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Cited by 280

The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.

Combining EEG and fMRI: A multimodal tool for epilepsy research

Open access
Gotman, Jean, Kobayashi, Eliane, Bagshaw, Andrew P., Bénar, Christian‐G., Dubeau, François·2006·Journal of Magnetic Resonance Imaging

Abstract

Patients with epilepsy often present in their electroencephalogram (EEG) short electrical potentials (spikes or spike‐wave bursts) that are not accompanied by clinical manifestations but are of important diagnostic significance. They result from a population of abnormally hyperactive and hypersynchronous neurons. It is not easy to determine the location of the cerebral generators and the other brain regions that may be involved as a result of this abnormal activity. The possibility to combine EEG recording with functional MRI (fMRI) scanning opens the opportunity to uncover the regions of the brain showing changes in the fMRI signal in response to epileptic spikes seen in the EEG. These regions are presumably involved in the abnormal neuronal activity at the origin of epileptic discharges. This paper reviews the methodology involved in performing such studies, particularly the challenge of recording a good quality EEG inside the MR scanner while scanning is taking place, and the methods required for the statistical analysis of the combined EEG and fMRI time series. We review the results obtained in patients with different types of epileptic disorders and discuss the difficult theoretical problems raised by the interpretation of an increase (activation) and decrease (deactivation) in blood oxygen level dependent (BOLD) signal, both frequently seen in response to spikes. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.

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Metadata

Authors
Gotman, J., Kobayashi, E., Bagshaw, A. P., Bénar, C., & Dubeau, F.
Venue
Journal of Magnetic Resonance Imaging
Publisher
Wiley
Published
2006-04-28
Volume
23
Issue
6
Pages
906-920
ISSN
  • 1053-1807 (ISSN-L)
  • 1522-2586
OpenAlex
W2035252615
Cited by
280
References
117
FWCI
13.41
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Combining EEG and fMRI: A multimodal tool for epilepsy research. https://app.cochat.ai/papers/10.1002/jmri.20577
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Gotman, J., Kobayashi, E., Bagshaw, A. P., Bénar, C., & Dubeau, F. (2006). Combining EEG and fMRI: A multimodal tool for epilepsy research. Journal of Magnetic Resonance Imaging. https://doi.org/10.1002/jmri.20577

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