The DOI matches its Crossref record; 152 of the 152 references it cites were found in a registry or an index.
Cellular and molecular mechanisms of sarcopenia: the S100B perspective
Open accessAbstract
Abstract Primary sarcopenia is a condition of reduced skeletal muscle mass and strength, reduced agility, and increased fatigability and risk of bone fractures characteristic of aged, otherwise healthy people. The pathogenesis of primary sarcopenia is not completely understood. Herein, we review the essentials of the cellular and molecular mechanisms of skeletal mass maintenance; the alterations of myofiber metabolism and deranged properties of muscle satellite cells (the adult stem cells of skeletal muscles) that underpin the pathophysiology of primary sarcopenia; the role of the Ca 2+ ‐sensor protein, S100B, as an intracellular factor and an extracellular signal regulating cell functions; and the functional role of S100B in muscle tissue. Lastly, building on recent results pointing to S100B as to a molecular determinant of myoblast–brown adipocyte transition, we propose S100B as a transducer of the deleterious effects of accumulation of reactive oxygen species in myoblasts and, potentially, myofibers concurring to the pathophysiology of sarcopenia.
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“Second, gApN induces the expression of MyoD that allows myoblast proliferation and differentiation [56,69,70].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [70]
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1 retracted
Immunohistochemical detection of interleukin‐6 in human skeletal muscle fibers following exercise
Penkowa, M., Keller, C., Keller, P., Jauffred, S., & Pedersen, B. K. (2003) · The FASEB Journal · doi:10.1096/fj.03-0311fje · Cited by 157
RetractedSandri, M., Sandri, C., Gilbert, A., Skurk, C., Calabria, E., Picard, A., Walsh, K., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2004) · Cell · doi:10.1016/s0092-8674(04)00400-3 · Cited by 3,012 · cited 1×
“They are activated in multiple models of muscle atrophy and are both suf fi cient and required for muscle atrophy 38 ( Figure 2).”
Cellular and Molecular Regulation of Muscle Regeneration
CHARGÉ, S. B. P., & Rudnicki, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00019.2003 · Cited by 2,691 · cited 1×
“…released from damaged muscle tissue — collectively known as damage-associated molecular patterns (DAMPs) — or secreted by in fi ltrating immune cells (i.e. hormones, growth factors, and cytokines) and components of the extracellular matrix 17 – 24 ( Figure 1) acting via cell surface receptors.”
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287 · cited 1×
“From the side of SCs, extrinsic, niche-related factors and intrinsic, cell-autonomous factors concur to determine changes in SCs with aging ultimately leading to reduced SCs ’ ability to maintain muscle mass 5,18,66 – 73 ( Figure 3).”
Nrf2-Keap1 signaling in oxidative and reductive stress
Bellezza, I., Giambanco, I., Minelli, A., & Donato, R. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.02.010 · Cited by 2,134 · cited 1×
“sue (reviewed by Bellezza et al.(43)), an event counteracted by a”
Arnold, L., Henry, A., Poron, F., Baba-Amer, Y., van Rooijen, N., Plonquet, A., Gherardi, R. K., & Chazaud, B. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070075 · Cited by 2,002
RAGE Mediates a Novel Proinflammatory Axis
Hofmann, M. A., Drury, S., Fu, C., Qu, W., Taguchi, A., Lu, Y., Avila, C., Kambham, N., Bierhaus, A., Nawroth, P., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80801-6 · Cited by 1,864
Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis
Joe, A. W. B., Yi, L., Natarajan, A., Le Grand, F., So, L., Wang, J., Rudnicki, M. A., & Rossi, F. M. V. (2010) · Nature Cell Biology · doi:10.1038/ncb2015 · Cited by 1,690
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Core Trainee Prize 2021 Winner
Rigney, B. (2022) · Bone and Joint 360 · doi:10.1302/2048-0105.113.360967
Darden, N., Sharma, S., Wu, X., Mancini, B., Karamchandani, K., & Bonavia, A. S. (2023) · medRxiv · doi:10.1101/2023.04.12.23288490
“While the pathophysiology of primary sarcopenia is not completely understood [13], it involves changes in both muscle size and muscle quality.”
