Concise Review: The Role of Oxygen in Hematopoietic Stem Cell Physiology
Abstract
Molecular dioxygen, O 2, is an important element in cellular microenvironment in vivo, and often overlooked in standard in vitro and ex vivo cell culture systems. Molecular oxygen is the ultimate electron acceptor in oxidative cellular respiration, and also a signal that regulates cell fate through concentration gradients. Recent advances in physiology of oxygen and adult stem cell research have shown that apart from being important for oxidative phosphorylation, thus energy metabolism, oxygen is also important as a signaling molecule and an integral part of the stem cell niche. This review article covers the influence of physiologically relevant oxygen levels on adult stem cells through highlighting the research on the effect of oxygen concentration on hematopoietic stem cell maintenance, proliferation and differentiation. This is important particularly to understand the embryonic and adult stem cell biology and physiology. The new discoveries in this field will help to further improve current tissue engineering and clinical applications. In addition, understanding the relationship between oxygen and stemness is invaluable for the advanced treatments of neoplastic diseases. Authors believe that in the future, active and programmed dynamic of oxygen levels will be routinely used for the programmed in vitro and ex vivo expansion of different adult stem cell types and tissue regeneration purposes. J. Cell. Physiol. 230: 1999–2005, 2015. © 2015 Wiley Periodicals, Inc.
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Reduced oxygen tension can have a significant impact on cell culture phenotype and is considered beneficial for the culture and differentiation of PSCs.
“Reduced oxygen tension can have a significant impact on cell culture phenotype and is considered beneficial for the culture and differentiation of PSCs (Ivanovic, 2009; Jez et al., 2015; Pamies et al., 2013).”
From Guidance document on Good cell and tissue culture practice 2.0 (GCCP 2.0) (2021) · cites this paper as Jez et al., 2015
Cites
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Fluctuations in Precambrian atmospheric oxygenation recorded by chromium isotopes
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Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity
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Very Low O2 Concentration (0.1%) Favors G0 Return of Dividing CD34+ Cells
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Oxygenation in Cell Culture: Critical Parameters for Reproducibility Are Routinely Not Reported
Al-Ani, A., Toms, D., Kondro, D., Thundathil, J., Yu, Y., & Ungrin, M. (2018) · PLOS ONE · doi:10.1371/journal.pone.0204269 · Cited by 152 · see citing works
Guidance document on Good cell and tissue culture practice 2.0 (GCCP 2.0)
Pamies, D. (2021) · ALTEX · doi:10.14573/altex.2111011 · Cited by 100 · see citing works
- Authors
- Jež, M., Rožman, P., Ivanović, Z., & Bas, T.
- Affiliations
- Department of Immunohematology Blood Transfusion Centre of Slovenia Šlajmerjeva 6, Ljubljana Slovenia
- Aquitaine‐Limousin Branch of French Blood Institute CNRS/Bordeaux University UMR 5164 Bordeaux France
- Department of Medicine Albert Einstein College of Medicine 1300 Morris Park Avenue, Bronx New York
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2015-05-26
- Volume
- 230
- Issue
- 9
- Pages
- 1999-2005
- ISSN
- 0021-9541
- 1097-4652
- Cited by
- 41
- References
- 6
- Language
- en
- Funders
- Slovenian Research Agency (ARRS) (P3-0371)
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