuki, F., AKIYAMA, Y., KOIKE, K., Ozawa, K., Hirano, T., Kishimoto, T., Nakahata, T., & ASANO, S. (1989) · Transplantation · doi:10.1097/00007890-198909000-00028 · Cited by 46 · see citing works

Induction by recombinant human granulocyte colony‐stimulating factor of differentiation of mouse myeloid leukemic M1 cells

Tomida, M., Yamamoto-Yamaguchi, Y., Hozumi, M., Okabe, T., & Takaku, F. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)81503-4 · Cited by 44 · see citing works

The Serum Factor Stimulating Colony Formation In Vitro by Murine Plasmacytoma Cells: Response to Antigens and Mineral Oil

Metcalf, D. (1974) · The Journal of Immunology · doi:10.4049/jimmunol.113.1.235 · Cited by 37 · see citing works

A new interleukin with pleiotropic activities

Kishimoto, T., & Hirano, T. (1988) · BioEssays · doi:10.1002/bies.950090104 · Cited by 29 · see citing works

T Cell Replacing Factor

(2008) · Springer eBooks · doi:10.1007/978-1-4020-6754-9_16597 · Cited by 1 · see citing works

IL-6 in inflammation, autoimmunity and cancer

Hirano, T. (2021) · International Immunology · doi:10.1093/intimm/dxaa078 · Cited by 1,453 · see citing works

Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors

Hirano, T., Ishihara, K., & Hibi, M. (2000) · Oncogene · doi:10.1038/sj.onc.1203551 · Cited by 1,187 · see citing works

Interleukin 6 and its receptor: ten years later

Hirano, T. (1998) · International Reviews of Immunology · doi:10.3109/08830189809042997 · Cited by 788 · see citing works

A weak signal for strong responses: interferon-alpha/beta revisited

Taniguchi, T., & Takaoka, A. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35073080 · Cited by 483 · see citing works

Effect of Human Recombinant Interleukin-6 and Interleukin-8 on Monocyte Procoagulant Activity

Neumann, F., Ott, I., Marx, N., Luther, T., Kenngott, S., Gawaz, M., Kotzsch, M., & Schömig, A. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.12.3399 · Cited by 308 · see citing works

Role of Cytokines in Sepsis

Hack, C. E., Aarden, L. A., & THUS, L. G. (1997) · Advances in immunology · doi:10.1016/s0065-2776(08)60597-0 · Cited by 284 · see citing works

IL-6 signal transduction and its physiological roles: the signal orchestration model

Kamimura, D., Ishihara, K., & Hirano, T. (2003) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/s10254-003-0012-2 · Cited by 673 · see citing works

The Signalling Pathways of Interleukin-6 and Gamma Interferon Converge by the Activation of Different Transcription Factors Which Bind to Common Responsive DNA Elements

Yuan, J., Wegenka, U. M., Lütticken, C., Buschmann, J., Decker, T., Schindler, C., Heinrich, P. C., & Horn, F. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.1657 · Cited by 179 · see citing works

Interleukin 6 in autoimmune and inflammatory diseases: a personal memoir

HIRANO, T. (2010) · Proceedings of the Japan Academy, Series B · doi:10.2183/pjab.86.717 · Cited by 172 · see citing works

Interleukin 6 (IL‐6) and its receptor: Their role in plasma cell neoplasias

Hirano, T. (1991) · The International Journal Of Cell Cloning · doi:10.1002/stem.5530090303 · Cited by 121 · see citing works

Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding

van Dam, M., Müllberg, J., Schooltink, H., Stoyan, T., Brakenhoff, J. P. J., Graeve, L., Heinrich, P. C., & Rose‐John, S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82467-x · Cited by 113 · see citing works

Expression and function of interleukin‐6 in epithelial cells

Krueger, J. G., Ray, A., Tamm, I., & Sehgal, P. B. (1991) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240450404 · Cited by 110 · see citing works

Cross talk of the interferon‐α/β signalling complex with gp130 for effective interleukin‐6 signalling

Mitani, Y., Takaoka, A., Kim, S. H., Kato, Y. H., Yokochi, T., Tanaka, N., & Taniguchi, T. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00448.x · Cited by 106 · see citing works

Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor.

