Cited by 7,507Medical Image Segmentation TechniquesBrain Tumor Detection and ClassificationAdvanced MRI Techniques and Applications

Unified segmentation

Ashburner, John, Friston, Karl J.·2005·NeuroImage

Abstract

A probabilistic framework is presented that enables image registration, tissue classification, and bias correction to be combined within the same generative model. A derivation of a log-likelihood objective function for the unified model is provided. The model is based on a mixture of Gaussians and is extended to incorporate a smooth intensity variation and nonlinear registration with tissue probability maps. A strategy for optimising the model parameters is described, along with the requisite partial derivatives of the objective function.

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Crossref · 10.1016/j.neuroimage.2005.02.018

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Authors
Ashburner, J., & Friston, K. J.
Affiliations
National Hospital for Neurology and Neurosurgery (GB)
Corresponding author
Ashburner, John
Venue
NeuroImage
Publisher
Elsevier BV
Published
2005-07
Volume
26
Issue
3
Pages
839-851
ISSN
1053-8119 (ISSN-L)
OpenAlex
W4230920194
Cited by
7,507
References
59
Citations by year
2026: 314 · 2025: 414 · 2024: 450 · 2023: 386 · 2022: 460 · 2021: 507 · 2020: 479 · 2019: 449 · 2018: 434 · 2017: 442 · 2016: 445 · 2015: 458 · 2014: 441 · 2013: 454 · 2012: 380
FWCI
81.00
Type
journal article
Language
en
Open access
closed
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
Wellcome Trust
Topics
  • Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
  • Life Sciences › Neuroscience › Neurology › Brain Tumor Detection and Classification
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
probabilistic segmentation, image registration, tissue classification, bias correction, Gaussian mixture model, nonlinear registration, tissue probability maps, parameter optimization
MeSH terms
Algorithms, Brain Mapping, Data Interpretation, Statistical, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Models, Neurological, Probability Theory, Models, Statistical, Normal Distribution, Likelihood Functions, Fuzzy Logic, Nonlinear Dynamics

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