The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Distinct genomic copy number in mitochondria of different mammalian organs.
Abstract
This study shows that mitochondria in liver, kidney, heart, and brain of the mouse have a distinct mitochondrial density. It also demonstrates that the mtDNA copy number per mitochondrion is organ-specific. A reliable method of determining mitochondrial density per organ is by stereological analysis of tissue sections while mtDNA quantitation is by the use of radiolabelled mtDNA probe. This is the first study in which a comprehensive examination of mitochondrial density and quantitation of mitochondrial genomes in mouse organs have been done. In summary the variability is not only in mitochondrial density but also in genomic copy number in mitochondria of various tissues.
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“Electron microscopy demonstrates that mitochondrial area is 44% lower in liver than in heart (210) with smaller size, fewer cristae, and lower matrix density.”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [210]
Citations
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Metadata
- Authors
- Veltri, K. L., Espiritu, M., & Singh, G.
- Affiliations
- McMaster University (CA)
- Corresponding author
- Singh, Gurmit
- ORCID
- Singh, Gurmit
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 1990-04
- Volume
- 143
- Issue
- 1
- Pages
- 160-164
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2030868673
- Cited by
- 242
- References
- 19
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 6 · 2023: 17 · 2022: 9 · 2021: 19 · 2020: 20 · 2019: 19 · 2018: 18 · 2017: 7 · 2016: 6 · 2015: 10 · 2014: 13 · 2013: 13 · 2012: 6
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- McMaster University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial density, mitochondrial DNA copy number, mouse organs, liver, kidney, heart, brain, stereology
- MeSH terms
- Animals, Brain, DNA, Mitochondrial, Kidney, Mice, Inbred C57BL, Microscopy, Electron, Mitochondria, Mitochondria, Heart, Mitochondria, Liver, Mice
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