Dittrich, E., Rose‐John, S., Gerhartz, C., Müllberg, J., Stoyan, T., Yasukawa, K., Heinrich, P. C., & Graeve, L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32267-6 · Cited by 91 · see citing works

Transforming growth factor β induces the production of interleukin 6 by human peripheral blood mononuclear cells

Turner, M., Chantry, D., & Feldmann, M. (1990) · Cytokine · doi:10.1016/1043-4666(90)90018-o · Cited by 85 · see citing works

Induction of stable microtubules in 3T3 fibroblasts by TGF-β and serum

Gundersen, G. G., Kim, I., & Chapin, C. J. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.3.645 · Cited by 75 · see citing works

Cytokine and Cellular Inflammatory Sequence in Enteroviral Meningitis

Sato, M., Hosoya, M., Honzumi, K., Watanabe, M., Ninomiya, N., Shigeta, S., & Suzuki, H. (2003) · PEDIATRICS · doi:10.1542/peds.112.5.1103 · Cited by 65 · see citing works

The Molecular Biology of Interleukin 6 and its Receptor

Kishimoto, T., Hibi, M., Murakami, M., Narazaki, M., Saito, M., & Taga, T. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514269.ch2 · Cited by 65 · see citing works

Regulation of tumour necrosis factor and interleukin-6 gene transcription by β2-adrenoceptor in the rat astrocytes

Nakamura, A., Johns, E. J., Imaizumi, A., Abe, T., & Kohsaka, T. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00109-x · Cited by 61 · see citing works

Interleukin 6 (IL-6)

Matsuda, T., & Hirano, T. (1990) · Biotherapy · doi:10.1007/bf02170085 · Cited by 60 · see citing works

EFFECT OF β2-ADRENOCEPTOR ACTIVATION AND ANGIOTENSIN II ON TUMOUR NECROSIS FACTOR AND INTERLEUKIN 6 GENE TRANSCRIPTION IN THE RAT RENAL RESIDENT MACROPHAGE CELLS

Nakamura, A., Johns, E. J., Imaizumi, A., Yanagawa, Y., & Kohsaka, T. (1999) · Cytokine · doi:10.1006/cyto.1999.0488 · Cited by 58 · see citing works

DNA Dendrons as Agents for Intracellular Delivery

Distler, M. E., Teplensky, M. H., Bujold, K. E., Kusmierz, C. D., Evangelopoulos, M., & Mirkin, C. A. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c07240 · Cited by 56 · see citing works

Increased serum interleukin-6 in cardiac myxoma

Saji, T., Yanagawa, E., Matsuura, H., Yamamoto, S., Ishikita, T., Matsuo, N., Yoshirwara, K., & Takanashi, Y. (1991) · American Heart Journal · doi:10.1016/0002-8703(91)91022-f · Cited by 51 · see citing works

The hepatic interleukin-6 receptor. Studies on its structure and regulation by phorbol 12-myristate 13-acetate-dexamethasone.

Pietzko, D., Zohlnhöfer, D., Graeve, L., Fleischer, D., Stoyan, T., Schooltink, H., Rose‐John, S., & Heinrich, P. C. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53603-6 · Cited by 45 · see citing works

High-Level Direct Expression of Semi-Synthetic Human Interleukin-6 in Escherichia coli and Production of N-Terminus Met-Free Product

Yasueda, H., Nagase, K., Hosoda, A., Akiyama, Y., & Yamada, K. (1990) · Nature Biotechnology · doi:10.1038/nbt1190-1036 · Cited by 42 · see citing works

Effects of diode laser (980 nm) on orthodontic tooth movement and interleukin 6 levels in gingival crevicular fluid in female subjects

Yassaei, S., Aghili, H. A., Afshari, J. T., Bagherpour, A., & Eslami, F. (2016) · Lasers in Medical Science · doi:10.1007/s10103-016-2045-1 · Cited by 39 · see citing works

Association of Stat3-Dependent Transcriptional Activation of p19INK4Dwith IL-6-Induced Growth Arrest

Narimatsu, M., Nakajima, K., Ichiba, M., & Hirano, T. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7387 · Cited by 38 · see citing works

The in vivo Anti‐tumor Effect of Human Recombinant Interleukin‐6

Kitahara, M., Kishimoto, S., Hirano, T., Kishimoto, T., & Okada, M. (1990) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1990.tb03342.x · Cited by 34 · see citing works

