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Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: A proton MR spectroscopy study
Open accessAbstract
Purpose: To use proton magnetic resonance spectroscopy ( 1 H‐MRS) to evaluate vertebral marrow fat, and to determine whether bone density correlates with fat content and fat unsaturation levels in postmenopausal women. Materials and Methods: Fifty‐three women (mean age = 70 years) underwent dual energy x‐ray absorptiometry and 1 H‐MRS, and 12 young female controls (mean age = 28 years) underwent 1 H‐MRS of the lumber spine. Water and lipid peak amplitudes were measured to calculate fat content and fat unsaturation index. Spearman's correlation tests and a t‐test comparison of means were applied. Results: 1 H‐MRS was successful in 15 normal, 15 osteopenic, and 20 osteoporotic subjects, and in all controls. Marrow fat content was significantly elevated in osteoporotic (65.5% ± 10%) and osteopenic (63.5% ± 9.3%) subjects compared to normal subjects (56.3% ± 11.2%) and young controls (29% ± 9.6%). The fat unsaturation index was significantly decreased in osteoporotic (0.091 ± 0.013) and osteopenic (0.097 ± 0.014) subjects compared to normal subjects (0.114 ± 0.016) and young controls (0.127 ± 0.031). A good inverse correlation was observed between the fat content and the unsaturation index (r s = −0.53, P < 0.0001). Conclusion: Osteoporosis is associated with increased marrow fat. As marrow fat increases, saturated lipids appear to increase preferentially to unsaturated lipids. J. Magn. Reson. Imaging 2005;22:279–285. © 2005 Wiley‐Liss, Inc.
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Epidemiology and outcomes of osteoporotic fractures
Cummings, S. R., & Melton, L. J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08657-9 · Cited by 3,821
Schellinger, D., Lin, C. S., Lim, J., Hatipoglu, H. G., Pezzullo, J. C., & Singer, A. J. (2004) · American Journal of Roentgenology · doi:10.2214/ajr.183.6.01831761 · Cited by 132
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Age-related changes in total and regional fat distribution
Kuk, J. L., Saunders, T. J., Davidson, L. E., & Ross, R. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.06.001 · Cited by 778
Scheller, E. L., Doucette, C. R., Learman, B. S., Cawthorn, W. P., Khandaker, S., Schell, B., Wu, B., Ding, S.-Y., Bredella, M. A., Fazeli, P. K., et al. (2015) · Nature Communications · doi:10.1038/ncomms8808 · Cited by 433
Patsch, J. M., Li, X., Baum, T., Yap, S. P., Karampinos, D. C., Schwartz, A. V., & Link, T. M. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1950 · Cited by 332
Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis
Elabd, C., Basillais, A., Beaupied, H., Breuil, V., Wagner, N., Scheideler, M., Zaragosi, L.-E., Massiéra, F., Lemichez, E., Trajanoski, Z., et al. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0127 · Cited by 202
Quantitative imaging techniques for the assessment of osteoporosis and sarcopenia
Guerri, S., Mercatelli, D., Aparisi Gómez, M. P., Napoli, A., Battista, G., Guglielmi, G., & Bazzocchi, A. (2018) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims.2018.01.05 · Cited by 169
Metadata
- Authors
- Yeung, D. K. W., Griffith, J. F., Antonio, G. E., Lee, F. K. H., Woo, J., & Leung, P. C.
- Venue
- Journal of Magnetic Resonance Imaging
- Publisher
- Wiley
- Published
- 2005-07-18
- Volume
- 22
- Issue
- 2
- Pages
- 279-285
- ISSN
- 1053-1807 (ISSN-L)
- 1522-2586
- OpenAlex
- W1993500165
- Cited by
- 477
- References
- 2
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yeung, D. K. W., Griffith, J. F., Antonio, G. E., Lee, F. K. H., Woo, J., & Leung, P. C. (2005). Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: A proton MR spectroscopy study. Journal of Magnetic Resonance Imaging. https://doi.org/10.1002/jmri.20367
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