Evading innate immunity in nonviral mRNA delivery: don't shoot the messenger.

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221 · see citing works

Dendritic cells and the control of immunity

Banchereau, J., & Steinman, R. M. (1998) · Nature · doi:10.1038/32588 · Cited by 14,244 · see citing works

Pathogen Recognition and Innate Immunity

Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,974 · see citing works

Toll-like receptor signalling

Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312 · see citing works

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129 · see citing works

Toll-like receptors: critical proteins linking innate and acquired immunity

Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777 · see citing works

Direct Gene Transfer into Mouse Muscle in Vivo

Wolff, J. A., Malone, R. W., Williams, P., Chong, W., Acsadi, G., Jani, A., & Felgner, P. L. (1990) · Science · doi:10.1126/science.1690918 · Cited by 4,173 · see citing works

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H., & Bauer, S. (2004) · Science · doi:10.1126/science.1093620 · Cited by 3,947 · see citing works

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

Yoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K., Akira, S., & Fujita, T. (2004) · Nature Immunology · doi:10.1038/ni1087 · Cited by 3,935 · see citing works

CpG motifs in bacterial DNA trigger direct B-cell activation

Krieg, A. M., Yi, A.-K., Matson, S., Waldschmidt, T. J., Bishop, G. A., Teasdale, R., Koretzky, G. A., & Klinman, D. M. (1995) · Nature · doi:10.1038/374546a0 · Cited by 3,508 · see citing works

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444 · see citing works

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA

Karikó, K., Buckstein, M., Ni, H., & Weissman, D. (2005) · Immunity · doi:10.1016/j.immuni.2005.06.008 · Cited by 2,728 · see citing works

Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA

Warren, L., Manos, P. D., Ahfeldt, T., Loh, Y.-H., Li, H., Lau, F., Ebina, W., Mandal, P. K., Smith, Z. D., Meissner, A., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.08.012 · Cited by 2,662 · see citing works

mRNA-based therapeutics--developing a new class of drugs

Sahin, U., Karikó, K., & Türeci, Ö. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4278 · Cited by 2,474 · see citing works

5'-Triphosphate RNA Is the Ligand for RIG-I

Hornung, V., Ellegast, J., Kim, S., Brzózka, K., Jung, A., Kato, H., Poeck, H., Akira, S., Conzelmann, K.-K., Schlee, M., et al. (2006) · Science · doi:10.1126/science.1132505 · Cited by 2,474 · see citing works

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

Auphan, N., DiDonato, J. A., Rosette, C., Helmberg, A., & Karin, M. (1995) · Science · doi:10.1126/science.270.5234.286 · Cited by 2,390 · see citing works

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5’-phosphates

Pichlmair, A., Schulz, O., Tan, C. P., Näslund, T. I., Liljeström, P., Weber, F., & Reis e Sousa, C. (2006) · Science · doi:10.1126/science.1132998 · Cited by 2,210 · see citing works

Interferon-inducible antiviral effectors

Sadler, A. J., & Williams, B. R. G. (2008) · Nature Reviews Immunology · doi:10.1038/nri2314 · Cited by 2,160 · see citing works

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

Karikó, K., Muramatsu, H., Welsh, F. A., Ludwig, J., Kato, H., Akira, S., & Weissman, D. (2008) · Molecular Therapy · doi:10.1038/mt.2008.200 · Cited by 1,930 · see citing works

Innate immune recognition of viral infection

Kawai, T., & Akira, S. (2006) · Nature Immunology · doi:10.1038/ni1303 · Cited by 1,899 · see citing works

Role of Transcriptional Activation of IκBα in Mediation of Immunosuppression by Glucocorticoids

Scheinman, R. I., Cogswell, P. C., Lofquist, A. K., & Baldwin, A. S. (1995) · Science · doi:10.1126/science.270.5234.283 · Cited by 1,676 · see citing works

Functional messenger RNAs are produced by SP6 <i>in vitro</i> transcription of cloned cDNAs

Krieg, P. A., & Melton, D. A. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.18.7057 · Cited by 1,533 · see citing works

Genetic immunization is a simple method for eliciting an immune response

Tang, D.-C. C., DeVit, M. J., & Johnston, S. A. (1992) · Nature · doi:10.1038/356152a0 · Cited by 1,504 · see citing works

Toll-like receptors and innate immunity

Kumar, H., Kawai, T., & Akira, S. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.08.062 · Cited by 1,171 · see citing works

Interferons at age 50: past, current and future impact on biomedicine

Borden, E. C., Sen, G. C., Uze, G., Silverman, R. H., Ransohoff, R. M., Foster, G. R., & Stark, G. R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2422 · Cited by 1,154 · see citing works

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

Allen, I. C., Scull, M. A., Moore, C. B., Holl, E. K., McElvania-TeKippe, E., Taxman, D. J., Guthrie, E. H., Pickles, R. J., & Ting, J. P.-Y. (2009) · Immunity · doi:10.1016/j.immuni.2009.02.005 · Cited by 1,113 · see citing works

mRNA is an endogenous ligand for toll-like receptor 3

Karikó, K., Ni, H., Capodici, J., Lamphier, M., & Weissman, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310175200 · Cited by 1,062 · see citing works

Circularization of mRNA by Eukaryotic Translation Initiation Factors

Wells, S. E., Hillner, P. E., Vale, R. D., & Sachs, A. B. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80122-7 · Cited by 968 · see citing works

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

Karikó, K., Muramatsu, H., Ludwig, J., & Weissman, D. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr695 · Cited by 898 · see citing works

The IKK Complex, a Central Regulator of NF- B ActivationPreprint

Israël, A. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000158 · Cited by 853 · see citing works

Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms

Quintás-Cardama, A., Vaddi, K., Liu, P., Manshouri, T., Li, J., Scherle, P. A., Caulder, E., Wen, X., Li, Y., Waeltz, P., et al. (2010) · Blood · doi:10.1182/blood-2009-04-214957 · Cited by 843 · see citing works

Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

Züst, R., Cervantes-Barragan, L., Habjan, M., Maier, R., Neuman, B. W., Ziebuhr, J., Szretter, K. J., Baker, S. C., Barchet, W., Diamond, M. S., et al. (2011) · Nature Immunology · doi:10.1038/ni.1979 · Cited by 811 · see citing works

Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

Schlee, M., Roth, A. H. F. J., Hornung, V., Hagmann, C. A., Wimmenauer, V., Barchet, W., Coch, C., Janke, M., Mihailovic, A., Wardle, G. S., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.008 · Cited by 792 · see citing works

Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA

Ballas, Z. K., Rasmussen, W. L., & KRIEG, A. M. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.5.1840 · Cited by 758 · see citing works

Activation of innate immune antiviral responses by Nod2

Sabbah, A., Chang, T. H., Harnack, R., Frohlich, V. C., Tominaga, K., Dube, P. H., Xiang, Y., & Bose, S. (2009) · Nature Immunology · doi:10.1038/ni.1782 · Cited by 754 · see citing works

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

Kormann, M. S. D., Hasenpusch, G., Aneja, M. K., Nica, G., Flemmer, A. W., Herber-Jonat, S., Huppmann, M., Mays, L. E., Illenyi, M., Schams, A., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1733 · Cited by 733 · see citing works

Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA

Kanneganti, T., Body–Malapel, M., Amer, A. O., Park, J., Whitfield, J. R., Franchi, L., Taraporewala, Z. F., Miller, D. J., Patton, J. T., Inohara, N., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607594200 · Cited by 706 · see citing works

Interleukin‐12 is produced by dendritic cells and mediates T helper 1 development as well as interferon‐γ production by T helper 1 cells

Heufler, C., Koch, F., Stanzl, U., Topar, G., Wysocka, M., Trinchieri, G., Enk, A., Steinman, R. M., Romani, N., & Schuler, G. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260323 · Cited by 700 · see citing works

LGP2 is a positive regulator of RIG-I– and MDA5-mediated antiviral responses

Satoh, T., Kato, H., Kumagai, Y., Yoneyama, M., Sato, S., Matsushita, K., Tsujimura, T., Fujita, T., Akira, S., & Takeuchi, O. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912986107 · Cited by 697 · see citing works

Innate Recognition of Viruses

Pichlmair, A., & Sousa, C. R. E. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.012 · Cited by 690 · see citing works

Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation

Anderson, B. R., Muramatsu, H., Nallagatla, S. R., Bevilacqua, P. C., Sansing, L. H., Weissman, D., & Karikó, K. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq347 · Cited by 682 · see citing works

