Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity
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The accessibility to stem cells from healthy or diseased individuals, and the maintenance of their potency are challenging issues for stem cell biology. Here we report the isolation of viable and functional skeletal myogenic cells from humans up to 17 days, and mice up to 14 days post mortem, much longer beyond previous reports. Muscle stem cells are enriched in post mortem tissue, suggesting a selective survival advantage compared with other cell types. Transplantation of mouse muscle and haematopoietic stem cells regenerates tissues robustly. Cellular quiescence contributes to this cell viability where cells adopt a reversible dormant state characterized by reduced metabolic activity, a prolonged lag phase before the first cell division, elevated levels of reactive oxygen species and a transcriptional status less primed for commitment. Finally, severe hypoxia, or anoxia is critical for maintaining stem cell viability and regenerative capacity. Thus, these cells provide a useful resource for studying stem cell biology.
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Quiescent MuSCs and HSCs can remain viable in post-mortem tissue.
“quiescent MuSCs and HSCs were found viable in post-mortem tissue109.”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [109]
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Association of reactive oxygen species levels and radioresistance in cancer stem cells
Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555 · see citing works
Hypoxia-inducible factors and the response to hypoxic stress
Majmundar, A. J., Wong, W. J., & Simon, M. C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.022 · Cited by 2,380 · see citing works
Pax7 Is Required for the Specification of Myogenic Satellite Cells
Seale, P., Sabourin, L. A., Girgis-Gabardo, A., Mansouri, A., Gruß, P., & Rudnicki, M. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00066-0 · Cited by 2,345 · see citing works
Crosstalk in NF-κB Signaling Pathways
Oeckinghaus, A., Hayden, M. S., & Ghosh, S. (2011) · Nature Immunology · doi:10.1038/ni.2065 · Cited by 1,942 · see citing works
Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.048 · Cited by 1,908 · see citing works
Kruse, J.-P., & Gu, W. (2009) · Cell · doi:10.1016/j.cell.2009.04.050 · Cited by 1,610 · see citing works
NF-κB activation by reactive oxygen species: Fifteen years later
Gloire, G., Legrand-Poels, S., & Piette, J. G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.04.011 · Cited by 1,540 · see citing works
Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche
Mohyeldin, A., Garzón-Muvdi, T., & Quiñones‐Hinojosa, A. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.07.007 · Cited by 1,536 · see citing works
Ying, W. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1672 · Cited by 1,494 · see citing works
Murphy, M. M., Lawson, J. A., Mathew, S. J., Hutcheson, D. A., & Kardon, G. (2011) · Development · doi:10.1242/dev.064162 · Cited by 1,249 · see citing works
Lepper, C., Partridge, T. A., & Fan, C.-M. (2011) · Development · doi:10.1242/dev.067595 · Cited by 1,105 · see citing works
Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration
Sambasivan, R., Yao, R., Kissenpfennig, A., Van Wittenberghe, L., Paldi, A., Gayraud-Morel, B., Guenou, H., Malissen, B., Tajbakhsh, S., & Galy, A. (2011) · Development · doi:10.1242/dev.067587 · Cited by 939 · see citing works
Self-citationMuscle satellite cells adopt divergent fates
Zammit, P. S., Golding, J. P., Nagata, Y., Hudon, V., Partridge, T. A., & Beauchamp, J. R. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312007 · Cited by 924 · see citing works
Expression of Cd34 and Myf5 Defines the Majority of Quiescent Adult Skeletal Muscle Satellite Cells
Beauchamp, J. R., Heslop, L., Yu, D. S., Tajbakhsh, S., Kelly, R. G., Wernig, A., BUCKINGHAM, M. E., Partridge, T. A., & Zammit, P. S. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.6.1221 · Cited by 917 · see citing works
Self-citationThe Human Mitochondrial Transcriptome
Mercer, T. R., Neph, S., Dinger, M. E., Crawford, J., Smith, M. A., Shearwood, A.-M. J., Haugen, E., Bracken, C. P., Rackham, O., Stamatoyannopoulos, J. A., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.051 · Cited by 905 · see citing works
Garlanda, C., Bottazzi, B., Bastone, A., & Mantovani, A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115756 · Cited by 885 · see citing works
Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation
Owusu-Ansah, E., & Banerjee, U. (2009) · Nature · doi:10.1038/nature08313 · Cited by 742 · see citing works
Muscle Satellite Cells and Endothelial Cells: Close Neighbors and Privileged Partners