BackgroundPleiotropic effects on Sarcopenia subphenotypes point to potential molecular markers for the disease
Fonseca, I. D., Fabbri, L. E., de Moraes, L. Â. G., Coelho, D. B., Santos, F. C. D., & Rosse, I. C. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2024.105553
The cross-talk between autoimmune diseases and sarcopenia (Preprint)Preprint
Gao, Y., Zhang, Y., Wu, Q., Chen, Q., Wang, Y., Li, B., Zhao, Q., Wang, Q., Wang, Y., & Han, S. (2024) · doi:10.2196/preprints.64456
Circulating BMP-7 Level is Independent of Sarcopenia in Older Asian Adults
Choi, A., Baek, J. Y., Ji, E., Jang, I., Jung, H., Park, S. J., Jo, Y., Lee, E., Ryu, D., & Kim, B. (2024) · Annals of Geriatric Medicine and Research · doi:10.4235/agmr.24.0153
Ontoenergetics: A Thermodynamic Theory of Life, Aging, and DeathPreprint
Decker, S. T. (2025) · OSF Preprints (OSF Preprints) · doi:10.31219/osf.io/ya9us_v1
Sun, Y., Luo, Z., Ling, H., Wu, S., Shen, H., Fu, Y., Ngo, T., Wang, W., & Kong, Y. (2025) · PubMed · doi:10.11817/j.issn.1672-7347.2025.240669
“All rights reserved. by transcriptionally repressing myogenesis-related genes [46] , and abnormal myogenesis is one of the important mechanisms underlying sarcopenia [47] .”
Asadpour, S. M., Daryanoosh, F., & Zarifkar, A. H. (2025) · Biogerontology · doi:10.1007/s10522-025-10363-3
“…to the main myostatin-SMAD pathway, Other possible mechanisms, including the mTOR signaling pathway, especially through PI3K and AKT proteins (Riuzzi et al. 2018), autophagy pathway through the family of FOXO proteins (Fan et al. 2017), and the MAP kinase pathway (Hinkley et al. 2017) can…”
Baygi, F., Buhl, S. F., Thilsing, T., Søndergaard, J., & Nielsen, J. B. (2024) · Figshare · doi:10.6084/m9.figshare.26719845
Hämäläinen, O., Tirkkonen, A., Savikangas, T., Alén, M., Sipilä, S., & Hautala, A. (2024) · Figshare · doi:10.6084/m9.figshare.26687184
Liao, P.-H., Chang, H.-M., Wang, Y.-J., How, C., Yen, D. H.-T., Kuo, J., & Huang, H. (2025) · Journal of the Chinese Medical Association · doi:10.1097/jcma.0000000000001329
“10 The molecular mechanisms underlying sarcopenia primarily involve the transdifferentiation of myoblasts into fat cells, 11,12 the influence of mitochondria 13–16 and kinesin-1 on myoblast differentiation, 17,18 and the impact of cellular glucose uptake on myogenesis.”
Жукова, Н. Г., Матвеева, М. В., Kazantseva, P., Samoilova, I. G., Masenko, A. Y., Gaponova, O. V., & Zhukova, I. A. (2026) · Annals of the Russian academy of medical sciences · doi:10.15690/vramn18037
Intérêt des biomarqueurs cérébraux dans la prise en charge du traumatisme crânien
Oris, C. (2021) · theses.fr (ABES) · doi:10.70675/67e4562az92fbz47b9z9a68zc756ddc18c90
García-Cabello, R., Reyes-Torres, C. A., Cepeda-Nieto, A. C., & López-Topete, I. (2026) · Journal of Gerontology and Geriatrics · doi:10.3390/jgg74020015
“Its pathophysiology involves complex mechanisms including chronic inflammation, hormonal changes, mitochondrial dysfunction, and neuromuscular alterations [21,22].”
Metadata
- Authors
- Riuzzi, F., Sorci, G., Arcuri, C., Giambanco, I., Bellezza, I., Minelli, A., & Donato, R.
- Affiliations
- University of Perugia (IT)
- Corresponding author
- Donato, Rosario
- ORCID
- Venue
- Journal of Cachexia Sarcopenia and Muscle
- Publisher
- Wiley
- Published
- 2018-11-30
- Volume
- 9
- Issue
- 7
- Pages
- 1255-1268
- ISSN
- 2190-5991 (ISSN-L)
- 2190-6009
- PMC
- PMC6351675
- OpenAlex
- W2903461337
- Cited by
- 114
- References
- 152
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 22 · 2023: 16 · 2022: 17 · 2021: 13 · 2020: 16 · 2019: 5 · 2018: 1
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Cachexia Sarcopenia and Muscle (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Fondazione Cassa di Risparmio di Perugia (2016‐0136.021, 2012.0241.021, 2015.0325.021)
- Associazione Italiana per la Ricerca sul Cancro (17581)
- French Muscular Dystrophy Association (16812, 12992)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Keywords
- sarcopenia, S100B, satellite cells, calcium-sensing proteins, reactive oxygen species, aging, muscle stem cells
- MeSH terms
- Humans, Biomarkers, Muscle, Skeletal, Muscle Fibers, Skeletal, Satellite Cells, Skeletal Muscle, Sarcopenia, S100 Calcium Binding Protein beta Subunit
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