The DOI matches its Crossref record; 231 of the 231 references it cites were found in a registry or an index.
Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia
Open accessAbstract
Cancer cachexia is a multifactorial syndrome characterized by a progressive loss of skeletal muscle mass, along with adipose tissue wasting, systemic inflammation and other metabolic abnormalities leading to functional impairment. Cancer cachexia has long been recognized as a direct cause of complications in cancer patients, reducing quality of life and worsening disease outcomes. Some related conditions, like sarcopenia (age‐related muscle wasting), anorexia (appetite loss) and asthenia (reduced muscular strength and fatigue), share some key features with cancer cachexia, such as weakness and systemic inflammation. Understanding the interplay and the differences between these conditions is critical to advance basic and translational research in this field, improving the accuracy of diagnosis and contributing to finally achieve effective therapies for affected patients.
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Cites
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Sarcopenia: revised European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Bahat, G., Bauer, J., Boirie, Y., Bruyère, O., Cederholm, T., Cooper, C., Landi, F., Rolland, Y., Sayer, A. A., et al. (2019) · Age and Ageing · doi:10.1093/ageing/afy169 · Cited by 13,818
Toxicity and response criteria of the Eastern Cooperative Oncology Group
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Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601
Definition and classification of cancer cachexia: an international consensus
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Sarcopenia: revised European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Bahat, G., Bauer, J., Boirie, Y., Bruyère, O., Cederholm, T., Cooper, C., Landi, F., Rolland, Y., Sayer, A. A., et al. (2019) · Age and Ageing · doi:10.1093/ageing/afz046 · Cited by 3,803
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“67kg/m(2) for men and women, respectively).(184) The”
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“512 for women), in the presence of low muscle strength (grip strength <26 kg for men or <16 kg for women).(185) The FNIH definition is more restrictive than the EWGSOP and IWG criteria, which may result in sarcopenia being diagnosed less frequently.”
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Cited by
Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions
Wang, T., Zhou, D., & Hong, Z. (2025) · MedComm · doi:10.1002/mco2.70030 · Cited by 46
The Role of Exercise in Cancer-Related Sarcopenia and Sarcopenic Obesity
Papadopetraki, A., Giannopoulos, A., Maridaki, M., Zagouri, F., Droufakou, S., Koutsilieris, M., & Philippou, A. (2023) · Cancers · doi:10.3390/cancers15245856 · Cited by 34
Master Regulators of Muscle Atrophy: Role of Costamere Components
Gorza, L., Sorge, M., Seclì, L., & Brancaccio, M. (2021) · Cells · doi:10.3390/cells10010061 · Cited by 31
An overview of anamorelin as a treatment option for cancer-associated anorexia and cachexia
Fonseca, G. W. P. D., & von Haehling, S. (2021) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2021.1873954 · Cited by 25
Othman, N. O., Abdel-Aal, H. H., Elsherief, W. A., Farag, D. E., Hunter, C. N., & Alsirafy, S. A. (2025) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2025.7033 · Cited by 11
Metadata
- Authors
- Peixoto da Silva, S., Santos, J. M. O., Costa e Silva, M. P., Gil da Costa, R. M., & Medeiros, R.
- Venue
- Journal of Cachexia, Sarcopenia and Muscle
- Publisher
- Wiley
- Published
- 2020-03-06
- Volume
- 11
- Issue
- 3
- Pages
- 619-635
- ISSN
- 2190-5991 (ISSN-L)
- 2190-6009
- OpenAlex
- W3009100563
- Cited by
- 371
- References
- 231
- FWCI
- 22.00
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia. https://app.cochat.ai/papers/10.1002/jcsm.12528
- The paper
- Peixoto da Silva, S., Santos, J. M. O., Costa e Silva, M. P., Gil da Costa, R. M., & Medeiros, R. (2020). Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia. Journal of Cachexia, Sarcopenia and Muscle. https://doi.org/10.1002/jcsm.12528
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