Viral Encounters with 2′,5′-Oligoadenylate Synthetase and RNase L during the Interferon Antiviral Response

Silverman, R. H. (2007) · Journal of Virology · doi:10.1128/jvi.01471-07 · Cited by 677 · see citing works

CpG‐DNA‐specific activation of antigen‐presenting cells requires stress kinase activity and is preceded by non‐specific endocytosis and endosomal maturation

Häcker, H., Mischak, H., Miethke, T., Liptay, S., Schmid, R. M., Sparwasser, T. D., Heeg, K. M., Lipford, G. B., & Wagner, H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.21.6230 · Cited by 654 · see citing works

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

Zangi, L., Lui, K. O., von Gise, A., Ma, Q., Ebina, W., Ptaszek, L. M., Später, D., Xu, H., Tabebordbar, M., Gorbatov, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2682 · Cited by 646 · see citing works

The RNA Helicase Lgp2 Inhibits TLR-Independent Sensing of Viral Replication by Retinoic Acid-Inducible Gene-I

Rothenfußer, S., Goutagny, N., DiPerna, G., Gong, M., Monks, B. G., Schoenemeyer, A., Yamamoto, M., Akira, S., & Fitzgerald, K. A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.8.5260 · Cited by 645 · see citing works

The dsRNA protein kinase PKR: Virus and cell control

García, M. A., Meurs, E. F., & Esteban, M. (2007) · Biochimie · doi:10.1016/j.biochi.2007.03.001 · Cited by 644 · see citing works

Gene delivery by lipoplexes and polyplexes

de Ilarduya, C. T., Sun, Y., & Düzgüneş, N. (2010) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2010.03.019 · Cited by 626 · see citing works

Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines

Kužnik, A., Benčina, M., Švajger, U., Jeras, M., Rozman, B., & Jerala, R. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1000702 · Cited by 606 · see citing works

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

Kumar, A., Haque, J., Lacoste, J., Hiscott, J. B., & Williams, B. R. G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.14.6288 · Cited by 568 · see citing works

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates

Goubau, D., Schlee, M., Deddouche, S., Pruijssers, A. J., Zillinger, T., Goldeck, M., Schuberth, C., Van der Veen, A. G., Fujimura, T., Rehwinkel, J., et al. (2014) · Nature · doi:10.1038/nature13590 · Cited by 557 · see citing works

Essential Role for the dsRNA-Dependent Protein Kinase PKR in Innate Immunity to Viral Infection

Balachandran, S., Roberts, P. C., Brown, L. E., Truong, H., Pattnaik, A. K., Archer, D. R., & Barber, G. N. (2000) · Immunity · doi:10.1016/s1074-7613(00)00014-5 · Cited by 527 · see citing works

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling

Hartner, J. C., Walkley, C. R., Lü, J., & Orkin, S. H. (2008) · Nature Immunology · doi:10.1038/ni.1680 · Cited by 493 · see citing works

Eukaryotic mRNA Decapping

Coller, J., & Parker, R. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.074032 · Cited by 484 · see citing works

Induction of virus‐specific cytotoxic T lymphocytes <i>in vivo</i> by liposome‐entrapped mRNA

Martinon, F., Krishnan, S., Lenzen, G., Magné, R., Gomard, E., Guillet, J., Lévy, J., & Meulien, P. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230749 · Cited by 473 · see citing works

Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection

Pichlmair, A., Schulz, O., Tan, C.-P., Rehwinkel, J., Kato, H., Takeuchi, O., Akira, S., Way, M., Schiavo, G., & Sousa, C. R. E. (2009) · Journal of Virology · doi:10.1128/jvi.00770-09 · Cited by 469 · see citing works

Small Interfering RNAs Mediate Sequence-Independent Gene Suppression and Induce Immune Activation by Signaling through Toll-Like Receptor 3

Karikó, K., Bhuyan, P. K., Capodici, J., & Weissman, D. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.11.6545 · Cited by 446 · see citing works

5′-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I

Schmidt, A., Schwerd, T., Hamm, W., Hellmuth, J. C., Cui, S., Wenzel, M., Hoffmann, F. S., Michallet, M.-C., Besch, R., Hopfner, K.-P., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900971106 · Cited by 398 · see citing works

Bacterial DNA Induces Murine Interferon-γ Production by Stimulation of Interleukin-12 and Tumor Necrosis Factor-α

Halpern, M. D., Kurlander, R. J., & Pisetsky, D. S. (1996) · Cellular Immunology · doi:10.1006/cimm.1996.0009 · Cited by 395 · see citing works

Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and IκB Kinase ϵ

Clark, K., Plater, L., Peggie, M. W., & Cohen, P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.000414 · Cited by 389 · see citing works

Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines

Mantovani, A., Locati, M., Vecchi, A., Sozzani, S., & Allavena, P. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(01)01941-x · Cited by 383 · see citing works

Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity

Smith, G. L., Benfield, C. T. O., de Motes, C. M., Mazzon, M., Ember, S. W., Ferguson, B. J., & Sumner, R. P. (2013) · Journal of General Virology · doi:10.1099/vir.0.055921-0 · Cited by 359 · see citing works

Purification of mRNA guanylyltransferase and mRNA (guanine-7-) methyltransferase from vaccinia virions.

Martin, S., Paoletti, E., & Moss, B. A. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40646-7 · Cited by 355 · see citing works

Activation of Innate Immunity Is Required for Efficient Nuclear Reprogramming

Lee, J., Sayed, N., Hunter, A. L., Au, K. F., Wong, W. H., Mocarski, E. S., Pera, R. A. R., Yakubov, E., & Cooke, J. P. (2012) · Cell · doi:10.1016/j.cell.2012.09.034 · Cited by 338 · see citing works

Messenger RNA-based Vaccines With Dual Activity Induce Balanced TLR-7 Dependent Adaptive Immune Responses and Provide Antitumor Activity

Fotin-Mleczek, M., Duchardt, K. M., Lorenz, C., Pfeiffer, R., Ojkić-Zrna, S., Probst, J., & Kallen, K.-J. (2011) · Journal of Immunotherapy · doi:10.1097/cji.0b013e3181f7dbe8 · Cited by 335 · cited 2× · see citing works

Untitled work

(1995) · PubMed · Cited by 330 · see citing works

Efficient generation of human iPSCs by a synthetic self-replicative RNA

Yoshioka, N., Gros, E., Li, H.-R., Kumar, S., Deacon, D. C., Maron, C., Muotri, A. R., Chi, N. C., Fu, X.-D., Yu, B. D., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.06.001 · Cited by 312 · see citing works

Recognition of viral nucleic acids in innate immunity

Yoneyama, M., & Fujita, T. (2009) · Reviews in Medical Virology · doi:10.1002/rmv.633 · Cited by 303 · see citing works

RNA- and Virus-Independent Inhibition of Antiviral Signaling by RNA Helicase LGP2

Komuro, A., & Horvath, C. M. (2006) · Journal of Virology · doi:10.1128/jvi.01325-06 · Cited by 298 · see citing works

Molecular Pathways: JAK/STAT Pathway: Mutations, Inhibitors, and Resistance

Quintás‐Cardama, A., & Verstovšek, S. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0284 · Cited by 284 · see citing works

Increased erythropoiesis in mice injected with submicrogram quantities of pseudouridine-containing mRNA encoding erythropoietin

Karikó, K., Muramatsu, H., Keller, J. M., & Weissman, D. (2012) · Molecular Therapy · doi:10.1038/mt.2012.7 · Cited by 282 · see citing works

Reversal of Diabetes Insipidus in Brattleboro Rats: Intrahypothalamic Injection of Vasopressin mRNA

Jirikowski, G. F., Sanna, P. P., Maciejewski-Lenoir, D., & Bloom, F. E. (1992) · Science · doi:10.1126/science.1546298 · Cited by 282 · see citing works

Nucleic acid agonists for Toll‐like receptor 7 are defined by the presence of uridine ribonucleotides

Diebold, S. S., Massacrier, C., Akira, S., Paturel, C., Morel, Y., & Sousa, C. R. E. (2006) · European Journal of Immunology · doi:10.1002/eji.200636617 · Cited by 281 · see citing works

A tale of two termini:

Gallie, D. R. (1998) · Gene · doi:10.1016/s0378-1119(98)00318-7 · Cited by 280 · see citing works

Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I

Wang, Y., Ludwig, J., Schuberth, C., Goldeck, M., Schlee, M., Li, H., Juranek, S., Sheng, G., Micura, R., Tuschl, T., et al. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1863 · Cited by 256 · see citing works

