Multiple control of interleukin-8 gene expression

Hoffmann, Elke; Dittrich-Breiholz, Oliver; Holtmann, Helmut; Kracht, Michael

doi:10.1189/jlb.72.5.847

Cited by 1,058Chemokine receptors and signalingNF-κB Signaling PathwaysCytokine Signaling Pathways and Interactions

Multiple control of interleukin-8 gene expression

Hoffmann, Elke, Dittrich-Breiholz, Oliver, Holtmann, Helmut, Kracht, Michael·2002·Journal of Leukocyte Biology

DOI 10.1189/jlb.72.5.847

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Abstract

Interleukin (IL)-8, a prototypic human chemokine, was detected more than a decade ago as the founding member of the chemokine superfamily. One of the most remarkable properties of IL-8 is the variation of its expression levels. In healthy tissues, IL-8 is barely detectable, but it is rapidly induced by ten- to 100-fold in response to proinflammatory cytokines such as tumor necrosis factor or IL-1, bacterial or viral products, and cellular stress. Recently, significant advances in the understanding of signaling pathways, which coordinately regulate IL-8 transcription as well as mRNA stabilization in response to external stimuli, have been made. Maximal IL-8 amounts are generated by a combination of three different mechanisms: first, derepression of the gene promoter; second, transcriptional activation of the gene by nuclear factor-κB and JUN-N-terminal protein kinase pathways; and third, stabilization of the mRNA by the p38 mitogen-activated protein kinase pathway. In that way, cells are able to rapidly increase and at the same time, to fine-tune the amount of IL-8 secreted and thereby control the extent of leukocytes attracted to sites of tissue injury.

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Binding sites for C/EBPβ and NF-κB are present in neighboring positions in the IL-8 and GROα promoters and these transcription factors regulate synergistically IL-8 and GROα during viral infection and stress.
“binding sites for C/EBPβ and NF-κB are present in neighboring positions in the IL-8 and GROα promoters and these transcription factors regulate synergistically IL-8 and GROα during viral infection and stress (Hoffmann et al., 2002”
From Chemokine signaling via the CXCR2 receptor reinforces senescence (2008) · cites this paper as Hoffmann et al., 2002

