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Cited by 10Cardiovascular Function and Risk FactorsAdvanced MRI Techniques and ApplicationsCardiac Imaging and Diagnostics

High frame rate cardiac cine MRI for the evaluation of diastolic function and its direct correlation with echocardiography.

Zhang, Jiming, Chen, Jie, Cheong, Benjamin, Pednekar, Amol, Muthupillai, Raja·2019·Journal of Magnetic Resonance Imaging
DOI 10.1002/jmri.26791
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Abstract

Background Breath‐hold cine MR is the method of choice for evaluating left ventricular (LV) systolic function; however, the evaluation of diastolic function remains in the domain of high frame rate echocardiography. Thus, a cine MR technique for simultaneously evaluating LV systolic and diastolic function would be clinically valuable. Purpose To test the feasibility of extracting indices that characterize LV diastolic function from high frame rate cine MR. Study Type Single center, prospective. Population Asymptomatic volunteers (N = 24; age 45.8 ± 12.3 years). Field Strength/Sequence High frame rate (70 fps) cine MR and phase‐contrast MR during free breathing were acquired at 1.5T. Assessment The following MR‐based LV filling metrics were extracted from LV volume changes during the cardiac cycle: 1) the volume–rate ratio, REFP/RLFP (ratio of the peak LV filling rate during the early filling period [EFP] to that during the late filling period [LFP]); and 2) the volume ratio, VEFP/VLFP (the ratio of cumulative LV volume change between the EFP and LFP). These metrics were then compared with traditional transmitral blood flow‐based MR and echocardiographic indices. The effect of temporal resolution on these metrics was also evaluated. Statistical Tests Bland–Altman and linear regression analyses were used to evaluate the performance of the proposed metrics against traditional indices of diastolic function. Results The REFP/RLFP and VEFP/VLFP correlated well with E/AQ‐flow (r 2 = 0.66 and 0.54, respectively) and E/Aecho (r 2 = 0.58 and 0.49, respectively). Systolic indices remained robust (<3% error) for frame rates ≥20 fps. Although the proposed VEFP/VLFP was robust (<5% error) up to 25 fps, the proposed volume–rate diastolic function metrics were less reliable (>8% error) for frame rates below 35 fps. Data Conclusion In asymptomatic volunteers, cardiac cine MR images acquired at frame rates >35 fps can be used to extract LV diastolic function indices from the temporal changes in LV volume. Level of Evidence: 1 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2019;50:1571–1582.

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Authors
Zhang, J., Chen, J., Cheong, B., Pednekar, A., & Muthupillai, R.
Affiliations
  • Department of Diagnostic and Interventional Radiology CHI St. Luke's Health—Baylor St. Luke's Medical Center Houston Texas USA
  • Texas Children's Hospital (US)
Corresponding author
Muthupillai, Raja
ORCID
Venue
Journal of Magnetic Resonance Imaging
Publisher
Wiley
Published
2019-05-21
Volume
50
Issue
5
Pages
1571-1582
ISSN
  • 1053-1807 (ISSN-L)
  • 1522-2586
DOI
10.1002/jmri.26791
OpenAlex
W2945645738
Cited by
10
References
43
Citations by year
2025: 1 · 2024: 1 · 2022: 3 · 2021: 3 · 2020: 2
FWCI
1.45
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Magnetic Resonance Imaging (publishedVersion)
  • PubMed (publishedVersion)
Funders
Texas Heart Institute
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Keywords
left ventricular diastolic function, left ventricular filling, temporal resolution, transmitral blood flow, E/A ratio, phase-contrast MRI, asymptomatic volunteers
MeSH terms
Adult, Algorithms, Diastole, Echocardiography, Feasibility Studies, Female, Heart Ventricles, Humans, Image Interpretation, Computer-Assisted, Male, Middle Aged, Prospective Studies, Stroke Volume, Ventricular Function, Left, Magnetic Resonance Imaging, Cine, Breath Holding, Healthy Volunteers

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