Cited by 903Virus-based gene therapy researchRNA Interference and Gene DeliveryCAR-T cell therapy research

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Gene therapy clinical trials worldwide to 2017: An update

Ginn, Samantha L., Amaya, Anais K., Alexander, Ian E., Edelstein, Michael, Abedi, Mohammad R.·2018·The Journal of Gene Medicine

DOI 10.1002/jgm.3015

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Abstract

To date, almost 2600 gene therapy clinical trials have been completed, are ongoing or have been approved worldwide. Our database brings together global information on gene therapy clinical activity from trial databases, official agency sources, published literature, conference presentations and posters kindly provided to us by individual investigators or trial sponsors. This review presents our analysis of clinical trials that, to the best of our knowledge, have been or are being performed worldwide. As of our November 2017 update, we have entries on 2597 trials undertaken in 38 countries. We have analysed the geographical distribution of trials, the disease indications (or other reasons) for trials, the proportions to which different vector types are used, and the genes that have been transferred. Details of the analyses presented, and our searchable database are available via The Journal of Gene Medicine Gene Therapy Clinical Trials Worldwide website at: http://www.wiley.co.uk/genmed/clinical. We also provide an overview of the progress being made in gene therapy clinical trials around the world, and discuss key trends since the previous review, namely the use of chimeric antigen receptor T cells for the treatment of cancer and advancements in genome editing technologies, which have the potential to transform the field moving forward.

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Authors: Ginn, S. L., Amaya, A. K., Alexander, I. E., Edelstein, M., & Abedi, M. R.
Affiliations: The University of Sydney (AU)
Chatham House (GB)
Uppsala University Hospital (SE)
Corresponding author: Ginn, Samantha L.
ORCID: Ginn, Samantha L.
Amaya, Anais K.
Alexander, Ian E.
Edelstein, Michael
Venue: The Journal of Gene Medicine
Publisher: Wiley
Published: 2018-04-19
Volume: 20
Issue: 5
Pages: e3015-e3015
ISSN: 1099-498X (ISSN-L)
1521-2254
DOI: 10.1002/jgm.3015
OpenAlex: W2983048398
Cited by: 903
References: 146
Citations by year: 2026: 31 · 2025: 68 · 2024: 86 · 2023: 77 · 2022: 124 · 2021: 141 · 2020: 151 · 2019: 148 · 2018: 36
FWCI: 16.66
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Journal of Gene Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Health Sciences › Medicine › Oncology › CAR-T cell therapy research
Keywords: gene therapy, clinical trials, clinical trial database, gene therapy vectors, disease indications, chimeric antigen receptor T cells, cancer immunotherapy, genome editing, clinical trial trends
MeSH terms: Clinical Trials as Topic, Humans, Neoplasms, Global Health, Genetic Therapy, Immunotherapy, Adoptive, Outcome Assessment, Health Care

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Gene therapy clinical trials worldwide to 2017: An update

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