More than one way to skin . . .
Open accessAbstract
Epithelial stem cells in the skin are specified during development and are governed by epithelial–mesenchymal interactions to differentially adopt the cell fates that enable them to form the epidermis, hair follicle, and sebaceous gland. In the adult, each of three epithelial lineages maintains their own stem cell population for self-renewal and normal tissue homeostasis. However, in response to injury, at least some of these stem cell niches can be mobilized to repair an epithelial tissue whose resident stem cells have been damaged. How do these stem cell populations respond to multiple signaling networks, activate migration, and proliferation, and differentiate along a specific lineage? Recent clues add new pieces to this multidimensional puzzle. Understanding how these stem cells maintain normal homeostasis and wound repair in the skin is particularly important, as these mechanisms, when defective, lead to skin tissue diseases including cancers.
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Epidermal keratinocytes require continuous upward extrusion in order to turn over and renew the tissue.
“In contrast, epidermal keratinocytes require continuous upward extrusion in order to turn over and renew the tissue37.”
From E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning (2017) · cites this paper as [37]
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- Authors
- Fuchs, E., & Horsley, V.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2008-04-15
- Volume
- 22
- Issue
- 8
- Pages
- 976-985
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC2732395
- OpenAlex
- W2024962684
- Cited by
- 224
- References
- 65
- Citations by year
- 2026: 3 · 2025: 2 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 5 · 2019: 11 · 2018: 7 · 2017: 12 · 2016: 6 · 2015: 11 · 2014: 19 · 2013: 27 · 2012: 25
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (K99AR054775)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- stem cell niche, epithelial-mesenchymal interactions, epidermis, hair follicle, sebaceous glands, tissue homeostasis, wound healing, stem cell mobilization, stem cell differentiation, skin cancer, cell fate specification
- MeSH terms
- Animals, Cell Differentiation, Cell Division, Epidermis, Humans, Models, Biological, Sebaceous Glands, Skin, Stem Cells, Hair Follicle
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