Christov, C., Chrétien, F. C., Abou-Khalil, R., Bassez, G., Vallet, G., Authier, F., Bassaglia, Y., Shinin, V., Tajbakhsh, S., Chazaud, B., et al. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-08-0693 · Cited by 702 · see citing works
Self-citationRocheteau, P., Gayraud-Morel, B., Siegl-Cachedenier, I., Blasco, M. A., & Tajbakhsh, S. (2012) · Cell · doi:10.1016/j.cell.2011.11.049 · Cited by 510 · see citing works
Self-citationNiche Regulation of Muscle Satellite Cell Self-Renewal and Differentiation
Kuang, S., Gillespie, M. A., & Rudnicki, M. A. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2007.12.012 · Cited by 507 · see citing works
Muscle stem cells in development, regeneration, and diseasePreprint
Shi, X., & Garry, D. J. (2006) · Genes & Development · doi:10.1101/gad.1419406 · Cited by 502 · see citing works
Isolation of Adult Mouse Myogenic Progenitors
Sherwood, R. I., Christensen, J. L., Conboy, I. M., Conboy, M. J., Rando, T. A., Weissman, I. L., & Wagers, A. J. (2004) · Cell · doi:10.1016/j.cell.2004.10.021 · Cited by 491 · see citing works
Generating green fluorescent mice by germline transmission of green fluorescent ES cells
Hadjantonakis, A., Gertsenstein, M., Ikawa, M., Okabe, M., & Nagy, A. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00093-8 · Cited by 483 · see citing works
Progenitor cells from human brain after death
Palmer, T. D., Schwartz, P. H., Taupin, P., Kaspar, B. K., Stein, S. A., & Gage, F. H. (2001) · Nature · doi:10.1038/35075141 · Cited by 457 · see citing works
Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
Gan, B., HU, J. L., Jiang, S., Liu, Y., Sahin, E., Li, Z., Fletcher-Sananikone, E., Colla, S., Wang, Y., Chin, L., et al. (2010) · Nature · doi:10.1038/nature09595 · Cited by 437 · see citing works
Distinct Regulatory Cascades Govern Extraocular and Pharyngeal Arch Muscle Progenitor Cell Fates
Sambasivan, R., Gayraud-Morel, B., Dumas, G., Cimper, C., Paisant, S., Kelly, R. G., & Tajbakhsh, S. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.05.008 · Cited by 400 · see citing works
Self-citationThe Lkb1 metabolic sensor maintains haematopoietic stem cell survival
Gurumurthy, S., Xie, S. Z.-J., Alagesan, B., Kim, J., Yusuf, R. Z., Sáez, B., Tzatsos, A., Ozsolak, F., Milos, P. M., Ferrari, F., et al. (2010) · Nature · doi:10.1038/nature09572 · Cited by 391 · see citing works
The role of NF-κB in the regulation of cell stress responses
Wang, T., Zhang, X., & Li, J. J. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(02)00058-9 · Cited by 345 · see citing works
Response of Skeletal Muscle Mitochondria to Hypoxia
Hoppeler, H. H., Vogt, M., Weibel, E. R., & Flück, M. (2003) · Experimental Physiology · doi:10.1113/eph8802513 · Cited by 329 · see citing works
Moodie, F. M., Marwick, J. A., Anderson, C. S., Szulakowski, P., Biswas, S. K., Bauter, M. R., Kilty, I., & Rahman, I. (2004) · The FASEB Journal · doi:10.1096/fj.04-1506fje · Cited by 322 · see citing works
A role for the myogenic determination gene Myf5 in adult regenerative myogenesis
Gayraud-Morel, B., Chrétien, F. C., Flamant, P., Gomès, D., Zammit, P. S., & Tajbakhsh, S. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.08.059 · Cited by 240 · see citing works
Self-citationAutocrine and Paracrine Angiopoietin 1/Tie-2 Signaling Promotes Muscle Satellite Cell Self-Renewal
Abou-Khalil, R., Grand, F. L., Pallafacchina, G., Valable, S., Authier, F., Rudnicki, M. A., Gherardi, R. K., Germain, S., Chrétien, F. C., Sotiropoulos, A., et al. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.06.001 · Cited by 236 · see citing works
Self-citationNF-κB activity in transgenic mice: developmental regulation and tissue specificity
Schmidt‐Ullrich, R., Mémet, S., Lilienbaum, A., Feuillard, J., Raphaël, M., & Israël, A. (1996) · Development · doi:10.1242/dev.122.7.2117 · Cited by 227 · see citing works
Self-citationGelfand, R., & Attardi, G. M. (1981) · Molecular and Cellular Biology · doi:10.1128/mcb.1.6.497 · Cited by 212 · see citing works
Prospective Isolation of Skeletal Muscle Stem Cells with a Pax7 Reporter
Bosnakovski, D., Xu, Z., Li, W., Thet, S., Cleaver, O., Perlingeiro, R. C. R., & Kyba, M. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1017 · Cited by 187 · see citing works
Enver, T., & Greaves, M. F. (1998) · Cell · doi:10.1016/s0092-8674(00)81215-5 · Cited by 185 · see citing works
Mitochondria as ATP consumers: Cellular treason in anoxia
St‐Pierre, J., Brand, M. D., & Boutilier, R. G. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.140093597 · Cited by 177 · see citing works
Oxidative Stress Regulation of Stem and Progenitor Cells
Pervaiz, S., Taneja, R., & Ghaffari, S. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2804 · Cited by 176 · see citing works