A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation

Zhu, F. X., King, S. M., Smith, E., Levy, D. E., & Yuan, Y. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082420599 · Cited by 241 · see citing works

Reprogramming of human fibroblasts to pluripotent stem cells using mRNA of four transcription factors

Yakubov, E., Rechavi, G., Rozenblatt, S., & Givol, D. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.150 · Cited by 240 · see citing works

mRNA as gene therapeutic: How to control protein expression

Tavernier, G., Andries, O., Demeester, J., Sanders, N. N., De Smedt, S. C., & Rejman, J. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.10.020 · Cited by 232 · see citing works

Negative regulation of the interferon response by an interferon-induced long non-coding RNA

Kambara, H., Niazi, F., Kostadinova, L., Moonka, D., Siegel, C., Post, A. B., Carnero, E., Barriocanal, M., Fortes, P., Anthony, D. D., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku713 · Cited by 230 · see citing works

Non-Viral Gene Delivery Methods

Wang, W., Li, W., Ma, N., & Steinhoff, G. (2013) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201011314010008 · Cited by 229 · see citing works

5’-triphosphate-dependent activation of PKR by RNAs with short stem-loops

Nallagatla, S. R., Hwang, J., Toroney, R., Zheng, X., Cameron, C. E., & Bevilacqua, P. C. (2007) · Science · doi:10.1126/science.1147347 · Cited by 222 · see citing works

Cationic lipids activate intracellular signaling pathways

Lonez, C., Vandenbranden, M., & Ruysschaert, J.-M. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.05.009 · Cited by 221 · see citing works

Reprogramming human fibroblasts to pluripotency using modified mRNA

Mandal, P., & Rossi, D. J. (2013) · Nature Protocols · doi:10.1038/nprot.2013.019 · Cited by 219 · see citing works

Vaccinia virus serpin B13R (SPI-2) inhibits interleukin-1beta-converting enzyme and protects virus-infected cells from TNF- and Fas-mediated apoptosis, but does not prevent IL-1beta-induced fever.

Kettle, S., Khanna, A., Alcam√≠, A., Jassoy, C., Ehret, R., & Smith, G. L. (1997) · Journal of General Virology · doi:10.1099/0022-1317-78-3-677 · Cited by 207 · see citing works

Small molecule inhibitors of the RNA-dependent protein kinase

Jammi, N. V., Whitby, L. R., & Beal, P. A. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01318-4 · Cited by 205 · see citing works

In Vitro Transcription of Long RNA Containing Modified Nucleosides

Pardi, N., Muramatsu, H., Weissman, D., & Karikó, K. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-260-5_2 · Cited by 204 · see citing works

Toll‐like receptor‐dependent activation of several human blood cell types by protamine‐condensed mRNA

Scheel, B., Teufel, R., Probst, J., Carralot, J., Geginat, J., Radsak, M. P., Jarrossay, D., Wagner, H., Jung, G., Rammensee, H., et al. (2005) · European Journal of Immunology · doi:10.1002/eji.200425656 · Cited by 198 · see citing works

Chicken Cells Sense Influenza A Virus Infection through MDA5 and CARDIF Signaling Involving LGP2

Liniger, M., Summerfield, A., Zimmer, G., McCullough, K. C., & Ruggli, N. (2011) · Journal of Virology · doi:10.1128/jvi.00742-11 · Cited by 196 · see citing works

Current prospects for mRNA gene delivery

Yamamoto, A., Kormann, M., Rosenecker, J., & Rudolph, C. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.09.016 · Cited by 193 · see citing works

Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation

Diken, M., Kreiter, S., Selmi, A., Britten, C. M., Huber, C. G., Türeci, Ö., & Şahin, U. (2011) · Gene Therapy · doi:10.1038/gt.2011.17 · Cited by 192 · see citing works

Enhancing the T-cell Stimulatory Capacity of Human Dendritic Cells by Co-electroporation With CD40L, CD70 and Constitutively Active TLR4 Encoding mRNA

Bonehill, A., Tuyaerts, S., Nuffel, A. M. T. V., Heirman, C., Bos, T. J., Fostier, K., Neyns, B., & Thielemans, K. (2008) · Molecular Therapy · doi:10.1038/mt.2008.77 · Cited by 185 · see citing works

Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent, initiation factor 2 alpha-specific protein kinase

Carroll, K. L., Elroy‐Stein, O., Moss, B., & Jagus, R. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31463-7 · Cited by 184 · see citing works

Blockade of Interferon Induction and Action by the E3L Double-Stranded RNA Binding Proteins of Vaccinia Virus

Xiang, Y., CONDIT, R. C., Vijaysri, S., Jacobs, B. L., Williams, B. R. G., & Silverman, R. H. (2002) · Journal of Virology · doi:10.1128/jvi.76.10.5251-5259.2002 · Cited by 177 · see citing works

Peptide-mediated Interference of TIR Domain Dimerization in MyD88 Inhibits Interleukin-1-dependent Activation of NF-κB

Loiarro, M., Sette, C., Gallo, G., Ciacci, A., Fantò, N., Mastroianni, D., Carminati, P., & Ruggiero, V. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c400613200 · Cited by 177 · see citing works

Recent trends in non‐viral vector‐mediated gene delivery

Pathak, A., Patnaik, S., & Gupta, K. C. (2009) · Biotechnology Journal · doi:10.1002/biot.200900161 · Cited by 166 · see citing works

Identification of genes regulated by Dexamethasone in multiple myeloma cells using oligonucleotide arrays

Chauhan, D., Auclair, D., Robinson, E. K., Hideshima, T., Li, G., Podar, K., Gupta, D., Richardson, P. G. G., Schlossman, R. L., Krett, N. L., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205205 · Cited by 165 · see citing works

Feeder-Free Derivation of Human Induced Pluripotent Stem Cells with Messenger RNA

Warren, L., Ni, Y., Wang, J., & Guo, X. (2012) · Scientific Reports · doi:10.1038/srep00657 · Cited by 154 · see citing works

Protein expression from exogenous mRNA: Uptake by receptor-mediated endocytosis and trafficking via the lysosomal pathway

Lorenz, C., Fotin‐Mleczek, M., Roth, G. D., Becker, C., Dam, T. C., Verdurmen, W. P. R., Brock, R. E., Probst, J., & Schlake, T. (2011) · RNA Biology · doi:10.4161/rna.8.4.15394 · Cited by 152 · see citing works

Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cells

Grudzien‐Nogalska, E., Jemielity, J., Kowalska, J., Darżynkiewicz, E., & Rhoads, R. E. (2007) · RNA · doi:10.1261/rna.701307 · Cited by 152 · see citing works

The Interferon-Stimulated Genes: Targets of Direct Signaling by Interferons, Double-Stranded RNA, and Viruses

Sen, G. C., & Sarkar, S. N. (2007) · Springer eBooks · doi:10.1007/978-3-540-71329-6_12 · Cited by 148 · see citing works

Regulation of mRNA decapping

Li, Y., & Kiledjian, M. (2010) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.15 · Cited by 145 · see citing works

Protein kinase PKR and RNA adenosine deaminase ADAR1: new roles for old players as modulators of the interferon response

Pfaller, C. K., Li, Z., George, C. X., & Samuel, C. E. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.08.009 · Cited by 140 · see citing works

Nucleoside modifications modulate activation of the protein kinase PKR in an RNA structure-specific manner

Nallagatla, S. R., & Bevilacqua, P. C. (2008) · RNA · doi:10.1261/rna.1007408 · Cited by 137 · see citing works

Challenges and advances towards the rational design of mRNA vaccines

Pollard, C., Koker, S. D., Saelens, X., Vanham, G. L., & Grooten, J. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.09.002 · Cited by 134 · see citing works

mRNA transfection of cervical carcinoma and mesenchymal stem cells mediated by cationic carriers

Rejman, J., Tavernier, G., Bavarsad, N., Demeester, J., & Smedt, S. C. D. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.07.124 · Cited by 133 · see citing works

Vaccination with Messenger RNA (mRNA)

Pascolo, S. (2008) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-540-72167-3_11 · Cited by 126 · see citing works

Involvement of the ubiquitin‐like domain of TBK1/IKK‐i kinases in regulation of IFN‐inducible genes

Ikeda, F., Hecker, C., Rozenknop, A., Nordmeier, R. D., Rogov, V. V., Hofmann, K., Akira, S., Dötsch, V., & Đikić, I. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601773 · Cited by 121 · see citing works

Tumor vaccination using messenger RNA: prospects of a future therapy

Kreiter, S., Diken, M., Selmi, A., Türeci, Ö., & Şahin, U. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.03.007 · Cited by 120 · see citing works

