The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
The Wittig and Related Reactions in Natural Product Synthesis
Abstract
Originally reported in Liebigs Annalen in 1953 (then called Justus Liebigs Annalen der Chemie), the Wittig reaction has evolved to include the Horner–Wittig and Horner–Wadsworth–Emmons reactions and several other variations. Today, these reactions constitute some of the most powerful processes for the construction of carbon–carbon bond frameworks, facilitating the chemical synthesis of myriads of organic molecules both in research laboratories and industrial settings. The Wittig and related reactions were proven particularly useful in the field of total synthesis, where they enabled the construction of highly complex structures and had a significant impact in shaping the art to its present state of sophistication. In this article the authors focus, after a brief introduction, on total syntheses from their own laboratories that employ such processes. These examples, together with the numerous others adorning the chemical literature, illustrate amply the importance of the Wittig and related reactions and point to their continuing prominence in organic synthesis.
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Cites
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The Utility of Phosphonate Carbanions in Olefin Synthesis
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Self-citationDirect synthesis of Z-unsaturated esters. A useful modification of the horner-emmons olefination.
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Zur Reaktionsweise des Pentaphenyl‐phosphors und einiger Derivate
Wittig, G., & Geissler, G. (1953) · Justus Liebigs Annalen der Chemie · doi:10.1002/jlac.19535800107 · Cited by 714
GERTH, K., BEDORF, N., HÖFLE, G., IRSCHIK, H., & REICHENBACH, H. (1996) · The Journal of Antibiotics · doi:10.7164/antibiotics.49.560 · Cited by 631
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Synthesis of epothilones A and B in solid and solution phase
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Self-citationStereochemistry and Mechanism in the Wittig Reaction
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Cited by
Functions, Therapeutic Applications, and Synthesis of Retinoids and Carotenoids
Álvarez, R., Vaz, B., Gronemeyer, H., & de Lera, Á. R. (2014) · Chemical Reviews · doi:10.1021/cr400126u · Cited by 260
Metadata
- Authors
- Nicolaou, K. C., Härter, M. W., Gunzner, J. L., & Nadin, A.
- Venue
- Liebigs Annalen
- Publisher
- Wiley
- Published
- 1997-07
- Volume
- 1997
- Issue
- 7
- Pages
- 1283-1301
- ISSN
- 0947-3440 (ISSN-L)
- OpenAlex
- W2107586991
- Cited by
- 262
- References
- 15
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- closed
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