Inhibition of the Multidrug Resistance P-Glycoprotein: Time for a Change of Strategy?

Multidrug resistance in cancer: role of ATP–dependent transporters

Gottesman, M. M., Fojo, T., & Bates, S. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc706 · Cited by 5,536 · see citing works

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

Juliano, R. L., & Ling, V. W. T. (1976) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(76)90160-7 · Cited by 3,317 · see citing works

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

Cole, S. P. C., Bhardwaj, G., Gerlach, J. H., Mackie, J. E., Grant, C. E., Almquist, K. C., Stewart, A. J., Kurz, E. U., Duncan, A. M. V., & Deeley, R. G. (1992) · Science · doi:10.1126/science.1360704 · Cited by 3,037 · see citing works

A multidrug resistance transporter from human MCF-7 breast cancer cells

Doyle, L. A., Yang, W., Abruzzo, L. V., Krogmann, T. A., Gao, Y., Rishi, A. K., & Ross, D. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15665 · Cited by 2,319 · see citing works

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

György, B., Szabó, T. G., Pásztói, M., Pál, Z., Misják, P., Aradi, B., László, V., Pállinger, É., Pap, E., Kittel, Á., et al. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0689-3 · Cited by 2,075 · see citing works

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

Chen, C.-J., Chin, J. E., Ueda, K., Clark, D. P., Pastan, I., Gottesman, M. M., & Roninson, I. B. (1986) · Cell · doi:10.1016/0092-8674(86)90595-7 · Cited by 1,898 · see citing works

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

Cordon‐Cardo, C., O’Brien, J. P., Casals, D., Rittmann-Grauer, L., Biedler, J. L., Melamed, M. R., & Bertino, J. R. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.2.695 · Cited by 1,750 · see citing works

Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense

Leslie, E. M., Deeley, R. G., & Cole, S. P. C. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.10.012 · Cited by 1,407 · see citing works

Selective laser photo-thermal therapy of epithelial carcinoma using anti-EGFR antibody conjugated gold nanoparticles

El‐Sayed, I. H., Huang, X., & ElSayed, M. E. H. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.07.035 · Cited by 1,354 · see citing works

Induction of phase I, II and III drug metabolism/transport by xenobiotics

Xu, C., Li, C. Y.-T., & Kong, A. T. (2005) · Archives of Pharmacal Research · doi:10.1007/bf02977789 · Cited by 1,272 · see citing works

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

Cordon‐Cardo, C., O’Brien, J. P., Boccia, J. P., Casals, D., Bertino, J. R., & Melamed, M. R. (1990) · Journal of Histochemistry & Cytochemistry · doi:10.1177/38.9.1974900 · Cited by 1,062 · see citing works

pH-Responsive Nanoparticles for Drug Delivery

Gao, W., Chan, J. M., & Farokhzad, O. C. (2010) · Molecular Pharmaceutics · doi:10.1021/mp100253e · Cited by 1,044 · see citing works

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

Gros, P., Croop, J. M., & Housman, D. E. (1986) · Cell · doi:10.1016/0092-8674(86)90594-5 · Cited by 1,043 · see citing works

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

Kartner, N., Evernden-Porelle, D., Bradley, G., & Ling, V. W. T. (1985) · Nature · doi:10.1038/316820a0 · Cited by 908 · see citing works

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapy

Wacher, V. J., Wu, C., & Benet, L. Z. (1995) · Molecular Carcinogenesis · doi:10.1002/mc.2940130302 · Cited by 862 · see citing works

Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin

Geick, A., Eichelbaum, M. F., & Burk, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010173200 · Cited by 845 · see citing works

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

Synold, T. W., Dussault, I., & FORMAN, B. M. (2001) · Nature Medicine · doi:10.1038/87912 · Cited by 840 · see citing works

Untitled work

(2002) · PubMed · Cited by 840 · see citing works

The Role of ABC Transporters in Clinical Practice

Leonard, G. D., Fojo, T., & Bates, S. E. (2003) · The Oncologist · doi:10.1634/theoncologist.8-5-411 · Cited by 819 · see citing works

Is the multidrug transporter a flippase?

Higgins, C. F., & Gottesman, M. M. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90419-a · Cited by 726 · see citing works

Membrane Microparticles: Two Sides of the Coin

Hugel, B., Martínez, M. C., Kunzelmann, C., & Freyssinet, J.-M. (2005) · Physiology · doi:10.1152/physiol.00029.2004 · Cited by 698 · see citing works

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

Tsuruo, T., Iida, H., Tsukagoshi, S., et al. (1982) · PubMed · Cited by 664 · see citing works

Histone deacetylases, transcriptional control, and cancer

Cress, W. D., & Seto, E. (2000) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(200007)184:1 · Cited by 619 · see citing works

Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.

Dalton, W. S., Grogan, T. M., Meltzer, P. S., Scheper, R. J., Durie, B. G. M., Taylor, C. W., Miller, T., & Salmon, S. E. (1989) · Journal of Clinical Oncology · doi:10.1200/jco.1989.7.4.415 · Cited by 556 · see citing works

Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.

Cornwell, M. M., Pastan, I. H., & Gottesman, M. M. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61633-3 · Cited by 530 · see citing works

A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics

Whitnall, M., Howard, J., Ponka, P., & Richardson, D. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604979103 · Cited by 510 · see citing works

Multidrug Resistance: Retrospect and Prospects in Anti-Cancer Drug Treatment

Pérez‐Tomás, R. (2006) · Current Medicinal Chemistry · doi:10.2174/092986706777585077 · Cited by 509 · see citing works

Fluorescent cellular indicators are extruded by the multidrug resistance protein.