A development that may evolve into a revolution in medicine: mRNA as the basis for novel, nucleotide-based vaccines and drugs

Kallen, K., & Theß, A. (2013) · Therapeutic Advances in Vaccines · doi:10.1177/2051013613508729 · Cited by 120 · see citing works

The potential of antigen and TriMix sonoporation using mRNA-loaded microbubbles for ultrasound-triggered cancer immunotherapy

Dewitte, H., Lint, S. V., Heirman, C., Thielemans, K., Smedt, S. C. D., Breckpot, K., & Lentacker, I. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.08.011 · Cited by 118 · see citing works

Single-cell mRNA transfection studies: Delivery, kinetics and statistics by numbers

Leonhardt, C., Schwake, G., Stögbauer, T. R., Rappl, S., Kuhr, J.-T., Ligon, T. S., & Rädler, J. O. (2014) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2013.11.008 · Cited by 117 · see citing works

Cutting Edge: Innate Immune System Discriminates between RNA Containing Bacterial versus Eukaryotic Structural Features That Prime for High-Level IL-12 Secretion by Dendritic Cells

Koski, G. K., Karikó, K., Xu, S., Weissman, D., Cohen, P. A., & Czerniecki, B. J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.3989 · Cited by 116 · see citing works

2-Aminopurine Inhibits the Double-Stranded RNA-Dependent Protein Kinase Both In Vitro and In Vivo

HU, Y., & Conway, T. W. (1993) · Journal of Interferon Research · doi:10.1089/jir.1993.13.323 · Cited by 115 · see citing works

Modified Foxp3 mRNA protects against asthma through an IL-10-dependent mechanism

Mays, L. E., Ammon-Treiber, S., Mothes, B., Alkhaled, M., Rottenberger, J., Müller-Hermelink, E. S., Grimm, M., Mezger, M., Beer-Hammer, S., von Stebut, E., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65351 · Cited by 113 · see citing works

Treatment of neurological disorders by introducing mRNA in vivo using polyplex nanomicelles

Baba, M., Itaka, K., Kondo, K., Yamasoba, T., & Kataoka, K. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.01.017 · Cited by 109 · see citing works

Particle size and activation threshold: a new dimension of danger signaling

Rettig, L., Haen, S. P., Bittermann, A. G., von Boehmer, L., Fontecedro, A. C., Krämer, S. D., Knuth, A. K., & Pascolo, S. (2010) · Blood · doi:10.1182/blood-2009-11-247817 · Cited by 108 · see citing works

Thyrocytes Express a Functional Toll-Like Receptor 3: Overexpression Can Be Induced by Viral Infection and Reversed by Phenylmethimazole and Is Associated with Hashimoto’s Autoimmune Thyroiditis

Harii, N., Lewis, C. J., Vasko, V., McCall, K. D., Benavides-Peralta, U., Sun, X., Ringel, M. D., Saji, M., Giuliani, C., Napolitano, G., et al. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0100 · Cited by 106 · see citing works

ADARs: Viruses and Innate Immunity

Samuel, C. E. (2011) · Current topics in microbiology and immunology · doi:10.1007/82_2011_148 · Cited by 103 · see citing works

Activation of Pluripotency Genes in Human Fibroblast Cells by a Novel mRNA Based Approach

Plews, J. R., Li, J., Jones, M., Moore, H. D. M., Mason, C., Andrews, P. W., & Na, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014397 · Cited by 101 · see citing works

The ReNAissanCe of mRNA-based cancer therapy

Van Lint, S., Renmans, D., Broos, K., Dewitte, H., Lentacker, I., Heirman, C., Breckpot, K., & Thielemans, K. (2015) · Expert Review of Vaccines · doi:10.1586/14760584.2015.957685 · Cited by 95 · see citing works

Innate Immune Suppression Enables Frequent Transfection with RNA Encoding Reprogramming Proteins

Angel, M., & Yanik, M. F. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011756 · Cited by 91 · see citing works

Differential Involvement of BB Loops of Toll-IL-1 Resistance (TIR) Domain-Containing Adapter Proteins in TLR4- versus TLR2-Mediated Signal Transduction

Toshchakov, V. Y., Basu, S., Fenton, M. J., & Vogel, S. N. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.494 · Cited by 90 · see citing works

Inhibition of RNase L and RNA-dependent Protein Kinase (PKR) by Sunitinib Impairs Antiviral Innate Immunity

Jha, B. K., Polyakova, I. V., Kessler, P., Dong, B., Dickerman, B. K., Sen, G. C., & Silverman, R. H. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.253443 · Cited by 85 · see citing works

Adenosine Deaminase Acting on RNA 1 Limits RIG-I RNA Detection and Suppresses IFN Production Responding to Viral and Endogenous RNAs

Yang, S., Deng, P., Zhu, Z., Zhu, J., Wang, G., Zhang, L., Chen, A. F., Wang, T., Sarkar, S. N., Billiar, T. R., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401136 · Cited by 83 · see citing works

The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation

Ingrand, S., Barrier, L., Lafay-Chebassier, C., Fauconneau, B., Page, G., & Hugon, J. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.08.022 · Cited by 80 · see citing works

Vaccinia Virus E3 Suppresses Expression of Diverse Cytokines through Inhibition of the PKR, NF-κB, and IRF3 Pathways

Myskiw, C., Arsenio, J., van Bruggen, R., Deschambault, Y., & Cao, J. (2009) · Journal of Virology · doi:10.1128/jvi.02570-08 · Cited by 77 · see citing works

Suppression of Antiviral Innate Immunity by Sunitinib Enhances Oncolytic Virotherapy

Jha, B. K., Dong, B., Nguyen, C. T., Polyakova, I. V., & Silverman, R. H. (2013) · Molecular Therapy · doi:10.1038/mt.2013.112 · Cited by 71 · see citing works

ADAR1 is essential for intestinal homeostasis and stem cell maintenance

Qiu, W., Wang, X., Buchanan, M. E., He, K., Sharma, R. B., Zhang, L., Wang, Q., & Yu, J. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.125 · Cited by 71 · see citing works

Nanoparticle design to induce tumor immunity and challenge the suppressive tumor microenvironment

Dewitte, H., Verbeke, R., Breckpot, K., Smedt, S. C. D., & Lentacker, I. (2014) · Nano Today · doi:10.1016/j.nantod.2014.10.001 · Cited by 71 · see citing works

An RNA Editor, Adenosine Deaminase Acting on Double-Stranded RNA (ADAR1)

George, C. X., John, L., & Samuel, C. E. (2014) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2014.0001 · Cited by 69 · see citing works

Phenylmethimazole Decreases Toll-Like Receptor 3 and Noncanonical Wnt5a Expression in Pancreatic Cancer and Melanoma Together with Tumor Cell Growth and Migration

Schwartz, A. L., Malgor, R., Dickerson, E., Weeraratna, A. T., Slominski, A. T., Wortsman, J., Harii, N., Kohn, A. D., Moon, R. T., Schwartz, F., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0005 · Cited by 68 · see citing works

Stability of mRNA/Cationic Lipid Lipoplexes in Human and Rat Cerebrospinal Fluid: Methods and Evidence for Nonviral mRNA Gene Delivery to the Central Nervous System

Anderson, D. M., Hall, L. L., Ayyalapu, A. R., Irion, V. R., Nantz, M. H., & Hecker, J. G. (2003) · Human Gene Therapy · doi:10.1089/10430340360535751 · Cited by 66 · see citing works

Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways

Rajsbaum, R., & García‐Sastre, A. (2013) · Trends in Microbiology · doi:10.1016/j.tim.2013.06.006 · Cited by 66 · see citing works

RIG-I Detects mRNA of Intracellular Salmonella enterica Serovar Typhimurium during Bacterial Infection

Schmolke, M., Patel, J. R., de Castro, E., Sánchez-Aparicio, M. T., Uccellini, M. B., Miller, J. C., Manicassamy, B., Satoh, T. K., Kawai, T., Akira, S., et al. (2014) · mBio · doi:10.1128/mbio.01006-14 · Cited by 63 · see citing works

Antagonism of Host Antiviral Responses by Kaposi's Sarcoma-Associated Herpesvirus Tegument Protein ORF45

Zhu, F. X., Sathish, N., & Yuan, Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010573 · Cited by 56 · see citing works

Innate immune response and programmed cell death following carrier-mediated delivery of unmodified mRNA to respiratory cells

Andries, O., Filette, M. D., Smedt, S. C. D., Demeester, J., Poucke, M. V., Peelman, L. J., & Sanders, N. N. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.01.033 · Cited by 54 · see citing works

