The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Distinct genomic copy number in mitochondria of different mammalian organs.
Abstract
This study shows that mitochondria in liver, kidney, heart, and brain of the mouse have a distinct mitochondrial density. It also demonstrates that the mtDNA copy number per mitochondrion is organ-specific. A reliable method of determining mitochondrial density per organ is by stereological analysis of tissue sections while mtDNA quantitation is by the use of radiolabelled mtDNA probe. This is the first study in which a comprehensive examination of mitochondrial density and quantitation of mitochondrial genomes in mouse organs have been done. In summary the variability is not only in mitochondrial density but also in genomic copy number in mitochondria of various tissues.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Electron microscopy demonstrates that mitochondrial area is 44% lower in liver than in heart (210) with smaller size, fewer cristae, and lower matrix density.”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [210]
Citations
Cites
A low-viscosity epoxy resin embedding medium for electron microscopy.
Spurr, A. (1969) · Journal of Ultrastructure Research · doi:10.1016/s0022-5320(69)90033-1 · Cited by 13,268
Sequence and organization of the human mitochondrial genome
Anderson, S., Bankier, A. T., Barrell, B. G., de Bruijn, M. H. L., Coulson, A. R., Drouin, J., Eperon, I. C., Nierlich, D. P., Roe, B. A., Sanger, F., et al. (1981) · Nature · doi:10.1038/290457a0 · Cited by 9,740
Sequence and gene organization of mouse mitochondrial DNA.
Bibb, M., Etten, R. V., Wright, C. T., Walberg, M. W., & Clayton, D. A. (1981) · Cell · doi:10.1016/0092-8674(81)90300-7 · Cited by 1,619
Replication of animal mitochondrial DNA
Clayton, D. A. (1982) · Cell · doi:10.1016/0092-8674(82)90049-6 · Cited by 1,243
Mitochondrial DNA molecules and virtual number of mitochondria per cell in mammalian cells
Robin, E. D., & Wong, R. J. (1988) · Journal of Cellular Physiology · doi:10.1002/jcp.1041360316 · Cited by 660
The Number of Mitochondrial Deoxyribonucleic Acid Genomes in Mouse L and Human HeLa Cells
Bogenhagen, D. F., & Clayton, D. A. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42063-2 · Cited by 526
TRANSCRIPTION OF THE MAMMALIAN MITOCHONDRIAL GENOME
Clayton, D. A. (1984) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.53.070184.003041 · Cited by 446
Williams, R. S. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67252-7 · Cited by 273
Mitochondrial DNA: Advances, Problems, and Goals
Nass, M. M. K. (1969) · Science · doi:10.1126/science.165.3888.25 · Cited by 212
Mitochondrial DNA I. Preparation and properties of mitochondrial DNA from chick liver
Borst, P., Ruttenberg, G. J. C. M., & Kroon, A. M. (1967) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(67)90697-1 · Cited by 120
Research works printed but not linked: 2
- Allard C., 1952, Mitochondrial populatin in mammalian cells, Cancer Res., 12, 407
- Tzagoloff A., 1982, Mitochondria
Cited by
Sorted by citations
Items 201–240 of 240
Central and peripheral mechanisms regulating energy and glucose homeostasis
Tom, R. Z. (2013) · Figshare
The pathophysiology of respiratory chain dysfunction
Silva, J. P. (2005) · Figshare
Current Methods for the Prevention of Transmission of Mitochondrial DNA
Turner, D., & Choy, F. Y. M. (2014)
Genome Exchange in Human Oocytes
Paull, D. J., & Egli, D. M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-386541-0.00039-4
Oxidative Mitochondrial DNA Damage Resistance and Repair
Shadel, G. S. (2005) · doi:10.1201/9780849352683-26
Vrana, J. A. (2015) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.6880
Regulation of mitochondrial transport in mesenchymal stromal cells
Mukherjee, S., Bhatraju, N. K., Ahmad, T., & Agrawal, A. (2016) · doi:10.1002/9781118907474.ch10
Lewis, S. E. (2011) · Digital Commons - DU (University of Denver)
Malik, A. N. (2018) · Wiley eBooks · doi:10.1002/9781119329725.ch25
Sim, J. (2018) · Murdoch University Research Portal
A Toxicological Application of Signal Transduction
Miller, J. V., Prince, N., Mouch, J. A., & Boyd, J. W. (2019) · doi:10.1002/9781119060208.ch8
Rowe, M. R. (2020) · Open Access Victoria University of Wellington | Te Herenga Waka (Figshare) · doi:10.26686/wgtn.17145686.v1 · Cited by 2
Phospholamban - Identification of novel interaction partners