Homolya, L., Holló, Z., Germann, U. A., PASTAN, I., Gottesman, M. M., & Sarkadi, B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80566-3 · Cited by 496 · see citing works

Polyethylenglykol-umhülltes (pegyliertes) liposomales Doxorubicin

Gabizón, A., & Martin, F. (1997) · Drugs · doi:10.2165/00003495-199700544-00005 · Cited by 478 · see citing works

Cellular microparticles: a disseminated storage pool of bioactive vascular effectors

Morel, O., Toti, F., Hugel, B., & Freyssinet, J. (2004) · Current Opinion in Hematology · doi:10.1097/01.moh.0000131441.10020.87 · Cited by 454 · see citing works

Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients.

Ozols, R. F., Cunnion, R. E., Klecker, R. W., Hamilton, T. C., Ostchega, Y., Parrillo, J. E., & Young, R. C. (1987) · Journal of Clinical Oncology · doi:10.1200/jco.1987.5.4.641 · Cited by 426 · see citing works

GENETIC STUDIES ON MICROBIAL CROSS RESISTANCE TO TOXIC AGENTS I. ,

Szybalski, W., & Bryson, V. (1952) · Journal of Bacteriology · doi:10.1128/jb.64.4.489-499.1952 · Cited by 424 · see citing works

Cell-derived microparticles in haemostasis and vascular medicine

Burnier, L., Fontana, P., Kwak, B. R., & Angelillo‐Scherrer, A. (2009) · Thrombosis and Haemostasis · doi:10.1160/th08-08-0521 · Cited by 416 · see citing works

Characterization of Nanoparticles for Therapeutics

Hall, J. B., Dobrovolskaia, M. A., Patri, A. K., & McNeil, S. E. (2007) · Nanomedicine · doi:10.2217/17435889.2.6.789 · Cited by 413 · see citing works

Cellular microparticles: what are they bad or good for?

Freyssinet, J. M. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.00309.x · Cited by 399 · see citing works

Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells.

Raviv, Y., Pollard, H. B., Bruggemann, E. P., Pastan, I. H., & Gottesman, M. M. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39690-5 · Cited by 388 · see citing works

Circumvention of vincristine and Adriamycin resistance in vitro and in vivo by calcium influx blockers.

Tsuruo, T., Iida, H., Nojiri, M., et al. (1983) · PubMed · Cited by 380 · see citing works

Transferrin-Containing, Cyclodextrin Polymer-Based Particles for Tumor-Targeted Gene Delivery

Bellocq, N. C., Pun, S. H., Jensen, G. S., & Davis, M. E. (2003) · Bioconjugate Chemistry · doi:10.1021/bc034125f · Cited by 350 · see citing works

Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells

Bebawy, M., Combes, V., Lee, E., Jaiswal, R., Gong, J., Bonhoure, A., & Grau, G. E. (2009) · Leukemia · doi:10.1038/leu.2009.76 · Cited by 323 · see citing works

Pleiotropic phenotype of colchicine‐resistant CHO cells: Cross‐resistance and collateral sensitivity

Bech‐Hansen, N. T., Till, J. E., & Ling, V. W. T. (1976) · Journal of Cellular Physiology · doi:10.1002/jcp.1040880104 · Cited by 314 · see citing works

Phase II study of tariquidar, a selective P‐glycoprotein inhibitor, in patients with chemotherapy‐resistant, advanced breast carcinoma

Pusztai, L., Wagner, P., Ibrahim, N. K., Rivera, E., Theriault, R. L., Booser, D. J., Symmans, W. F., Wong, F. C., Blumenschein, G., Fleming, D. R., et al. (2005) · Cancer · doi:10.1002/cncr.21227 · Cited by 303 · see citing works

Platelet microparticles: a wide-angle perspective

Horstman, L. L., & Ahn, Y. S. (1999) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(98)00044-4 · Cited by 300 · see citing works

Polyethylenglykol-umhülltes (pegyliertes) liposomales Doxorubicin: Grundlagen für die Anwendung bei soliden Tumoren

Gabizón, A., & Martin, F. J. (1997) · Drugs · Cited by 292 · see citing works

P-Glycoprotein and Breast Cancer Resistance Protein: Two Dominant Transporters Working Together in Limiting the Brain Penetration of Topotecan

de Vries, N. A., Zhao, J., Kroon, E., Buckle, T., Beijnen, J. H., & van Tellingen, O. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1335 · Cited by 271 · see citing works

Extracellular membrane vesicles from tumor cells promote angiogenesis via sphingomyelin.

Kim, C. W., Lee, H. M., Lee, T. H., Kang, C., Kleinman, H. K., & Gho, Y. S. (2002) · PubMed · Cited by 265 · see citing works

Drug resistance: Still a daunting challenge to the successful treatment of AML

Shaffer, B., Gillet, J., Patel, C., Baer, M., Bates, S., & Gottesman, M. (2012) · Drug resistance updates · doi:10.1016/j.drup.2012.02.001 · Cited by 256 · see citing works

Modulation of multidrug resistance efflux pump activity to overcome chemoresistance in cancer

Modok, S., Mellor, H. R., & Callaghan, R. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.01.009 · Cited by 242 · see citing works

Nanoparticle therapeutics: a personal perspective

McNeil, S. E. (2009) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.6 · Cited by 231 · see citing works

Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance.

Bradshaw, D. M., & Arceci, R. J. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.11.3674 · Cited by 227 · see citing works

Endosomes, lysosomes: their implication in gene transfer

Wattiaux, R., Laurent, N., Coninck, S. W., & Jadot, M. (2000) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(99)00066-6 · Cited by 225 · see citing works

Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis?

