The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Neurotransmitters: The Critical Modulators Regulating Gut–Brain Axis
Open accessAbstract
Neurotransmitters, including catecholamines and serotonin, play a crucial role in maintaining homeostasis in the human body. Studies on these neurotransmitters mainly revolved around their role in the “fight or flight” response, transmitting signals across a chemical synapse and modulating blood flow throughout the body. However, recent research has demonstrated that neurotransmitters can play a significant role in the gastrointestinal (GI) physiology. Norepinephrine (NE), epinephrine (E), dopamine (DA), and serotonin have recently been a topic of interest because of their roles in the gut physiology and their potential roles in GI and central nervous system pathophysiology. These neurotransmitters are able to regulate and control not only blood flow, but also affect gut motility, nutrient absorption, GI innate immune system, and the microbiome. Furthermore, in pathological states, such as inflammatory bowel disease (IBD) and Parkinson's disease, the levels of these neurotransmitters are dysregulated, therefore causing a variety of GI symptoms. Research in this field has shown that exogenous manipulation of catecholamine serum concentrations can help in decreasing symptomology and/or disease progression. In this review article, we discuss the current state‐of‐the‐art research and literature regarding the role of neurotransmitters in regulation of normal GI physiology, their impact on several disease processes, and novel work focused on the use of exogenous hormones and/or psychotropic medications to improve disease symptomology. J. Cell. Physiol. 232: 2359–2372, 2017. © 2016 Wiley Periodicals, Inc.
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Cites
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Parkinson’s Disease: From Pathogenesis to Pharmacogenomics
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Gut microbiota and dysbiosis in Alzheimer's disease: Implications for pathogenesis and treatment
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Gut microbiome and depression: what we know and what we need to know
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Gut-brain Axis and migraine headache: a comprehensive review
On behalf of the School of Advanced Studies of the European Headache Federation (EHF-SAS), Arzani, M., Jahromi, S. R., Ghorbani, Z., Vahabizad, F., Martelletti, P., Ghaemi, A., Sacco, S., & Togha, M. (2020) · The Journal of Headache and Pain · doi:10.1186/s10194-020-1078-9 · Cited by 366
Metadata
- Authors
- Mittal, R., Debs, L. H., Patel, A. P., Nguyen, D., Patel, K., O'Connor, G., Grati, M., Mittal, J., Yan, D., Eshraghi, A. A., Deo, S. K., Daunert, S., & Liu, X. Z.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2017-04-10
- Volume
- 232
- Issue
- 9
- Pages
- 2359-2372
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2518460556
- Cited by
- 636
- References
- 17
- FWCI
- 24.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Mittal, R., Debs, L. H., Patel, A. P., Nguyen, D., Patel, K., O'Connor, G., Grati, M., Mittal, J., Yan, D., Eshraghi, A. A., Deo, S. K., Daunert, S., & Liu, X. Z. (2017). Neurotransmitters: The Critical Modulators Regulating Gut–Brain Axis. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.25518
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
