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Pleiotropic phenotype of colchicine‐resistant CHO cells: Cross‐resistance and collateral sensitivity
Abstract
Colchicine resistant (CH R) mutants of CHO cells with reduced permeability to colchicine display extensive cross‐resistance to a number of apparently unrelated compounds including puromycin, daunomycin, emetine, ethidium bromide and gramicidin D. A positive correlation was observed between the level of cross‐resistance and the relative hydrophobicity of these compounds. The mutants also showed increased (collateral) sensitivity to local anaesthetics (procaine, tetracaine, xylocaine and propanolol), steroid hormones (1‐dehydrotestosterone, corticosterone and 5β‐pregnan‐3,20‐dione) and some Triton × compounds. In general, the degree of the pleiotropic response (cross‐resistance or collateral sensitivity) correlated with the degree of colchicine resistance in mutant lines. These results are consistent with the pleiotropic phenotype being the result of the same mutation(s) which confer colchicine resistance and support a model for resistance in which the reduced permeability is assumed to be the result of an alteration in the modulation of the fluidity of the surface membrane.
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Citations
Cited by
Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines
Kartner, N., Riordan, J. R., & Ling, V. (1983) · Science · doi:10.1126/science.6137059 · Cited by 991
Self-citationThe molecular basis of multidrug resistance in cancer: The early years of P‐glycoprotein research
Gottesman, M. M., & Ling, V. (2006) · FEBS Letters · doi:10.1016/j.febslet.2005.12.060 · Cited by 558
Self-citationInhibition of the Multidrug Resistance P-Glycoprotein: Time for a Change of Strategy?
Callaghan, R., Luk, F., & Bebawy, M. (2014) · Drug Metabolism and Disposition · doi:10.1124/dmd.113.056176 · Cited by 453
Role of the Glutathione Redox Cycle in Acquired and de Novo Multidrug Resistance
Kramer, R. A., Zakher, J., & Kim, G. (1988) · Science · doi:10.1126/science.3399900 · Cited by 295
Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells.
Cornwell, M. M., Gottesman, M. M., & Pastan, I. H. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)57491-9 · Cited by 253
Metadata
- Authors
- Bech‐Hansen, N. T., Till, J. E., & Ling, V.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 1976-05
- Volume
- 88
- Issue
- 1
- Pages
- 23-31
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W1984516227
- Cited by
- 309
- References
- 0
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bech‐Hansen, N. T., Till, J. E., & Ling, V. (1976). Pleiotropic phenotype of colchicine‐resistant CHO cells: Cross‐resistance and collateral sensitivity. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.1040880104
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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