Gillies, R. J., & Gatenby, R. A. (2007) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-007-9085-y · Cited by 219 · see citing works

Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1

Hegedűs, T., Őrfi, L., Seprődi, A., Váradi, A., Sarkadi, B., & Kéri, G. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(02)00095-9 · Cited by 207 · see citing works

Photoaffinity labeling of the multidrug-resistance-related P-glycoprotein with photoactive analogs of verapamil.

Safa, A. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.19.7187 · Cited by 205 · see citing works

Tumor extracellular acidity-activated nanoparticles as drug delivery systems for enhanced cancer therapy

Du, J., Mao, C., Yuan, Y., Yang, X., & Wang, J. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.08.002 · Cited by 204 · see citing works

The Pharmacokinetics of Cell-Penetrating Peptides

Sarko, D., Beijer, B., Boy, R. G., Nothelfer, E.-M., Leotta, K., Eisenhut, M., Altmann, A., Haberkorn, U., & Mier, W. (2010) · Molecular Pharmaceutics · doi:10.1021/mp100223d · Cited by 199 · see citing works

The Contribution of P‐glycoprotein to Pharmacokinetic Drug‐Drug Interactions

Yu, D. K. (1999) · The Journal of Clinical Pharmacology · doi:10.1177/00912709922012006 · Cited by 199 · see citing works

Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells.

Chambers, T. C., McAvoy, E., Jacobs, J. W., et al. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39168-9 · Cited by 198 · see citing works

Molecular Pathways: Regulation and Therapeutic Implications of Multidrug Resistance

Chen, K. G., & Sikic, B. I. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-1590 · Cited by 197 · see citing works

Cancer's sweet tooth

Bui, T., & Thompson, C. B. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.05.012 · Cited by 195 · see citing works

Analysis of the tangled relationships between P‐glycoprotein‐mediated multidrug resistance and the lipid phase of the cell membrane

Ferté, J. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01046.x · Cited by 194 · see citing works

Function and role of microparticles in various clinical settings

Nomura, S., Ozaki, Y., & Ikeda, Y. (2008) · Thrombosis Research · doi:10.1016/j.thromres.2008.06.006 · Cited by 191 · see citing works

Procoagulant activity associated with plasma membrane vesicles shed by cultured tumor cells.

Dvorak, H. F., DeWater, L. V., Am, B., Dvořàk, A. M., Anderson, D. J., Harvey, V. S., Bach, R. R., Davis, G. L., DeWolf, W. C., & Carvalho, A. C. A. (1983) · PubMed · Cited by 186 · see citing works

Characterization of Phosphorylation-defective Mutants of Human P-glycoprotein Expressed in Mammalian Cells

Germann, U. A., Chambers, T. C., Ambudkar, S. V., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.3.1708 · Cited by 173 · see citing works

Urokinase Plasminogen Activator and Gelatinases Are Associated with Membrane Vesicles Shed by Human HT1080 Fibrosarcoma Cells

Ginestra, A., Monea, S., Seghezzi, G., Dolo, V., Nagase, H., Mignatti, P., & Vittorelli, M. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.17216 · Cited by 173 · see citing works

Resistance to Chemotherapy in Cancer: A Complex and Integrated Cellular Response

Mellor, H. R., & Callaghan, R. (2008) · Pharmacology · doi:10.1159/000115967 · Cited by 169 · see citing works

Matrix-degrading proteinases are shed in membrane vesicles by ovarian cancer cells in vivo and in vitro

Dolo, V., D’Ascenzo, S., Violini, S., Pompucci, L., Festuccia, C., Ginestra, A., Vittorelli, M. L., Canevari, S., & Pavan, A. (1999) · Clinical & Experimental Metastasis · doi:10.1023/a:1006500406240 · Cited by 167 · see citing works

Liposome imaging agents in personalized medicine

Petersen, A. L., Hansen, A. E., Gabizon, A., & Andresen, T. L. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.003 · Cited by 164 · see citing works

Microparticles and their emerging role in cancer multidrug resistance

Gong, J., Jaiswal, R., Mathys, J., Combes, V., Grau, G. E., & Bebawy, M. (2011) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2011.06.005 · Cited by 163 · see citing works

Identification of specific sites in human P-glycoprotein phosphorylated by protein kinase C.

Chambers, T. C., Pohl, J., Raynor, R. L., et al. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53436-0 · Cited by 157 · see citing works

Formation of procoagulant microparticles and properties

Freyssinet, J., & Toti, F. (2010) · Thrombosis Research · doi:10.1016/j.thromres.2010.01.036 · Cited by 157 · see citing works

Inhibition of ABCB1 (MDR1) Expression by an siRNA Nanoparticulate Delivery System to Overcome Drug Resistance in Osteosarcoma

Susa, M., Iyer, A. K., Ryu, K., Choy, E., Hornicek, F. J., Mankin, H. J., Milane, L. S., Amiji, M. M., & Duan, Z. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010764 · Cited by 157 · see citing works

New Insight into P-Glycoprotein as a Drug Target

Breier, A., Gibalová, L., Šereš, M., et al. (2012) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152013804487380 · Cited by 157 · see citing works

A Pharmacophore for Human Pregnane X Receptor Ligands

Ekins, S., & Erickson, J. A. (2002) · Drug Metabolism and Disposition · doi:10.1124/dmd.30.1.96 · Cited by 153 · see citing works

Action of calcium antagonists on multidrug resistant cells

Cano-Gauci, D. F., & Riorda, J. R. (1987) · Biochemical Pharmacology · doi:10.1016/0006-2952(87)90139-0 · Cited by 146 · see citing works

Molecular Mechanisms of Endocytosis

Riezman, H., Woodman, P. G., Gerrit van, M. E. E. R., & Marsh, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80461-4 · Cited by 146 · see citing works

pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents

Andreev, O. A., Engelman, D. M., & Reshetnyak, Y. K. (2010) · Molecular Membrane Biology · doi:10.3109/09687688.2010.509285 · Cited by 144 · see citing works