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Jobin, C., Holt, L. C., Bradham, C. A., Streetz, K. L., Brenner, D. A., & Sartor, R. B. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.8.4447 · Cited by 69 · see citing works
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Adenovirus Type 7 Induces Interleukin-8 Production via Activation of Extracellular Regulated Kinase 1/2
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Detection of cellular microchimerism of male or female origin in systemic sclerosis patients by polymerase chain reaction analysis of HLA–Cw antigens
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Endothelin-1–Induced Interleukin-8 Production in Human Brain-Derived Endothelial Cells Is Mediated by the Protein Kinase C and Protein Tyrosine Kinase Pathways
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The Transcriptional Silencer Protein NRF: A Repressor of NF-κB Enhancers
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Cytokines in Inflammatory Disease
Kany, S., Vollrath, J. T., & Relja, B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20236008 · Cited by 2,027 · see citing works
Chemokine signaling via the CXCR2 receptor reinforces senescence
Acosta, J. C., O'Loghlen, A., Banito, A., Guijarro, M. V., Augert, A., Raguz, S., Fumagalli, M., Da Costa, M., Brown, C., Popov, N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.038 · Cited by 1,801 · see citing works
Interleukin-1 (IL-1) Pathway
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Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis
Sparmann, A., & Bar‐Sagi, D. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.028 · Cited by 854 · see citing works
Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases
Ha, H., Debnath, B., & Neamati, N. (2017) · Theranostics · doi:10.7150/thno.15625 · Cited by 788 · see citing works
Increased Number of Islet-Associated Macrophages in Type 2 Diabetes
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The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis
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Mechanisms of Action and Clinical Application of Macrolides as Immunomodulatory Medications
Kanoh, S., & Rubin, B. K. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00078-09 · Cited by 710 · see citing works
Involvement of Toll-like Receptor 3 in the Immune Response of Lung Epithelial Cells to Double-stranded RNA and Influenza A Virus
Guillot, L., Le Goffic, R., Bloch, S., Escriou, N., Akira, S., Chignard, M., & Si-Tahar, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410592200 · Cited by 689 · see citing works
Long Noncoding RNA NEAT1-Dependent SFPQ Relocation from Promoter Region to Paraspeckle Mediates IL8 Expression upon Immune Stimuli
Imamura, K., Imamachi, N., Akizuki, G., Kumakura, M., Kawaguchi, A., Nagata, K., Kato, A., Kawaguchi, Y., Sato, H., Yoneda, M., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.01.009 · Cited by 680 · see citing works
Release of Interleukins and Other Inflammatory Cytokines by Human Adipose Tissue Is Enhanced in Obesity and Primarily due to the Nonfat Cells
Fain, J. N. (2006) · Vitamins and hormones · doi:10.1016/s0083-6729(06)74018-3 · Cited by 679 · see citing works
Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow
Wang, L., Luo, J., Li, B., Tian, X. Y., Chen, L., Huang, Y., Liu, J., Deng, D., Lau, C. W., Wan, S., et al. (2016) · Nature · doi:10.1038/nature20602 · Cited by 672 · see citing works
The CXCL8-CXCR1/2 pathways in cancer
Liu, Q., Li, A., Tian, Y., Wu, J. D., Liu, Y., Li, T., Chen, Y., Han, X., & Wu, K. (2016) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.08.002 · Cited by 666 · see citing works
The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention
Cambier, S., Gouwy, M., & Proost, P. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-00974-6 · Cited by 605 · see citing works
Oxidative stress and apoptosis induced by titanium dioxide nanoparticles in cultured BEAS-2B cells
Park, E., Yi, J., Chung, K., Ryu, D., Choi, J., & Park, K. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2008.06.869 · Cited by 563 · see citing works
Interleukin-8: An evolving chemokine
Matsushima, K., Yang, D., & Oppenheim, J. J. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155828 · Cited by 527 · see citing works
A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages
Lu, H., Clauser, K. R., Tam, W. L., Fröse, J., Ye, X., Eaton, E. N., Reinhardt, F., Donnenberg, V. S., Bhargava, R., Carr, S. A., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3041 · Cited by 457 · see citing works
Cxcl8 (IL-8) Mediates Neutrophil Recruitment and Behavior in the Zebrafish Inflammatory Response
de Oliveira, S., Reyes‐Aldasoro, C. C., Candel, S., Renshaw, S. A., Mulero, V., & Calado, Â. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203266 · Cited by 385 · see citing works
An injected bacterial effector targets chromatin access for transcription factor NF-κB to alter transcription of host genes involved in immune responses
