The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Phase I clinical evaluation of a new iron oxide MR contrast agent
Abstract
The safety and magnetic resonance (MR) imaging potential of BMS 180549, a new superparamagnetic iron oxide contrast agent, were evaluated in a phase I, open‐label, placebo‐controlled study involving 41 healthy subjects. No clinically significant postdose changes in physical examination findings, vital signs, or electrocardiogram results were reported for any of the subjects evaluated. No clinically significant changes in clinical laboratory values were noted by the investigators. Fourteen adverse events considered not serious and considered possibly or definitely related to the drug were reported, three of which required minor treatment. Relaxation time measurements in plasma samples showed a strong, dose‐dependent, and persistent decrease in T1 and T2 values. Significant changes in MR signal intensity of the blood pool and wellperfused organs (liver and spleen) were noted on both T1‐ and T2‐weighted images. Changes in signal intensity of cervical lymph nodes were also observed at the higher doses and late postdose imaging times.
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Cites
Marchal, G., Van Hecke, P., Demaerel, P., Decrop, E., Kennis, C., Baert, A., & van der Schueren, E. (1989) · American Journal of Roentgenology · doi:10.2214/ajr.152.4.771 · Cited by 122
Cited by
Laurent, S., Forge, D., Port, M., Roch, A., Robic, C., Vander Elst, L., & Muller, R. N. (2008) · Chemical Reviews · doi:10.1021/cr068445e · Cited by 6,852
Wang, Y.-X. J., Hussain, S. M., & Krestin, G. P. (2001) · European Radiology · doi:10.1007/s003300100908 · Cited by 1,381
In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles
Arami, H., Khandhar, A., Liggitt, D., & Krishnan, K. M. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00541h · Cited by 830
Clinical Translation of Nanomedicine
Min, Y., Caster, J. M., Eblan, M. J., & Wang, A. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00116 · Cited by 772
Characterization of aqueous dispersions of Fe3O4 nanoparticles and their biomedical applications
Cheng, F.-Y., Su, C.-H., Yang, Y.-S., Yeh, C.-S., Tsai, C.-Y., Wu, C.-L., Wu, M.-T., & Shieh, D.-B. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.03.016 · Cited by 668
Metadata
- Authors
- McLachlan, S. J., Morris, M. R., Lucas, M. A., Fisco, R. A., Eakins, M. N., Fowler, D. R., Scheetz, R. B., & Olukotun, A. Y.
- Venue
- Journal of Magnetic Resonance Imaging
- Publisher
- Wiley
- Published
- 1994-05
- Volume
- 4
- Issue
- 3
- Pages
- 301-307
- ISSN
- 1053-1807 (ISSN-L)
- 1522-2586
- OpenAlex
- W1981616235
- Cited by
- 194
- References
- 1
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- McLachlan, S. J., Morris, M. R., Lucas, M. A., Fisco, R. A., Eakins, M. N., Fowler, D. R., Scheetz, R. B., & Olukotun, A. Y. (1994). Phase I clinical evaluation of a new iron oxide MR contrast agent. Journal of Magnetic Resonance Imaging. https://doi.org/10.1002/jmri.1880040313
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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