Cerebral malaria: role of microparticles and platelets in alterations of the blood–brain barrier

Combes, V., Coltel, N., Faille, D., Wassmer, S. C., & Grau, G. E. (2006) · International Journal for Parasitology · doi:10.1016/j.ijpara.2006.02.005 · Cited by 143 · see citing works

Signal Transduction Pathways and Transcriptional Mechanisms of ABCB1 /Pgp-mediated Multiple Drug Resistance in Human Cancer Cells

Sui, H. X., Fan, Z.-Z., & Li, Q. (2012) · Journal of International Medical Research · doi:10.1177/147323001204000204 · Cited by 142 · see citing works

Computational models for predicting substrates or inhibitors of P-glycoprotein

Chen, L., Li, Y., Yu, H., Zhang, L., & Hou, T. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.11.003 · Cited by 140 · see citing works

Stability and covalent modification of P-glycoprotein in multidrug-resistant KB cells

Richert, N. D., Aldwin, L. A., Nitecki, D. E., et al. (1988) · Biochemistry · doi:10.1021/bi00420a006 · Cited by 128 · see citing works

Phosphorylation of the multidrug resistance associated glycoprotein

Mellado, W., & Horwitz, S. B. (1987) · Biochemistry · doi:10.1021/bi00396a005 · Cited by 127 · see citing works

ABC transporters and drug resistance in leukemia: was P-gp nothing but the first head of the Hydra?

Steinbach, D., & Legrand, O. (2007) · Leukemia · doi:10.1038/sj.leu.2404692 · Cited by 127 · see citing works

Long-circulating liposomes.

Oku, N., & Namba, Y. (1994) · PubMed · Cited by 125 · see citing works

Glucose depletion enhances P-glycoprotein expression in hepatoma cells: role of endoplasmic reticulum stress response.

Ledoux, S., Yang, R., Friedlander, G., & Laouari, D. (2003) · PubMed · Cited by 125 · see citing works

P‐glycoprotein: So Many Ways to Turn It On

Callaghan, R., Crowley, E. H., Biochem, M., Potter, S., & Kerr, I. D. (2007) · The Journal of Clinical Pharmacology · doi:10.1177/0091270007311568 · Cited by 123 · see citing works

Protein Kinase C-mediated Phosphorylation Does Not Regulate Drug Transport by the Human Multidrug Resistance P-glycoprotein

Goodfellow, H. R., Sardini, A., Ruetz, S., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.23.13668 · Cited by 122 · see citing works

Protection against cerebral malaria by the low-molecular-weight thiol pantethine

Penet, M., Abou-Hamdan, M., Coltel, N., Cornille, E., Grau, G. E., Reggi, M. L. D., & Gharib, B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706867105 · Cited by 117 · see citing works

Novel approaches for drug delivery systems in nanomedicine: effects of particle design and shape

Schneider‐Daum, N., Tscheka, C., Neumeyer, A., et al. (2011) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.165 · Cited by 117 · see citing works

Genetic Studies on Microbial Cross Resistance to Toxic Agents

Szybalski, W. (1954) · Applied Microbiology · doi:10.1128/aem.2.2.57-63.1954 · Cited by 117 · see citing works

A Phase I Study of the P-Glycoprotein Antagonist Tariquidar in Combination with Vinorelbine

Abraham, J., Edgerly, M., Wilson, R. H., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0938 · Cited by 116 · see citing works

Microparticle‐associated nucleic acids mediate trait dominance in cancer

Jaiswal, R., Gong, J., Sambasivam, S., et al. (2011) · The FASEB Journal · doi:10.1096/fj.11-186817 · Cited by 115 · see citing works

Synthesis and Structure–Activity Evaluation of Isatin-β-thiosemicarbazones with Improved Selective Activity toward Multidrug-Resistant Cells Expressing P-Glycoprotein

Hall, M. D., Brimacombe, K. R., Varonka, M. S., Pluchino, K. M., Monda, J. K., Li, J., Walsh, M. J., Boxer, M. B., Warren, T. H., Fales, H. M., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm2006047 · Cited by 114 · see citing works

Regulation by phorbol ester and protein kinase C inhibitors, and by a protein phosphatase inhibitor (okadaic acid), of P-glycoprotein phosphorylation and relationship to drug accumulation in multidrug-resistant human KB cells.

Chambers, T. C., Zheng, B., & Kuo, J. F. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09221-1 · Cited by 111 · see citing works

Induction by verapamil of a rapid increase in ATP consumption in multidrug‐resistant tumor cells

Broxterman, H. J., Pinedo, H. M., Kuiper, C. M., et al. (1988) · The FASEB Journal · doi:10.1096/fasebj.2.7.3350243 · Cited by 107 · see citing works

P-glycoprotein Substrate Models Using Support Vector Machines Based on a Comprehensive Data set

Wang, Z., Chen, Y., Hu, L., Bender, A., Glen, R. C., & Yan, A. (2011) · Journal of Chemical Information and Modeling · doi:10.1021/ci2001583 · Cited by 107 · see citing works

Inhibition of Wnt/β‐catenin signaling downregulates P‐glycoprotein and reverses multi‐drug resistance of cholangiocarcinoma

Shen, D., Zhang, W., Zeng, X., & Liu, C. (2013) · Cancer Science · doi:10.1111/cas.12223 · Cited by 105 · see citing works

Breast Cancer-Derived Microparticles Display Tissue Selectivity in the Transfer of Resistance Proteins to Cells

Jaiswal, R., Luk, F., Dalla, P. V., Grau, G. E., & Bebawy, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061515 · Cited by 103 · see citing works

Microparticle conferred microRNA profiles - implications in the transfer and dominance of cancer traits

Jaiswal, R., Luk, F., Gong, J., Mathys, J., Grau, G. E., & Bebawy, M. (2012) · Molecular Cancer · doi:10.1186/1476-4598-11-37 · Cited by 103 · see citing works

Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.

