Keratinocyte stem cells: Friends and foes
Open accessAbstract
Skin and its appendages provide a protective barrier against the assaults of the environment. To perform its role, epidermis undergoes an ongoing renewal through a balance of proliferation and differentiation/apoptosis called homeostasis. Keratinocyte stem cells reside in a special microenvironment called niche in basal epidermis, adult hair follicle, and sebaceous glands. While a definite marker has yet to be detected, data raised part in humans and part in the mouse system point to a critical role of stem and its progeny transit amplifying cells in epidermal homeostasis. Stem cells are protected from apoptosis and are long resident in adult epidermis. This renders them more prone to be the origin of skin cancer. In this review, we will outline the main features of adult stem cells in mouse and humans and discuss their fate in relation to differentiation, apoptosis, and cancer.
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The terminal differentiation process in the cornified layer represents the prototype of physiological apoptosis in the human epidermis.
“Thus, the terminal differentiation process in the cornified layer in this way represents the prototype of physiological apoptosis in the human epidermis [4].”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [4]
In “Stem cells and apoptosis” (page unavailable), the paper says epidermal differentiation and apoptosis are clearly different at the molecular level. It describes terminal differentiation as a normal epidermal process, not as the prototype of physiological apoptosis. (LLM, conf=0.88)
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Cites
Epidermal homeostasis: a balancing act of stem cells in the skin
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p63 Is Essential for the Proliferative Potential of Stem Cells in Stratified Epithelia
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“DNp63, a member of the p53 family, is critical for epidermal commitment of embryonic stem cells (Medawar et al., 2008) and identifies epidermal stem cells (Senoo et al., 2007).”
A single type of progenitor cell maintains normal epidermis
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A skin microRNA promotes differentiation by repressing ‘stemness’
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More than one way to skin . . .
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β1 Integrin-Mediated Adhesion Signalling Is Essential for Epidermal Progenitor Cell Expansion
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Research works printed but not linked: 3
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Lee, C.-H., Wu, S.-B., Hong, C.-H., Yu, H.-S., & Wei, Y.-H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14036414 · Cited by 271 · see citing works
- Authors
- Pincelli, C., & Marconi, A.
- Affiliations
- University of Modena and Reggio Emilia (IT)
- Corresponding author
- Pincelli, Carlo
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2010-06-21
- Volume
- 225
- Issue
- 2
- Pages
- 310-315
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W1990895777
- Cited by
- 89
- References
- 7
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 9 · 2019: 4 · 2018: 1 · 2017: 5 · 2016: 4 · 2015: 8 · 2014: 8 · 2013: 12 · 2012: 11
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- epidermal stem cells, epidermal homeostasis, stem cell niche, basal epidermis, hair follicle stem cells, sebaceous glands, transit amplifying cells, apoptosis, skin cancer, stem cell differentiation, skin barrier
- MeSH terms
- Animals, Biological Products, Cell Differentiation, Humans, Skin Neoplasms, Stem Cells, Keratinocytes, Apoptosis
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