Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

Sellon, Rance K.; Tonkonogy, Susan; Schultz, Michael; Dieleman, Levinus A.; Grenther, Wetonia; Balish, Ed; Rennick, Donna M.; Sartor, R. Balfour

doi:10.1128/iai.66.11.5224-5231.1998

Cited by 1,483Inflammatory Bowel DiseaseGut microbiota and healthT-cell and B-cell Immunology

Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

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Sellon, Rance K., Tonkonogy, Susan, Schultz, Michael, Dieleman, Levinus A., Grenther, Wetonia, Balish, Ed, Rennick, Donna M., Sartor, R. Balfour·1998·Infection and Immunity

DOI 10.1128/iai.66.11.5224-5231.1998PMC PMC108652

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Abstract

Mice with targeted deletion of the gene for interleukin-10 (IL-10) spontaneously develop enterocolitis when maintained in conventional conditions but develop only colitis when kept in specific-pathogen-free (SPF) environments. This study tested the hypothesis that enteric bacteria are necessary for the development of spontaneous colitis and immune system activation in IL-10-deficient mice. IL-10-deficient mice were maintained in either SPF conditions or germfree conditions or were populated with bacteria known to cause colitis in other rodent models. IL-10-deficient mice kept in SPF conditions developed colitis in all segments of the colon (cecum and proximal and distal colon). These mice exhibited immune system activation as evidenced by increased expression of CD44 on CD4 + T cells; increased mesenteric lymph node cell numbers; and increased production of immunoglobulin A (IgA), IgG1, and IL-12 p40 from colon fragment cultures. Mice populated with bacterial strains, including Bacteroides vulgatus , known to induce colitis in other rodent models had minimal colitis. Germfree IL-10-deficient mice had no evidence of colitis or immune system activation. We conclude therefore that resident enteric bacteria are necessary for the development of spontaneous colitis and immune system activation in IL-10-deficient mice.

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Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect. Immun
Sellon, R. K., Tonkonogy, S. L., Schultz, M., Rennick, M., Sartor, R. B., Schultz, M., Dieleman, L. A., Grenther, W. B., & Rennick, D. M. (1998)
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Self-citation

Authors: Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B.
Affiliations: Department of Companion Animal and Special Species1 and
North Carolina State University (US)
University of North Carolina at Chapel Hill (US)
Departments of Surgery and Microbiology, University of Wisconsin, Madison, Wisconsin,4 and
Department of Immunology, DNAX Corporation, Palo Alto, California5
ORCID: Schultz, Michael
Dieleman, Levinus A.
Sartor, R. Balfour
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 1998-11
Volume: 66
Issue: 11
Pages: 5224-5231
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.66.11.5224-5231.1998
PMC: PMC108652
OpenAlex: W2165528446
Cited by: 1,483
References: 56
Citations by year: 2026: 24 · 2025: 26 · 2024: 37 · 2023: 34 · 2022: 48 · 2021: 48 · 2020: 42 · 2019: 71 · 2018: 61 · 2017: 55 · 2016: 61 · 2015: 73 · 2014: 89 · 2013: 77 · 2012: 70
FWCI: 15.03
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
PubMed Central (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: interleukin-10 deficiency, spontaneous colitis, enteric bacteria, germ-free mice, specific pathogen-free mice, immune activation, Bacteroides vulgatus, CD4+ T cells, CD44, mesenteric lymph nodes, immunoglobulin A, IL-12p40
MeSH terms: Animals, Colitis, Disease Models, Animal, Enterobacteriaceae, Immune System, Inflammation, Intestine, Large, Lymphocyte Activation, Mice, Inbred C57BL, Specific Pathogen-Free Organisms, Interleukin-10, Mice, Knockout, Mice

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Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

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