Diddens, H. C., NIETHAMMER, D., & Jackson, R. (1983) · PubMed · Cited by 100 · see citing works

Therapeutic Efficacy and Safety of Paclitaxel/Lonidamine Loaded EGFR-Targeted Nanoparticles for the Treatment of Multi-Drug Resistant Cancer

Milane, L. S., Duan, Z., & Amiji, M. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024075 · Cited by 99 · see citing works

Staurosporine, a potent inhibitor of C-kinase, enhances drug accumulation in multidrug-resistant cells

Sato, W., Yusa, K., Naito, M., et al. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)80921-0 · Cited by 97 · see citing works

Targeting Prostaglandin E2 EP1 Receptors Prevents Seizure-Associated P-glycoprotein Up-Regulation

Pekcec, A., Unkrüer, B., Schlichtiger, J., Soerensen, J., Hartz, A. M. S., Bauer, B., van Vliet, E. A., Gorter, J. A., & Potschka, H. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.152520 · Cited by 97 · see citing works

Grape Seed Procyanidin Reversal of P-glycoprotein Associated Multi-Drug Resistance via Down-regulation of NF-κB and MAPK/ERK Mediated YB-1 Activity in A2780/T Cells

Zhao, B., Sun, Y., Wang, S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071071 · Cited by 89 · see citing works

Molecular and magnetic resonance imaging: The value of immunoliposomes

Kozlowska, D., Foran, P., MacMahon, P. J., et al. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.09.003 · Cited by 89 · see citing works

Epidermal Growth Factor Receptor-Targeted Gelatin-Based Engineered Nanocarriers for DNA Delivery and Transfection in Human Pancreatic Cancer Cells

Magadala, P., & Amiji, M. M. (2008) · The AAPS Journal · doi:10.1208/s12248-008-9065-0 · Cited by 87 · see citing works

Vesicle-associated urokinase plasminogen activator promotes invasion in prostate cancer cell lines

Angelucci, A., D’Ascenzo, S., Festuccia, C., Gravina, G. L., Bologna, M., Dolo, V., & Pavan, A. (2000) · Clinical & Experimental Metastasis · doi:10.1023/a:1006778000173 · Cited by 87 · see citing works

Modulation of P-glycoprotein phosphorylation and drug transport by sodium butyrate

Bates, S. E., Currier, S. J., Alvarez, M. G., et al. (1992) · Biochemistry · doi:10.1021/bi00143a002 · Cited by 86 · see citing works

Microparticles mediate MRP1 intercellular transfer and the re-templating of intrinsic resistance pathways

Lu, J. F., Luk, F., Gong, J., Jaiswal, R., Grau, G. E., & Bebawy, M. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2013.07.009 · Cited by 85 · see citing works

Superhigh-magnetization nanocarrier as a doxorubicin delivery platform for magnetic targeting therapy

Hua, M., Yang, H., Liu, H.-L., Tsai, R., Pang, S., Chuang, K., Chang, Y., Hwang, T., Chang, Y., Chuang, H., et al. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.08.014 · Cited by 85 · see citing works

R(h)oads to microvesicles

Antonyak, M. A., Wilson, K. F., & Cerione, R. A. (2012) · Small GTPases · doi:10.4161/sgtp.20755 · Cited by 84 · see citing works

Emerging Metabolic Targets in Cancer Therapy

Zhao, Y. (2010) · Frontiers in bioscience · doi:10.2741/3826 · Cited by 82 · see citing works

A Mechanism for P-Glycoprotein-Mediated Apoptosis As Revealed by Verapamil Hypersensitivity

Karwatsky, J., Lincoln, M. C., & Georges, E. (2003) · Biochemistry · doi:10.1021/bi034149+ · Cited by 82 · see citing works

Regulation of the multidrug resistance transporter P-glycoprotein in multicellular prostate tumor spheroids by hyperthermia and reactive oxygen species

Wartenberg, M., Gronczynska, S., Bekhite, M. M., Saric, T., Niedermeier, W., Hescheler, J., & Sauer, H. (2005) · International Journal of Cancer · doi:10.1002/ijc.20596 · Cited by 82 · see citing works

Expression of ATP-Binding Cassette Membrane Transporters in Rodent and Human Sertoli Cells: Relevance to the Permeability of Antiretroviral Therapy at the Blood-Testis Barrier

Robillard, K. R., Hoque, T., & Bendayan, R. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.186916 · Cited by 76 · see citing works

Characterization of a membrane-associated protein kinase of multidrug-resistant HL60 cells which phosphorylates P-glycoprotein.

Staats, J., & Marquardt, D. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39705-4 · Cited by 72 · see citing works

Effect of nifedipine on adiponectin in hypertensive patients with type 2 diabetes mellitus

Nomura, S., Inami, N., Kimura, Y., Omoto, S., Shouzu, A., Nishikawa, M., & Iwasaka, T. (2006) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002100 · Cited by 71 · see citing works

Inhibition of Endothelial Activation: A New Way to Treat Cerebral Malaria?

