Magnetic resonance elastography of frontotemporal dementia
Open accessAbstract
Purpose: To investigate the feasibility of utilizing brain stiffness as a potential biomarker for behavioral variant frontotemporal dementia (bvFTD) patients. Magnetic resonance elastography (MRE) is a noninvasive technique for evaluating the mechanical properties of brain tissue in vivo. MRE has demonstrated decreased brain stiffness in patients with Alzheimer's disease. Materials and Methods: We examined five male subjects with bvFTD and nine cognitively normal age‐matched male controls (NC) with brain 3T MRE. Stiffness was calculated in nine regions of interest (ROIs): whole brain (entire cerebrum excluding cerebellum), frontal lobes, occipital lobes, parietal lobes, temporal lobes, deep gray matter / white matter (GM/WM; insula, deep gray nuclei and white matter tracts), cerebellum, sensorimotor cortex (pre‐ and postcentral gyri), and a composite region labeled FT (frontal and temporal lobes excluding the pre‐ and postcentral gyri). Results: Significantly lower stiffness values were observed in the whole brain (P = 0.007), frontal lobe (P = 0.001), and temporal lobes (P = 0.005) of bvFTD patients compared to NC. No significant stiffness differences were observed in any other ROIs of bvFTD patients compared to NC (P > 0.05). These results demonstrate that statistically significant brain softening occurs in the frontal and temporal lobes of bvFTD patients, which corresponds to the expected pathophysiology of bvFTD. Conclusion: Future studies evaluating the feasibility of brain MRE for early disease detection and monitoring disease progression could shed new insights into understanding the mechanisms involved in bvFTD. J. Magn. Reson. Imaging 2016;43:474–478.
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Cross-sectional studies detected reduced brain stiffness (magnetic resonance elastography, N = 5), which is hypothesized to occur prior to gliosis and cellular damage.
“reduced brain stiffness, which is hypothesized to occur prior to gliosis and cellular damage (magnetic resonance elastography, N = 5) (Huston et al., 2016)”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Huston et al., 2016
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- Authors
- Huston, J., Murphy, M. C., Boeve, B. F., Fattahi, N., Arani, A., Glaser, K. J., Manduca, A., Jones, D. T., & Ehman, R. L.
- Affiliations
- Mayo Clinic (US)
- University of Pittsburgh (US)
- Corresponding author
- Huston, John
- ORCID
- Venue
- Journal of Magnetic Resonance Imaging
- Publisher
- Wiley
- Published
- 2015-06-30
- Volume
- 43
- Issue
- 2
- Pages
- 474-478
- ISSN
- 1053-1807 (ISSN-L)
- 1522-2586
- PMC
- PMC4696917
- OpenAlex
- W1482687773
- Cited by
- 68
- References
- 30
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 9 · 2022: 6 · 2021: 8 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 9 · 2016: 10
- FWCI
- 6.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Magnetic Resonance Imaging (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (NIH) (R01 EB001981, AG11378)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Ultrasound Imaging and Elastography
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- magnetic resonance elastography, behavioral variant frontotemporal dementia, brain stiffness, cerebral softening, biomarkers, frontal lobe, temporal lobe, cerebellum, sensorimotor cortex, deep gray matter, white matter, early disease detection, disease progression monitoring
- MeSH terms
- Aged, Brain, Brain Mapping, Feasibility Studies, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Reproducibility of Results, Elasticity Imaging Techniques, Frontotemporal Dementia
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