Myocardial function improved by electromagnetic field induction of stress protein hsp70

George, Isaac; Geddis, Matthew S.; Lill, Zachary; Lin, Hana; Gomez, Teodoro; Blank, Martin; Oz, Mehmet C.; Goodman, Reba

doi:10.1002/jcp.21461

Cited by 44Cardiac Ischemia and ReperfusionHeat shock proteins researchElectromagnetic Fields and Biological Effects

Myocardial function improved by electromagnetic field induction of stress protein hsp70

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George, Isaac, Geddis, Matthew S., Lill, Zachary, Lin, Hana, Gomez, Teodoro, Blank, Martin, Oz, Mehmet C., Goodman, Reba·2008·Journal of Cellular Physiology

DOI 10.1002/jcp.21461PMC PMC3075533

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Abstract

Studies on myocardial function have shown that hsp70, stimulated by an increase in temperature, leads to improved survival following ischemia‐reperfusion (I‐R). Low frequency electromagnetic fields (EMFs) also induce the stress protein hsp70, but without elevating temperature. We have examined the hemodynamic changes in concert with EMF pre‐conditioning and the induction of hsp70 to determine whether improved myocardial function occurs following I‐R injury in Sprague–Dawley rats. Animals were exposed to EMF (60 Hz, 8 µT) for 30 min prior to I‐R. Ischemia was then induced by ligation of left anterior descending coronary artery (LAD) for 30 min, followed by 30 min of reperfusion. Blood and heart tissue levels for hsp70 were determined by Western blot and RNA transcription by rtPCR. Significant upregulation of the HSP70 gene and increased hsp70 levels were measured in response to EMF pre‐exposures. Invasive hemodynamics, as measured using a volume conductance catheter, demonstrated significant recovery of systolic contractile function after 30 min of reperfusion following EMF exposure. Additionally, isovolemic relaxation, a measure of ventricular diastolic function, was markedly improved in EMF‐treated animals. In conclusion, non‐invasive EMF induction of hsp70 preserved myocardial function and has the potential to improve tolerance to ischemic injury. J. Cell. Physiol. 216: 816–823, 2008, © 2008 Wiley‐Liss, Inc.

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Coherent fields, including pulsed ELFs, upregulate HSP70, improve ischemia-reperfusion recovery, and enhance antioxidant effects.
“coherent fields, including pulsed ELFs, upregulate heat shock protein 70 (HSP70), improve ischemia–reperfusion recovery, and enhance antioxidant effects [25,79,80,81]”
From The Heart’s Electromagnetic Field in Emotions, Empathy and Human Connection: Biosensor-Derived Insights into Heart–Brain Axis Mechanisms and a Basis for Novel BioMagnetoTherapies (2026) · cites this paper as [80]
The Abstract and Discussion report that pre-exposure to a 60 Hz electromagnetic field increased HSP70 and improved cardiac function after ischemia–reperfusion in rats. The Methods describe a 60 Hz field, not a pulsed or specifically coherent field. The paper discusses prior findings on resistance to oxidation, but does not report an antioxidant effect from its own EMF exposure. (LLM, conf=0.88)
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Authors: George, I., Geddis, M. S., Lill, Z., Lin, H., Gomez, T., Blank, M., Oz, M. C., & Goodman, R.
Affiliations: Columbia University Irving Medical Center (US)
Corresponding author: Goodman, Reba
ORCID: George, Isaac
Blank, Martin
Oz, Mehmet C.
Venue: Journal of Cellular Physiology
Publisher: Wiley
Published: 2008-04-29
Volume: 216
Issue: 3
Pages: 816-823
ISSN: 0021-9541 (ISSN-L)
1097-4652
DOI: 10.1002/jcp.21461
PMC: PMC3075533
OpenAlex: W1982718433
Cited by: 44
References: 54
Citations by year: 2026: 3 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 4
FWCI: 3.56
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Cellular Physiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (T32-HL-07854, T32HL007854)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electromagnetic Fields and Biological Effects
Keywords: HSP70, heat shock proteins, low-frequency electromagnetic fields, myocardial ischemia-reperfusion injury, cardioprotection, cardiac contractility, diastolic function, ischemic preconditioning, coronary artery ligation
MeSH terms: Aged, Animals, Electromagnetic Fields, Female, Hemodynamics, Humans, Male, Myocardial Contraction, Myocardium, Reperfusion Injury, Rats, Sprague-Dawley, HSP70 Heat-Shock Proteins, Rats

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Myocardial function improved by electromagnetic field induction of stress protein hsp70

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