Arbibe, L., Kim, D. W., Batsché, É., Pédron, T., Mateescu, B., Muchardt, C., Parsot, C., & Sansonetti, P. J. (2006) · Nature Immunology · doi:10.1038/ni1423 · Cited by 376 · see citing works
Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells
Iourgenko, V., Zhang, W., Mickanin, C., Daly, I., Jiang, C., Hexham, J. M., Orth, A. P., Miraglia, L. J., Meltzer, J., Garza, D., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1932773100 · Cited by 362 · see citing works
Constitutive and Interleukin-1-inducible Phosphorylation of p65 NF-κB at Serine 536 Is Mediated by Multiple Protein Kinases Including IκB Kinase (IKK)-α, IKKβ, IKKϵ, TRAF Family Member-associated (TANK)-binding Kinase 1 (TBK1), and an Unknown Kinase and Couples p65 to TATA-binding Protein-associated Factor II31-mediated Interleukin-8 Transcription
Buss, H., Dörrie, A., Schmitz, M. L., Hoffmann, E., Resch, K., & Kracht, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409825200 · Cited by 362 · see citing works
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Response of Human Pulmonary Epithelial Cells to Lipopolysaccharide Involves Toll-like Receptor 4 (TLR4)-dependent Signaling Pathways
Guillot, L., Medjane, S., Le-Barillec, K., Balloy, V., Danel, C. J., Chignard, M., & Si‐Tahar, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m305790200 · Cited by 360 · see citing works
Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice
Lohmann, N., Schirmer, L., Atallah, P., Wandel, E., Ferrer, R. A., Werner, C., Simon, J. C., Franz, S., & Freudenberg, U. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aai9044 · Cited by 355 · see citing works
Expression and function of Toll-like receptors 2 and 4 in human keratinocytes
Pivarcsi, A. (2003) · International Immunology · doi:10.1093/intimm/dxg068 · Cited by 352 · see citing works
Potential roles and targeted therapy of the CXCLs/CXCR2 axis in cancer and inflammatory diseases
Cheng, Y., Ma, X., Wei, Y.-Q., & Wei, X. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.01.005 · Cited by 343 · see citing works
CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer
Wang, D., Wang, H., Brown, J. R., Daikoku, T., Wei, N., Shi, Q., Richmond, A. J., Strieter, R. M., Dey, S. K., & DuBois, R. N. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052124 · Cited by 337 · see citing works
Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis
Ishizu, T., Osoegawa, M., Mei, F.-J., Kikuchi, H., Tanaka, M., Takakura, Y., Minohara, M., Murai, H., Mihara, F., Taniwaki, T., et al. (2005) · Brain · doi:10.1093/brain/awh453 · Cited by 335 · see citing works
RelB, a New Partner of Aryl Hydrocarbon Receptor-Mediated Transcription
Vogel, C. F. A., Sciullo, E. M., Li, W., Wong, P., Lazennec, G., & Matsumura, F. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0211 · Cited by 320 · see citing works
Validation and comparison of luminex multiplex cytokine analysis kits with ELISA: Determinations of a panel of nine cytokines in clinical sample culture supernatants
duPont, N. C., Wang, K., Wadhwa, P. D., Culhane, J. F., & Nelson, E. L. (2005) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2005.03.005 · Cited by 319 · see citing works
Determinants of Cell- and Gene-Specific Transcriptional Regulation by the Glucocorticoid Receptor
So, A. Y., Chaivorapol, C., Bolton, E. C., Li, H., & Yamamoto, K. R. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030094 · Cited by 304 · see citing works
Influenza Virus Evades Innate and Adaptive Immunity via the NS1 Protein
Fernández-Sesma, A., Marukian, S., Ebersole, B. J., Kaminski, D. A., Park, M., Yuen, T., Sealfon, S. C., García‐Sastre, A., & Moran, T. M. (2006) · Journal of Virology · doi:10.1128/jvi.02381-05 · Cited by 305 · see citing works
NK Cell Compartments and Their Activation by Dendritic Cells
Ferlazzo, G., & Münz, C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.3.1333 · Cited by 297 · see citing works
Toll-Like Receptor 4 and MYD88-Dependent Signaling Mechanisms of the Innate Immune System Are Essential for the Response to Lipopolysaccharide by Epithelial and Stromal Cells of the Bovine Endometrium1
Cronin, J., Turner, M. L., Goetze, L., Bryant, C. E., & Sheldon, I. M. (2011) · Biology of Reproduction · doi:10.1095/biolreprod.111.092718 · Cited by 277 · see citing works
Recent Advances in Underlying Pathologies Provide Insight into Interleukin-8 Expression-Mediated Inflammation and Angiogenesis
Qazi, B. S., Tang, K., & Qazi, A. S. (2011) · International Journal of Inflammation · doi:10.4061/2011/908468 · Cited by 271 · see citing works
IL8, Neutrophils, and NETs in a Collusion against Cancer Immunity and Immunotherapy
Teijeira, Á., Garasa, S., Ochoa, M. C., Villalba-Esparza, M., Olivera, I., Cirella, A., Eguren‐Santamaría, I., Berraondo, P., Schalper, K. A., de Andrea, C. E., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-1319 · Cited by 270 · see citing works
NFκB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP
