The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Human Tribbles, a Protein Family Controlling Mitogen-activated Protein Kinase Cascades
Open accessAbstract
Control of mitogen-activated protein kinase (MAPK) cascades is central to regulation of many cellular responses. We describe here human tribbles homologues (Htrbs) that control MAPK activity. MAPK kinases interact with Trbs and regulate their steady state levels. Further, Trbs selectively regulate the activation of extracellular signal-regulated kinases, c-Jun NH2-terminal kinases, and p38 MAPK with different relative levels of activity for the three classes of MAPK observed depending on the level of Trb expression. These results suggest that Trbs control both the extent and the specificity of MAPK kinase activation of MAPK.
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Cites
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,287
Mitogen-activated protein kinase pathways
Robinson, M. J., & Cobb, M. H. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80061-0 · Cited by 2,474
The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation
Hoffmann, A., Levchenko, A., Scott, M. L., & Baltimore, D. (2002) · Science · doi:10.1126/science.1071914 · Cited by 1,858
Organization and regulation of mitogen-activated protein kinase signaling pathways
Garrington, T. P., & Johnson, G. L. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80028-3 · Cited by 1,275
TRB3: A tribbles Homolog That Inhibits Akt/PKB Activation by Insulin in Liver
Du, K., Herzig, S., Kulkarni, R. N., & Montminy, M. (2003) · Science · doi:10.1126/science.1079817 · Cited by 842
Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase
Bulavin, D. V., Higashimoto, Y., Popoff, I. J., Gaarde, W. A., Basrur, V., Potapova, O., Appella, E., & Fornace, A. J. (2001) · Nature · doi:10.1038/35075107 · Cited by 532
Levchenko, A., Bruck, J., & Sternberg, P. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.11.5818 · Cited by 486
The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins
Yasuda, J., Whitmarsh, A. J., Cavanagh, J., Sharma, M., & Davis, R. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.10.7245 · Cited by 458
Molecular mechanism of interleukin-8 gene expression
Mukaida, N., Okamoto, S.-I., Ishikawa, Y., & Matsushima, K. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.56.5.554 · Cited by 452
Roulston, A., Reinhard, C., Amiri, P., & Williams, L. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10232 · Cited by 376
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Dastani, Z., Hivert, M.-F., Timpson, N., Perry, J. R. B., Yuan, X., Scott, R. A., Henneman, P., Heid, I. M., Kizer, J. R., Lyytikäinen, L.-P., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002607 · Cited by 494
Distinct Innate Immune Responses to Infection and Wounding in the C. elegans Epidermis
Pujol, N., Cypowyj, S., Ziegler, K., Millet, A., Astrain, A., Goncharov, A., Jin, Y., Chisholm, A. D., & Ewbank, J. J. (2008) · Current Biology · doi:10.1016/j.cub.2008.02.079 · Cited by 320
Ni, Y. G., Wang, N., Cao, D. J., Sachan, N., Morris, D. J., Gerard, R. D., Kuro-o, M., Rothermel, B. A., & Hill, J. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610290104 · Cited by 279
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Metadata
- Authors
- Kiss-Toth, E., Bagstaff, S. M., Sung, H. Y., Jozsa, V., Dempsey, C., Caunt, J. C., Oxley, K. M., Wyllie, D. H., Polgar, T., Harte, M., O'Neill, L. A. J., Qwarnstrom, E. E., & Dower, S. K.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2004-10
- Volume
- 279
- Issue
- 41
- Pages
- 42703-42708
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2157845607
- Cited by
- 300
- References
- 33
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Human Tribbles, a Protein Family Controlling Mitogen-activated Protein Kinase Cascades. https://app.cochat.ai/papers/10.1074/jbc.m407732200
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- Kiss-Toth, E., Bagstaff, S. M., Sung, H. Y., Jozsa, V., Dempsey, C., Caunt, J. C., Oxley, K. M., Wyllie, D. H., Polgar, T., Harte, M., O'Neill, L. A. J., Qwarnstrom, E. E., & Dower, S. K. (2004). Human Tribbles, a Protein Family Controlling Mitogen-activated Protein Kinase Cascades. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m407732200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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