Yeast cells can access distinct quiescent statesPreprint
Klosinska, M. M., Crutchfield, C. A., Bradley, P. H., Rabinowitz, J. D., & Broach, J. R. (2011) · Genes & Development · doi:10.1101/gad.2011311 · Cited by 168 · see citing works
Yablonka‐Reuveni, Z., & Anderson, J. E. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20602 · Cited by 123 · see citing works
Watanabe, T., Sagisaka, H., Arakawa, S., Shibaya, Y., Watanabe, M., Igarashi, I., Tanaka, K., Totsuka, S., Takasaki, W., & Manabe, S. (2003) · The Journal of Toxicological Sciences · doi:10.2131/jts.28.455 · Cited by 113 · see citing works
Wang, Y., Plane, J. M., Jiang, P., Zhou, C. J., & Deng, W. (2011) · Stem Cells · doi:10.1002/stem.644 · Cited by 113 · see citing works
Gruber, J., Ng, L. F., Fong, S., Wong, Y. T., Koh, S. A., Chen, C.-B., Shui, G., Cheong, W. F., Schaffer, S., Wenk, M. R., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019444 · Cited by 96 · see citing works
Guitart, A. V., Hammoud, M., Sbarba, P. D., Ivanović, Z., & Praloran, V. (2010) · Experimental Hematology · doi:10.1016/j.exphem.2010.06.002 · Cited by 94 · see citing works
Skeletal Muscle as a Paradigm for Regenerative Biology and Medicine
Gayraud-Morel, B., Chrétien, F. C., & Tajbakhsh, S. (2009) · Regenerative Medicine · doi:10.2217/17460751.4.2.293 · Cited by 93 · see citing works
Self-citationIdentification and Functional Analysis of Human Tom22 for Protein Import into Mitochondria
Yano, M., Hoogenraad, N. J., Terada, K., & Mori, M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.19.7205-7213.2000 · Cited by 81 · see citing works
Bourraindeloup, M., Adamy, C., Candiani, G., Cailleret, M., Bourin, M., Badoual, T., Su, J. B., Adubeiro, S., Roudot‐Thoraval, F., Dubois‐Randé, J., et al. (2004) · Circulation · doi:10.1161/01.cir.0000143630.14515.7c · Cited by 80 · see citing works
Rocher, C., Taanman, J., Pierron, D., Faustin, B., Benard, G., Rossignol, R., Malgat, M., Pédespan, L., & Letellier, T. (2008) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-008-9130-5 · Cited by 63 · see citing works
Xu, Y., Kimura, K., Matsumoto, N., & Idé, C. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10769 · Cited by 49 · see citing works
Acute anoxia stimulates proliferation in adult neural stem cells from the rat brain
Bürgers, H. F., Schelshorn, D. W., Wagner, W., Kuschinsky, W., & Maurer, M. H. (2008) · Experimental Brain Research · doi:10.1007/s00221-008-1336-6 · Cited by 43 · see citing works
Adult Stem Cells Exhibit Global Suppression of RNA Polymerase II Serine-2 Phosphorylation
Freter, R., Osawa, M., & Nishikawa, S.-I. (2010) · Stem Cells · doi:10.1002/stem.476 · Cited by 43 · see citing works
Chronic hypoxia aggravates renal injury via suppression of Cu/Zn-SOD: a proteomic analysis
Son, D., Kojima, I., Inagi, R., Matsumoto, M., Fujita, T., & Nangaku, M. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00113.2007 · Cited by 39 · see citing works
Chronic hypoxia aggravates renal injury via suppression of Cu/Zn-SOD : a proteomic analysis
孫, 大. (2008) · Medical Entomology and Zoology · Cited by 36 · see citing works
Therapeutic Liver Reconstitution With Murine Cells Isolated Long After Death
Erker, L., Azuma, H., Lee, A. Y., Guo, C., Orloff, S., Eaton, L., Benedetti, E., Jensen, B., Finegold, M., Willenbring, H., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.05.082 · Cited by 34 · see citing works
Successful donor cell engraftment in a recipient of bone marrow from a cadaveric donor
Blazar, B., Lasky, L., Perentesis, J., Watson, K., Steinberg, S., Filipovich, A. H., Orr, H. T., & Ramsay, N. (1986) · Blood · doi:10.1182/blood.v67.6.1655.1655 · Cited by 31 · see citing works
Alterations in mitochondrial RNA expression after renal ischemia
Itallie, C. M. V., Why, S. K. V., Thulin, G., Kashgarian, M. J., & Siegel, N. J. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.265.3.c712 · Cited by 27 · see citing works
Successful donor cell engraftment in a recipient of bone marrow from a cadaveric donor
Blazar, B., Lasky, L., Perentesis, J., et al. (1986) · Blood · doi:10.1182/blood.v67.6.1655.bloodjournal6761655 · Cited by 22 · see citing works
Sustained hypoxia modulates mitochondrial DNA content in the neonatal rat brain
Lee, H. M., Greeley, G. H., & Englander, E. W. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.11.005 · Cited by 22 · see citing works
Bone marrow transplantation from a cadaveric donor
Kapelushnik, J., Aker, M., Pugatsch, T., Samuel, S., & Slavin, S. (1998) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1701165 · Cited by 22 · see citing works
Isolation of neural stem cells from the spinal cords of low temperature preserved abortuses