Kreuz, S., Siegmund, D., Rumpf, J., Samel, D., Leverkus, M., Janßen, O., Häcker, G. A., Dittrich‐Breiholz, O., Kracht, M., Scheurich, P., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200401036 · Cited by 257 · see citing works
Self-citation
Serum Interleukin-8 Reflects Tumor Burden and Treatment Response across Malignancies of Multiple Tissue Origins
Sanmamed, M. F., Carranza-Rua, O., Alfaro, C., Oñate, C., Martín‐Algarra, S., Pérez, G., Landazuri, S. F., González, Á., Groß, S., Rodríguez, I., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-3203 · Cited by 256 · see citing works
The role of interleukin-8 in cancer cells and microenvironment interaction
Yuan, A. (2005) · Frontiers in bioscience · doi:10.2741/1579 · Cited by 253 · see citing works
Characterisation and expression analysis of the interleukin genes, IL-1β, IL-8 and IL-10, in Atlantic cod (Gadus morhua L.)
Seppola, M., Larsen, A. N., Steiro, K., Robertsen, B., & Jensen, I. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.08.003 · Cited by 251 · see citing works
Inflammation and Extracellular Matrix Degradation Mediated by Activated Transcription Factors Nuclear Factor-κB and Activator Protein-1 in Inflammatory Acne Lesions in Vivo
Kang, S., Cho, S., Chung, J. H., Hammerberg, C., Fisher, G. J., & Voorhees, J. J. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62479-0 · Cited by 251 · see citing works
Activation of Proinflammatory Responses in Cells of the Airway Mucosa by Particulate Matter: Oxidant- and Non-Oxidant-Mediated Triggering Mechanisms
Øvrevik, J., Refsnes, M., Låg, M., Holme, J. A., & Schwarze, P. E. (2015) · Biomolecules · doi:10.3390/biom5031399 · Cited by 240 · see citing works
Lead (Pb) Exposure Enhances Expression of Factors Associated with Inflammation
Metryka, E., Chibowska, K., Gutowska, I., Falkowska, A., Kupnicka, P., Barczak, K., Chlubek, D., & Baranowska‐Bosiacka, I. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061813 · Cited by 237 · see citing works
Curcumin‐induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IκB kinase and nuclear factor κB activity and are independent of the B‐Raf/mitogen‐activated/extracellular signal‐regulated protein kinase pathway and the Akt pathway
Siwak, D. R., Shishodia, S., Aggarwal, B. B., & Kurzrock, R. (2005) · Cancer · doi:10.1002/cncr.21216 · Cited by 235 · see citing works
Macrolide antibiotics as immunomodulatory medications: Proposed mechanisms of action
Shinkai, M., Henke, M. O., & Rubin, B. K. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.11.001 · Cited by 228 · see citing works
Synergy in cytokine and chemokine networks amplifies the inflammatory response
Gouwy, M., Struyf, S., Proost, P., & Damme, J. V. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.03.005 · Cited by 224 · see citing works
Differential cytokine and chemokine responses of bovine mammary epithelial cells to Staphylococcus aureus and Escherichia coli
Lahouassa, H., Moussay, E., Rainard, P., & Riollet, C. (2007) · Cytokine · doi:10.1016/j.cyto.2007.04.006 · Cited by 219 · see citing works
Role of Inflammatory Pathways, Blood Mononuclear Cells, and Gut-Derived Bacterial Products in Alcohol Dependence
Leclercq, S., De Saeger, C., Delzenne, N., de Timary, P., & Stärkel, P. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.02.003 · Cited by 216 · see citing works
Mast cells induce epithelial-to-mesenchymal transition and stem cell features in human thyroid cancer cells through an IL-8–Akt–Slug pathway
Visciano, C., Liotti, F., Prevete, N., Calı̀, G., Franco, R., Collina, F., de Paulis, A., Marone, G., Santoro, M. M., & Melillo, R. M. (2015) · Oncogene · doi:10.1038/onc.2014.441 · Cited by 214 · see citing works
Inflammatory parameters in Caco-2 cells: effect of stimuli nature, concentration, combination and cell differentiation.
Walle, J. V. D., Hendrickx, A., Romier, B., Larondelle, Y., & Schneider, Y. (2010) · Toxicology in Vitro · doi:10.1016/j.tiv.2010.04.002 · Cited by 196 · see citing works
Novel host response therapeutic approaches to treat periodontal diseases
Kirkwood, K. L., Cirelli, J. A., Rogers, J. E., & Giannobile, W. V. (2007) · Periodontology 2000 · doi:10.1111/j.1600-0757.2006.00166.x · Cited by 210 · see citing works
Hypoxia Increases Resistance of Human Pancreatic Cancer Cells to Apoptosis Induced by Gemcitabine
Yokoi, K., & Fidler, I. J. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0488 · Cited by 199 · see citing works
Gene Array Expression Profiling in Acne Lesions Reveals Marked Upregulation of Genes Involved in Inflammation and Matrix Remodeling
Trivedi, N. R., Gilliland, K. L., Zhao, W., Liu, W., & Thiboutot, D. M. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700213 · Cited by 196 · see citing works
Drug-Induced Nephrotoxicity: Clinical Impact and Preclinicalin VitroModels
Tiong, H. Y., Huang, P., Xiong, S., Li, Y., Vathsala, A., & Zink, D. (2014) · Molecular Pharmaceutics · doi:10.1021/mp400720w · Cited by 193 · see citing works