Wassmer, S. C., Cianciolo, G. J., Combes, V., & Grau, G. E. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020245 · Cited by 68 · see citing works

Comparative Proteomic Analysis of Paclitaxel Sensitive A2780 Epithelial Ovarian Cancer Cell Line and Its Resistant Counterpart A2780TC1 by 2D-DIGE: The Role of ERp57

Cicchillitti, L., Michele, M. D., Urbani, A., et al. (2009) · Journal of Proteome Research · doi:10.1021/pr800856b · Cited by 68 · see citing works

Effects of phosphorylation of P-glycoprotein on multidrug resistance

Germann, U. A., Chambers, T. C., Ambudkar, S. V., et al. (1995) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf02110331 · Cited by 63 · see citing works

Dioscin Restores the Activity of the Anticancer Agent Adriamycin in Multidrug-Resistant Human Leukemia K562/Adriamycin Cells by Down-Regulating MDR1 via a Mechanism Involving NF-κB Signaling Inhibition

Wang, L., Meng, Q., Wang, C., et al. (2013) · Journal of Natural Products · doi:10.1021/np400071c · Cited by 62 · see citing works

Identification of the major phosphorylation domain of murine mdr1b P-glycoprotein. Analysis of the protein kinase A and protein kinase C phosphorylation sites.

Orr, G. A., Han, E. K.-H., Browne, P. C., et al. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74570-0 · Cited by 61 · see citing works

Sigma‐2 Receptor Agonists as Possible Antitumor Agents in Resistant Tumors: Hints for Collateral Sensitivity

Niso, M., Abate, C., Contino, M., Ferorelli, S., Azzariti, A., Perrone, R., Colabufo, N. A., & Berardi, F. (2013) · ChemMedChem · doi:10.1002/cmdc.201300291 · Cited by 60 · see citing works

Adriamycin resistance in HL60 cells and accompanying modification of a surface membrane protein contained in drug-sensitive cells.

Marsh, W., & M S Center (1987) · PubMed · Cited by 55 · see citing works

Probucol and ticlopidine: effect on platelet and monocyte activation markers in hyperlipidemic patients with and without type 2 diabetes

Nomura, S., Takahashi, N., Inami, N., et al. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.01.027 · Cited by 54 · see citing works

P‐glycoprotein stability is affected by serum deprivation and high cell density in multidrug‐resistant cells

Müller, C., Laurent, G., & Ling, V. W. T. (1995) · Journal of Cellular Physiology · doi:10.1002/jcp.1041630314 · Cited by 54 · see citing works

Potential of the novel antiretroviral drug rilpivirine to modulate the expression and function of drug transporters and drug-metabolising enzymes in vitro

Weiß, J., & Haefeli, W. E. (2013) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2013.01.004 · Cited by 53 · see citing works

Generating Inhibitors of P-Glycoprotein: Where to, Now?

Crowley, E. H., McDevitt, C. A., & Callaghan, R. (2009) · Methods in molecular biology · doi:10.1007/978-1-60761-416-6_18 · Cited by 52 · see citing works

Cell-Derived Microparticles: New Targets in the Therapeutic Management of Disease

Bebawy, M., Roseblade, A., Luk, F., et al. (2013) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j3989x · Cited by 49 · see citing works

Circumvention of P-glycoprotein-mediated Multiple Drug Resistance by Phosphorylation Modulators Is Independent of Protein Kinases

Smith, C. D., & Zilfou, J. T. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.47.28145 · Cited by 49 · see citing works

Benidipine improves oxidized LDL-dependent monocyte and endothelial dysfunction in hypertensive patients with type 2 diabetes mellitus

Nomura, S., Shouzu, A., Omoto, S., Nishikawa, M., & Iwasaka, T. (2005) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001863 · Cited by 48 · see citing works

Investigation of folate-conjugated fluorescent silica nanoparticles for targeting delivery to folate receptor-positive tumors and their internalization mechanism

Liu, Y., Yang, Lou, et al. (2011) · International Journal of Nanomedicine · doi:10.2147/ijn.s24792 · Cited by 48 · see citing works

Interaction of Tyrosine Kinase Inhibitors with the MDR-Related ABC Transporter Proteins

Wang, X.-K., & Fu, L. (2010) · Current Drug Metabolism · doi:10.2174/138920010792927316 · Cited by 44 · see citing works

Biosynthesis, processing and half-life of P-glycoprotein in a human multidrug-resistant KB cell

Yoshimura, A., Kuwazuru, Y., Sumizawa, T., et al. (1989) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(89)90089-5 · Cited by 42 · see citing works

Selective modulation of P-glycoprotein-mediated drug resistance

Bebawy, M., Morris, M. B., & Roufogalis, B. D. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.2184 · Cited by 42 · see citing works

Cross-resistance of vinblastine- and taxol-resistant mutants of Chinese hamster ovary cells to other anticancer drugs.

Gupta, R. S. (1985) · PubMed · Cited by 41 · see citing works

Interaction of P-glycoprotein with protein kinase C in human multidrug resistant carcinoma cells.

Yang, J., Chin, K., & Hait, W. N. (1996) · PubMed · Cited by 39 · see citing works

Parthenolide reverses doxorubicin resistance in human lung carcinoma A549 cells by attenuating NF-κB activation and HSP70 up-regulation

Xin, Y., Yin, F., Qi, S., et al. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.06.215 · Cited by 38 · see citing works

Doxorubicin-loaded micelles of reverse poly(butylene oxide)–poly(ethylene oxide)–poly(butylene oxide) block copolymers as efficient “active” chemotherapeutic agents

Cambón, A., Rey‐Rico, A., Mistry, D., Brea, J. M., Loza, M. I., Attwood, D., Barbosa, S., Alvarez‐Lorenzo, C., Concheiro, Á., Taboada, P., et al. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.01.056 · Cited by 37 · see citing works

Multidrug Resistance in Chinese Hamster Cells: Effect of Liposome-Encapsulated Doxorubicin

