The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines
Abstract
The plasma membranes of hamster, mouse, and human tumor cell lines that display multiple resistance to drugs were examined by gel electrophoresis and immunoblotting. In every case, increased expression of a 170,000-dalton surface antigen was found to be correlated with multidrug resistance. This membrane component is of identical molecular size and shares some immunogenic homology with the previously characterized P-glycoprotein of colchicine-resistant Chinese hamster ovary cells. This finding may have application to cancer therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
Juliano, R. L., & Ling, V. (1976) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(76)90160-7 · Cited by 3,296
Self-citationA highly sensitive silver stain for detecting proteins and peptides in polyacrylamide gels
Switzer, R. C., Merril, C. R., & Shifrin, S. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90732-2 · Cited by 1,085
Reduced permeability in CHO cells as a mechanism of resistance to colchicine
Ling, V., & Thompson, L. H. (1974) · Journal of Cellular Physiology · doi:10.1002/jcp.1040830114 · Cited by 686
Self-citationMolecular Actions and Targets for Cancer Chemotherapeutic Agents
Sartorelli, A. C., Lazo, J. S., & Bertino, J. R. (1981) · Medical Entomology and Zoology · Cited by 360
Pleiotropic phenotype of colchicine‐resistant CHO cells: Cross‐resistance and collateral sensitivity
Bech‐Hansen, N. T., Till, J. E., & Ling, V. (1976) · Journal of Cellular Physiology · doi:10.1002/jcp.1040880104 · Cited by 309
Self-citationDNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression.
Debenham, P. G., Kartner, N., Siminovitch, L., Riordan, J. R., & Ling, V (1982) · Molecular and Cellular Biology · doi:10.1128/mcb.2.8.881 · Cited by 201
Self-citationKartner, N., Shales, M., Riordan, J. R., & Ling, V. W. T. (1983) · PubMed · Cited by 199
Self-citationHoechst 33342 dye uptake as a probe of membrane permeability changes in mammalian cells.
Lalande, M., Ling, V. W. T., & Miller, R. G. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.1.363 · Cited by 148
Self-citationDRUG RESISTANCE AND MEMBRANE ALTERATION IN MUTANTS OF MAMMALIAN CELLS
Ling, V. W. T. (1975) · Canadian Journal of Genetics and Cytology · doi:10.1139/g75-064 · Cited by 128
Self-citationBrown, P. C., Beverley, S. M., & SCHIMKE, R. T. (1981) · Molecular and Cellular Biology · doi:10.1128/mcb.1.12.1077 · Cited by 125
Cited by
Chen, C.-J., Chin, J. E., Ueda, K., Clark, D. P., Pastan, I., Gottesman, M. M., & Roninson, I. B. (1986) · Cell · doi:10.1016/0092-8674(86)90595-7 · Cited by 1,898
Sarkadi, B., Price, E. M., Boucher, R. C., Germann, U. A., & Scarborough, G. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42909-2 · Cited by 632
The molecular basis of multidrug resistance in cancer: The early years of P‐glycoprotein research
Gottesman, M. M., & Ling, V. (2006) · FEBS Letters · doi:10.1016/j.febslet.2005.12.060 · Cited by 558
Self-citationCircumventing cancer drug resistance in the era of personalized medicine
Garraway, L. A., & Jänne, P. A. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0012 · Cited by 503
Matsuo, H., Takada, T., Ichida, K., Nakamura, T., Nakayama, A., Ikebuchi, Y., Ito, K., Kusanagi, Y., Chiba, T., Tadokoro, S., et al. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000237 · Cited by 437
Metadata
- Authors
- Kartner, N., Riordan, J. R., & Ling, V.
- Venue
- Science
- Published
- 1983-09-23
- Volume
- 221
- Issue
- 4617
- Pages
- 1285-1288
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1997241897
- Cited by
- 991
- References
- 15
- FWCI
- 12.59
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines. https://app.cochat.ai/papers/10.1126/science.6137059
- The paper
- Kartner, N., Riordan, J. R., & Ling, V. (1983). Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines. Science. https://doi.org/10.1126/science.6137059
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