TAK1 targeting by glucocorticoids determines JNK and IκB regulation in Toll-like receptor–stimulated macrophages

Bhattacharyya, S., Ratajczak, C. K., Vogt, S. K., Kelley, C., Colonna, M., Schreiber, R. D., & Muglia, L. J. (2010) · Blood · doi:10.1182/blood-2009-06-224782 · Cited by 53 · see citing works

Activation of pluripotency-associated genes in mouse embryonic fibroblasts by non-viral transfection with in vitro-derived mRNAs encoding Oct4, Sox2, Klf4 and cMyc

Tavernier, G., Wolfrum, K., Demeester, J., Smedt, S. C. D., Adjaye, J., & Rejman, J. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.09.062 · Cited by 53 · see citing works

The cytotoxic and immunogenic hurdles associated with non-viral mRNA-mediated reprogramming of human fibroblasts

Drews, K., Tavernier, G., Demeester, J., Lehrach, H. R., Smedt, S. C. D., Rejman, J., & Adjaye, J. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.02.025 · Cited by 46 · see citing works

The messenger's great message for vaccination

Pascolo, S. (2015) · Expert Review of Vaccines · doi:10.1586/14760584.2015.1000871 · Cited by 40 · see citing works

Recognition of pathogen-associated nucleic acids by endosomal nucleic acid-sensing toll-like receptors

He, X., Jia, H., Jing, Z., & Liu, D. X. (2013) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gms122 · Cited by 40 · see citing works

Bax mRNA therapy using cationic liposomes for human malignant melanoma

Okumura, K., Nakase, M., Inui, M., Nakamura, S., Watanabe, Y., & Tagawa, T. (2008) · The Journal of Gene Medicine · doi:10.1002/jgm.1214 · Cited by 31 · see citing works

Differential effect of thalidomide and dexamethasone on the transcription factor NF-κB

Rowland, T. L., McHugh, S. M., Deighton, J., Ewan, P. W., Dearman, R. J., & Kimber, I. (2001) · International Immunopharmacology · doi:10.1016/s0162-3109(00)00265-4 · Cited by 30 · see citing works

A cell-permeable peptide inhibits activation of PKR and enhances cell proliferation

Nekhai, S. A., Bottaro, D. P., Woldehawariat, G., Spellerberg, A., & Petryshyn, R. (2000) · Peptides · doi:10.1016/s0196-9781(00)00297-7 · Cited by 24 · see citing works

BAY11 enhances OCT4 synthetic mRNA expression in adult human skin cells

Awe, J. P., Crespo, A. V., Li, Y., Kiledjian, M., & Byrne, J. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt163 · Cited by 18 · see citing works

Phenylmethimazole Blocks dsRNA-Induced IRF3 Nuclear Translocation and Homodimerization

Courreges, M. C., Kantake, N., Goetz, D. J., Schwartz, F., & McCall, K. D. (2012) · Molecules · doi:10.3390/molecules171012365 · Cited by 17 · see citing works

Mechanism of inhibition of lipopolysaccharide-induced interferon-β production by 2-aminopurine

Sugiyama, T., Gotou, T., Moriyama, K., Kajiura, N., Hasegawa, T., Tomida, J., Takahashi, K., Komatsu, T., Ueda, H., Sato, K., et al. (2012) · Molecular Immunology · doi:10.1016/j.molimm.2012.06.008 · Cited by 15 · see citing works

Curcumin, a Natural Antioxidant, Acts as a Noncompetitive Inhibitor of Human RNase L in Presence of Its Cofactor 2-5AIn Vitro

Gupta, A., & Rath, P. C. (2014) · BioMed Research International · doi:10.1155/2014/817024 · Cited by 13 · see citing works

Pluripotent State Induction in Mouse Embryonic Fibroblast Using mRNAs of Reprogramming Factors

Elsayed, A. K., Zhang, Z., Zhang, L., Liu, Z., Abbott, L. C., Zhang, Y., & Li, B. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151221840 · Cited by 12 · see citing works

Untitled work

Hoerr, I. (2000) · doi:10.1002/1521-4141(200001)30:1

Advances in COVID-19 mRNA vaccine development

Fang, E., Liu, X., Li, M., Zhang, Z., Song, L., Zhu, B., Wu, X., Liu, J., Zhao, D., & Li, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00950-y · Cited by 601 · see citing works

Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

Wadhwa, A., Aljabbari, A., Lokras, A., Foged, C., & Thakur, A. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12020102 · Cited by 584 · see citing works

Nanomaterial Delivery Systems for mRNA Vaccines

Buschmann, M. D., Carrasco, M. J., Alishetty, S., Paige, M., Alameh, M. G., & Weissman, D. (2021) · Vaccines · doi:10.3390/vaccines9010065 · Cited by 582 · see citing works

Immunological mechanisms of vaccine-induced protection against COVID-19 in humans

Sadarangani, M., Marchant, A., & Kollmann, T. R. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00578-z · Cited by 560 · see citing works

The landscape of mRNA nanomedicine

Huang, X., Kong, N., Zhang, X., Cao, Y., Langer, R., & Tao, W. (2022) · Nature Medicine · doi:10.1038/s41591-022-02061-1 · Cited by 511 · see citing works

Tailoring mRNA Vaccine to Balance Innate/Adaptive Immune Response

Linares-Fernández, S., Lacroix, C., Exposito, J.-Y., & Verrier, B. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.10.002 · Cited by 376 · see citing works

Impact of mRNA chemistry and manufacturing process on innate immune activation

Nelson, J., Sorensen, E. W., Mintri, S., Rabideau, A. E., Zheng, W., Besin, G., Khatwani, N., Su, S. V., Miracco, E. J., Issa, W. J., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaz6893 · Cited by 354 · see citing works

COVID-19 mRNA vaccines: Platforms and current developments

Szabó, G. T., Mahiny, A. J., & Vlatkovic, I. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.02.016 · Cited by 308 · see citing works

Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9

Zhang, H., Zhang, Y., & Yin, H. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.01.014 · Cited by 248 · see citing works

Lipopolyplex potentiates anti-tumor immunity of mRNA-based vaccination

Persano, S., Guevara, M. L., Li, Z., Mai, J., Ferrari, M., Pompa, P. P., & Shen, H. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.02.019 · Cited by 187 · see citing works

Nanoscale platforms for messenger RNA delivery

Li, B., Zhang, X., & Dong, Y. (2019) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1530 · Cited by 170 · see citing works

Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across

Minnaert, A.-K., Vanluchene, H., Verbeke, R., Lentacker, I., De Smedt, S. C., Raemdonck, K., Sanders, N. N., & Remaut, K. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113900 · Cited by 157 · see citing works

Delivering the right message: Challenges and opportunities in lipid nanoparticles-mediated modified mRNA therapeutics—An innate immune system standpoint

Granot-Matok, Y., & Peer, D. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.08.015 · Cited by 154 · see citing works

Non-viral delivery of the CRISPR/Cas system: DNA versus RNA versus RNP

Lin, Y., Wagner, E., & Lächelt, U. (2022) · Biomaterials Science · doi:10.1039/d1bm01658j · Cited by 141 · see citing works

Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy: restoring the immunogenicity of immunosilent mRNA

Verbeke, R., Lentacker, I., Wayteck, L., Breckpot, K., Van Bockstal, M., Descamps, B., Vanhove, C., De Smedt, S. C., & Dewitte, H. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.041 · Cited by 132 · see citing works

Particle-mediated intravenous delivery of antigen mRNA results in strong antigen-specific T-cell responses despite the induction of type I interferon

Broos, K., Van der Jeught, K., Puttemans, J., Goyvaerts, C., Heirman, C., Dewitte, H., Verbeke, R., Lentacker, I., Thielemans, K., & Breckpot, K. (2016) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2016.38 · Cited by 121 · see citing works

mRNA therapeutics deliver a hopeful message

Zhong, Z., Cafferty, S. M., Combes, F., Huysmans, H., Temmerman, J. D., Gitsels, A., Vanrompay, D. C. G., Catani, J. P., & Sanders, N. N. (2018) · Nano Today · doi:10.1016/j.nantod.2018.10.005 · Cited by 120 · see citing works

Non-immunotherapy application of LNP-mRNA: Maximizing efficacy and safety

Vlatkovic, I. (2021) · Biomedicines · doi:10.3390/biomedicines9050530 · Cited by 112 · see citing works

Engineering of the current nucleoside-modified mRNA-LNP vaccines against SARS-CoV-2

