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Cited by 31Extracellular vesicles in diseaseNanoparticle-Based Drug DeliveryMolecular Communication and Nanonetworks

Extracellular vesicles and lipoproteins – Smart messengers of blood cells in the circulation

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Nguyen, Phuong H.D., Le, Anh Hong, Pek, Jonetta Shi Qi, Pham, Thach Tuan, Jayasinghe, Migara Kavishka, Do, Dang Vinh, Phung, Cao Dai, Le, Minh T.N.·2022·Journal of Extracellular Biology
DOI 10.1002/jex2.49PMC PMC11080875
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Abstract

Blood cell‐derived extracellular vesicles (BCEVs) and lipoproteins are the major circulating nanoparticles in blood that play an important role in intercellular communication. They have attracted significant interest for clinical applications, given their endogenous characteristics which make them stable, biocompatible, well tolerated, and capable of permeating biological barriers efficiently. In this review, we describe the basic characteristics of BCEVs and lipoproteins and summarize their implications in both physiological and pathological processes. We also outline well accepted workflows for the isolation and characterization of these circulating nanoparticles. Importantly, we highlight the latest progress and challenges associated with the use of circulating nanoparticles as diagnostic biomarkers and therapeutic interventions in multiple diseases. We spotlight novel engineering approaches and designs to facilitate the development of these nanoparticles by enhancing their stability, targeting capability, and delivery efficiency. Therefore, the present work provides a comprehensive overview of composition, biogenesis, functions, and clinical translation of circulating nanoparticles from the bench to the bedside.

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Authors
Nguyen, P. H. D., Le, A. H., Pek, J. S. Q., Pham, T. T., Jayasinghe, M. K., Do, D. V., Phung, C. D., & Le, M. T. N.
Affiliations
National University of Singapore (SG)
Corresponding author
  • Nguyen, Phuong H.D.
  • Le, Minh T.N.
ORCID
Venue
Journal of Extracellular Biology
Publisher
Wiley
Published
2022-07
Volume
1
Issue
7
Pages
e49-e49
ISSN
2768-2811 (ISSN-L)
DOI
10.1002/jex2.49
PMC
PMC11080875
OpenAlex
W4283825012
Cited by
31
References
8
Citations by year
2026: 14 · 2025: 4 · 2024: 8 · 2023: 5
FWCI
0.45
Type
journal article
Language
en
Update notices
correction (2025-07-24)
Open access
Licence
Locations
  • Journal of Extracellular Biology (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Molecular Communication and Nanonetworks
Keywords
extracellular vesicles, lipoproteins, intercellular communication, vesicle biogenesis, diagnostic biomarkers, nanotherapeutics, nanoparticle engineering, clinical translation

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