Kownatzki-Danger, D. (2020) · doi:10.53846/goediss-8114
Zhou, G., Li, Y., Li, S., Liu, H., Xu, F., Lai, X., Zhang, Q., Xu, J., & Wan, S. (2021) · Research Square · doi:10.21203/rs.3.rs-540053/v1
Tsyba, N., & Patel, M. R. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.30.454495
Zhang, W., Lin, S., Zeng, B., Chen, X., Chen, L., Chen, M., Guo, W., Lin, Y., Yu, L., Hou, J., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1223162/v1
Oxidative Mitochondrial DNA Damage Resistance and Repair
Shadel, G. S. (2005) · CRC Press eBooks · doi:10.1201/9780849352683.ch20
RNA Chimeras as a Gene Signature of Breast Cancer
Liao, D. J. (2014) · Defense Technical Information Center (DTIC) · doi:10.21236/ada612049
Jayasekera, L., Senanayake, K., Ranasinghe, R., & Tennekoon, K. H. (2022) · EMBnet journal · doi:10.14806/ej.28.0.1007
Nanotechnology to Correct Mitochondrial Disorders in Cancer Diseases
Faria, R., Albuquerque, T., Neves, A. R., Sousa, Â., & Costa, D. R. B. (2022) · Springer eBooks · doi:10.1007/978-3-031-17831-3_6
Albosale, A. H., & Mashkina, E. V. (2023) · RESEARCH RESULTS IN BIOMEDICINE · doi:10.18413/2658-6533-2023-9-2-0-2
Yousif, P., & Taha, H. (2023) · Emirates Journal of Food and Agriculture · doi:10.9755/ejfa.2023.3143
Ribeiro, D. L. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2018.tde-28062024-145003
Macrophage Mertk mediates pressure overload-induced heart failure via type I interferon response
Cui, Y., Liu, L., Zhang, J., Zou, X., Li, G., Jiang, H., Yao, Z., & Ge, J. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152767
Zhang, W., Lin, S., Zeng, B., Chen, X., Chen, L., Chen, M., Guo, W., Lin, Y., Yu, L., Hou, J., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22697159
Orge, I. D., Gadd, V. L., Barouh, J. L., Rossi, E. A., Carvalho, R. H., Smith, I. P., Allahdadi, K. J., Paredes, B. D., Silva, D. N., Damasceno, P. K. F., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12577148
Zhang, W., Lin, S., Zeng, B., Chen, X., Chen, L., Chen, M., Guo, W., Lin, Y., Yu, L., Hou, J., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22697162
Zhang, W., Lin, S., Zeng, B., Chen, X., Chen, L., Chen, M., Guo, W., Lin, Y., Yu, L., Hou, J., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22697156
Zhang, W., Lin, S., Zeng, B., Chen, X., Chen, L., Chen, M., Guo, W., Lin, Y., Yu, L., Hou, J., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22697153
Orge, I. D., Gadd, V. L., Barouh, J. L., Rossi, E. A., Carvalho, R. H., Smith, I. P., Allahdadi, K. J., Paredes, B. D., Silva, D. N., Damasceno, P. K. F., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12577157
Orge, I. D., Gadd, V. L., Barouh, J. L., Rossi, E. A., Carvalho, R. H., Smith, I. P., Allahdadi, K. J., Paredes, B. D., Silva, D. N., Damasceno, P. K. F., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12577163
Botero-Castro, F. (2014) · theses.fr (ABES) · doi:10.70675/98efd384zdb06z4edez89c2z7207630ad7aa
Dynamiques intra- et interannuelles du régime alimentaire des carabes dans les champs de colza
Graux, Y. (2023) · theses.fr (ABES) · doi:10.70675/ffd71b43z5375z41f5za204z1bdb734066da
Mootha, V. K., Bunkenborg, J., Olsen, J. V., Hjerrild, M., Wiśniewski, J. R., Stahl, E., Bolouri, M. S., Ray, H. N., Sihag, S., Kamal, M., et al. (2003) · University of Southern Denmark Research Portal (University of Southern Denmark)
Investigating the role and regulation of human mitochondrial poly(A) polymerase
Wilson, W. C. (2013)
Metadata
- Authors
- Veltri, K. L., Espiritu, M., & Singh, G.
- Affiliations
- McMaster University (CA)
- Corresponding author
- Singh, Gurmit
- ORCID
- Singh, Gurmit
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 1990-04
- Volume
- 143
- Issue
- 1
- Pages
- 160-164
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2030868673
- Cited by
- 242
- References
- 19
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 6 · 2023: 17 · 2022: 9 · 2021: 19 · 2020: 20 · 2019: 19 · 2018: 18 · 2017: 7 · 2016: 6 · 2015: 10 · 2014: 13 · 2013: 13 · 2012: 6
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- McMaster University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial density, mitochondrial DNA copy number, mouse organs, liver, kidney, heart, brain, stereology
- MeSH terms
- Animals, Brain, DNA, Mitochondrial, Kidney, Mice, Inbred C57BL, Microscopy, Electron, Mitochondria, Mitochondria, Heart, Mitochondria, Liver, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review