Liu, X., Zhu, Y., & Gao, W. (2006) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2006.03.025 · Cited by 22 · see citing works
An optimization of isolation of early hematopoietic cells from heparinized cadaveric organ donors
Machaliński, B., Paczkowski, M., Kawa, M. P., Paczkowska, E., & Ostrowski, M. (2003) · Transplantation Proceedings · doi:10.1016/j.transproceed.2003.10.082 · Cited by 19 · see citing works
Aly, A., Peterson, K. M., Lerman, A., Lo, L., & Rodriguez-Porcel, M. G. (2011) · PubMed · Cited by 17 · see citing works
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Sorted by citations
Molecular regulation of stem cell quiescence
Cheung, T. H., & Rando, T. A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3591 · Cited by 1,148 · see citing works
Metabolic Plasticity in Stem Cell Homeostasis and Differentiation
Folmes, C. D. L., Dzeja, P. P., Nelson, T. J., & Terzic, A. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.10.002 · Cited by 664 · see citing works
Comparative Study of Injury Models for Studying Muscle Regeneration in Mice
Hardy, D., Besnard, A., Latil, M., Jouvion, G., Briand, D., Thépenier, C., Pascal, Q., Guguin, A., Gayraud-Morel, B., Cavaillon, J., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147198 · Cited by 508 · see citing works
Self-citationPerspectives on skeletal muscle stem cells
Relaix, F., Bencze, M., Borok, M. J., Vartanian, A. D., Gattazzo, F., Mademtzoglou, D., Perez-Diaz, S., Prola, A., Fernandez, P. C. R., Rotini, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20760-6 · Cited by 389 · see citing works
Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause
Scognamiglio, R., Cabezas-Wallscheid, N., Thier, M. C., Altamura, S., Reyes, A., Prendergast, Á. M., Baumgärtner, D., Carnevalli, L. S., Atzberger, A., Haas, S., et al. (2016) · Cell · doi:10.1016/j.cell.2015.12.033 · Cited by 271 · see citing works
Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity
de Morrée, A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00568-6 · Cited by 243 · see citing works
Rocheteau, P., Châtre, L., Briand, D., Mebarki, M., Jouvion, G., Bardon, J., Crochemore, C., Serrani, P., Lecci, P. P., Latil, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms10145 · Cited by 237 · see citing works
Self-citationLying low but ready for action: the quiescent muscle satellite cell
Montarras, D., L’honoré, A., & BUCKINGHAM, M. E. (2013) · FEBS Journal · doi:10.1111/febs.12372 · Cited by 199 · see citing works
Regulation and phylogeny of skeletal muscle regeneration
Baghdadi, M. B., & Tajbakhsh, S. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.07.026 · Cited by 186 · see citing works
Self-citationPala, F., Di Girolamo, D., Mella, S., Yennek, S., Chatre, L., Ricchetti, M., & Tajbakhsh, S. (2018) · Journal of Cell Science · doi:10.1242/jcs.212977 · Cited by 184 · see citing works
Self-citationMechanisms, Hallmarks, and Implications of Stem Cell Quiescence
Cho, I., Lui, P. P., Obajdin, J., Riccio, F., Stroukov, W., Willis, T. L., Spagnoli, F. M., & Watt, F. M. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.05.012 · Cited by 163 · see citing works
Vitamin D Promotes Skeletal Muscle Regeneration and Mitochondrial Health
Latham, C. M., Brightwell, C. R., Keeble, A. R., Munson, B. D., Thomas, N. T., Zagzoog, A. M., Fry, C. S., & Fry, J. L. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.660498 · Cited by 163 · see citing works
Tracing the dynamics of gene transcripts after organismal death
Pozhitkov, A. E., Neme, R., Domazet‐Lošo, T., Leroux, B. G., Soni, S., Tautz, D., & Noble, P. A. (2017) · Open Biology · doi:10.1098/rsob.160267 · Cited by 142 · see citing works
AMPKα1‐LDH pathway regulates muscle stem cell self‐renewal by controlling metabolic homeostasis
Théret, M., Gsaier, L., Schaffer, B. E., Juban, G., Larbi, S. B., Weiss‐Gayet, M., Bultot, L., Collodet, C., Foretz, M., Dominique Desplanches, C., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201695273 · Cited by 138 · see citing works
Skeletal muscle stem cells in comfort and stress
Evano, B., & Tajbakhsh, S. (2018) · npj Regenerative Medicine · doi:10.1038/s41536-018-0062-3 · Cited by 132 · see citing works
Self-citationSkeletal Muscle Microvasculature: A Highly Dynamic Lifeline
Latroche, C., Gitiaux, C., Chrétien, F., Desguerre, I., Mounier, R., & Chazaud, B. (2015) · Physiology · doi:10.1152/physiol.00026.2015 · Cited by 134 · see citing works
Self-citationWang, Y. X., Dumont, N. A., & Rudnicki, M. A. (2014) · Journal of Cell Science · doi:10.1242/jcs.151209 · Cited by 125 · see citing works
Metabolic regulation of the hallmarks of stem cell biology
Jackson, B. T., & Finley, L. W. S. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.01.003 · Cited by 122 · see citing works