Inflammation and cardiopulmonary bypass

Levy, J. H., & Kelly, A. B. (1993) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03009469 · Cited by 33 · see citing works

Revisiting the 1986 Molecular Cloning of Interleukin 6

Hirano, T. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00456 · Cited by 30 · see citing works

Use of immobilized synthetic peptides for the identification of contact sites between human interleukin‐6 and its receptor

Weiergräber, O. H., Schneider‐Mergener, J., Grötzinger, J., Wollmer, A., Küster, A., Exner, M., & Heinrich, P. C. (1996) · FEBS Letters · doi:10.1016/0014-5793(95)01482-9 · Cited by 29 · see citing works

Identification of a Novel Interleukin-6 Response Element Containing an Ets-Binding Site and a CRE-Like Site in thejunBPromoter

Nakajima, K., Kusafuka, T., Takeda, T., Fujitani, Y., Nakae, K., & Hirano, T. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.5.3027-3041.1993 · Cited by 29 · see citing works

Suppression of Endotoxin-Induced Renal Tumor Necrosis Factor-α and Interleukin-6 mRNA by Renin-Angiotensin System Inhibitors

Niimi, R., Nakamura, A., & Yanagawa, Y. (2002) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.88.139 · Cited by 28 · see citing works

Kininogen expression by rat vascular smooth muscle cells: Stimulation by lipopolysaccharide and angiotensin II

Okamoto, H., Yayama, K., Shibata, H., Nagaoka, M., & Takano, M. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(98)00074-3 · Cited by 27 · see citing works

Low doses of radiation induce systemic production of cytokines: Possible contribution to leukemogenesis

Tartakovsky, B., Goldstein, O., Krautghamer, R., & Haran‐Ghera, N. (1993) · International Journal of Cancer · doi:10.1002/ijc.2910550217 · Cited by 26 · see citing works

Salivary cystatins induce interleukin-6 expression via cell surface molecules in human gingival fibroblasts

Kato, T., Imatani, T., Minaguchi, K., Saitoh, E., & Okuda, K. (2002) · Molecular Immunology · doi:10.1016/s0161-5890(02)00144-x · Cited by 26 · see citing works

Membrane‐bound and Soluble Interleukin‐6 Receptor: Studies on Structure, Regulation of Expression, and Signal Transductiona

Heinrich, P. C., Graeve, L., Rose‐John, S., Schneider‐Mergener, J., Dittrich, E., Erren, A., Gerhartz, C., Hemmann, U., Lütticken, C., Wegenka, U. M., et al. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb32328.x · Cited by 26 · see citing works

Regulation of interleukin‐6 receptor expression by interleukin‐6 in human monocytes — a re‐examination

Schoester, M., Heinrich, P. C., & Graeve, L. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00416-1 · Cited by 16 · see citing works

Hematopoiesis/Erythropoiesis in Myocardial Infarcts

Goldman, B., & WURZEL, J. M. (2001) · Modern Pathology · doi:10.1038/modpathol.3880356 · Cited by 15 · see citing works

Cytokines and Their Role as Growth Factors and in Regulation of Immune Responses

Georgiev, V. S., & Albright, J. F. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb35922.x · Cited by 15 · see citing works

Two novel somatic mutations in the human interleukin 6 promoter region in a patient with sporadic breast cancer

Saha, A., Bairwa, N. K., Ranjan, A., Gupta, V., & Bamezai, R. N. K. (2003) · European Journal of Immunogenetics · doi:10.1111/j.1365-2370.2003.00423.x · Cited by 14 · see citing works

Regulation of α2‐Macroglobulin Gene Expression by Interleukin‐6 a

Horn, F., Wegenka, U., Lütticken, C., Yuan, J.-L., Roeb, E., Boers, W., Buschmann, J., & Heinrich, P. C. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb44320.x · Cited by 14 · see citing works

Signal transduction mechanism of interleukin 6 in cultured rat mesangial cells

Fukunaga, M., Fujiwara, Y., Fujibayashi, M., Ochi, S., Yokoyama, K., Ando, A., Hirano, T., Ueda, N., & Kamada, T. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80813-i · Cited by 13 · see citing works

The Role of Interleukin 6 in Plasmacytomagenesis

Hirano, T., Suematsu, S., Matsusaka, T., Matsuda, T., & Kishimoto, T. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514269.ch12 · Cited by 13 · see citing works

