The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Studies with IL-10-/- mice: an overview
Abstract
Our studies have elucidated, in part, the mechanism whereby persistent stimulation by normal enteric antigens leads to the development of chronic enterocolitis in interleukin 10-deficient (IL-10-/-) mice. This disease is mediated by IL-10-/-CD4+ T cells as evidenced by their ability to transfer colitis to immunodeficient RAG-2-/-mice. Furthermore, the CD4+ T cells recovered from the affected colons of IL-10-/- mice consisted of a highly polarized Th1-like population because they produced interferon-γ (IFN-γ) but not IL-4. We found that enterocolitis could be prevented if 3-week-old mutants were treated for 6–8 weeks with either anti-IL-12 or anti-IFN-γ monoclonal antibodies (mAb). These results were consistent with the findings of in vitro studies suggesting that IFN-γ and, in particular, IL-12 direct the differentiation of naive T cells toward a Th1 phenotype. Apparently, the uncontrolled production of IL-12 and IFN-γ by accessory cells and T cells, respectively, in IL-10-/- mice ultimately resulted in the excessive generation and activation of Th1 cells, hence, immunopathology. IL-10-/- mice have also been used to evaluate the importance of IL-10 in regulating immune responses outside of the gastrointestinal (GI) tract. In these studies, IL-10-/-mice were challenged with a variety of foreign antigens using different routes of administration. In general, the results repeatedly demonstrated that a major function of IL-10 is to protect the host from the harmful side effects of an overly zealous immuneinflammatory response. However, other studies have confirmed speculations that the potent immunosuppressive activities of IL-10 may, under certain circumstances, increase the host's susceptibility to infection with certain types of pathogenic organisms.
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Cites
Interleukin-10-deficient mice develop chronic enterocolitis
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Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
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Interleukin 10 protects mice from lethal endotoxemia.
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Cited by
IL-17 family cytokines and the expanding diversity of effector T cell lineages
Weaver, C. T., Hatton, R. D., Mangan, P. R., & Harrington, L. E. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141557 · Cited by 1,842
Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10
Steidler, L., Hans, W., Schotte, L., Neirynck, S., Obermeier, F., Falk, W., Fiers, W., & Remaut, E. (2000) · Science · doi:10.1126/science.289.5483.1352 · Cited by 1,513
Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5224-5231.1998 · Cited by 1,483
Self-citationGrimbaldeston, M. A., Nakae, S., Kalesnikoff, J., Tsai, M., & Galli, S. J. (2007) · Nature Immunology · doi:10.1038/ni1503 · Cited by 485
Elson, C. O., Cong, Y., McCracken, V. J., Dimmitt, R. A., Lorenz, R. G., & Weaver, C. T. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00291.x · Cited by 469
Metadata
- Authors
- Rennick, D. M., Fort, M. M., & Davidson, N. J.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-04-01
- Volume
- 61
- Issue
- 4
- Pages
- 389-396
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W1832936335
- Cited by
- 302
- References
- 37
- FWCI
- 9.49
- Type
- journal article
- Language
- en
- Open access
- closed
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