Nadal‐Ginard, B., Ellison, G. M., & Torella, D. (2014) · Stem Cell Research · doi:10.1016/j.scr.2014.04.008 · Cited by 98 · see citing works
Impact of vaginal parity and aging on the architectural design of pelvic floor muscles
Alperin, M., Cook, M. S., Tuttle, L. J., Esparza, M. C., & Lieber, R. L. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.02.033 · Cited by 96 · see citing works
Recent progress in satellite cell/myoblast engraftment – relevance for therapy
Briggs, D. A., & Morgan, J. E. (2013) · FEBS Journal · doi:10.1111/febs.12273 · Cited by 93 · see citing works
Châtre, L., & Ricchetti, M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt015 · Cited by 92 · see citing works
Self-citationUnique Metabolic Features of Stem Cells, Cardiomyocytes, and Their Progenitors
Gaspar, J. A., Doss, M. X., Hengstler, J. G., Cadenas, C., Hescheler, J., & Sachinidis, A. (2014) · Circulation Research · doi:10.1161/circresaha.113.302021 · Cited by 90 · see citing works
L’honoré, A., Commère, P., Négroni, E., Pallafacchina, G., Friguet, B., Drouin, J., BUCKINGHAM, M. E., & Montarras, D. (2018) · eLife · doi:10.7554/elife.32991 · Cited by 87 · see citing works
Human satellite cells have regenerative capacity and are genetically manipulable
Marg, A., Escobar, H., Gloy, S., Kufeld, M., Zacher, J., Spuler, A., Birchmeier, C., Izsvák, Z., & Spuler, S. (2014) · Journal of Clinical Investigation · doi:10.1172/jci63992 · Cited by 88 · see citing works
Doridot, L., Châtre, L., Ducat, A., Vilotte, J.-L., Lombès, A., Méhats, C., Barbaux, S., Calicchio, R., Ricchetti, M., & Vaiman, D. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5661 · Cited by 90 · see citing works
Self-citationMitochondrial Function in Muscle Stem Cell Fates
Bhattacharya, D., & Scimè, A. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00480 · Cited by 88 · see citing works
Metabolic reprogramming as a novel regulator of skeletal muscle development and regeneration
Ryall, J. G. (2013) · FEBS Journal · doi:10.1111/febs.12189 · Cited by 83 · see citing works
Transient HIF2A inhibition promotes satellite cell proliferation and muscle regeneration
Xie, L., Yin, A., Nichenko, A. S., Beedle, A. M., Call, J. A., & Yin, H. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96208 · Cited by 81 · see citing works
Muscle Stem Cell Quiescence: Controlling Stemness by Staying Asleep
Ancel, S., Stuelsatz, P., & Feige, J. N. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.02.006 · Cited by 75 · see citing works
Hwang, A. B., & Brack, A. S. (2017) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2017.08.008 · Cited by 80 · see citing works
High-Yield Purification, Preservation, and Serial Transplantation of Human Satellite Cells
Garcia, S. M., Tamaki, S. J., Lee, S., Wong, A., Jose, A., Dreux, J., Kouklis, G. K., Sbitany, H., Seth, R., Knott, P. D., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.01.022 · Cited by 75 · see citing works
Moya, A., Larochette, N., Paquet, J., Deschepper, M., Bensidhoum, M., Izzo, V., Kroemer, G., Petite, H., & Logeart‐Avramoglou, D. (2016) · Stem Cells · doi:10.1002/stem.2493 · Cited by 71 · see citing works
Hommel, B., Sturny-Leclère, A., Volant, S., Veluppillai, N., Duchateau, M., Yu, C.-H. A., Hourdel, V., Varet, H., Matondo, M., Perfect, J. R., et al. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007945 · Cited by 69 · see citing works
An interdisciplinary review of the thanatomicrobiome in human decomposition
Javan, G. T., Finley, S. J., Tuomisto, S., Hall, A., Benbow, M. E., & Mills, D. (2018) · Forensic Science Medicine and Pathology · doi:10.1007/s12024-018-0061-0 · Cited by 68 · see citing works
Identification and characterization
Bernstein, J., & Reutzel‐Edens, S. M. (2019) · urn:isbn:978-1-118-41628-0 · Cited by 112 · see citing works
Parte, S. C., Bhartiya, D., Manjramkar, D. D., Chauhan, A. R., & Amita, J. (2013) · Journal of Ovarian Research · doi:10.1186/1757-2215-6-20 · Cited by 62 · see citing works
Human skeletal muscle xenograft as a new preclinical model for muscle disorders
Zhang, T., King, O. D., Rahimov, F., Jones, T. I., Ward, C. W., Kerr, J. P., Liu, N., Emerson, C. P., Kunkel, L. M., Partridge, T. A., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu028 · Cited by 61 · see citing works
Čamernik, K., Barlič, A., Drobnič, M., Marc, J., Jeras, M., & Zupan, J. (2018) · Stem Cell Reviews and Reports · doi:10.1007/s12015-018-9800-6 · Cited by 61 · see citing works
Mechanisms of muscle cells alterations and regeneration decline during aging
Chinvattanachot, G., Rivas, D., & Duque, G. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102589 · Cited by 59 · see citing works
Concise Review: The Role of Oxygen in Hematopoietic Stem Cell Physiology
