Very Low O2 Concentration (0.1%) Favors G0 Return of Dividing CD34+ Cells

Hermitte, Francis; Brunet de la Grange, Philippe; Belloc, Francis; Praloran, Vincent; Ivanovic, Zoran

doi:10.1634/stemcells.2004-0351

Cited by 133Hematopoietic Stem Cell TransplantationMesenchymal stem cell researchCancer, Hypoxia, and Metabolism

Very Low O2 Concentration (0.1%) Favors G0 Return of Dividing CD34+ Cells

Hermitte, Francis, Brunet de la Grange, Philippe, Belloc, Francis, Praloran, Vincent, Ivanovic, Zoran·2006·Stem Cells

DOI 10.1634/stemcells.2004-0351

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Abstract

Physiological bone marrow oxygen concentrations are everywhere lower than 4% and almost null in some areas. We compared the effects of 20%, 3%, and 0.1% O2 concentrations on cord blood CD34+ cell survival, cycle, and functionality in serum-free cultures for 72 hours with or without interleukin-3 (IL-3). As from 24 hours, IL-3 improved cell survival and proliferation in all conditions. After 72 hours, cells were 1.5 and 2.5 times more in quiescence (G0) at 3% and 0.1% O2, respectively, than at 20%; transforming growth factor-β signaling seemed not to be involved. To explore cell cycle further, fresh CD34+ cells were stained with PKH26 and cultured for 72 hours, and then undivided and divided cells were sorted. At 0.1% O2, 46.5% ± 19.1% of divided cells returned to G0 compared with 7.9% ± 0.3% at 20%. Colony formation and nonobese diabetic/severe combined immunodeficient mice engraftment efficiency were similar after 3 days at 20% and 0.1% O2 concentrations but lower than at T0. In conclusion, a low O2 concentration, close to those found in bone marrow stem cell niches, induces the G0 return of CD34+ cells without impairing their functional capacity.

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Very low oxygen concentration (0.1%) reveals two FDCP-Mix cell subpopulations that differ by their cell cycling, differentiation and p27KIP1 expression
Guitart, A. V., Debeissat, C., Hermitte, F., Villacreces, A., Ivanović, Z., Bœuf, H., & Praloran, V. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.85 · Cited by 20 · see citing works
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Simultaneous Maintenance of Human Cord Blood SCID‐Repopulating Cells and Expansion of Committed Progenitors at Low O 2 Concentration (3%)
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Combination of low O2 concentration and mesenchymal stromal cells during culture of cord blood CD34+ cells improves the maintenance and proliferative capacity of hematopoietic stem cells
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CD34+ cells from steady state peripheral blood : Elution from leucoreduction filters : Study of low oxygen concentrations (0.1%) effects on hematopoietic stem cells biology
Peytour, Y. (2011) · theses.fr (ABES)
低氧对CD34^＋造血干／祖细胞增殖分化及其对细胞因子依赖性的影响
孙兵, & 白慈贤 (2000) · 生理学报

Authors: Hermitte, F., Brunet de la Grange, P., Belloc, F., Praloran, V., & Ivanovic, Z.
Affiliations: Centre National de la Recherche Scientifique (FR)
CNRS UMR 5164: University of Bordeaux 2, Bordeaux, France
University Hospital, Hematology Laboratory, Bordeaux, France
French Blood Transfusion Organisation in Aquitaine-Limousin, Bordeaux, France
Corresponding author: Praloran, Vincent
Venue: Stem Cells
Publisher: Oxford University Press (OUP)
Published: 2006-01-01
Volume: 24
Issue: 1
Pages: 65-73
ISSN: 1066-5099 (ISSN-L)
1549-4918
DOI: 10.1634/stemcells.2004-0351
OpenAlex: W1968276167
Cited by: 133
References: 48
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 9 · 2017: 5 · 2016: 3 · 2015: 8 · 2014: 9 · 2013: 19 · 2012: 14
FWCI: 0.98
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Stem Cells (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords: hypoxia, CD34+ cells, hematopoietic stem cells, G0 quiescence, cell cycle, interleukin-3, umbilical cord blood, stem cell niche, colony formation, engraftment
MeSH terms: Animals, Cell Cycle, Cell Survival, Hematopoietic Stem Cells, Humans, Interleukin-3, Oxygen, Resting Phase, Cell Cycle, Mice, SCID, Mice, Inbred NOD, Hematopoietic Stem Cell Transplantation, Antigens, CD34, Stem Cell Factor, Mice

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Very Low O2 Concentration (0.1%) Favors G0 Return of Dividing CD34+ Cells

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