Granados-Riveron, J. T., & Aquino‐Jarquín, G. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111953 · Cited by 115 · see citing works

Exosomes for mRNA delivery: a novel biotherapeutic strategy with hurdles and hope

Aslan, C., Kiaie, S. H., Zolbanin, N. M., Lotfinejad, P., Ramezani, R., Kashanchi, F., & Jafari, R. (2021) · BMC Biotechnology · doi:10.1186/s12896-021-00683-w · Cited by 111 · see citing works

Neo-Antigen mRNA Vaccines

Esprit, A., de Mey, W., Shahi, R. B., Thielemans, K., Franceschini, L., & Breckpot, K. (2020) · Vaccines · doi:10.3390/vaccines8040776 · Cited by 105 · see citing works

The advent of clinical self-amplifying RNA vaccines

Casmil, I. C., Jin, J., Won, E.-J., Huang, C., Liao, S., Cha‐Molstad, H., & Blakney, A. K. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.03.060 · Cited by 105 · see citing works

Broadening the Message: A Nanovaccine Co-loaded with Messenger RNA and α-GalCer Induces Antitumor Immunity through Conventional and Natural Killer T Cells

Verbeke, R., Lentacker, I., Breckpot, K., Janssens, J., Calenbergh, S. V., Smedt, S. C. D., & Dewitte, H. (2019) · ACS Nano · doi:10.1021/acsnano.8b07660 · Cited by 82 · see citing works

Eliciting antitumor immunity via therapeutic cancer vaccines

Peng, K., Zhao, X., Fu, Y., & Liang, Y. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01316-4 · Cited by 89 · see citing works

mRNA in cancer immunotherapy: beyond a source of antigen

Hoecke, L. V., Verbeke, R., Dewitte, H., Lentacker, I., Vermaelen, K. Y., Breckpot, K., & Lint, S. V. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01329-3 · Cited by 80 · see citing works

Chemical modification of uridine modulates mRNA-mediated proinflammatory and antiviral response in primary human macrophages

Moradian, H., Roch, T., Anthofer, L., Lendlein, A., & Gossen, M. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.01.004 · Cited by 75 · see citing works

Concise Review: Application of In Vitro Transcribed Messenger RNA for Cellular Engineering and Reprogramming: Progress and Challenges

Steinle, H., Behring, A., Schlensak, C., Wendel, H. P., & Avci‐Adali, M. (2016) · Stem Cells · doi:10.1002/stem.2402 · Cited by 78 · see citing works

Intracellular Delivery of mRNA in Adherent and Suspension Cells by Vapor Nanobubble Photoporation

Raes, L., Stremersch, S., Fraire, J. C., Brans, T., Goetgeluk, G., Munter, S. D., Hoecke, L. V., Verbeke, R., Hoeck, J. V., Xiong, R., et al. (2020) · Nano-Micro Letters · doi:10.1007/s40820-020-00523-0 · Cited by 74 · see citing works

Non-viral delivery of chemically modified mRNA to the retina: Subretinal versus intravitreal administration

Devoldere, J., Peynshaert, K., Dewitte, H., Vanhove, C., Groef, L. D., Moons, L., Özcan, S. Y., Dalkara, D., Smedt, S. C. D., & Remaut, K. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.06.042 · Cited by 66 · see citing works

Towards the future exploration of mucosal mRNA vaccines against emerging viral diseases; lessons from existing next-generation mucosal vaccine strategies

Hameed, S. A., Paul, S., Dellosa, G. K. Y., Jaraquemada, D., & Bello, M. B. (2022) · npj Vaccines · doi:10.1038/s41541-022-00485-x · Cited by 64 · see citing works

Delivery of mRNA for regulating functions of immune cells

Shi, J. Y., Huang, M., Lu, Z.-D., Du, X., Shen, S., Xu, C., & Wang, J. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.03.033 · Cited by 62 · see citing works

Therapeutic mRNA delivery to leukocytes

Granot-Matok, Y., Kon, E., Dammes, N., Mechtinger, G., & Peer, D. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.05.032 · Cited by 61 · see citing works

Understanding the impact of in vitro transcription byproducts and contaminants

Lenk, R., Kleindienst, W., Szabó, G. T., Baiersdörfer, M., Boros, G., Keller, J. M., Mahiny, A. J., & Vlatkovic, I. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1426129 · Cited by 63 · see citing works

Subretinal therapy: technological solutions to surgical and immunological challenges

Ladha, R., Caspers, L. E., Willermain, F., & de Smet, M. D. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.846782 · Cited by 54 · see citing works

Biologics and their delivery systems: Trends in myocardial infarction

Borrelli, M. A., Turnquist, H. R., & Little, S. R. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.03.014 · Cited by 53 · see citing works

Analyzing immune responses to varied mRNA and protein vaccine sequences

Park, H.-J., Bang, Y., Kwon, S. P., Kwak, W., Park, S., Roh, G., Bae, S., Kim, J., Kwak, H. W., Kim, Y., et al. (2023) · npj Vaccines · doi:10.1038/s41541-023-00684-0 · Cited by 53 · see citing works

Emerging Concepts of Nanobiotechnology in mRNA Delivery

Wang, Y., & Yu, C. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202003545 · Cited by 52 · see citing works

Modulating intracellular pathways to improve non-viral delivery of RNA therapeutics

de Vyver, T. V., Smedt, S. C. D., & Raemdonck, K. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114041 · Cited by 51 · see citing works

The Ins and Outs of Messenger RNA Electroporation for Physical Gene Delivery in Immune Cell-Based Therapy

Campillo-Davó, D., Laere, M. D., Roex, G., Versteven, M., Flumens, D., Berneman, Z. N., Tendeloo, V. F. V., Anguille, S., & Lion, E. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13030396 · Cited by 50 · see citing works

Corticosteroids and cellulose purification improve, respectively, the in vivo translation and vaccination efficacy of sa-mRNAs

Zhong, Z., McCafferty, S., Opsomer, L., Wang, H., Huysmans, H., De Temmerman, J., Lienenklaus, S., Portela Catani, J. P., Combes, F., & Sanders, N. N. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.01.023 · Cited by 48 · see citing works

The Dual Role of the Innate Immune System in the Effectiveness of mRNA Therapeutics

Muslimov, A. R., Tereshchenko, V., Shevyrev, D., Rogova, A. S., Lepik, K. V., Reshetnikov, V. V., & Ivanov, R. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914820 · Cited by 50 · see citing works

Fluorescence Correlation Spectroscopy to find the critical balance between extracellular association and intracellular dissociation of mRNA complexes

Zhang, H., Smedt, S. C. D., & Remaut, K. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.05.016 · Cited by 46 · see citing works

RNA Therapeutics: How Far Have We Gone?

Coutinho, M. F., Matos, L., Santos, J. I., & Alves, S. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-19966-1_7 · Cited by 44 · see citing works

Delivery vehicle and route of administration influences self-amplifying RNA biodistribution, expression kinetics, and reactogenicity

Bathula, N. V., Friesen, J. J., Casmil, I. C., Wayne, C. J., Liao, S., Soriano, S. K. V., Ho, C.-H., Strumpel, A., & Blakney, A. K. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.07.078 · Cited by 42 · see citing works

Together is Better: mRNA Co‐Encapsulation in Lipoplexes is Required to Obtain Ratiometric Co‐Delivery and Protein Expression on the Single Cell Level

Zhang, H., Bussmann, J., Huhnke, F. H., Devoldere, J., Minnaert, A., Jiskoot, W., Serwane, F., Spatz, J. P., Röding, M., Smedt, S. C. D., et al. (2021) · Advanced Science · doi:10.1002/advs.202102072 · Cited by 37 · see citing works

Sustained release of PKR inhibitor C16 from mesoporous silica nanoparticles significantly enhances mRNA translation and anti-tumor vaccination

Zhang, W., Liu, Y., Chin, J. M., & Phua, K. K. L. (2021) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2021.03.011 · Cited by 33 · see citing works

Pre-clinical non-viral vectors exploited for in vivo CRISPR/Cas9 gene editing: an overview

Rouatbi, N., McGlynn, T., & Al‐Jamal, K. T. (2022) · Biomaterials Science · doi:10.1039/d1bm01452h · Cited by 33 · see citing works

In Vitro Transcribed mRNA Vaccines with Programmable Stimulation of Innate Immunity