Jež, M., Rožman, P., Ivanović, Z., & Bas, T. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.24953 · Cited by 41 · see citing works
The Role of Mitophagy in Skeletal Muscle Damage and Regeneration
Chatzinikita, E., Maridaki, M. D., Palikaras, K., Koutsilieris, M., & Philippou, Α. (2023) · Cells · doi:10.3390/cells12050716 · Cited by 53 · see citing works
Kaszynski, R. H., Nishiumi, S., Azuma, T., Yoshida, M., Kondo, T., Takahashi, M., Asano, M., & Ueno, Y. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-9355-9 · Cited by 50 · see citing works
Skrivergaard, S., Rasmussen, M. K., Therkildsen, M., & Young, J. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168376 · Cited by 46 · see citing works
Mitochondrial Function and Reactive Oxygen/Nitrogen Species in Skeletal Muscle
Chen, M., Li, Y., Deng, S., Zhao, Y., Lian, Z., & Yu, K. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.826981 · Cited by 42 · see citing works
Cellular Therapies for Treatment of Radiation Injury: Report from a NIH/NIAID and IRSN Workshop
DiCarlo, A. L., Tamarat, R., Rios, C. I., Benderitter, M., Czarniecki, C. W., Allio, T., Macchiarini, F., Maidment, B. W., & Jourdain, J.-R. (2017) · Radiation Research · doi:10.1667/rr14810.1 · Cited by 41 · see citing works
Châtre, L., Fernandes, J., Michel, V., Fiette, L., Avé, P., Arena, G., Jain, U., Haas, R., Wang, T. C., Ricchetti, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-15567-3 · Cited by 41 · see citing works
Self-citationChâtre, L., & Ricchetti, M. (2012) · Journal of Cell Science · doi:10.1242/jcs.114322 · Cited by 39 · see citing works
Self-citationSatellite cell therapy – from mice to men
Bareja, A., & Billin, A. N. (2013) · Skeletal Muscle · doi:10.1186/2044-5040-3-2 · Cited by 35 · see citing works
Valente, S., Alviano, F., Ciavarella, C., Buzzi, M., Ricci, F., Tazzari, P. L., Pagliaro, P., & Pasquinelli, G. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt397 · Cited by 35 · see citing works
Isesele, P., & Mazurak, V. C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.682091 · Cited by 33 · see citing works
Dormancy and Quiescence of Skeletal Muscle Stem Cells
Rocheteau, P., Vinet, M., & Chrétien, F. C. (2014) · Results and problems in cell differentiation · doi:10.1007/978-3-662-44608-9_10 · Cited by 35 · see citing works
Self-citationSpermidine-eIF5A axis is essential for muscle stem cell activation via translational control
Zhang, Q., Han, W., Wu, R., Deng, S., Meng, J., Yang, Y., Li, L. Y., Sun, M., Ai, H., Chen, Y., et al. (2024) · Cell Discovery · doi:10.1038/s41421-024-00712-w · Cited by 35 · see citing works
Estimation of early postmortem interval in rats by GC–MS-based metabolomics
Wu, Z., Lü, X., Chen, F., Dai, X., Ye, Y., Yan, Y., & Liao, L. (2017) · Legal Medicine · doi:10.1016/j.legalmed.2017.12.014 · Cited by 31 · see citing works
A novel paradigm links mitochondrial dysfunction with muscle stem cell impairment in sepsis
Châtre, L., Verdonk, F., Rocheteau, P., Crochemore, C., Chrétien, F., & Ricchetti, M. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.04.019 · Cited by 29 · see citing works
Self-citationLoss of heterogeneity, quiescence, and differentiation in muscle stem cells
Sutcu, H. H., & Ricchetti, M. (2018) · Stem Cell Investigation · doi:10.21037/sci.2018.03.02 · Cited by 28 · see citing works
Self-citationHypoxia further exacerbates woody breast myopathy in broilers via alteration of satellite cell fate
Emami, N. K., Cauble, R. N., Dhamad, A. E., Greene, E. S., Coy, C. S., Velleman, S. G., Orlowski, S., Anthony, N. B., Bedford, M. R., & Dridi, S. (2021) · Poultry Science · doi:10.1016/j.psj.2021.101167 · Cited by 26 · see citing works
Emerging role of mitophagy in myoblast differentiation and skeletal muscle remodeling
Rahman, F. A., & Quadrilatero, J. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.11.026 · Cited by 25 · see citing works
Quiescence of human muscle stem cells is favored by culture on natural biopolymeric films
Monge, C., Distasio, N., Rossi, T., Sébastien, M., Sakai, H., Kalman, B., Boudou, T., Tajbakhsh, S., Marty, I., Bigot, A., et al. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0556-8 · Cited by 25 · see citing works
Self-citationHuman muscle stem cells are refractory to aging
Novak, J. S., Mázala, D. A. G., Nearing, M., Hindupur, R., Uapinyoying, P., Habib, N. F., Dickson, T., Ioffe, O. B., Harris, B. T., Fidelia‐Lambert, M. N., et al. (2021) · Aging Cell · doi:10.1111/acel.13411 · Cited by 24 · see citing works
Muscle Regeneration and Function in Sports: A Focus on Vitamin D
Iolascon, G., Moretti, A., Paoletta, M., Liguori, S., & Munno, O. D. (2021) · Medicina · doi:10.3390/medicina57101015 · Cited by 24 · see citing works
Marchildon, F., Fu, D., Lala-Tabbert, N., & Wiper‐Bergeron, N. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.4 · Cited by 24 · see citing works