Interleukin 6 and disease transformation in chronic myeloid leukemia: A Northeast Indian population study

Sharma, K., Singh, U., Rai, M., Shukla, J., Gupta, V., Narayan, G., & Kumar, S. (2018) · Journal of Cancer Research and Therapeutics · doi:10.4103/jcrt.jcrt_137_17 · Cited by 10 · see citing works

Fasting Exacerbates Acute Pancreatitis by Occlusion of the Common Bile Duct in Rats

Yoshinaga, K., Washizuka, M., & Segawa, Y. (2000) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.84.455 · Cited by 7 · see citing works

Autism: genetics, environmental stressors, maternal immune activation, and the male bias in autism

Otaru, S., & Lawrence, D. A. (2022) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2022.00025 · Cited by 6 · see citing works

CSF-1 and Interferon-γ Act Synergistically to Promote Differentiation of FDC-P1 Cells into Macrophages

Novak, U., Nicholson, S. E., Bourette, R. P., Rohrschneider, L. R., Alexander, W. S., & Paradiso, L. (1998) · Growth Factors · doi:10.3109/08977199809002114 · Cited by 6 · see citing works

Quantitative Analysis of Interleukin-6 Expression in Porcine Spleen Cells and Alveolar Macrophages using Real-Time PCR

Lee, D. Y., Cho, Y.-W., Kang, S. G., Shin, N.-R., Choi, I., Shin, S. J., & Yoo, H. S. (2004) · Veterinary Research Communications · doi:10.1023/b:verc.0000040242.85968.e0 · Cited by 6 · see citing works

Interleukin 6

Matsuda, T., & Kishimoto, T. (1998) · Elsevier eBooks · doi:10.1006/rwei.1999.0371 · Cited by 6 · see citing works

Role of antidiarrheal agents nifuroxazide in antitumor multi‑target anticancer, multi‑mechanism anticancer drug (Review)

Liu, L., Ma, C.-S., Ji, J., Gao, R., & Li, D. (2025) · Oncology Letters · doi:10.3892/ol.2025.15006 · Cited by 2 · see citing works

Ocular inflammation stimulated by the immunomodulator AS101 [ammonium trichloro(dioxyethelene-O-O') tellurate]

Dastgheib, K., Hikita, N., Sredni, B., Albeck, M., Sredni, D., Nussenblatt, R. B., & Chan, C. (1994) · Current Eye Research · doi:10.3109/02713689408999894 · Cited by 2 · see citing works

Interleukin 6: a consequence of inflammation

Evans, S. W. (1992) · Springer eBooks · doi:10.1007/978-94-011-2996-1_12 · Cited by 1 · see citing works

Effect of particulate emissions from road transportation vehicles on health of communities in urban and rural areas, Kano State, Nigeria

Sadiq, A. A. (2022) · doi:10.70675/48c36f30za7acz41d9z9bc3zc112ba09c027 · Cited by 2 · see citing works

IL ‐6/ IL ‐ 6R ‐Mediated Mechanisms in Lung Cancer: From Pathogenesis to Potential Therapeutic Targets

Abuhassan, Q., Al‐Ameer, H. J., Jyothi, S. R., Nayak, P. P., Pandurangan, P., Mukherjee, G., Sinha, A., & Hazratkulova, O. (2026) · Immunology · doi:10.1111/imm.70170

Interleukin 6: a consequence of inflammation

Evans, S. W. (1992) · Springer eBooks · doi:10.1007/978-94-011-2996-1_12 · Cited by 1 · see citing works

Interleukin-6: historical background, genetics and biological significance

Wolvekamp, M. C. J., & Marquet, R. L. (1990) · Immunology Letters · doi:10.1016/0165-2478(90)90028-o · Cited by 100 · see citing works

Interleukin-6 (IL-6)

Kishimoto, T. (2003) · Elsevier eBooks · doi:10.1016/b978-012689663-3/50016-8 · Cited by 14 · see citing works

A Multifunctional Cytokine (IL-6/BSF-2) and Its Receptor

Hirano, T., Taga, T., Yamasaki, K., Matsuda, T., Tang, B., Muraguchi, A., Horii, Y., Suematsu, S., Hirata, Y., Yawata, H., et al. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000234743 · Cited by 32 · see citing works

WITH INTERLEUKIN 6 cDNA

Transfected, I. D. B. C. (2013)