The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Dynamics of exosome internalization and trafficking
Abstract
Cells release exosomes into extracellular medium. Although the important roles of exosomes in many physiological and pathological processes are being revealed, the mechanism of exosome–cell interaction remains unclear. In this article, employing real‐time fluorescence microscopy, the motion of exosomes on the plasma membrane or in the cytoplasm of recipient PC12 cells was observed directly. In addition, several motion modes of exosomes were revealed by single particle tracking (SPT). The changes between motion modes were also detected, presenting the dynamic courses of exosome attachment onto plasma membrane and exosome uptake. Octadecyl rhodamine B chloride (R18) was found to be useful to distinguish endocytosis from fusion during exosome uptake. Colocalization with organelle markers showed exosomes were sorted to acidic vesicles after internalization. The results provide new sight into the exosome–cell interaction mode and the intercellular trafficking of exosomes. This study will help to understand the roles of exosomes at cell level. J. Cell. Physiol. 228: 1487–1495, 2013. © 2012 Wiley Periodicals, Inc.
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1 retracted
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Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
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Membrane vesicles as conveyors of immune responses
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Exosomes: Extracellular organelles important in intercellular communication
Mathivanan, S., Ji, H., & Simpson, R. J. (2010) · Journal of Proteomics · doi:10.1016/j.jprot.2010.06.006 · Cited by 2,537
Exosomes – vesicular carriers for intercellular communication
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Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles
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SINGLE-PARTICLE TRACKING:Applications to Membrane Dynamics
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Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells
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Cited by
Routes and mechanisms of extracellular vesicle uptake
Mulcahy, L. A., Pink, R. C., & Carter, D. R. F. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24641 · Cited by 2,832
“Examples of such dyes include PKH67 (23 29), PKH26 (28,30 32), rhodamine B (also known as R18) (22,33 38), DiI (30,33,39) and DiD (40) which are lipophilic dyes.”
BackgroundRegulation of immune responses by extracellular vesicles
Robbins, P. D., & Morelli, A. E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3622 · Cited by 2,260
Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function
Zhang, J., Li, S., Li, L., Li, M., Guo, C., Yao, J., & Mi, S. (2015) · Genomics, Proteomics & Bioinformatics · doi:10.1016/j.gpb.2015.02.001 · Cited by 1,901
Exosomes: Therapy delivery tools and biomarkers of diseases
Barile, L., & Vassalli, G. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.020 · Cited by 1,038
Engineering hybrid exosomes by membrane fusion with liposomes
Sato, Y. T., Umezaki, K., Sawada, S., Mukai, S.-A., Sasaki, Y., Harada, N., Shiku, H., & Akiyoshi, K. (2016) · Scientific Reports · doi:10.1038/srep21933 · Cited by 744
Metadata
- Authors
- Tian, T., Zhu, Y., Hu, F., Wang, Y., Huang, N., & Xiao, Z.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2013-03-21
- Volume
- 228
- Issue
- 7
- Pages
- 1487-1495
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W1970870994
- Cited by
- 340
- References
- 42
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- closed
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