Thierry, A. R., Jorgensen, T. J., Forst, D., Belli, J. A., Dritschilo, A., & Rahman, A. (1989) · Cancer Communications · doi:10.3727/095535489820874931 · Cited by 37 · see citing works

Collateral drug sensitivity induced in CPT-11 (a novel derivative of camptothecin)-resistant cell lines

Oguro, M., Seki, Y., Okada, K., et al. (1990) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(90)90026-6 · Cited by 36 · see citing works

Differential pharmacological regulation of drug efflux and pharmacoresistant schizophrenia

Bebawy, M., & Chetty, M. (2008) · BioEssays · doi:10.1002/bies.20706 · Cited by 33 · see citing works

Effect of Ticlopidine on Monocyte-derived Microparticles and Activated Platelet Markers in Diabetes Mellitus

Shouzu, A., Nomura, S., Omoto, S., Hayakawa, T., Nishikawa, M., & Iwasaka, T. (2004) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/107602960401000207 · Cited by 33 · see citing works

Activation of P-glycoprotein (Pgp)-mediated drug efflux by extracellular acidosis: in vivo imaging with 68Ga-labelled PET tracer

Thews, O., Dillenburg, W., Fellner, M., Buchholz, H., Bausbacher, N., Schreckenberger, M., & Rösch, F. (2010) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-010-1504-3 · Cited by 32 · see citing works

Pentose phosphate pathway alterations in multi-drug resistant leukemic T-cells: 31P NMR and enzymatic studies.

Ferretti, A., Chen, L. L., Vito, M. D., et al. (1993) · PubMed · Cited by 30 · see citing works

Collateral sensitivity of multidrug resistant cells to narcotic analgesics is due to effects on the plasma membrane

Callaghan, R., & Riordan, J. R. (1995) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(95)00042-2 · Cited by 29 · see citing works

Cytocompatibility and P-glycoprotein Inhibition of Block Copolymers: Structure–Activity Relationship

Cambón, A., Brea, J. M., Loza, M. I., et al. (2013) · Molecular Pharmaceutics · doi:10.1021/mp4002848 · Cited by 29 · see citing works

Poly(styrene oxide)-poly(ethylene oxide) block copolymers: From “classical” chemotherapeutic nanocarriers to active cell-response inducers

Cambón, A., Rey‐Rico, A., Barbosa, S., Soltero, J. F. A., Yeates, S. G., Brea, J. M., Loza, M. I., Alvarez‐Lorenzo, C., Concheiro, Á., Taboada, P., et al. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.01.010 · Cited by 28 · see citing works

Modeling Cyclosporine A Inhibition of the Distribution of a P-Glycoprotein PET Ligand,11C-Verapamil, into the Maternal Brain and Fetal Liver of the Pregnant Nonhuman Primate: Impact of Tissue Blood Flow and Site of Inhibition

Ke, A. B., Eyal, S., Chung, F., Link, J. M., Mankoff, D. A., Muzi, M., & Unadkat, J. D. (2013) · Journal of Nuclear Medicine · doi:10.2967/jnumed.112.111732 · Cited by 28 · see citing works

Evidence of post-translational regulation of P-glycoprotein associated with the expression of a distinctive multiple drug-resistant phenotype in Chinese hamster ovary cells

McClean, S., & Hill, B. T. (1993) · European Journal of Cancer · doi:10.1016/0959-8049(93)90215-2 · Cited by 27 · see citing works

Antitumor Agents 260. New Desmosdumotin B Analogues with Improved In Vitro Anticancer Activity

Nakagawa‐Goto, K., Bastow, K. F., Chen, T.-H., et al. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm701208v · Cited by 27 · see citing works

In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity at CYP-450

Labrie, P., Maddaford, S. P., Lacroix, J., et al. (2006) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2006.07.055 · Cited by 25 · see citing works

Relevance of Multidrug Resistance Proteins on the Clinical Efficacy of Cancer Therapy

Merino, V., Jiménez-Torres, N. V., & Merino‐Sanjuán, M. (2004) · Current Drug Delivery · doi:10.2174/1567201043334650 · Cited by 25 · see citing works

Collateral sensitivity to cross-linking agents exhibited by cultured L1210 cells resistant to oxazaphosphorines.

Sládek, N. E., Low, J. E., & Landkamer, G. J. (1985) · PubMed · Cited by 25 · see citing works

Cell Penetrating Peptides for Tumor Targeting

Choi, Y., Lee, J. Y., Suh, J. S., et al. (2011) · Current Pharmaceutical Biotechnology · doi:10.2174/138920111796117391 · Cited by 24 · see citing works

PEITC reverse multi‐drug resistance of human gastric cancer SGC7901/DDP cell line

Tang, T., Song, X., Liu, Y., et al. (2013) · Cell Biology International · doi:10.1002/cbin.10169 · Cited by 23 · see citing works

In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity on CYP-450 (Part 2)

Labrie, P., Maddaford, S. P., Lacroix, J., et al. (2007) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2007.03.014 · Cited by 23 · see citing works

An MDR-EGFP Gene Fusion Allows for Direct Cellular Localization, Function and Stability Assessment of P-Glycoprotein

Pétriz, J., Gottesman, M. M., & Aran, J. M. (2004) · Current Drug Delivery · doi:10.2174/1567201043480072 · Cited by 22 · see citing works

Reversal of multidrug resistance in HL-60 cells by verapamil and liposome-encapsulated doxorubicin

Sadasivan, R., Morgan, R., Fabian, C. J., et al. (1991) · Cancer Letters · doi:10.1016/0304-3835(91)90211-y · Cited by 21 · see citing works

Collateral sensitivity to methotrexate in cells resistant to adriamycin.