Riddle, E. S., Bender, E. L., & Thalacker‐Mercer, A. E. (2018) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00135.2018 · Cited by 23 · see citing works
Analysis of human satellite cell dynamics on cultured adult skeletal muscle myofibers
Feige, P., Tsai, E. C., & Rudnicki, M. A. (2021) · Skeletal Muscle · doi:10.1186/s13395-020-00256-z · Cited by 22 · see citing works
A Three-Dimensional Culture Model of Reversibly Quiescent Myogenic Cells
Aguanno, S., Petrelli, C., Siena, S. D., Angelis, L. D., Pellegrini, M., & Naro, F. (2019) · Stem Cells International · doi:10.1155/2019/7548160 · Cited by 19 · see citing works
p66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence
Potes, Y., Bermejo-Millo, J. C., Mendes, C., Castelão-Baptista, J. P., Díaz-Luis, A., Pérez-Martínez, Z., Solano, J. J., Sardão, V. A., Oliveira, P. J., Caballero, B., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06582-0 · Cited by 19 · see citing works
A Long Journey before Cycling: Regulation of Quiescence Exit in Adult Muscle Satellite Cells
Zhou, S., Han, L., & Wu, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031748 · Cited by 18 · see citing works
Telzrow, C. L., Esher, S. K., Castro-Lopez, N., Campuzano, A., Brooks, J. T., Carney, J. M., Wormley, F. L., & Alspaugh, J. A. (2022) · Infection and Immunity · doi:10.1128/iai.00580-21 · Cited by 17 · see citing works
Muscle regeneration after sepsis
Bouglé, A., Rocheteau, P., Sharshar, T., & Chrétien, F. C. (2016) · Critical Care · doi:10.1186/s13054-016-1308-3 · Cited by 18 · see citing works
Self-citationRieger, M. M., Duran, P., Cook, M. S., Schenk, S., Shah, M. M., Jacobs, M. B., Christman, K. L., Kado, D. M., & Alperin, M. (2021) · Annals of Biomedical Engineering · doi:10.1007/s10439-021-02748-5 · Cited by 18 · see citing works
Adult Muscle Stem Cells: Exploring the Links Between Systemic and Cellular Metabolism
Purohit, G., & Dhawan, J. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00312 · Cited by 17 · see citing works
Cadaveric Stem Cells: Their Research Potential and Limitations
Cieśla, J., & Tomsia, M. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.798161 · Cited by 17 · see citing works
Francis, T., Jaka, O., Ellison, G. M., Lazarus, N. R., & Harridge, S. D. R. (2022) · JCSM Rapid Communications · doi:10.1002/rco2.67 · Cited by 16 · see citing works
Fu, Y., Wu, Z., Wei, Y., Wang, X., Zou, J., Li, X., Fan, W., Yang, H. F., & Liao, L. (2024) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2024.116443 · Cited by 16 · see citing works
Ciavarella, C., Fittipaldi, S., Pedrini, S., Vasuri, F., Gallitto, E., Freyrie, A., Stella, A., Gostjeva, E. V., & Pasquinelli, G. (2015) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2015.00036 · Cited by 15 · see citing works
Recovery of fibroblast-like cells from refrigerated goat skin up to 41 d of animal death
Okonkwo, C., & Singh, M. (2014) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-014-9856-9 · Cited by 15 · see citing works
Mitsiadis, T. A., & Woloszyk, A. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00099 · Cited by 15 · see citing works
Replication stress in mitochondria
Ricchetti, M. (2018) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2018.01.005 · Cited by 14 · see citing works
Self-citationVlaski‐Lafarge, M., Négroni, L., Filipović, M. K., Guibert, C., de la Grange, P. B., Rossignol, R., Chevaleyre, J., Duchez, P., Lafarge, X., Praloran, V., et al. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24678 · Cited by 13 · see citing works
Zhu, X., Liu, Z., Deng, W., Zhang, Z., Liu, Y., Wei, L., Zhang, Y., Zhou, L., & Wang, Y. (2017) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2017.01.022 · Cited by 13 · see citing works
Zufiría, M., Pikatza‐Menoio, O., Garciandia-Arcelus, M., Bengoetxea, X., Jiménez-Zúñiga, A., Elicegui, A., Levchuk, M., Arnold-García, O., Ondaro, J., Iruzubieta, P., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02794-y · Cited by 13 · see citing works
García-Parra, P., Naldaiz‐Gastesi, N., Maroto, M., Padín, J. F., Goicoechea, M., Aiastui, A., Fernández‐Morales, J., García‐Belda, P., Prieto, J. L., Álava, J. I., et al. (2013) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2013.0146 · Cited by 11 · see citing works
Sun, Y., Chi, D., Tan, M., Kang, K., Zhang, M., Jin, X., Leng, X., Cao, R., Liu, X., Yu, B., et al. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1160973 · Cited by 11 · see citing works
Hodgetts, S. I., Stagg, K., Sturm, M., Edel, M. J., & Blancafort, P. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.09.028 · Cited by 10 · see citing works
Insights into human muscle biology from human primary skeletal muscle cell culture