Nuclear Localization of Dengue Virus Nonstructural Protein 5 Through Its Importin α/β–Recognized Nuclear Localization Sequences is Integral to Viral Infection
Pryor, M. J., Rawlinson, S. M., Butcher, R. E., Barton, C. L., Waterhouse, T. A., Vasudevan, S. G., Bardin, P. G., Wright, P. J., Jans, D. A., & Davidson, A. D. (2007) · Traffic · doi:10.1111/j.1600-0854.2007.00579.x · Cited by 191 · see citing works
Role of Human CD36 in Bacterial Recognition, Phagocytosis, and Pathogen-Induced JNK-Mediated Signaling
Baranova, I. N., Kurlander, R. J., Bocharov, A. V., Vishnyakova, T. G., Chen, Z., Remaley, A. T., Csákó, G., Patterson, A. P., & Eggerman, T. L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.7147 · Cited by 184 · see citing works
Liver fibrosis and inflammation. A review
Stalnikowitz, D. K., & Weissbrod, A. B. (2003) · Annals of Hepatology · doi:10.1016/s1665-2681(19)32127-1 · Cited by 183 · see citing works
Acidosis Activation of the Proton-Sensing GPR4 Receptor Stimulates Vascular Endothelial Cell Inflammatory Responses Revealed by Transcriptome Analysis
Dong, L., Li, Z., Leffler, N. R., Asch, A. S., Chi, J., & Yang, L. V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061991 · Cited by 181 · see citing works
Kaposi's sarcoma-associated herpesvirus infection of blood endothelial cells induces lymphatic differentiation
Carroll, P. A., Brazeau, E., & Lagunoff, M. (2004) · Virology · doi:10.1016/j.virol.2004.07.008 · Cited by 181 · see citing works
Nutrient Modification of the Innate Immune Response
Schwartz, E. A., Zhang, W.-Y., Karnik, S. K., Borwege, S., Anand, V. R., Laine, P. S., Su, Y., & Reaven, P. D. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.201681 · Cited by 180 · see citing works
Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin
Elmezayen, R., Gazzar, M. E., Seeds, M. C., McCall, C. E., Dreskin, S. C., & Nicolls, M. R. (2007) · Immunology Letters · doi:10.1016/j.imlet.2007.04.011 · Cited by 178 · see citing works
Activated human astrocyte‐derived extracellular vesicles modulate neuronal uptake, differentiation and firing
You, Y., Borgmann, K., Edara, V. V., Stacy, S., Ghorpade, A., & Ikezu, T. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1706801 · Cited by 176 · see citing works
Effects of vitamin C on intracytoplasmic cytokine production in human whole blood monocytes and lymphocytes
Härtel, C., Strunk, T., Bucsky, P., & Schultz, C. (2004) · Cytokine · doi:10.1016/j.cyto.2004.02.004 · Cited by 175 · see citing works
Tumor Cell Apoptosis Polarizes Macrophages—Role of Sphingosine-1-Phosphate
Weigert, A., Tzieply, N., von Knethen, A., Johann, A. M., Schmidt, H., Geißlinger, G., & Brüne, B. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-12-1096 · Cited by 171 · see citing works
The House Dust Mite Allergen Der p 1, Unlike Der p 3, Stimulates the Expression of Interleukin-8 in Human Airway Epithelial Cells via a Proteinase-activated Receptor-2-independent Mechanism
Adam, E., Hansen, K. K., Astudillo, O., Coulon, L., Bex, F., Duhant, X., Jaumotte, E., Hollenberg, M. D., & Jacquet, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507140200 · Cited by 166 · see citing works
Influence of apple polyphenols on inflammatory gene expression
Jung, M., Triebel, S., Anke, T., Richling, E., & Erkel, G. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800575 · Cited by 161 · see citing works
Parthenolide Inhibits IκB Kinase, NF-κB Activation, and Inflammatory Response in Cystic Fibrosis Cells and Mice
Saadane, A., Masters, S., DiDonato, J. A., Li, J., & Berger, M. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0323oc · Cited by 161 · see citing works
Radiotherapy orchestrates natural killer cell dependent antitumor immune responses through CXCL8
Walle, T., Kraske, J. A., Liao, B., Lenoir, B., Timke, C., Halbach, E. V. B. U., Tran, F., Griebel, P., Albrecht, D., Ahmed, A., et al. (2022) · Science Advances · doi:10.1126/sciadv.abh4050 · Cited by 158 · see citing works
Post-transcriptional control during chronic inflammation and cancer: a focus on AU-rich elements
Khabar, K. S. A. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0383-x · Cited by 157 · see citing works
A novel purified Lactobacillus acidophilus 20079 exopolysaccharide, LA-EPS-20079, molecularly regulates both apoptotic and NF-κB inflammatory pathways in human colon cancer
El-Deeb, N., Yassin, A. M., Al-Madboly, L. A., & El-Hawiet, A. M. (2018) · Microbial Cell Factories · doi:10.1186/s12934-018-0877-z · Cited by 144 · see citing works
Cytokine gene expression in human skeletal muscle during concentric contraction: evidence that IL-8, like IL-6, is influenced by glycogen availability
Chan, S. M. H., Carey, A. L., Watt, M. J., & Febbraio, M. A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00030.2004 · Cited by 156 · see citing works
Macrolide antibiotics modulate ERK phosphorylation and IL-8 and GM-CSF production by human bronchial epithelial cells
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Self-citation

