The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Molecular mechanism of interleukin-8 gene expression
Abstract
A potent leukocyte chemotactic and activating cytokine, interleukin-8 (IL-8), is produced by numerous types of cells in response to inflammatory stimuli. Accumulating evidence indicate that the transcription of IL-8 gene requires the activation of either the combination of NF-xB and AP-1 or that of NF-xB and NF-IL6, depending on the type of cells. Alternatively, the activation of NF-xB is indispensable for IL-8 gene activation in any types of cells examined. On the other hand, an immunosuppressant, FK506, and a glucocorticoid inhibit the gene transcription as well as the production of IL-8. Molecular analyses of IL-8 gene repression by these agents revealed that both affected the activity of the transcription factor(s) bound to the NF-xB site, albeit in different ways, thereby suppressing IL-8 gene transcription. Collectively, IL-8 production seems to be controlled mainly at the activation step of the transcription factor(s) bound to the NF-xB site. J. Leukoc. Biol. 56: 554–558; 1994.
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Cites
The mechanism of action of cyclosporin A and FK506
Schreiber, S. L., & Crabtree, G. R. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90111-j · Cited by 2,127
Yang-Yen, H.-F., Chambard, J.-C., Sun, Y.-L., Smeal, T., Schmidt, T. J., Drouin, J., & Karin, M. (1990) · Cell · doi:10.1016/0092-8674(90)90396-v · Cited by 1,553
Matsusaka, T., Fujikawa, K., Nishio, Y., Mukaida, N., Matsushima, K., Kishimoto, T., & Akira, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.10193 · Cited by 959
Self-citationModulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.
Toledano, M. B., & Leonard, W. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4328 · Cited by 657
Cited by
Multiple control of interleukin-8 gene expression
Hoffmann, E., Dittrich-Breiholz, O., Holtmann, H., & Kracht, M. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.5.847 · Cited by 1,058
Oxidative stress and gene expression in sepsis
Macdonald, J., Galley, H. F., & Webster, N. R. (2003) · British Journal of Anaesthesia · doi:10.1093/bja/aeg034 · Cited by 497
Serum amyloid A induces IL-8 secretion through a G protein–coupled receptor, FPRL1/LXA4R
He, R., Sang, H., & Ye, R. D. (2003) · Blood · doi:10.1182/blood-2002-05-1431 · Cited by 329
Immune cells: free radicals and antioxidants in sepsis
Victor, V. M., Rocha, M., & De la Fuente, M. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.01.020 · Cited by 310
Human Tribbles, a Protein Family Controlling Mitogen-activated Protein Kinase Cascades
Kiss-Toth, E., Bagstaff, S. M., Sung, H. Y., Jozsa, V., Dempsey, C., Caunt, J. C., Oxley, K. M., Wyllie, D. H., Polgar, T., Harte, M., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407732200 · Cited by 300
Metadata
- Authors
- Mukaida, N., Okamoto, S.-I., Ishikawa, Y., & Matsushima, K.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-11-01
- Volume
- 56
- Issue
- 5
- Pages
- 554-558
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2424607300
- Cited by
- 452
- References
- 4
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mukaida, N., Okamoto, S.-I., Ishikawa, Y., & Matsushima, K. (1994). Molecular mechanism of interleukin-8 gene expression. Journal of Leukocyte Biology. https://doi.org/10.1002/jlb.56.5.554
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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