Francis, T., Soendenbroe, C., Lazarus, N. R., Mackey, A. L., & Harridge, S. D. R. (2025) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-025-09696-w · Cited by 10 · see citing works
Structure–function relationship of the human external anal sphincter
Stewart, A. M., Cook, M. S., Dyer, K. Y., & Alperin, M. (2017) · International Urogynecology Journal · doi:10.1007/s00192-017-3404-6 · Cited by 9 · see citing works
Serotonin reuptake inhibitors improve muscle stem cell function and muscle regeneration in male mice
Fefeu, M., Blatzer, M., Kneppers, A. E. M., Briand, D., Rocheteau, P., Haroche, A., Hardy, D., Juchet-Martin, M., Danckaert, A., Coudoré, F., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50220-4 · Cited by 8 · see citing works
Self-citationWalcott, B., & Singh, M. (2017) · Cogent Biology · doi:10.1080/23312025.2017.1333760 · Cited by 8 · see citing works
Saito, T., Sato, T., & Suzuki, K. (2019) · Journal of Forensic and Legal Medicine · doi:10.1016/j.jflm.2019.101875 · Cited by 9 · see citing works
New Perspectives for Postmortem Human Satellite Cells of Different Embryological Origin
Pietrangelo, T., Demontis, R., Santangelo, C., Pini, N., Bonelli, M., Rosato, E., Roberti, P., Locatelli, M., Tartaglia, A., Marramiero, L., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.886149 · Cited by 7 · see citing works
Mansilla, E. (2013) · Journal of Transplantation Technologies & Research · doi:10.4172/2161-0991.1000118 · Cited by 7 · see citing works
How stem cells manage to escape senescence and ageing – while they can
Ricchetti, M. (2016) · BioEssays · doi:10.1002/bies.201600064 · Cited by 6 · see citing works
Self-citationPerán, M., López‐Ruiz, E., González-Herrera, L., Bustamante, M., Valenzuela, A., & Marchal, J. A. (2013) · Cytotherapy · doi:10.1016/j.jcyt.2013.06.016 · Cited by 6 · see citing works
Time for a new definition of death?
Charlier, P., & Annane, D. (2018) · Resuscitation · doi:10.1016/j.resuscitation.2018.04.012 · Cited by 6 · see citing works
Stem Cell-Based and Tissue Engineering Approaches for Skeletal Muscle Repair
Domenig, S. A., Palmer, A. S., & Bar‐Nur, O. (2021) · Reference series in biomedical engineering · doi:10.1007/978-3-030-44211-8_19 · Cited by 5 · see citing works
Ex-vivo Expansion of Muscle-Regenerative Cells for the Treatment of Muscle Disorders
Schaaf, G. (2012) · Journal of Stem Cell Research & Therapy · doi:10.4172/2157-7633.s11-003 · Cited by 5 · see citing works
Tissues from Post-Mortem Donors as Alternative Sources of Stem Cells for Regenerative Medicine
Haring, G., & Zupan, J. (2020) · Advances in experimental medicine and biology · doi:10.1007/5584_2020_492 · Cited by 5 · see citing works
Altered senescence and mitochondrial transcriptome defines age-related changes in satellite cells
Rahman, F. A., & Quadrilatero, J. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1699206 · Cited by 4 · see citing works
Ex vivo functional whole organ in biomedical research: a review
Chelladurai, K. S., Christyraj, J. D. S., Rajagopalan, K., Vadivelu, K., Chandrasekar, M., Das, P., Kalishwaralal, K., Balamurugan, N., Subramanian, V., & Christyraj, J. R. S. S. (2024) · Journal of Artificial Organs · doi:10.1007/s10047-024-01478-4 · Cited by 4 · see citing works
Initial nutrient condition determines the recovery speed of quiescent cells in fission yeast
Liu, Q., Sheng, N., Zhang, Z., He, C., Zhao, Y. L., Sun, H., Chen, J., Yang, X., & Tang, C. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e26558 · Cited by 4 · see citing works
- Authors
- Latil, M., Rocheteau, P., Châtre, L., Sanulli, S., Mémet, S., Ricchetti, M., Tajbakhsh, S., & Chrétien, F.
- Affiliations
- Institut Pasteur (FR)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Chrétien, Fabrice
- ORCID
- Venue
- Nature Communications
- Published
- 2012-06-12
- Volume
- 3
- Issue
- 1
- Pages
- 903-903
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2039350499
- Cited by
- 165
- References
- 61
- Citations by year
- 2026: 8 · 2025: 3 · 2024: 17 · 2023: 5 · 2022: 9 · 2021: 20 · 2020: 9 · 2019: 7 · 2018: 21 · 2017: 15 · 2016: 10 · 2015: 13 · 2014: 14 · 2013: 10 · 2012: 4
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Communications (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Agence Nationale de la Recherche
- Université Paris Descartes
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- skeletal muscle stem cells, quiescent cells, stem cell quiescence, regenerative capacity, hypoxia, anoxia, reactive oxygen species, myogenic cells, cell transplantation, tissue regeneration, hematopoietic stem cells, cadaveric tissue
- MeSH terms
- Animals, Cell Survival, Humans, Mice, Inbred C57BL, Stem Cells, Muscle, Skeletal, Mice
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