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Understanding pulsed magnetization transfer
Abstract
Using a two‐pool exchange model of magnetization transfer (MT), numeric simulations were developed to predict the time dependence of longitudinal magnetization in both semisolid and liquid pools for arbitrary pulsed radiofrequency (RF) irradiation. Whereas RF excitation of the liquid pool was modeled using the time‐dependent Bloch equations, RF saturation of the semi‐solid pool was described by a time‐dependent rate proportional to both the absorption lineshape of the semisolid pool and the square of the RF pulse amplitude. Simulations show good agreement with experimental results for a 4% agar gel aqueous system in which the two‐pool kinetics have been well studied previously. These simulations provide a method for interpreting pulsed MT effects, are easily extended to biologic tissues, and provide a basis for optimizing clinical imaging applications that exploit MT contrast.
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Cited by
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van Zijl, P. C. M., & Yadav, N. N. (2011) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22761 · Cited by 1,155
Quantitative imaging of magnetization transfer exchange and relaxation properties in vivo using MRI
Sled, J. G., & Pike, G. B. (2001) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1278 · Cited by 419
Helms, G., Dathe, H., Kallenberg, K., & Dechent, P. (2008) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21732 · Cited by 332
Heterogeneity in age-related white matter changes
Schmidt, R., Schmidt, H., Haybaeck, J., Loitfelder, M., Weis, S., Cavalieri, M., Seiler, S., Enzinger, C., Ropele, S., Erkinjuntti, T., et al. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0851-x · Cited by 328
Gelman, N., Ewing, J. R., Gorell, J. M., Spickler, E. M., & Solomon, E. G. (2001) · Magnetic Resonance in Medicine · doi:10.1002/1522-2594(200101)45:1<71::aid-mrm1011>3.0.co;2-2 · Cited by 268
Metadata
- Authors
- Graham, S. J., & Henkelman, R. M.
- Venue
- Journal of Magnetic Resonance Imaging
- Publisher
- Wiley
- Published
- 1997-09
- Volume
- 7
- Issue
- 5
- Pages
- 903-912
- ISSN
- 1053-1807 (ISSN-L)
- 1522-2586
- OpenAlex
- W2004135386
- Cited by
- 159
- References
- 0
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Graham, S. J., & Henkelman, R. M. (1997). Understanding pulsed magnetization transfer. Journal of Magnetic Resonance Imaging. https://doi.org/10.1002/jmri.1880070520
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