Loomis, K. H., Lindsay, K. E., Zurla, C., Bhosle, S. M., Vanover, D. A., Blanchard, E. L., Kirschman, J. L., Bellamkonda, R. V., & Santangelo, P. J. (2018) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.8b00443 · Cited by 32 · see citing works

mRNA-Based Vaccines and Mode of Action

Gergen, J., & Petsch, B. (2020) · Current topics in microbiology and immunology · doi:10.1007/82_2020_230 · Cited by 32 · see citing works

The obstacle course to the inner retina: Hyaluronic acid-coated lipoplexes cross the vitreous but fail to overcome the inner limiting membrane

Devoldere, J., Wels, M., Peynshaert, K., Dewitte, H., Smedt, S. C. D., & Remaut, K. (2019) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2019.05.023 · Cited by 30 · see citing works

An old problem with new solutions: Strategies to improve vaccine efficacy in the elderly

Bell, M. R., & Kutzler, M. A. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114175 · Cited by 29 · see citing works

Inhibition of the Inflammatory Pathway Enhances Both the in Vitro and in Vivo Transfection Activity of Exogenous in Vitro-Transcribed mRNAs Delivered by Lipid Nanoparticles

Ohto, T., Konishi, M., Tanaka, H., Onomoto, K., Yoneyama, M., Nakai, Y., Tange, K., Yoshioka, H., & Akita, H. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00783 · Cited by 29 · see citing works

Clinical potential of oligonucleotide-based therapeutics in the respiratory system

Moschos, S. A., Usher, L., & Lindsay, M. A. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.10.009 · Cited by 26 · see citing works

Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity

Gong, N., Kim, D., Alameh, M., El-Mayta, R. D., Han, E. L., Dwivedi, G., Palanki, R., Shi, Q., Han, X., Xue, L., et al. (2025) · Nature Biomedical Engineering · doi:10.1038/s41551-025-01422-8 · Cited by 27 · see citing works

Tackling pharmacological response heterogeneity by PBPK modeling to advance precision medicine productivity of nanotechnology and genomics therapeutics

Vizirianakis, I. S., Miliotou, Α. N., Mystridis, G. A., Andriotis, E. G., Andreadis, I. I., Papadopoulou, L. C., & Fatouros, D. G. (2019) · Expert Review of Precision Medicine and Drug Development · doi:10.1080/23808993.2019.1605828 · Cited by 25 · see citing works

Aerosolized Non-viral Nucleic Acid Delivery in the Vaginal Tract of Pigs

Remaut, K., Clercq, E. D., Andries, O., Rombouts, K., Gils, M. V., Cicchelero, L., Vandenbussche, I., Praet, S. V., Benito, J. M., Fernández, J. M. G., et al. (2015) · Pharmaceutical Research · doi:10.1007/s11095-015-1796-x · Cited by 25 · see citing works

Strategies for modulating innate immune activation and protein production of in vitro transcribed mRNAs

Loomis, K. H., Kirschman, J. L., Bhosle, S. M., Bellamkonda, R. V., & Santangelo, P. J. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb01753j · Cited by 24 · see citing works

Co-Delivery of mRNA and pDNA Using Thermally Stabilized Coacervate-Based Core-Shell Nanosystems

Nasr, S. S., Lee, S., Thiyagarajan, D., Boese, A. S., Loretz, B., & Lehr, C. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111924 · Cited by 22 · see citing works

Messenger RNA translation enhancement by immune evasion proteins: a comparative study between EKB (vaccinia virus) and NS1 (influenza A virus)

Liu, Y., Chin, J. M., Choo, E. L., & Phua, K. K. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-48559-6 · Cited by 22 · see citing works

mRNA Therapies: New Hope in the Fight against Melanoma

van Dülmen, M., & Rentmeister, A. (2020) · Biochemistry · doi:10.1021/acs.biochem.0c00181 · Cited by 22 · see citing works

Kinetic analysis of IFIT1 and IFIT5 interactions with different native and engineered RNAs and its consequences for designing mRNA-based therapeutics

Miedziak, B., Dobieżyńska, A., Darżynkiewicz, Z. M., Bartkowska, J., Miszkiewicz, J., Kowalska, J., Warmiński, M., Tyras, M., Trylska, J., Jemielity, J., et al. (2019) · RNA · doi:10.1261/rna.073304.119 · Cited by 21 · see citing works

Protein Expression Correlates Linearly with mRNA Dose over Up to Five Orders of Magnitude In Vitro and In Vivo

van Asbeck, A. H., Dieker, J. W. C., Egberink, R. O., van den Berg, L., van der Vlag, J., & Brock, R. E. (2021) · Biomedicines · doi:10.3390/biomedicines9050511 · Cited by 21 · see citing works

Efficient reduction of synthetic mRNA induced immune activation by simultaneous delivery of B18R encoding mRNA

Michel, T., Golombek, S., Steinle, H., Hann, L., Velić, A., Maček, B., Krajewski, S., Schlensak, C., Wendel, H. P., & Avci‐Adali, M. (2019) · Journal of Biological Engineering · doi:10.1186/s13036-019-0172-5 · Cited by 20 · see citing works

Less is more: Self-amplifying mRNA becomes self-killing upon dose escalation in immune-competent retinal cells

Vanluchene, H., Gillon, O., Peynshaert, K., Smedt, S. C. D., Sanders, N. N., Raemdonck, K., & Remaut, K. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114204 · Cited by 19 · see citing works

Off the beaten path: Novel mRNA-nanoformulations for therapeutic vaccination against HIV

D’haese, S., Lacroix, C., García, F., Plana, M., Ruță, S. M., Vanham, G. L., Verrier, B., & Aerts, J. L. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.11.009 · Cited by 18 · see citing works

Low Resource Integrated Platform for Production and Analysis of Capped mRNA

Nwokeoji, A. O., Chou, T.-C., & Nwokeoji, E. A. (2022) · ACS Synthetic Biology · doi:10.1021/acssynbio.2c00609 · Cited by 18 · see citing works

Analysis of critical protein–protein interactions of SARS-CoV-2 capping and proofreading molecular machineries towards designing dual target inhibitory peptides

Arabi-Jeshvaghani, F., Javadi‐Zarnaghi, F., & Ganjalikhany, M. R. (2023) · Scientific Reports · doi:10.1038/s41598-022-26778-8 · Cited by 17 · see citing works

Co-delivery of NS1 and BMP2 mRNAs to murine pluripotent stem cells leads to enhanced BMP-2 expression and osteogenic differentiation

Wang, P., Logeart‐Avramoglou, D., Petite, H., Gonçalves, C., Midoux, P., Perche, F., & Pichon, C. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.03.045 · Cited by 17 · see citing works

Small molecules convey big messages: Boosting non-viral nucleic acid delivery with low molecular weight drugs

Joris, F., Smedt, S. C. D., & Raemdonck, K. (2017) · Nano Today · doi:10.1016/j.nantod.2017.06.012 · Cited by 17 · see citing works

Keratinocyte Growth Factor Modified Messenger RNA Accelerating Cell Proliferation and Migration of Keratinocytes

Denzinger, M., Link, A., Kurz, J., Krauß, S., Thoma, R., Schlensak, C., Wendel, H. P., & Krajewski, S. (2018) · Nucleic Acid Therapeutics · doi:10.1089/nat.2018.0737 · Cited by 17 · see citing works

Localized chemotherapy approaches and advanced drug delivery strategies: a step forward in the treatment of peritoneal carcinomatosis from ovarian cancer

Breusa, S., Zilio, S., Catania, G., Bakrin, N., Kryza, D., & Lollo, G. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1125868 · Cited by 16 · see citing works

Emerging Therapeutic RNAs for the Targeting of Cancer Associated Fibroblasts

Santana-Viera, L., Ibba, M. L., Rotoli, D., Catuogno, S., & Esposito, C. L. (2020) · Cancers · doi:10.3390/cancers12061365 · Cited by 15 · see citing works

Application of Peptides in Construction of Nonviral Vectors for Gene Delivery

Yang, Y., Liu, Z., Ma, H., & Cao, M. (2022) · Nanomaterials · doi:10.3390/nano12224076 · Cited by 14 · see citing works

MAGT1 messenger RNA-corrected autologous T and natural killer cells for potential cell therapy in X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia disease

Brault, J., Meis, R. J., Li, L., Bello, E. A., Liu, T., Sweeney, C. L., Koontz, S. M., Dowdell, K., Theobald, N., Lee, J. S., et al. (2020) · Cytotherapy · doi:10.1016/j.jcyt.2020.08.013 · Cited by 14 · see citing works

The Interplay Between Therapeutic Self-Amplifying RNA and the Innate Immune System: Balancing Efficiency and Reactogenicity

