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Cited by 830Nanoparticle-Based Drug DeliveryCharacterization and Applications of Magnetic NanoparticlesIron Metabolism and Disorders

In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles

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Arami, Hamed, Khandhar, Amit, Liggitt, Denny, Krishnan, Kannan M.·2015·Chemical Society Reviews
DOI 10.1039/c5cs00541hPMC PMC4648695
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Abstract

This review discusses the physiochemical parameters, hindering translation of iron oxide nanoparticles to clinics, using most recent in vivo biodistribution, clearance and toxicity studies.

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  • Toxicological studies on organic and inorganic drug delivery systems revealed neurotoxicity and inflammatory damages in the brain.

    “toxicological studies on organic and inorganic drug delivery systems revealed neurotoxicity and inflammatory damages in the brain.”

    From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [380]

    Section 5.1 (page unavailable) reports that acute oral exposure to iron oxide nanoparticles can inhibit enzyme activities in the brain, supporting a narrower claim of adverse brain effects. But its reported inflammatory effects concern bronchoalveolar lavage fluid, not brain tissue. The review does not establish brain inflammation or the claim’s broader conclusion about both organic and inorganic drug-delivery systems. (LLM, conf=0.82)

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Authors
Arami, H., Khandhar, A., Liggitt, D., & Krishnan, K. M.
Affiliations
  • University of Washington (US)
  • LodeSpin Labs (United States) (US)
Corresponding author
  • Liggitt, Denny
  • Krishnan, Kannan M.
ORCID
Venue
Chemical Society Reviews
Publisher
Royal Society of Chemistry (RSC)
Published
2015
Volume
44
Issue
23
Pages
8576-8607
ISSN
  • 0306-0012 (ISSN-L)
  • 1460-4744
DOI
10.1039/c5cs00541h
PMC
PMC4648695
OpenAlex
W1707007402
Cited by
830
References
13
Citations by year
2026: 45 · 2025: 71 · 2024: 79 · 2023: 70 · 2022: 84 · 2021: 103 · 2020: 98 · 2019: 103 · 2018: 73 · 2017: 59 · 2016: 42 · 2015: 3
FWCI
3.56
Type
journal article
Language
en
Open access
Locations
  • Chemical Society Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (1R41EB013520-01, 1RO1EB013689-01, 2R42EB013520-02A1)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords
iron oxide nanoparticles, pharmacokinetics, tissue distribution, nanoparticle toxicity, nanoparticle design, surface coating, plasma protein adsorption, biological barriers, drug delivery, MRI contrast agents, nanocarriers
MeSH terms
Administration, Oral, Animals, Cell Line, Ferric Compounds, Humans, Tissue Distribution, Mice, Rats, Magnetite Nanoparticles, Administration, Intravenous

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