Authors: Hoffmann, E., Dittrich-Breiholz, O., Holtmann, H., & Kracht, M.
Affiliations: Medizinische Hochschule Hannover (DE)
Institute of Pharmacology, Medical School Hannover , Germany
Corresponding author: Kracht, Michael
ORCID: Hoffmann, Elke
Kracht, Michael
Venue: Journal of Leukocyte Biology
Publisher: Oxford University Press (OUP)
Published: 2002-11-01
Volume: 72
Issue: 5
Pages: 847-855
ISSN: 0741-5400 (ISSN-L)
1938-3673
DOI: 10.1189/jlb.72.5.847
OpenAlex: W2149122802
Cited by: 1,058
References: 87
Citations by year: 2026: 15 · 2025: 20 · 2024: 17 · 2023: 35 · 2022: 37 · 2021: 35 · 2020: 31 · 2019: 35 · 2018: 37 · 2017: 39 · 2016: 49 · 2015: 79 · 2014: 64 · 2013: 54 · 2012: 39
FWCI: 17.59
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Journal of Leukocyte Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Keywords: interleukin-8, chemokines, gene expression regulation, transcriptional activation, NF-κB, JNK signaling, p38 MAPK, mRNA stabilization, inflammatory cytokines, chemokine induction, leukocyte recruitment
MeSH terms: Animals, Base Sequence, DNA-Binding Proteins, Gene Expression Regulation, Humans, Molecular Sequence Data, Repressor Proteins, Transcription Factors, Transcription, Genetic, Signal Transduction, Transcriptional Activation, Interleukin-8, NF-kappa B, RNA Stability, Mitogen-Activated Protein Kinases, MAP Kinase Kinase Kinases, Mice

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Multiple control of interleukin-8 gene expression

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