The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Overview of interleukin-18: more than an interferon-γ inducing factor
Abstract
Initially described in 1989 as interferon-γ (IFN-γ) inducing factor (IGIF), interleukin-18 (IL-18) is a novel proinflammatory cytokine that is clearly more than an inducer of IFN-γ The cytokine possesses several biological properties such as activation of nuclear factor-κB (NF-κB), Fas ligand expression, the induction of both CC and CXC chemokines, and increased production of competent human immunodeficiency virus. Most activities are due to a receptor complex that recruits the IL-1 receptor-activating kinase (IRAK), leading to translocation of NF-κB. This property and others support the concept that IL-18 is related to the IL-1 family. Indeed, one of the IL-18 receptor chains is the IL-1 receptor-related protein, a member of the IL-1R family. In addition, IL-18 is structurally similar to IL-1β and like IL-1β is first synthesized as a leaderless precursor requiring the IL-1β converting enzyme for cleavage into an active molecule. The biology of IL-18 is reviewed in the overview and the implication for a role for this cytokine in disease is presented.
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Citations
Cites
Biologic basis for interleukin-1 in disease.
Dinarello, C. (1996) · Blood · doi:10.1182/blood.v87.6.2095.bloodjournal8762095 · Cited by 4,344
Self-citationHuman ICE/CED-3 Protease Nomenclature
Alnemri, E. S., Livingston, D. J., Nicholson, D. W., Salvesen, G., Thornberry, N. A., Wong, W. W., & Yuan, J. (1996) · Cell · doi:10.1016/s0092-8674(00)81334-3 · Cited by 2,372
Elliott, M. J., Maini, R. N., Feldmann, M., Kalden, J. R., Antoni, C., Smolen, J. S., Leeb, B., Breedveld, F. C., Macfarlane, J. D., Bijl, J. A., et al. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90628-9 · Cited by 1,682
Moreland, L. W., Baumgartner, S. W., Schiff, M. H., Tindall, E. A., Fleischmann, R. M., Weaver, A. L., Ettlinger, R. E., Cohen, S., Koopman, W. J., Mohler, K., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707173370301 · Cited by 1,622
Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production
Ghayur, T., Banerjee, S., Hugunin, M., Butler, D., Herzog, L., Carter, A., Quintal, L., Sekut, L., Talanian, R., Paskind, M., et al. (1997) · Nature · doi:10.1038/386619a0 · Cited by 1,203
Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme
Gu, Y., Kuida, K., Tsutsui, H., Ku, G., Hsiao, K., Fleming, M. A., Hayashi, N., Higashino, K., Okamura, H., Nakanishi, K., et al. (1997) · Science · doi:10.1126/science.275.5297.206 · Cited by 1,155
Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2)
van Dullemen, H. M., van Deventer, S. J. H., Hommes, D. W., Bijl, H. A., Jansen, J., Tytgat, G. N. J., & Woody, J. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90277-5 · Cited by 1,084
Ferber, I. A., Brocke, S., Taylor-Edwards, C., Ridgway, W., Dinisco, C., Steinman, L., Dalton, D., & Fathman, C. G. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.1.5 · Cited by 989
Robinson, D., Shibuya, K., Mui, A., Zonin, F., Murphy, E., Sana, T., Hartley, S. B., Menon, S., Kastelein, R., Bazan, F., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80378-7 · Cited by 720
The human interferon $alpha;/$beta; receptor: Characterization and molecular cloning
NOVICK, D. (1994) · Cell · doi:10.1016/0092-8674(94)90154-6 · Cited by 667
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Cited by
Interleukin-18 Regulates Both Th1 and Th2 Responses
Nakanishi, K., Yoshimoto, T., Tsutsui, H., & Okamura, H. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.423 · Cited by 1,315
Interleukin-1 and neuronal injury
Allan, S. M., Tyrrell, P. J., & Rothwell, N. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1664 · Cited by 992
Interleukin‐18: Biological properties and role in disease pathogenesis
Kaplanski, G. (2018) · Immunological Reviews · doi:10.1111/imr.12616 · Cited by 606
Innate Immunity to Mycobacterium tuberculosis
van Crevel, R., Ottenhoff, T. H. M., & van der Meer, J. W. M. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.2.294-309.2002 · Cited by 598
Pizarro, T. T., Michie, M. H., Bentz, M., Woraratanadharm, J., Smith, M. F., Foley, E., Moskaluk, C. A., Bickston, S. J., & Cominelli, F. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.11.6829 · Cited by 572
Metadata
- Authors
- Dinarello, C. A., Novick, D., Puren, A. J., Fantuzzi, G., Shapiro, L., Mühl, H., Yoon, D.-Y., Reznikov, L. L., Kim, S.-H., & Rubinstein, M.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-06-01
- Volume
- 63
- Issue
- 6
- Pages
- 658-664
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W1900281246
- Cited by
- 374
- References
- 47
- FWCI
- 14.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dinarello, C. A., Novick, D., Puren, A. J., Fantuzzi, G., Shapiro, L., Mühl, H., Yoon, D.-Y., Reznikov, L. L., Kim, S.-H., & Rubinstein, M. (1998). Overview of interleukin-18: more than an interferon-γ inducing factor. Journal of Leukocyte Biology. https://doi.org/10.1002/jlb.63.6.658
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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