Kunyk, D., Plotnikova, M. A., Bespalov, M., Shevyrev, D., Klotchenko, S. A., Ivanov, R. A., & Reshetnikov, V. V. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26188986 · Cited by 14 · see citing works

Exploring the Potential and Advancements of Circular RNA Therapeutics

Wang, L., Wang, L., Dong, C., Liu, J., Cui, G., Gao, S., & Liu, Z. (2025) · Exploration · doi:10.1002/exp.20240044 · Cited by 11 · see citing works

Suppression of mRNA Nanoparticle Transfection in Human Fibroblasts by Selected Interferon Inhibiting Small Molecule Compounds

Liu, Y., Krishnan, M. N., & Phua, K. K. L. (2017) · Biomolecules · doi:10.3390/biom7030056 · Cited by 10 · see citing works

Engineering of regulatory T cells by means of mRNA electroporation in a GMP-compliant manner

Janssens, I., Campillo-Davó, D., den Bos, J. V., Reu, H. D., Berneman, Z. N., Wens, I., & Cools, N. (2022) · Cytotherapy · doi:10.1016/j.jcyt.2022.01.001 · Cited by 10 · see citing works

mRNA Vaccines: Design Principles, Mechanisms, and Manufacturing—Insights From COVID‐19 as a Model for Combating Infectious Diseases

Sokhangouy, S. K., Behzadi, M., Rezaei, S., Farjami, M., Haghshenas, M., Sefidbakht, Y., & Mozaffari‐Jovin, S. (2025) · Biotechnology Journal · doi:10.1002/biot.202400596 · Cited by 9 · see citing works

Charge-Complementary Polymersomes for Enhanced mRNA Delivery

Kim, H., Ahn, Y., Kim, M., Choi, J., Shin, S., & Kim, H. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15122781 · Cited by 8 · see citing works

Strategic deactivation of mRNA COVID‐19 vaccines: New applications for siRNA therapy and RIBOTACs

Hulscher, N., McCullough, P. A., & Marotta, D. E. (2024) · The Journal of Gene Medicine · doi:10.1002/jgm.3733 · Cited by 9 · see citing works

Influence of pathogenic stimuli on Müller cell transfection by lipoplexes

Peynshaert, K., Devoldere, J., Philips, F., Vergauwe, F., Smedt, S. C. D., & Remaut, K. (2020) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2020.03.009 · Cited by 8 · see citing works

Protein Transduction Domain-Mediated Delivery of Recombinant Proteins and In Vitro Transcribed mRNAs for Protein Replacement Therapy of Human Severe Genetic Mitochondrial Disorders: The Case of Sco2 Deficiency

Miliotou, Α. N., Foltopoulou, P. F., Ingendoh‐Tsakmakidis, A., Tsiftsoglou, A. S., Vizirianakis, I. S., Pappas, I. S., & Papadopoulou, L. C. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15010286 · Cited by 7 · see citing works

Supramolecular Gene Transfection Agents

Pitard, B., & Habrant, D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12563-6 · Cited by 7 · see citing works

Payload‐Driven Design of Polymeric Carriers for Nucleic Acid Delivery: Insights from Structure–Function Relationships

Moradian, H., Dunne, C. M., Gossen, M., & Hartlieb, M. (2025) · Advanced Science · doi:10.1002/advs.202512653 · Cited by 6 · see citing works

Vaccinia Virus Protein B18R: Influence on mRNA Immunogenicity and Translation upon Non-Viral Delivery in Different Ocular Cell Types

Minnaert, A., Devoldere, J., Peynshaert, K., Vercruysse, L., Smedt, S. C. D., & Remaut, K. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13010074 · Cited by 6 · see citing works

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

Michel, T., Link, A., Abraham, M.-K., Schlensak, C., Peter, K., Wendel, H.-P., Wang, X., & Krajewski, S. (2019) · Journal of Visualized Experiments · doi:10.3791/58444 · Cited by 7 · see citing works

Controlling Protein Expression by Delivery of RNA Therapeutics Using Lipid Nanoparticles

Lin, P. J. C., & Tam, Y. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814470-1.00009-5 · Cited by 6 · see citing works

Electroporation of mRNA as a Universal Technology Platform to Transfect a Variety of Primary Cells with Antigens and Functional Proteins

Sauerer, T., Albrecht, L., Sievers, N. M., Gerer, K. F., Hoyer, S., Dörrie, J., & Schaft, N. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3770-8_10 · Cited by 5 · see citing works

Intracellular RNase activity dampens zinc finger nuclease-mediated gene editing in hematopoietic stem and progenitor cells

Peterson, C. W., Venkataraman, R., Reddy, S. S., Pande, D., Enstrom, M., Radtke, S., Humbert, O., & Kiem, H. (2021) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2021.11.010 · Cited by 6 · see citing works

RNA technology and nanocarriers empowering in vivo chimeric antigen receptor therapy

Cai, J., Chen, S., Liu, Z., Li, H., Wang, P., Yang, F., Li, Y., Chen, K., Sun, M., & Qiu, M. (2024) · Immunology · doi:10.1111/imm.13861 · Cited by 5 · see citing works

General method for the production of hydrogel droplets from uniformly sized smart shell membranes

Gwon, S.-J., & Park, S. (2020) · Polymer Chemistry · doi:10.1039/d0py00679c · Cited by 5 · see citing works

Moderne Konzepte der Nanobiotechnologie für mRNA‐Abgabesysteme

Wang, Y., & Yu, C. (2020) · Angewandte Chemie · doi:10.1002/ange.202003545 · Cited by 4 · see citing works

NADPH oxidase correction by mRNA transfection of apheresis granulocytes in chronic granulomatous disease

Ravin, S. S. D., Brault, J., Meis, R. J., Li, L., Theobald, N., Bonifacino, A. C., Lei, H., Liu, T., Koontz, S. M., Corsino, C. I., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020003224 · Cited by 4 · see citing works

The Efficiency of Brain‐Derived Neurotrophic Factor Secretion by mRNA‐Electroporated Regulatory T Cells Is Highly Impacted by Their Activation Status

den Bos, J. V., Janssens, I., Vermeulen, M., Dams, A., Reu, H. D., Peeters, S., Faghel, C., Ouaamari, Y. E., Wens, I., & Cools, N. (2024) · European Journal of Immunology · doi:10.1002/eji.202451005 · Cited by 3 · see citing works

Harnessing dendritic cells as immunological bridges to potentiate mRNA cancer vaccines

Wu, R., Li, H., Li, Z., Hao, K., & Tian, H. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb00995b · Cited by 3 · see citing works

Deconvolution of synthetic mRNA expression: Nucleoside chemistry alters translatability

Moradian, H., Schwestka, M., Roch, T., & Gossen, M. (2023) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10622 · Cited by 3 · see citing works

Iterative Upgrading of mRNA Therapeutics by Modulating the Microenvironment for Translation

Shi, Y., Lou, Z., Wang, Y., Li, M., Wang, Y., & You, J. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202414722 · Cited by 1 · see citing works

Influenza A virus derived NS1 enhances translation of HPLC purified mRNA and interferon adjuvanted mRNA vaccination

Phua, K. K. L., Liu, Y., Zhang, W., Chin, J. M., Tang, H.-W., Pardi, N., & Nair, S. K. (2026) · Scientific Reports · doi:10.1038/s41598-026-35611-5 · Cited by 1 · see citing works

Elastin production by mRNA technology for rejuvenation of aged skin

Shi, Y., Lou, Z., Chen, Y., Xu, J., Zhang, Z., Zhang, Z., Gao, Y., Wang, Y., & You, J. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.115033 · Cited by 1 · see citing works

Potential and pitfalls of non-viral mRNA delivery for ocular therapies

Devoldere, J. (2019) · Ghent University Academic Bibliography (Ghent University)

The Dual Role of the Innate Immune System in the Effectiveness of mRNA Therapeutics

Muslimov, A. R., Tereshchenko, V., Shevyrev, D., Rogova, A. S., Lepik, K. V., Reshetnikov, V. V., & Ivanov, R. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914820 · Cited by 50 · see citing works

mRNA: Fulfilling the Promise of Gene Therapy

Weissman, D., & Karikó, K. (2015) · Molecular Therapy · doi:10.1038/mt.2015.138 · Cited by 111 · see citing works

Strategies for controlling the innate immune responses to in vitro transcribed messenger RNAs

Loomis, K. H. (2016) · SMARTech Repository (Georgia Institute of Technology)

Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems

Guan, S., & Rosenecker, J. (2017) · Gene Therapy · doi:10.1038/gt.2017.5 · Cited by 389 · see citing works