Herman, T. S., Cress, A. E., & Gerner, E. W. (1979) · PubMed · Cited by 20 · see citing works

Proteomic approaches for studying chemoresistance in cancer

Righetti, P. G., Castagna, A., Antonioli, P., et al. (2005) · Expert Review of Proteomics · doi:10.1586/14789450.2.2.215 · Cited by 20 · see citing works

Effects of ATP depletion and phosphate analogues on P‐glycoprotein conformation in live cells

Goda, K., Nagy, H., Mechetner, E. B., et al. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02929.x · Cited by 19 · see citing works

Doxorubicin sensitivity pattern in a panel of small-cell lung-cancer cell lines: correlation to etoposide and vincristine sensitivity and inverse correlation to carmustine sensitivity

Jensen, P. B., Roed, H., Sehested, M., et al. (1992) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00695993 · Cited by 18 · see citing works

2-deoxy-D-glucose toxicity and transport in human multidrug-resistant KB carcinoma cell lines.

Bentley, J., Bell, S., Quinn, D. M., et al. (1996) · PubMed · Cited by 18 · see citing works

Protein phosphorylation in multidrug resistant Chinese hamster cells.

Mb, M. (1989) · PubMed · Cited by 17 · see citing works

PHII-7 inhibits cell growth and induces apoptosis in leukemia cell line K562 as well as its MDR- counterpart K562/A02 through producing reactive oxygen species

Peng, H., Yuan, X., Shi, R., Wei, X., Ren, S., Yan, C., Ding, Y., Lin, Y., Fan, D., Yang, M., et al. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.07.038 · Cited by 15 · see citing works

Specific reversal of multidrug resistance to colchicine in CEM/VLB100 cells by Gynostemma pentaphyllum extract

Huang, T. H.-W., Bebawy, M., Tran, V. H., et al. (2007) · Phytomedicine · doi:10.1016/j.phymed.2007.09.006 · Cited by 15 · see citing works

The prediction of growth-inhibitory drug combinations showing enhanced differential toxicity and collateral sensitivity.

Paigen, K. (1962) · PubMed · Cited by 11 · see citing works

Proteomic analysis of cell lines to identify the irinotecan resistance proteins

Peng, X., Gong, F., Wei, M., Chen, X., Chen, Y., Cheng, K., Gao, F., Xu, F., Bi, F., & Liu, J. (2010) · Journal of Biosciences · doi:10.1007/s12038-010-0064-9 · Cited by 8 · see citing works

Progress in brain targeting drug delivery system by nasal route

Khan, A. R., Liu, M., Khan, M. W., & Zhai, G. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.001 · Cited by 402 · see citing works

Human iPSC-derived blood-brain barrier microvessels: validation of barrier function and endothelial cell behavior

Linville, R. M., DeStefano, J. G., Sklar, M. B., Xu, Z., Farrell, A. M., Bogorad, M. I., Chu, C., Walczak, P., Cheng, L., Mahairaki, V., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2018.10.023 · Cited by 199 · see citing works

Mechanisms of Taxane Resistance

Maloney, S., Spring, C., Morejon-Lasso, L., & Prosperi, J. (2020) · Cancers · doi:10.3390/cancers12113323 · Cited by 198 · see citing works

Clinical therapies and nano drug delivery systems for urinary bladder cancer

Jain, P., Kathuria, H., & Momin, M. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107871 · Cited by 89 · see citing works

Pharmacological features, health benefits and clinical implications of honokiol

Khatoon, F., Ali, S., Kumar, V., Elasbali, A. M., Alhassan, H. H., Alharethi, S. H., Islam, A., & Hassan, M. I. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2022.2120541 · Cited by 50 · see citing works

Nitrogen-containing ecdysteroid derivatives vs. multi-drug resistance in cancer: Preparation and antitumor activity of oximes, oxime ethers and a lactam

Vágvölgyi, M., Martins, A., Kulmány, Á., Zupkó, I., Gáti, T., Simon, A., Tóth, G., & Hunyadi, A. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.12.032 · Cited by 37 · see citing works

Short Peptide-Mediated Brain-Targeted Drug Delivery with Enhanced Immunocompatibility

Guan, J., Jiang, Z., Wang, M., Liu, Y., Liu, J., Yang, Y., Ding, T., Lu, W., Gao, C., Qian, J., et al. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b01216 · Cited by 34 · see citing works

The impact of P-glycoprotein mediated efflux on absorption of 11 sedating and less-sedating antihistamines using Caco-2 monolayers

Crowe, A. P., & Wright, C. M. (2011) · Xenobiotica · doi:10.3109/00498254.2011.643256 · Cited by 35 · see citing works

Why most transporter mutations that cause antibiotic resistance are to efflux pumps rather than to import transportersPreprint

Mendes, P., Girardi, E., Superti‐Furga, G., & Kell, D. B. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.16.909507 · Cited by 8 · see citing works

Effects of Two Natural Bisbenzylisoquinolines, Curine and Guattegaumerine, Extracted from Isolona hexaloba on Rhodamine Efflux by Abcb1b from Rat Glycocholic-Acid-Resistant Hepatocarcinoma Cells

Sergent, J., Mathouet, H., Hulen, C., et al. (2022) · Molecules · doi:10.3390/molecules27093030 · Cited by 4 · see citing works

Kinetics of daunorubicin transport in Ehrlich ascites tumor cells with different expression of P-glycoprotein

Nielsen, D. L., Maare, C., & Skovsgaard, T. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90247-x · Cited by 16 · see citing works

Antimicrobial Resistance: Two-Component Regulatory Systems and Multidrug Efflux Pumps

Gaetano, G. V. D., Lentini, G., Famà, A., et al. (2023) · Antibiotics · doi:10.3390/antibiotics12060965 · Cited by 92 · see citing works