Cited by 242Mitochondrial Function and PathologyAdipose Tissue and MetabolismAutophagy in Disease and Therapy

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Distinct genomic copy number in mitochondria of different mammalian organs.

Veltri, Karen L., Espiritu, Myrna, Singh, Gurmit·1990·Journal of Cellular Physiology

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Abstract

This study shows that mitochondria in liver, kidney, heart, and brain of the mouse have a distinct mitochondrial density. It also demonstrates that the mtDNA copy number per mitochondrion is organ-specific. A reliable method of determining mitochondrial density per organ is by stereological analysis of tissue sections while mtDNA quantitation is by the use of radiolabelled mtDNA probe. This is the first study in which a comprehensive examination of mitochondrial density and quantitation of mitochondrial genomes in mouse organs have been done. In summary the variability is not only in mitochondrial density but also in genomic copy number in mitochondria of various tissues.

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Authors: Veltri, K. L., Espiritu, M., & Singh, G.
Affiliations: McMaster University (CA)
Corresponding author: Singh, Gurmit
ORCID: Singh, Gurmit
Venue: Journal of Cellular Physiology
Publisher: Wiley
Published: 1990-04
Volume: 143
Issue: 1
Pages: 160-164
ISSN: 0021-9541 (ISSN-L)
1097-4652
DOI: 10.1002/jcp.1041430122
OpenAlex: W2030868673
Cited by: 242
References: 19
Citations by year: 2026: 1 · 2025: 6 · 2024: 6 · 2023: 17 · 2022: 9 · 2021: 19 · 2020: 20 · 2019: 19 · 2018: 18 · 2017: 7 · 2016: 6 · 2015: 10 · 2014: 13 · 2013: 13 · 2012: 6
FWCI: 0.84
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5423 d)
Locations: Journal of Cellular Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: McMaster University
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: mitochondrial density, mitochondrial DNA copy number, mouse organs, liver, kidney, heart, brain, stereology
MeSH terms: Animals, Brain, DNA, Mitochondrial, Kidney, Mice, Inbred C57BL, Microscopy, Electron, Mitochondria, Mitochondria, Heart, Mitochondria, Liver, Mice

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Distinct genomic copy number in mitochondria of different mammalian organs.

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